http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
입원중인 정신분열중환자의 약물거부 一투약거부자와 순웅자의 비교
윤진상,김중원 대한신경정신의학회 1988 신경정신의학 Vol.27 No.1
Hospitalized patients with schizophrenic disorder may directly refuse their offered antipsychotic medication. This study was designed to compare the refusers with the compliers in relation to some of the potential risk factors contributing to the refusal. The factors included in the present study were 1) sociodemographic characteristics, 2) the level of psychopathology by the BPRS, 3) the level of satisfaction with therapeutic team and ward environment, 4) the schedule of drug administration,5) the side effects requiring readjustment of the drug, and 6) the subjective response to current medication. 23 hospitalized psychiatric patients who overtly refused antipsychotic medication, and who according to DSM-111 were diagnosed as suffering from schizophrenic disorder,were recognized as the refusers. A sample of 23 compliers, who willingly accepted antipsychotic medication, was matched for age(± 5 years), sex, diagnosis, treatment ward and length of current hospitalization (±7days). The data was mainly collected by the investigator’ s semistructured interview with the patients and by review of medical records. The resurlts were as follow. 1) There was no significant difference in education, marital status, illness duration, frequency of previous psychiatric hospitalization, and type of admission between the two groups. 2) Raings on the BPRS showed the refusers were significantly (p<0.01) more symptomatic than the compliers. The refusers had significantly higher scores on the BPRS for anxiety (p〈0. 05), emotional withdrawal (p<0.005), depressive m ood(p<b.05), hostility (p< 0.05), uncooperativeness( P<0.00l), motor retardation (p<0.05), and blunted affect (p < 0 .0 l). 3) Although there was no significant difference in the level oi satisfaction with therapeutic team and ward environment between the two groups, both groups in general demonstrated satisfaction with the therapeutic team and dissatisfaction with ward environment. 4) Comparison of the prescribed neuroleptic dose per day in Chlorpromazine equivalents for the refusers and compliers showed no significant difference, while the total number of tablets and the frequency of administration each day were significantly (p<0.05, respectively) greater and more frequent in the refusers than in the compliers. 5) Severe side effects requiring readjustment of the current drugs were significantly (p<0.05) more frequently identified in the refusers than in the compliers. 6) Subjective response to their current antipsychotic medication was dysphoric in both groups, but significantly (p<0.05) more dysphoric in the refusers than in the compliers. In summary, our study reveals that drug refusal may result not only from the irrational symptoms of the patients, but also from their reasonable objections. So these findings need to be considered in order to enhance the understanding of durg refusal. In so doing, we might not only improve the clinical aspect of prevention and management of drug refuser, but also safeguard the patientf s rights both to receive and to refuse medication.
건강한 한국 성인에서 ALDH2 유전형에 따라 Metadoxine(Alcotel)이 알코올의 약동학 및 약역학에 미치는 영향
윤진상,윤보현,이용복,신일선,정재성,정원태,시영화 전남대학교 약품개발연구소 2000 약품개발연구지 Vol.9 No.1
Objectives : Mctadoxine is known to have accelerated the metabolism of alcohol in previous studies with Caucasian subjects. The purpose of this study was to evaluate the effects of metadoxine on alcohol pharmacokinetis and pharmacodynamics in normal Korean adults according to the low-Km aldehyde dehydrogenase(ALDH2) genotypes. Methods : Twenty healthy male volunteers(half with active ALDH2*1/*1 : active group, the other with inactive ALDH2*1/*1 : inactive group) were selected by genotyping. In a double-blind, counterbalanced design, can subject ingested 0.5g of alcohol per ㎏ of body weight with pretreatment of metadoxine or placebo on 2 acparate occasions. Blood alcohol concentration by breathanalyzer(BrAC), vital signs, negative physiological response and performance function using a battery of tests(critical flicker fusion threshold : CFFT, choice reaction time : CRT, compensatory tracking task : CTT and digit-symbol substitution : DSS) were measured at baseline and repeatedly over 3-hour period after intake of alcohol. Results : Among the pharmacokinetic parameters, Vmax and Km were significantly increased with pretreatment of metadoxine in both the active and inactive ALDH2 groups, but the ratio of Vmax/Km was decreased. In terms of pharmacodynamics, the pretreatment of metadoxine produced a significant improvement of performance such as CFFT and DSS in the active ALDH2 group, but did not in the inactive ALDH2 group. Conclusions : It may be concluded that metadoxine has little effect on alcohol metabolism in both groups with respect to phamacokinetics on the basis of BrAC. The pharmacodynamic results, however, indicated that metadoxine might be partially effective in counteracting the impairing effects of alcohol on the performance in the active ALDH2 group.
알쯔하이머병 환자의 행동심리적 증상에 대한 Donepezil의 효과
윤진상,김재민,이훈,신일선,이요한,이형영 대한정신약물학회 2003 대한정신약물학회지 Vol.14 No.2
Objective : The primary purpose of this study was to investigate the effects of donepezil on the behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimer’s disease (AD). Additionally, its effects on cognitive function, activities of daily living (ADL) and global severity were investigated, and its safety was evaluated. Methods : This was an 24 week prospective, open-labeled study with donepezil. The primary efficacy was measured by Behavior Pathology in Alzheimer’s Disease Rating Scale (BEHAVE-AD); additional efficacies were assessed by Korean version of Mini-Mental State Examination (MMSE-K), Barthel Activities of Daily Living (BADL), Blessed Dementia Rating Scale (BDRS), and Global Deterioration Scale (GDS). Efficacy measurements were conducted at baseline and at weeks 4, 8, 12, and 24. Adverse events were rated using the UKU side effect rating scale at each time point and were monitored as well at the time of development. Results : Of 40 patients recruited, 20 (50%) patients completed the study. The main reason for drop-out (N=14, 70%) was loss of follow-up. In the completers, scores on BEHAVE-AD were reduced significantly, particularly in subscales of ‘Activity Disturbances’, ‘Diurnal Rhythm Disturbances’, and ‘Affective Disturbances’, while no significant changes were found in subscales of ‘Hallucinations’ and ‘Anxieties & Phobias’. There were no significant changes in the scores on MMSE-K, BADL, BDRS and GDS. Neither change was found in the scores on the UKU side effect rating scale. Although there were a few adverse events potentially associated with donepezil, they were tolerable and transient. Conclusions : Donepezil treatment was effective in some aspects of BPSD, and delayed the decline of cognitive function, ADL, and global severity in patients with AD. In addition, it was generally well tolerated in terms of adverse events.
출생 시 Ureaplasma urealyticum 집락이 조산아의 임상 양상에 미치는 영향
윤진상,조희승,장선정,이규형 대한신생아학회 2009 Neonatal medicine Vol.16 No.1
Purpose : Present evidences suggest that Ureaplasma urealyticum is a cause of pneumonia, septicemia, and bronchopulmonary dysplasia (BPD) in newborn infants, particularly those born prematurely. The purpose of this work was to examine the relationship between Ureaplasma urealyticum in the tracheal aspirates and adverse outcomes, such as BPD and early onset neonatal sepsis in premature infants. Methods : A polymerase chain reaction (PCR) was performed on tracheal aspirates collected within 24 hour after birth in 176 premature infants less than 35 weeks of gestation and admitted to the neonatal intensive care unit of Bundang CHA Hospital. Results : U. urealyticum was detected in 37 of 176 preterm infants (21.0%). Gestational age (29+5±2+5 wk vs. 30+6±2+5 wk, P=0.013) and birth weight (1.39±0.44 kg vs. 1.59±0.55 kg, P=0.037) were lower in the U. urealyticum-positive group compared to the control group. The incidence of early onset neonatal sepsis (16.2% vs. 6.5%, P=0.045) and BPD (45.9% vs. 29.5%, P=0.047) was higher in the U. urealyticum-positive group compared to the control group, but the severity of BPD was not different between two groups. However, multiple logistic regression analysis revealed that the presence of U. urealyticum was not independently related to the development of early onset neonatal sepsis and BPD. Conclusion : The results suggest that colonization of the lower respiratory tract by U. urealyticum might not be related to the development of neonatal sepsis and BPD directly in preterm infants.
윤진상 大韓神經精神醫學會 1983 신경정신의학 Vol.22 No.3
In order to demonstrate objectively the possible relationship between hearing deficit and schizophrenic and paranoid tendency, paranoia and schizophrenia scales of MMPI were administered to 115 patients with hearing impairment and 39 controls. The results were as follows: 1. The scores of schizophrenia and paranoia scales were significantly higher in group with hearing impairment than in the control group. 2. Within the group with hearing impairment, the score of paranoia scale was significantly higher in the bilaterally impaired subgroup than in the unilaterally impaired subgroup. 3. The scores of schizophrenia and paranoia scales seemed to be increased relatively in accordance with severity and duration of hearing impairment.
윤진상 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.5
Except a few well-defined interactions, there is considerable uncertainty about the interactions between electroconvulsive therapy(ECT) and psychotropic and medical pharmacological agents used during ECT course mainly because the interaction with ECT has not been adequately tested at any stage in drug development. Most of the available knowledge on ECT-drug interactions in human are based on clinical experience and inferred from animal studies. This article reviews ECT-drug interactions in terms of safety and/or efficacy rather than theoretical issues to be helpful for clinical practitioners. Drugs are divided into three categories : psychotropic and medical pharmacological agents taken by patients prior to initiation of the ECT course and agents given in conjunction with ECT to modify the seizure itself or the effects of the seizure.
윤진상 대한생물치료정신의학회 1997 생물치료정신의학 Vol.3 No.1
This article was written in the hopes of providing clinicians with the practical guideline for the pharmacotherapy of atypical depression. However, the concept of atypical depression and acceptance of the term as a distinct clinical entity are still somewhat controversial. First, the clinical validity of atypical depression is reviewed from the standpoints of symptomatology and pharmacological response as well as biological findings. Then, issues relevant to the practical guidline for the pharmacotherapy of atypical depression is discussed. Finally, psychotherapy of atypical depression is examined in the context of pharmacotherapy.