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        • KCI등재후보SCOPUS
        • KCI등재SCOPUS

          Comparison of cardiac function and coronary angiography between conventional pigs and micropigs as measured by multidetector row computed tomography

          안영근,유정민,정해창,김윤현,정명호,이민영,Sang,Hun,Lee,Jae,Hong,Park,윤승필,한호재 대한수의학회 2008 JOURNAL OF VETERINARY SCIENCE Vol.9 No.2

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          Pigs are the most likely source animals for cardiac xenotransplantation. However, an appropriate method for estimating the cardiac function of micropigs had not been established. Computed tomography (CT) analysis aimed at estimating cardiac function and assessing the coronary arteries has not been carried out in micropigs. This study determined the feasibility of evaluating cardiac function in a micropig model using multidetector row computed tomography (MDCT) and compared the cardiac function values with those of conventional pigs. The mean age of the conventional pigs and micropigs was approximately 80 days and approximately 360 days, respectively. The mean body weight in the conventional pigs and micropigs was 29.70 ± 0.73 and 34.10 ± 0.98 kg, respectively. Cardiac MDCT detected ejection fractions of 52.93 ± 3.10% and 59.00 ± 5.56% and cardiac outputs of 1.46 ± 0.64 l/min and 1.21 ± 0.24 l/min in conventional pigs and micropigs, respectively. There were no significant differences in cardiac function between conventional pigs and micropigs in the reconstructed CT images. There were also no differences in the coronary angiographic images obtained by MDCT. It is expected that the results of this study will help improve understanding of cardiac function in micropigs. The data presented in this study suggest that MDCT is a feasible method for evaluating cardiac function in micropigs.

        • Shikonin에 關한 衛生化學的 硏究

          安榮根 圓光大學校 1980 論文集 Vol.14 No.2

          1) Lethal toxicity of the pigmental subistance from Lithospermum Erythrorhyzon Siebet Zucc. is ?? 345mg/kg. 2) Shikonin was fed for 20 weeks to mice (diet added with 1% Shikonin). The following results were obtained. Shikonin causes no ohanges in the way of life of the mice and exerts no influence on body weight. Modification of Blood picture did not appear, no morphological alteration of vital organs were observed. The dye is excreted in the urine and dung, and does not accumlate in the abdominate fat.

        • KCI등재SCOPUS

          The Role of Nuclear Factor Kappa B Activation in Atherosclerosis and Ischemic Cardiac Injury

          안영근,김용숙,정명호 대한심장학회 2006 Korean Circulation Journal Vol.36 No.4

          The NF-κB family of transcription factors plays a critical role in many tissues by modulating both inflammation and cell survival, and this primarily comes about through transcriptional regulation of the downstream effecter genes. This central role of coordinating complex programs of gene induction suggests that the NF-κB transcription factors and/or the signaling pathways leading to their activation may present a prime opportunity for performing therapeutic intervention. However, the dual role of this pathway in inflammation and survival dictates rigorous and empiric validation of such interventions in realistic models of disease before we can translate research findings to the clinical arena. Interestingly, the precise approach chosen to modulate NF-κB activation appears to dramatically alter the balance of the downstream effects on apoptosis and inflammation. Here we provide a brief overview of NF-κB signaling and its role in atherogenesis as well as in acute coronary syndromes, while considering the clinical implications for therapeutic strategies. (Korean Circulation J 2006;36:245-251)

        • 마우스에 있어서 Olive Oil의 食餌가 免疫反應에 미치는 影響

          안영근,박병철,김정훈,이상근,박영길 원광대학교 식품약품안전성연구소 1991 食品藥品安全性硏究 Vol.4 No.-

          This study was performed to investigate the effect of olive oil diet on the immune response in ICR male mice. Experimental diets of 4 groups were fed ad libitum to the ICR male mice for 27 days. The results of this study were summarized as followings: 1. 10% Olive oil diet group as compared with the control diet group significantly decreased liver weight rate but significantly increased hemagglutination titer (HA), Arthus reaction, delayed type hypersensitivity reaction (DTH), rosette forming cell (RFC), and phagocyte activity. 2. 20% Olive oil diet group as compared with the control diet group significantly increased body weight gain, liver weight rate, and HA but significantly decreased Arthus reaction, DTH, RFC, phagocyte activity, and peripheral circulating white blood cell (WBC). 3. 30% Olive oil diet group as compared with the control diet group significantly increased liver weight rate but significantly decreased body weight gain, Arthus reaction, plaque forming cell (PFC), DTH, RFC, phagocyte activity, and WBC. The results showed that the increase of olive oil doses significantly decreased humoral and cellular immune responses, phagocyte activity, and WBC.

        • 2.4-Dichlorophenoxyacetic Acid의 독성에 대한 Ethanol의 영향

          안영근,선우연,정종갑,김정훈 환경독성보건학회 1989 환경독성보건학회지 Vol.4 No.3

          The effects of ethanol on the toxicity of 2, 4-Dichlorophenoxyacetic acid in ICR mice were examined. The results were summerized as follows; 1. The LD$\sub$50/ of 2.4-dichlorphenoxyacetic acid sodium injected intraperitoneally in mice was approximately 367 mg/kg. When the animals were administered with ethanol, 2 ml/kg or 4 ml/kg the LD$\sub$50/ of 2.4-D sodium were decreased to 338 mg/kg or 32 mg/kg, respectively. 2. In the acute experimental group, spontaneous motor activity in the ANIMEX system exhibited dose-dependent decrease in mice administered with 2.4-D sodium and ethanol. 3. However, in subacute experimental group, spontaneous motor activity in the ANIMEX system exhibited dose-dependent increase in mice treated with ethanol.

        • Aconitine 및 加熱處理한 Aconitine이 Mouse의 免疫反應에 미치는 影響

          安榮根,金正勳,鄭東煥 한국환경독성학회 1988 환경독성보건학회지 Vol.3 No.1

          Dose-dependent, immune modulatory effects of aconitine and heated aconitine were studied in mice. Mice, administered aconitine and heated aconitine intraperitoneally every other day for 4 weeks, were sensitized and challenged with sheep red blood cells. Serum antibody titer, foot pad swelling and rosette forming cell number were measured to evaluate hurmoral and cell mediated immune responses. The results show that Humoral immune response was suppressed by aconitine 0.05 mg/kg and heated aconitine but increased by aconitine 0.10 mg/kg administration. Cell mediated immune response was suppressed in all groups. Especially heated aconitine administration significantly suppressed the cell mediated immune response. The number of peripheral circulating white blood cell was reduced by aconitine but was not affected by heated aconitine.

        • 랏트에 있어서 Vitamin A Acetate의 독성에 미치는 $\alpha$-Tocopherol의 영향

          안영근,김성오,오연준,박영길 환경독성보건학회 1989 환경독성보건학회지 Vol.4 No.3

          Influences of u-tocopherol on the toxicity of vitamin A acetate in male rats were studied. The obtained results are as follows; 1) The administration of vitamin A acetate 500,000 IU/Kg i.p. twice at 3 days interval decreased the liver weight/body weight and increased the spleen weight/body weight, and increased activities of SGOT and alkaline phosphatase, and also increased BUN and creatinine. 2) ${\alpha}$-Tocopherol administered together with vitamin A acetate as given as the above 1) poteniated the increase of SGOT activity caused by vitamin A acetate and reduced the increase of alkaline phosphatase activity and creatinine which were caused by vitamin A acetate. 3) The administration of vitamin A acetate 500,000 IU/Kg i.p. twice a week for 4 weeks showed remarkable decrease of body weight gain and the effect of it was larger in later stage than in early. It increased significantly liver weight/body weight and further increased the activities of SGOT, SGPT and alkaline phosphatase, and showed no influnence on BUN and creatinine. 4) ${\alpha}$-Tocopherol administered together with vitamin A acetate as given as the above 3) reduced the decrease of body weight gain caused by vitamin A acetate, and potentiated remarkably the increased activities of SGOT and alkaline phosphatase which were caused by vitamin A acetate.

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