항정신병약물이 정신분열병 증상에 미치는 영향 : 리스페리돈과 할로페리돌의 임상적 효과 비교

정인원 충북대학교 의과대학 충북대학교 의학연구소 1999 忠北醫大學術誌 Vol.9 No.2

연구목적: 비정형 항정신병약물과 정형 항정신병약물을 비교하기 위해서 risperidone과 haloperidol의 임상효과와 부작용에 대한 후향성 개방 연구를 수행하였다. 대상 및 방법: 20명의 정신분열병환자를 대상으로 나이와 성별을 일치시켜 두 치료집단을 나누어 4주간 정신 증상을 측정하였다. 환자의 정신 증상은 정신분열병의 양성 음성 증후군 척도(PANSS), 단기 정신증 척도(BPRS), 해밀턴 우울 척도(HAMD), 해밀턴 불안 척도(HAMA), 전반적 공격성 척도(OAS), 예일-브라운 강박 척도(YBOCS)등을 사용하였다. 약물의 부작용은 추체외로 증상 평가 척도(ESRS)와 비정상적 불수의 운동 척도(AIMS)로 측정하였다. 결과: 두 치료 집단 모두에서 임상 증상의 호전을 보였다. 그러나 집단간에 증상 호전의 차이는 보이지 않았다. 그 외 추체외로 증상 및 부작용도 차이를 보이지 않았다. 결론: 비정형성 항정신병약물인 risperidone은 정신분열병환자의 치료에서 적어도 4주간의 치료 초기에는 정형 항정신병약물인 haloperidol에 비하여 우월한 임상 효과를 보이지 않았다. Purpose: A retrospective open clinical study was conducted to evaluate the clinical efficacy and the side effect of atypical antipsychotics in comparison with conventional antipsychotics. Materials and Methods: Twenty schizophrenic patients were divided to two groups and assessed the psychopathology once a week for four weeks. The symptoms were assessed by means of the Positive and Negative Syndrome Scale for Schizophrenia (PANSS), the Brief Psychotic Rating Scale (BPRS), the Hamilton Depression Rating Scale (HAM-D), the Hamilton Anxiety Rating Scale (HAM-A), the Overt Aggression Scale (OAS) and the Yale-Brown Obsessive Compulsive Scale (YBOCS). The side effects were assessed by the Extrapyramidal Symptom Rating Scale (ESRS) and the Abnormal Involuntary Movement Scale (AIMS). Results: The results indicated that two antipsychotics, risperidone and haloperidol showed improvements of clinical symptoms for four weeks of treatment. And any differences between two groups were not found. Conclusion: This study suggests that the superiority of risperidone over haloperidol is not apparent during the initial period of antipsychotic treatment.

하악 매복지치 발치술

정인원 대한치과의사협회 1997 대한치과의사협회지 Vol.35 No.9

조현병 환자에서 보이는 혼잣말 증상의 이해

정인원,정성훈,김임열,윤탁,김세현,김용식 대한신경정신의학회 2016 신경정신의학 Vol.55 No.4

Soliloquy is a significant symptom in schizophrenia and is usually regarded as being related to auditory hallucination. Elucidation of the psychopathology of soliloquy is incomplete. Soliloquy is also a normal human behavior that has multidimensional functions such as guiding internal cognitive processes and managing social interaction. In the young, soliloquy appears as egocentric speech and arises before maturation of the third-person perspective. Soliloquy has been regarded as indicative of an intermediary stage during the transformation of social speech into internalized thinking. Every thought process retains a social dimension because language itself is based on intersubjectively shared meanings, and internal thinking originates from interpersonal communication. Thus, soliloquy can be seen as a kind of thought process that accentuates the social dimension. This approach may help in understanding soliloquy in normal and pathological situations. Soliloquy was actively discussed in the late nineteenth and early twentieth century in European psychiatry. Since then it has received less attention and has been neglected as an academic concern, except in child developmental theory. Recently however, soliloquy has attracted more attention among neuroscientific researchers. To attain an advanced understanding of soliloquy, it is necessary to integrate the early European perception of soliloquy with current developmental theory. In this paper, we review past literature on the conceptualization of soliloquy and integrate those concepts into an explanatory framework. In addition, a case series and a discussion of the applicability of the explanatory framework are presented. Our results may help provide an insight into the contemporary understanding of soliloquy.

정신보건센터의 주간 및 직업재활 프로그램에 등록한 정신분열병 환자의 연령군간 특성

정인원,김헌,손정우,이선영,김혜영,서동우 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.1

향정신성 약물의 입체이성질체

정인원 대한정신약물학회 2003 대한정신약물학회지 Vol.14 No.1

Many psychotropic drugs are marketed and prescribed as a racemate form in a mixture of the stereoisomers. A chiral center or a center of unsaturation of carbon atoms in the chemical structures creates various stereoisomers of the psychotropic drugs, including antidepressants such as fluoxetine and venlafaxine, etc. The stereochemical significances of enantiomers on the pharmacokinetics and pharmacodynamics of several psychotropic drugs and their relationships with pharmacogenetic polymorphisms were reviewed. The single enantiomer drugs will be increasing more in the market shares replacing the racemic drugs by chiral switching, which is driven by the development of the analytical and preparative resolution techniques and will be of much benefit to the treatment from low dosages, simple dose-response curve, few adverse reactions, and so on.

항정신병약물에 의한 안구운동발작과 발작성 지각변화 증후군

정인원,김임열,윤탁,정성훈,정희연,김용식 대한조현병학회 2018 대한조현병학회지 Vol.21 No.1

During antipsychotic drug treatment, clinicians occasionally encounter sudden attacks of oculogyric crisis (OGC) and/or paroxysmal perceptual alteration (PPA) which occur mostly in the afternoon or early evening lasting for minutes to hours and are eventually remitted with rests or short sleep and/or medications such as benzodiazepines, anticholinergics and so forth. Moreover, these attacks are usually accompanied with psychiatric symptoms such as various modalities of hallucinations and illusions, delusions, obsessive thoughts, panic attacks, agitation as well as autonomic symptoms. These accompanying psychiatric symptoms can be perceived as a worsening of psychiatric symptoms if the clinician does not understand the symptoms due to the side effects of antipsychotic drugs, which may result in increasing the dosage of antipsychotics instead of reducing doses or switching to less offending drugs. On the other hand, patients could easily recognize the symptoms as the adverse effects of drugs. This literature review and case-series study is aimed to raise awareness of OGC and PPA by providing clinical cases and author’s views with the literature reviews about concepts, recognitions and managements from the works of Japanese authors who first reported the clinical importance of these attacks, particularly PPA.

放射線 照射가 人體의 口腔內 纖維芽細胞에 미치는 細胞毒性에 關한 實驗的 硏究

鄭仁源,金圭植 서울大學校 齒科大學 1992 齒大 論文集 Vol.16 No.1

정신보건센터의 주간재활 프로그램에 등록한 정신분열병 환자의 항정신병약물 복용 현황

정인원,서동우,손정우,이윤경 대한정신약물학회 2004 대한정신약물학회지 Vol.15 No.4

알코올 의존 환자에서의 Aldehyde Dehydrogenase II와 CYP2E1 유전자 다형성과 임상적 특성간의 연관성

정인원,김영랑,지경환,김헌,Chung, In-Won,Kim, Yeoung-Rang,Chi, Kyung-Hwan,Kim, Heon 대한생물정신의학회 2002 생물정신의학 Vol.9 No.1

Objective:This study was to explore the relation of genetic polymorphisms of ALDH2 and CYP2E1 to clinical characteristics of alcoholic patients and alcohol induced liver damage. Methods:The genotype and allele frequencies of 128 male hospitalized patients who met DSM-IV criteria for alcohol dependence were compared with 128 healthy male control subjects. The genetic informations of ALDH2 and CYP2E1 were identified with the technique of polymerase chain reaction and restriction fragment length polymorphism. The clinical characteristics of the alcoholic patients were assessed and analyzed in relation to the family history of alcoholism. For the relation of CYP2E1 genetic polymorphism to the liver damage, the blood levels of various liver function indicators such as ALT, AST, and protein were checked out. Results:1) The alcoholic patients with the family history of alcoholism had the earlier onset of age (p=0.001), the longer duration of illness(p=0.045), and higher NCA scores(p=0.018) than those without the family history of alcoholism. 2) Most alcoholic patients were homozygous for $ALDH2^*1$, compared to control subjects.(p=0.000) 3) There was no difference of CYP2E1 distribution between alcoholic patients and control subjects. However, alcoholic patients having mutant c2 allele showed higher alcoholism severity scores(p=0.004) and more hospitalizations(p=0.014) than those having c1 allele. 4) There was no relationship between CYP2E1 genotype and the functional abnormalities of the liver. Conclusion:This study suggests that $ALDH2^*1$ is highly related with alcohol dependence. Also mutant c2 allele of CYP2E1 is correlated with the severity of alcoholism and the number of hospitalization. But genetic polymorphim of CYP2E1 seems to have no relation to liver damages.

향정신성 약물의 맞춤형 약물치료

정인원,이규영 대한정신약물학회 2002 대한정신약물학회지 Vol.13 No.3

The pharmacotherapeutic responses such as clinical efficacy and adverse events exhibit wide variabilities in individuals and even in different races and populations. The human genetic diversity has been known as the one of the main factors in the variations of drug responses expressed in the area of pharmacokinetics and pharmacodynamics. Polygenetic implications have been suggested in the pathophysiology of psychiatric disorders. The risks in psychiatric disorders could be explored by combining the polymorphisms of multiple candidate genes. This suggests that drug therapy should be tailored to the genetic make-up of the individual. The emerging field of pharmacogenomics could be a landmark for the development of more effective clinical efficacy and less adverse events by individually tailored drugs.