천자서평 2 : 아빠를 젊고 건강하게 - 황성주 / 호도애 / 1990 -

황성주 한국상담선교연구원 1997 상담과 선교 Vol.5 No.2

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무분극 a-plane 질화물계 발광다이오드에서 SiO2 전류 제한 층을 통한 발광 효율 증가

황성주,곽준섭 한국전기전자재료학회 2017 전기전자재료학회논문지 Vol.30 No.3

In this study, we investigate the SiO2 current blocking layer (CBL) to improve light output powerefficiency in nonpolar a-plane (11-20) GaN LEDs on a r-plane sapphire substrate. The SiO2 CBL was producedunder the p-pad layer using plasma enhanced chemical vapor deposition (PECVD). The results show that nonpolarGaN LED light output power with the SiO2 CBL is considerably enhanced compared without the SiO2 CBL. Thiscan be attributed to reduced light absorption at the p-pad due to current blocking to the active layer by the SiO2CBL. 본 연구에서는 r-plane sapphire 기판에 성장된 무분극 a-plane (11-20) GaN LEDs의 발광효율 향상에 미치는 SiO2 전류제한층(current blocking layer, CBL) 효과를 연구하였다. SiO2 CBL은 PECVD를 이용하여 p-pad 금속 아래에 형성하였다. SiO2 CBL 이 형성된 무분극 GaN LEDs 는 CBL이 없는 무분극 GaN LED에 비하여 광출력이 크게 향상되었으며, 이는 SiO2 CBL에 의하여 활성층으로의 전류주입이 제한되어, p-pad 금속에서의 광 흡수가 줄어들고 전류 퍼짐이 향상되기 때문이다.

에어로솔제제의 최근 동향

황성주 한국약제학회 1995 신기술과제품현황 Vol.- No.-

Alginate Bead를 이용한 고분자 약물의 제어방출형 약물수송체

황성주,이계주,조항범,이기명,김종국 충남대학교 약학대학 의약품개발연구소 1993 藥學論文集 Vol.9 No.-

The purpose of this paper is to explore the possible applicability of alginate beads as an oral controlled release system of polymeric drugs. Cellulases was used as a model polymeric drug. The release of cellulase from alginate beads was moderately affected by the ratio of cellulase to sodium alginate and strongly affected by CaCl_2 concentration. However, the release was not particularly affected by the other factors such as sodium alginate concentration and curing time. The drug was not released from alginate beads at pH 1.2 but was released continuously up to 8 hr at pH 6.8. At pH 6.8, the beads were swollen highly up to 3 hr, thereafter, were eroded into the bulk solution up to 6 hr, completely. Drug release from the beads can be caused due to diffusion and erosion of the matrix. Activity of cellulase was reduced when alginate beads containing cellulase were stored in simulated gastric juice. Further investigation would be necessary to improve the acid resistance of beads. Since the release of cellulase as a model polymeric drug could be controlled by tthe regulation of the preparation conditions of alginate beads, the alginate beads may be used for a potential oral controlled release system of such polymeric drugs as polypeptide drugs.

수종의 붕해제가 살리실아미드정제의 제제특성에 미치는 영향

황성주,이계주,지웅길,곽효성,김종국 충남대학교 약학대학 의약품개발연구소 1992 藥學論文集 Vol.8 No.-

Six common tablet disintegrants (corn starch, Avicel PH102, calcium carboxymethylcellulose, Primojel, Kollidon CL and Ac-Di-Sol) were used at the concentration of 0, 2, 4 and 6% (w/w) in salicylamide tablets made with wet granulation method. Certain physical parameters of the disintegrants (moisture sorption, hydration capacity and bulk density) were determined to evaluate their relative efficiency. The disintegration time and dissolution rate of the tablets were correlated well with the ranks of initial rate of moisture sorption for each disintegrant as follows; Ac-Di-Sol, Kollidon CL, primojel, calcium CMC, corn starch and Avicel PH102. The initial rate of moisture sorption was important for the disintegration capacity as well as hydration capacity. The effect of storage at different temperatures and relative humidity upon the tablets containing various disintegrants was evaluated in terms of tablet hardness and disintegration time. Storage at high temperature reduced the hardness substantially and retarded the disintegration of the all tablets studied. Especially, the hardness of tablets containing Kollidon CL was significantly reduced. Although the tablet hardness was decreased and the disintegration time was increased under a moderate humid condition, both of them were decreased under the severely high humid condition of 80 or 90% RH, which was due to the breakrupture of tablet matrix bonds by the excessive uptake of moisture. Therefore, the stability caused by moisture sorption should be considered, when disintegrants having high moisture sorption such as Kollidon CL, Ac-Di-Sol and Primojel were employed in the tablets containing water-labile or hygroscopic drugs.

메토트렉세이트가 표면수식된 알부민미립구의 표적성

황성주,조항범,이계주,김종국 ( Sung Joo Hwang,Hang Bum Jo,Gye Ju Rhee,Chong Kook Kim ) 한국약제학회 1996 Journal of Pharmaceutical Investigation Vol.26 No.2

The surface of albumin microspheres was modified with methotrexate(MTX) by using 1.3-dicyclohexylcarbodiimide (DCC). Surface-modified albumin microspheres entrapping no MTX (SAMS), free MTX (SAMSF) and MTX-bovine serum albumin(BSA) conjugates(SAMSC) were prepared. The organ-targeting ability of free [³H]MTX, [³H]MTX-BSA conjugate and the above microspheres was evaluated after i.v. administration of the preparations, equivalent to 150 nCi via the tail vein of mice. The total radioactivity in the lung increased immediately in a few minutes after i.v. injection of the microspheres, and then declined for the period of 3-4 weeks. However, the radioactivity in the liver, spleen and kidney increased slowly during the rapid decrease in radioactivity in the lung. This suggested that the microspheres could be entrapped rapidly in the lung through mechanical filtration because of their large size and slowly redistributed to the liver, spleen and kidney due to either the microspheres being degraded enough for the size to allow passage through the capillary beds of the lung and/or the release of [³H]MTX or [³H]MTX-BSA conjugates from the microspheres. The amount of 60∼70% of the dose was targeted to the liver after the i.v. injection of SAMS. SAMSF and SAMSC, and the values of (R_e^*_e)_(liver) from the microspheres were 5∼7 compared to free MTX. This suggested that the liver-targeting ability from surface-modified albumin microspheres could be 5∼7 times as that of free MTX. The liver-targeted drug was accumulated in the Kupffer cells at the initial stage, thereafter the drug in the Kupffer cell was slowly transferred into the hepatocytes. The value of AUQ for liver from SAMS was higher than that from SAMSF, but much lower than that from SAMSC. This suggest that MTX bound to their surface could be eliminated slower than the entrapped free MTX, and faster than the entrapped MTX-BSA conjugates. This is consistent with the in vitro release rates order in the presence of a proteolytic enzyme. Also, surface-modified MTX was scarcely released in the absence of a proteolytic enzyme^(11) Therefore, the surface-modified MTX may be released (or eliminated) rapidly from SAMSC at the target site, and thereafter MTX may be released (or eliminated) slowly from the entrapped MTX-BSA conjugates in SAMSC for a long period.

원보 ; 오메프라졸복합체 함유 직장좌제의 특성비교

황성주,박성배,이계주 ( Sung Joo Hwang,Sung Bae Park,Gye Ju Rhee ) 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.3

Omeprazole(OMP) complexes such as inclusion complexes of OMP with hydroxypropyl-β-cyclodextrin(HPCD) and β-cyclodextrin(β-CD), OMP-cholestyramine(CHL) and OMP-ethylenediamine(OMP-ED) were prepared, respectively. The partition coefficients in Witepsol H-15/pH 7.4 phosphate buffer solution of OMP complexes(OMP-HPCD: 3.69±0.26, OMP-β-CD: 4.08±0.21, OMP-CHL: 4.36±0.25 and omeprazole sodium(OMP-Na): 3.64±0.37) were higher than that of OMP (2.66±0.47). OMP was not completely dissolved until even 3 hrs, but all the OMP complexes studied were released about 100% in 20 min. The rectal suppositories containing OMP or each above OMP complex were prepared using Witepsol H-15 base, and their dissolution and stability were examined, and pharmacokinetic study were investigated after their rectal ad ministrations to the rabbits. While the suppository containing OMP was released only less than 60% in 150 min, OMP-β-CD, OMP-CHL, OMP-Na and OMP-ED suppositories were all released about 65% in 20 min. Especially, OMP-HPCD suppository released OMP about 70% in 10 min. All the additives such as sodium laurylsulfate, eglumine, arginine and PVP increased drug release from OMP-HPCD suppository to some extent. The decomposition rate constants of OMP in the suppositories were 9.117×10^(-3) day^(-1) for OMP suppository, 2.121×10^(-2) for OMP-HPCD. 1. 607×10^(-2) for OMP-β-CD, 9.26×10^(-3) for OMP-Na. 6.769×10^(-3) for OMP-CHL and 5.58×10^(-3) day^(-1) for OMP-ED suppository, respectively. Additives such as arginine, eglumine and ED had some stabilizing effect for OMP-HPCD, OMP-CHL and OMP-Na suppositories, respectively. After 6 month-storage at 30℃. 75% RH, OMP-CHL suppository was most stable. The values of Tmax for OMP-HPCD and OMP-Na suppositories were 11.7±2.36 and 11.4±2.56 min, respectively. The values of Cmax for OMP-HPCD and OMP-CHL suppository were 2.31 ㎍/㎖ (p<0.01) and 1.89 ㎍/㎖ p<0.01), respectively. The values of AUC for OMP and OMP-β-CD suppository were 61.9±25.79 and 68.6±29.48 ㎍·min/㎖, and the corresponding values for OMP-HPCD and OMP-CHL were 106.1±43.16 (p<0.05) and 127.3±42.52 ㎍·min/㎖(p<0.01), respectively. The above results indicate the OMP-HPCD and OMP-CHL suppositories have the excellent bioavailabilities in vivo study.

제약선진국 진입을 위한 약사의 역할과 인력수급 방안

황성주 한국에프디시규제과학회(구 한국에프디시법제학회) 2009 한국에프디시법제학회 학술대회 Vol.2009 No.1

Designing and manufacturing a piezoelectric tile for harvesting energy from footsteps

황성주,정현준,김정훈,안정환,송다니엘,송예원,이희락,문성필,박현수,성태현 한국물리학회 2015 Current Applied Physics Vol.15 No.6

The objective of this research is to design a piezoelectric tile for harvesting energy from footsteps and to optimize the system for harvesting maximum energy. Because piezoelectric modules easily break when directly subjected to energy generated by human movements, we designed a tile that employs indirect energy transmission using springs and a tip mass. We aimed at matching the mechanical resonance frequency of the tile with that of the piezoelectric modules. The resonance frequency of a piezoelectric module with a 10-g tip mass was almost similar to the vibration frequency of the tile at 22.5 Hz when we dropped an 80-g steel ball from a 1-m height. We performed impedance matching and realized a matching value of 15 kU. Under these optimal mechanical and electrical conditions, we harvested 770- ΩW RMS and 55-μW peak output power.

바흐찐 미학에서 외재성(BHeHaXoЛHMOCTb)의 의미에 대한 고찰

황성주 한국러시아문학회 1996 러시아어문학 연구논집 Vol.2 No.-

в этоR статье ра сс аТРltва ется понятие от ношение автора k герою М. М . Бахтина. Зто понятие занимает особое м есто в эстеТltkе Бахтltна, в частности, в словесной эс т еПlkе. И это требует внимательн ого рас с мотрения от н сс л еlJова телеR , потому что творчества Бахтина И Здll.лись в разных времени. В к Фил ософНИ ПОСТУПkа обосновалнсь иесто эстеТНkН в его нрав стевен ноА фIIЛОСОфИИ. ЭстетнчеСkе 6НIJение играет важную роль ПОТОМУ. что оно ограничивается lJеАствительным шром и вместе с теи оно можно дать онтологичесую основу IJЛЯ героя . В ХУIJожеСТ6еннои событии эстетическим 6ИIJеЮlеи автора можно IJi1.Tb жизнь герою kll.k соз наниlO . а должен отметить то, что внеНlI.ХО/JIlИОСТЬ автора к герою показ ыв ается в двух направленнях, Во первых, вне нах од им ость автора з н а чит принцип худо ж естве нн ого прои зве дния , Во вторых, В конкретном пронзведении н ж а нрово й разделнеиии ви е - находиt.lОСТЬ м ожет служ и т как мерило, в э м о , ас п екте сказа н о ослаб - пение 1I усилен и е вненаходи~юсти автора и даже кризнс а вт ора, Так в этом есть трудность для понимания понятия в н е на ход ю .. ость, И вП ро бле мы п оэ тики Достоевского спецИ фич еск ий ха р ак т ер вненаходимости авт ора как , о мент ``ПОnИфоничесого романа`` п о к азался и это п о няти е св я залось с д и ало ги з м о м , В этом отно~енни в ~ Пробле мы п оэ тики Достоев - с к ого , , п онят и е вненаходююсть игр ает важную роль для п о нимания не только ``пол иф о нич еского романа``, но н диалогизмa.