정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

내시경적 점막절제술로 치험한 식도 과립상 세포종 1례

강혁주,김성욱,최석진,이중현,장재식,서영범,윤병구,박건욱,김성자,김용섭,강승완,이구,양창헌,이창우,김욱년,이광헌,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

과립상 세포종은 Schwann 세포 기원으로 생각되며 인체에 비교적 드물게 발생한다. 과립상 세포종은 전신 어느 곳에서나 발견될 수 있으나 주로 혀, 구강, 피부 혹은 유방 등에서 호발하며 드물게 위장관에서 발견된다. 위장관에서는 식도에서 가장 호발하며 다음으로 위, 대장 순이다. 과립상 세포종은 대부분, 특히 위장관에서는 양성이며 소수의 악성 병변이 보고되었다. 이러한 이유와 함께 수술 전의 진단이 어렵기 때문에 과립상 세포종에 대한 근본적인 치료는 현재까지 외과적 절제술이다. 최근에 시도되는 치료방법들로는 내시경적 레이저 치료, 용종절제술, 내시경적 점막 절제술 등이 있다. 저자들은 상부 소화관 내시경검사를 시행하여 식도 과립상 세포종을 진단하고 내시경적 점막 절제술을 시행하여 합병증 없이 퇴원하여 현재 재발없이 경과 관찰중인 1례를 경험하였기에 보고하는 바이다. Granular cell tumors, which occur infrequently, are probably of Schwann cell origin. They can occur almost anywhere in the body but usually affect the tongue, oral cavity, skin, or breasts and are rarely found in the gastrointestinal tracts. The esophagus is the most frequent gastrointestinal site, followed by the stomach and the colon. Granular cell tumors are generally benign, especially in the gastrointestinal tract, some malignant lesions have been reported. For this reason, and also because preoperative diagnosis is difficult, the standard treatment for granular cell tumor has until now been surgical excision. In recent years, other therapeutic methods is endoscopic laser therapy (ELT), polypectiomy, endoscopic mucosal resection (EMR). We report a case of esophageal granular cell tumor which was diagnosed by an endoscopy and managed using an endoscopic mucosal resection without complication.

Reference Map of Soluble Protenis from Salmonella enterica Serovar Enteritidis by Two-Dimensional Electrophoresis

김곤섭,Eung-goo Lee,Yong-hwan Kim,정태성,Yong-seung Shin,Gee-wook Shin,Hui-guen Cha,Mi-rim Park 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Map of Soluble Proteins from Salmonella enterica Serovar Enteritidis byTwo-Dimensional ElectrophoresisMi-rim Park, Eung-goo Lee, Yong-hwan Kim, Tae-sung Jung, Yong-seung Shin, Gee-wook Shin, Hui-guen Cha and Gon-sup Kim*Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju 660-701, KoreaReceived May 17, 2003 / Accepted July 23, 2003J. Vet. Sci. (2003), 4(2), 143-149JOURNAL OFVeterinaryScience*Corresponding author: Gon-sup Kim Laboratory of Veterinary Biochemistry, Collage of Veterinary Medicine, Gyeongsang National University, 900 Gazwa, Jinju 660-701 Korea Tel: +82-55-751-5823, Fax: +82-55-751-5803 E-mail: gonskim@nongae.gsnu.ac.kr

국내 순수 인터넷 기업평가에 관한 탐색적 연구 : An Exploratory Study

김정욱,정승렬,이재정 한국경영과학회 2000 經營 科學 Vol.17 No.3

Due to the potential growing capability that reflects future value, market value of internet business companies (IB) are still evaluated high although major players like Amazon continuously suffer losses. Then, how do investors valuate the potential growing capabilities given that traditional financial/accounting based valuation approaches seem to be inappropriate for IB. This study attempts to provide an answer to this issue. We, therefore, analyzed the predictability of various accounting and non-accounting variables for IB value. These include book value, net income, unique visitors, page view, reach rate, public float and institutional holdings. Because of being in infant stage and difficulties in obtaining necessary web traffic data, samples of 20 pure IB were selected from Korea Stock Exchange Market, KOSDAQ, and informal market. The results of this study showed that web traffic data had the strongest relationship with IB value, in particular, unique visitors and reach rate were found to be best predictors for IB value while page view was reasonable indicator. interestingly, net income was not found to related to IB value. This calls for an attention to the typical characteristics of IB that may hinder the usage of traditional valuation approaches for IB. Another results revealed that none of both public float and institutional holdings was significantly associated with IB value, indicating market's supply-demand factors were less important than traffic information.

파트너십에 의한 지하철 입구 공간의 쌈지공원 설계 및 시공

김승환,강현우,손용욱,박승범,남정칠,이기철,차민준 東亞大學校 建設技術硏究所 2009 硏究論文集 Vol.32 No.2

A pocket park is valued in securing green space in downtown and improving urban view in the aspect of natural and environmental values, and it signifies a lot as the center of local residents’ community and harmony as well. Since subway exits and surroundings that have high portions in taking up street space due to lack of green space in downtown aren't made full use of, valuable pocket park place. Dangni Pocket Park of subway exits is a park completed with cooperative works and partnership by students, specialists, administrative organizations, businesses and civilian organizations, etc. without support of special budget. The study site was finally chosen to the space between exit No.1 of Dangni subway station, after analyzing the surrounding circumstances, availability and accessibility of the space among the several subway station exits of Saha, Dangni, and Hadan Station in Busan Metropolitan city. For the designing process, The Citizens organization for Million Amenity Park performed the planning and project proceeding, and 19 design drafts were proposed during the class of landscape architecture in Dong-a University. Design review panel members discussed to select the best draft in practical and authentical, and the related experts reviewed and revised to present the final design plan. The construction was conducted was performed under the cooperation between the civil, authorities, and industrial organizations, among which Saha District office managed for the waste treatment and maintenance matters. The graduates of landscape architecture department of Dong-a University and related industrial enterprises supplied landscape materials and related labors, were supported by 20 members of GPM, one of clubs of Dong-a University volunteered durig the most of construction progress, completing the Pocket Park of subway exits through partnership.

요꼬가와흡충에 감염된 고양이 소장의 배세표 변화

김병욱,이정빈,조승열 중앙대학교 의과대학 의과학연구소 1983 中央醫大誌 Vol.8 No.3

To observe the chronologic change of goblet cells in the course of experimental metagonimiasis in cat, a total of 6 parasite-free cats were infected with 10,000 metacercariae respectively. The cats were killed on 5, 10, 15 days and 4, 8, 10 weeks after infection. Two normal control cats were also killed to observe the normal histology. Three cm longitudinal samples of small intestine were taken at the initial portion of jujunum and jujuno-ileal junction. The samples were processed by routine histologic technique, and stained with hematoxylin-eosin, alcian blue(pH 1.0)/PAS, alcian blue(pH 2.5)/PAS methods. The obtained results could be summarized as follows: 1. The most prominent pathological change was found at mucosa, especially at villi. The length of villi were shortened, whereas the length of Lieberku¨hn's crypt remained normal or slightly hypertrophied. The reduction of villi length were the most remarkable during the period of 5~15 days after infection. 2. During the course of infection, the goblet cells in villi and crypt decreased in their number. The mucopolysaccharide stainability with alcian blue(pH 1.0 or pH 2.5) or PAS was identical with normal control. The mucopolysaccharide stained positively with alcian blue at pH 2.5 but not at pH 1.0. 3. The number of goblet cells reduced during 5~15 days after infection most significantly. Later than this period, the number returned to normal. The number of globlet cells reduced more significantly at villi than at Lieberku¨hn's crypt. From the above results, the reduction in number of goblet cells at small intestine during the course of experimental metagonimiasis were thought as one of manifestations of mechanical destruction by young and adult worms either at crypt or at intervillous space.

아동의 눈-사지 협응과 물체조작 기술의 관계

김선진,한동욱,박승하,김용호 한국스포츠심리학회 2003 한국스포츠심리학회지 Vol.14 No.2

본 연구의 목적은 아동의 눈-사지 협응 능력과 물체조작 기술의 차이를 알아보고, 두 변인군의 관계를 구명하는 데 있다. 피험자는 남?여 5-10세의 아동 186명을 대상으로 하였다. 눈-사지 협응 능력은 예측 타이밍 능력, 추적 능력, 전신 반응 능력을 측정하여 분석하였으며, 물체조작 기술은 TGMD(Test of Gross Motor Development)에서 제시한 받기, 던지기, 치기, 차기, 튀기기 기술을 평가하였다. 먼저 눈-사지 협응 능력과 물체조작 기술의 연령과 성별에 따른 특성을 알아보기 위해 이원 변량분석을 실시한 결과, 5세의 아동 집단은 전반적으로 수행능력이 6세, 7세, 8세, 9세, 10세의 아동에 비하여 수행능력이 떨어졌으며, 10세의 아동은 다른 연령 집단에 비하여 우수한 수행능력을 나타냈다. 이러한 결과는 5-6세, 9-10세의 연령 시기가 눈-사지 협응 능력과 물체조작 기술이 변화되는 시기임을 나타내주고 있으며 이는 연령에 따른 특징을 보여주는 것이다. 다만 눈-사지 협응 능력과 다르게 물체조작 기술에 있어서는 성별에 따른 수행 능력이 9세와 10세의 연령 집단에 있어서 상반된 특징이 나타났다. 즉 남자 아이들의 경우, 9세의 연령 집단과 비교하여 10세의 연령 집단은 물체조작 기술의 수행 능력이 급격하게 증가한 반면에 여자 아이들은 수행 능력이 떨어지는 특징을 보였다. 또한 눈-사지 협응과 물체 조작 기술간의 관계를 알아보기 위해 정준 상관분석을 실시한 결과, 두 과제간 상관계수 .599로 통계적으로 유의한 상관관계를 보였다. 이러한 결과를 바탕으로 눈-사지 협응 능력과 물체조작 기술의 관계를 설명해 주는 각 변인들의 상대적 기여도를 살펴보면, 눈-사지 협응 능력에서 손과 발을 사용한 예측 타이밍 능력이 추적 및 전신 반응 능력보다 높은 기여도를 보였다. 또한 물체조작 기술에 있어서는 받기와 튀기기 능력이 눈-사지 협응 능력과 물체조작 기술의 상관관계를 설명하는데 많은 기여를 하는 것으로 나타났다. The purpose of this study was to investigate the difference of eye-limb coordination and the object-control skills with age and sex, and examine the relationship between two-variable groups. For this experiment, 186 children with the age of 5 to 10(99 boys and 87 girls) participated in the study. The eye-limb coordination ability(anticipation timing ability, pursuit ability and reaction ability) and the object-control skill(catching skill, throwing skill, striking skill, kicking skill, bouncing skill) suggested in TGMD(Test of Gross Motor Development)were tested. The two-way ANOVA was used to present the characteristics of the eye-limb coordination ability and the object-control skills according to age and sex. As a result, children with the age of 5 demonstrated the lowest performance while children with the age of 10 showed high performance significantly among age groups. The children with the age of 5 to 6 and 9 to 10 were found to be two critical periods of change with age. However, unlike the eye-limb coordination ability, there was a distinctive feature in the object-control skills of the age 9 and 10 over sex. 10 year-old boys showed a radical progress, but the 10 year-old girls showed a decline on the object-control skills compared with the 9 year-old. A canonical correlation analysis was used to examie the relationship between the eye-limb coordination and the object-control skills for the early childhood. The relationship revealed significantly showing canonical correlation with coefficient .599. Overall, the results indicated the eye-limb coordination ability such as anticipation timing ability with hand and foot showed higher role than pursuit and reaction ability. In addition, the object control skills such as catching and bouncing ability contributed importantly in explaining the relationship between the eye-limb coordination ability and the object control skill.