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        • KCI등재

          RAGE: The Beneficial and Deleterious Effects by Diverse Mechanisms of Actions

          한선호,Yoon,Hee,Kim,묵인희 한국분자세포생물학회 2011 Molecules and cells Vol.31 No.2

          Receptor for advanced glycation endproducts (RAGE) is a transmembrane protein that belongs to the immunoglobulin superfamily. RAGE is expressed ubiquitously-high in lung and moderate to low in a wide range of cells-in a tightly regulated manner at various stages of development. RAGE is a pattern recognition receptor that binds to multiple ligands, including amphoterin, members of the S100/calgranulin family, the integrin Mac-1, and amyloid β-peptide (Aβ). RAGE-ligand engagement effects the activation of diverse cascades that initiate and stimulate chronic stress pathways and repair, depending on the ligand, environment, and developmental stage. Further, RAGE-ligand interaction and the consequent upregulation of RAGE through a positive feedback loop are often associated with various diseases, including vascular disease, diabetes, cancer, and neurodegenerative disease. It is unknown how RAGE mediates these events, but such phenomena appear to be linked to the inflammatory response. In this review, we summarize the findings on RAGE from published reports and ongoing studies. Also, the implication of RAGE in Alzheimer disease, the most common neurodegenerative disease in the elderly population, will be discussed, with a focus on Aβ-RAGE interactions with regard to signaling pathways and their impact on cellular activity.

        • IMF와 관련된 스트레스로 신경정신과를 방문한 환자들의 사회정신의학적 특징

          한선호,한상우,정한용 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

          Object : The objective of this study was to evaluate how IMF in Korea influenced the Korean in the psycho-social and neuropsychiatric aspects. Method : First, authors compared the number of the patients who had admitted in Seoul Soonchunhyang university hospital and Chun-an Soonchunhyang hospital between the period of January to September 1997(before IMF), and January to September 1998(after TMF). Second, authors evaluated the demographic factors and clinical characteristics of 84 patients who complained psychiatric symptoms induced by IMF related stresses. Results First, the number of stress related patients after IMF was more than before IMF(increased 31%), which suggests that IMF is the stressor of the people enough for psychiatric intervention. Second, IMF plays the role of the various stressors to Koreans (i.e, unemployment, retirement, economic loss, decreased incomes, familial conflicts, change of residence, urge to unemployed, etc) Third, IMF affects not only the urban clerical workers and merchants' employment and economic state but also the rural farmer and stock-farmers' economic state. Conclusion : IMF affects the Koreans' mental health in various aspects. So, it is important and urge to analyze and solve the IMF stresses which affect Koreans' mental health by psychosocial & community health approach.

        • KCI등재SCIESCOPUS

          Diverse Molecular Targets for Therapeutic Strategies in Alzheimer's Disease

          한선호,묵인희 대한의학회 2014 Journal of Korean medical science Vol.29 No.7

          Alzheimer's disease (AD) is the most common form of dementia caused byneurodegenerative process and is tightly related to amyloid β (Aβ) and neurofibrillarytangles. The lack of early diagnostic biomarker and therapeutic remedy hinders theprevention of increasing population of AD patients every year. In spite of accumulatedscientific information, numerous clinical trials for candidate drug targets have failed to bepreceded into therapeutic development, therefore, AD-related sufferers including patientsand caregivers, are desperate to seek the solution. Also, effective AD intervention isdesperately needed to reduce AD-related societal threats to public health. In this review,we summarize various drug targets and strategies in recent preclinical studies and clinicaltrials for AD therapy: Allopathic treatment, immunotherapy, Aβ production/aggregationmodulator, tau-targeting therapy and metabolic targeting. Some has already failed in theirclinical trials and the others are still in various stages of investigations, both of which giveus valuable information for future research in AD therapeutic development.

        • 精神分裂症 臨床型의 特徵 및 그症狀에 對한 硏究

          韓善浩 고려대학교 의과대학 1972 고려대 의대 잡지 Vol.9 No.1

          In this clinical study, it was intended to asses the distribution of subtypes and their educational backgrounds, occupational histories, family histories, marital statuses, premorbid personalities, precipitating factors, ages of onset and symptomatology. The 242 cases of the schizophrenics were classified into 6 subtypes, which were 21 cases of simple type, 3 cases of hebephrenic type, 13 cases of catatonic type, 116 cases of paranoid type, 82 cases of latent type and 7 cases of schizoaffective type. The results were as follows: 1. Among the classified subtypes, the paranoid type and the latent type were most frequently observed in this order and the paranoid schizophrenics occupied frequently observed in this order and the paranoid schizophrenics occupied 47.9% of all and the latent schizophrenics occupied 33.9% of all. 2. As to the mean ages of each subtypes, the paranoid and the latent were eldest: the paranoid was 29.6 years old and the latent were 34.1 years old. The simple and the hebephrenic were youngest: the simple was 19.9 years old and the hebephrenic were 20.3 years old. 3. Educational background of each subtype revealed that the schizoaffective schizophrenics showed highest educational level of all. 4. As to the occupational histories, the jobless schizophrenics occupied the highest rate of 37.2%. 5. Family histories revealed that 35.9% of all schizophrenics had in their families some kinds of neurotic and psychotic patients. Among them 23.1% of schizophrenics had neurotic patients and 12.8% of schizophrenics had psychotic patients in their families. According to each subtype, the paranoid type with neurotic and psychotic diseases in their family occupied 35.4% and the latent type occupied 39.0%. In the paranoid type, the patients with psychotic disease in their family occupied 21.6%, on the other hand in the latent type, the patients with neurotic diseases in their family occupied 31.7%. 6. As to the premorbid personality, schizoid personality and paranoid personality were more frequent ones in general. According to each subtypes, the simple type and the catatonic type had significantly higher frequency of schizoid personality and the paranoid type had the higher frequency of paranoid personality and the latent type had the higher frequency of asthenic personality than the other types. The schizoaffective type almost exclusively had schizoid and paranoid personality. 7. In all schizophrenics, the most frequent symptoms were inappropriateness, emotional dullness, anxiety and fearfulness, decreased activity and incoherence. According to each subtypes, the character istic symptoms were as follows, the simple type had inappropriateness, emotional dullness. The catatonic type had negativism and blocking. The paranoid type had increased activity, auditory hallucination, delusion, incoherence and circumstantiality. Among the characteristic symptoms of paranoid type, the delusion were elicited from all of the paranoid schizophrenics. The latent type had inappropriateness, emotional dullness, anxiety and fearfulness, depressed mood, decreased activity, hypochondriasis and obsession.

        • KCI등재

          Ion Chromatography-Inductively Coupled Plasma-Mass Spectrometry에 의한 $U_3Si/Al$ 사용후핵연료 중 La의 분리 및 정량

          한선호,최광순,김정석,전영신,박양순,지광용,김원호,Han,,Sun,Ho,Choi,,Kwang,Soon,Kim,,Jung,Suk,Jeon,,Young,Shin,Park,,Yang,Soon,Jee,,Kwang,Yong,Kim,,Won,Ho 한국분석과학회 2000 분석과학 Vol.13 No.5

          Lanthanum has been used as one of the burnup monitor in spent nuclear fuel. $U_3Si/Al$ spent nuclear fuel contains small amount of La in high concentration of U and Al. Therefore, chemical separation of La is required to remove matrix elements. At first, ion chromatography (IC) and inductively coupled plasma systems were installed in radiation shielded glove box to handle the radioactive samples. Retention behavior of uranium, aluminum, lanthanum and some interesting fission products (Sr, Zr, Y, Mo, Ru, Pd, Rh, Cs, Ba, Ce, Pr, Nd, Sm, Eu and Cd) was investigated using the CG10 column and ${\alpha}$-HiBA eluent. As all elements were eluted earlier than lanthanum in 0.2 M ${\alpha}$-HiBA eluent, a portion of U and Al was directly passed to waste using a three way valve between the column and the nebulizer. Thus it was possible to determine the lanthanum in a high concentration of U and Al matrix. Retention time of La was about 12 minutes in this separation condition. Optimum range for the determination of La in $U_3Si/Al$ spent nuclear fuel was $1-10{\mu}g/L$ (ppb) with this system and detection limit was $0.25{\mu}g/L$ in case of $200{\mu}L$ of sample volume. 란탄은 사용후핵연료의 연소도 지표원소들 중 하나로써 이용되고 있다. $U_3Si/Al$ 사용후핵연료는 다량의 U과 Al 속에 미량의 La이 포함되어 있어 정량시 매질의 영향을 줄이기 위해 화학적 분리가 요구된다. La의 분리 및 측정을 위해 IC-ICP-MS를 이용하였으며, 우선 방사성 시료를 취급하기 위하여 유도결합 플라스마 질량분석기의 플라스마 부분 및 분리관을 방사선 차폐 글로브박스 내에 설치하였다. CG10 분리관과 ${\alpha}$-HiBA 용리액을 사용하여 U, Al, La 및 몇 가지 핵분열생성물 (Sr, Zr, Y, Mo, Ru, Pd, Rh, Cs, Ba, Ce, Pr, Nd, Sm, Eu 및 Cd)의 머무름 거동을 살펴보았다. 0.2 M ${\alpha}$-HiBA 용리액에서 U과 Al이 초기에 용출되므로 분리관과 ICP-MS의 시료분무기 사이에 3방향 밸브를 연결하여 다량의 U과 Al이 ICP-MS로 유입되지 않도록 하므로써 매질의 영향을 줄일 수 있었다. 이 조건에서 La은 약 12분 정도에 분리 및 측정이 가능하였으며, $1-10{\mu}g/L$ (ppb)의 농도범위가 측청에 적합하였고 시료양을 $200{\mu}L$ 취할 경우 La의 검출한계는 $0.25{\mu}g/L$이었다.

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