RAGE: The Beneficial and Deleterious Effects by Diverse Mechanisms of Actions

한선호,Yoon Hee Kim,묵인희 한국분자세포생물학회 2011 Molecules and cells Vol.31 No.2

Receptor for advanced glycation endproducts (RAGE) is a transmembrane protein that belongs to the immunoglobulin superfamily. RAGE is expressed ubiquitously-high in lung and moderate to low in a wide range of cells-in a tightly regulated manner at various stages of development. RAGE is a pattern recognition receptor that binds to multiple ligands, including amphoterin, members of the S100/calgranulin family, the integrin Mac-1, and amyloid β-peptide (Aβ). RAGE-ligand engagement effects the activation of diverse cascades that initiate and stimulate chronic stress pathways and repair, depending on the ligand, environment, and developmental stage. Further, RAGE-ligand interaction and the consequent upregulation of RAGE through a positive feedback loop are often associated with various diseases, including vascular disease, diabetes, cancer, and neurodegenerative disease. It is unknown how RAGE mediates these events, but such phenomena appear to be linked to the inflammatory response. In this review, we summarize the findings on RAGE from published reports and ongoing studies. Also, the implication of RAGE in Alzheimer disease, the most common neurodegenerative disease in the elderly population, will be discussed, with a focus on Aβ-RAGE interactions with regard to signaling pathways and their impact on cellular activity.

精神分裂症 臨床型의 特徵 및 그症狀에 對한 硏究

韓善浩 고려대학교 의과대학 1972 고려대학교 의과대학 잡지 Vol.9 No.1

勤勞 및 非行靑少年의 精神病理學的 硏究

韓善浩 순천향의과대학 1979 Journal of Soonchunhyang Medical Science Vol.2 No.2

In this study, it was aimed to reveal the psychopathological characteristics of the working adolescents and the juvenile delinpuents through the MMPI test. The subjects of the study were 203 male delinquents and 98 female delinquents, 109 malemale working adolescents and 90 female working adolescents. MMPI test was hiven to all 500 adolescents. The results were as follows: 1. F, Pa, Pt, and si scale were the high scores in the working adolescents and the delinquents compared with the normal akolescents. Between the working akolescents and the delinquents, the scores in these scales were higher for the delinquents than for the working akolescents, especially the Sc score. 2. In the delinquency, the delinquency sxale and the psychopathological scale, (critical itens), the scores for the delinquents were higher, and the scores for the working akolescents were also suggestive that the working group may have more problens than the normal adolescents. 3. fifty sevenpoint six percentage of the male delinquents and 29.4% of the male working adolescents were expected doing misdemeanour and for the female, 68.4% of the delinquents and 30.0% of the working group were expected doing so. 4. For the males, there is no difference in the frequency ratio of the psychopathological seriousness for the non expected delinquency group and the expected delinquency group respectively. But for the females, the psychopathological seriousness were the high scores for the non expected delinquency group. 5. from the previous results, it could be surmised that the working akolescents may have the delinquency and the psychopathological seriousness and that for the delinquents, the delinquency is remarkable at first but the psychopathological seriousness is a more important factor of their misdemeanour. Especially for the females, their psychopathological problems effected their misdeeds more than for the males.

For Layman 평신도를 품에 안고 : 주께 무릎 꿇고_기도의 힘 ; 금식기도는 자아를 죽이는 작업

한선호 기독교대한성결교회 출판부 2010 활천 Vol.674 No.-

精神分裂症 臨床型의 特徵 및 그症狀에 對한 硏究

韓善浩 고려대학교 의과대학 1972 고려대 의대 잡지 Vol.9 No.1

In this clinical study, it was intended to asses the distribution of subtypes and their educational backgrounds, occupational histories, family histories, marital statuses, premorbid personalities, precipitating factors, ages of onset and symptomatology. The 242 cases of the schizophrenics were classified into 6 subtypes, which were 21 cases of simple type, 3 cases of hebephrenic type, 13 cases of catatonic type, 116 cases of paranoid type, 82 cases of latent type and 7 cases of schizoaffective type. The results were as follows: 1. Among the classified subtypes, the paranoid type and the latent type were most frequently observed in this order and the paranoid schizophrenics occupied frequently observed in this order and the paranoid schizophrenics occupied 47.9% of all and the latent schizophrenics occupied 33.9% of all. 2. As to the mean ages of each subtypes, the paranoid and the latent were eldest: the paranoid was 29.6 years old and the latent were 34.1 years old. The simple and the hebephrenic were youngest: the simple was 19.9 years old and the hebephrenic were 20.3 years old. 3. Educational background of each subtype revealed that the schizoaffective schizophrenics showed highest educational level of all. 4. As to the occupational histories, the jobless schizophrenics occupied the highest rate of 37.2%. 5. Family histories revealed that 35.9% of all schizophrenics had in their families some kinds of neurotic and psychotic patients. Among them 23.1% of schizophrenics had neurotic patients and 12.8% of schizophrenics had psychotic patients in their families. According to each subtype, the paranoid type with neurotic and psychotic diseases in their family occupied 35.4% and the latent type occupied 39.0%. In the paranoid type, the patients with psychotic disease in their family occupied 21.6%, on the other hand in the latent type, the patients with neurotic diseases in their family occupied 31.7%. 6. As to the premorbid personality, schizoid personality and paranoid personality were more frequent ones in general. According to each subtypes, the simple type and the catatonic type had significantly higher frequency of schizoid personality and the paranoid type had the higher frequency of paranoid personality and the latent type had the higher frequency of asthenic personality than the other types. The schizoaffective type almost exclusively had schizoid and paranoid personality. 7. In all schizophrenics, the most frequent symptoms were inappropriateness, emotional dullness, anxiety and fearfulness, decreased activity and incoherence. According to each subtypes, the character istic symptoms were as follows, the simple type had inappropriateness, emotional dullness. The catatonic type had negativism and blocking. The paranoid type had increased activity, auditory hallucination, delusion, incoherence and circumstantiality. Among the characteristic symptoms of paranoid type, the delusion were elicited from all of the paranoid schizophrenics. The latent type had inappropriateness, emotional dullness, anxiety and fearfulness, depressed mood, decreased activity, hypochondriasis and obsession.

非行靑少年의 社會精神醫學的 硏究

韓善浩 고려대학교 의과대학 1979 고려대학교 의과대학 잡지 Vol.16 No.1

非行靑少年의 社會精神醫學的 硏究

韓善浩,李丙允 고려대학교 의과대학 1979 고려대 의대 잡지 Vol.16 No.1

The aim of this study was to reveal the sociopsychiatric characteristics of juvenile delinquents. The subjects of the study were 203 male delinquents and 98 female delinquents, and as a control group 109 male working adolescents and 99 female working adolescents were investigated. The analysis was conducted through questionnaires, MMPI and D.A.P. for all 500 adolescents. The results were as follows: 1. The residence of juvenile delinquents was mainly in cities whereas that of working group was in rural areas. 2. The number of siblings for the working group was significantly larger than that of delinquent group while the parity of both group were mostly first and second child. 3. The level of education for the delinquents was lower than that for the working. 4. The occupational background showed that delinquent group reported "no job" much more than the control group. 5. As to their religious background Christians were more among delinquents than working juveniles. 6. The parental loss was much more frequent for the delinquents. 7. The level of father's education was higher for the delinquents than that for the working group. 8. The occupational background of fathers showed that the prevailing job for the delinquents was in re??ails whereas that for the control group was in farming. 9. Complaints against the family were much more frequent for the delinquents than for the working group. 10. The economic level for both group was middle-lower class. 11. Complaints about school and negative attitude in studying were significantly more frequent for the delinquents compared with the working group. The reasons for the drop out from school were mainly problems with and negative attitudes toward their schools among delinquents whereas those were economic difficulties among working group. 12. Leisure was spent in nonproductive activities for the delinquents such as aimless peer gathering, drinking, etc., while for the working group in productive activities such as domestic chores, church attending and listening to music. 13. The most urgent necessity was parental love for delinquents whereas that was money for the working group. 14. Psychological instability in menstrual period was significantly frequent for the female delinquents compared with the control group. 15. The most prevalent offense type of delinquents was theft. (41.9% for male, 77.6% for female) 16. The analysis of MMPI showed that F scale was significantly higher in validity scale and Hy, Pd, Pa, Sc and Ma scores were higher in clinical scales for the delinquents compared with working group. 17. The results of interpretation of Draw-A-Person Test showed that the delinquents revealed immature, egocentric, narcissistic and dependent tendency and unstable social belongingness and poor sexual identity as well. From the investigation it can be surmised that insufficient parental love and the unharmonious atmosphere of the family were the factors of importance as a crime breeder among youth. These factors are supposed to be core problems for youth related to the inability to make a healthy self-identity and to their confusion in social value system.

정신질환자의 사회복귀

이승부,김동희,한선호 순천향대학교 1992 논문집 Vol.14 No.4

정신질환자의 사회복귀는 모든 사회복귀의학의 중요한 구성부분이며 그 중요성은 수용된 장애자의 40%이상이 모두 정신병과 연관되며 또한 정신병의 예방, 치료, 기능훈련은 단지 임상치료로만 해결할 수 없다는 사실에 있다. 사회복귀는 임상치료의 계속이고 점점 많은 사람들의 관심을 불러일으키고 있어 지속적으로 발전되고 있다. 연변사회정신병원(이하 병원이라고 줄임)은 1956년에 개원되어 현재 500베드를 구비한 민정계통에서 관할하는 자선의료사업단체이며 주로 연변지구 208만 인구중 의지할 곳 없고, 집이 없고, 경제적 능력이 없는 민정대상인 정신병환자들의 치료를 맡아보며 치료방법들로는 약물, 심리, 작업, 작문요법 즉 4결합요법을 위주로 하고 사회복귀사업을 폭넓게 추진하고 있으며 개방관리를 실시하고 있다. 본 논문은 주로 병원의 사회복귀병원인 분원의 정신질환자의 사회복귀사업에 관하여 소개, 토론, 연구하려 한다. 연변사회정신병원의 이승부 원장과 순천향대학병원의 한선호는 1990년 7월 30일부터 8월 17일까지 이 분원에 관하여 논문을 만들 것을 토의하였고 초안을 받고 중국과 한국에서 사용되는 한국어의 심한 차이로서 이해가 안되는 부분을 열심히 수정하면서도 뜻만 통한다면 되도록이면 원문에 충실하려고 노력하였기에 공저로써 발표한다. As a part of important problems in psychiatric area, the rehabilitation of psychiatric patients had been considered in many psychiatrists. The authous, thus, introduced rehabilitative programs in Yeonbyeon Social Psychiatric Hospital, China.

勤勞 및 非行靑少年의 精神病理學的 硏究

韓善浩 순천향대학교 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2

소매금융을 중심으로 한 은행 창구 프랜차이즈화 전략

한선호,이정규,우종필 한국프랜차이즈경영학회 2010 프랜차이즈경영연구 Vol. No.

Today, banks offer banking services to a large number of customers by a branch network spread all over the nation. The quantity and quality of services are advanced by fierce competition in their field. So they are attracting customers based on high confidence in the financial industry. In spite of these developments, the retail bank market currently does not satisfy customers demands and various desires.In this research, the problems with banking services were observed. It was proposed that the banking services apply a franchise business model. First, this proposal will reduce the business expenses by collaborating profits with head office of banks and affiliates. Second, it will offer greater satisfaction to the customers.Through the mutual collaboration with head office of banks and affiliates in this proposal, it is anticipated that banks will reduce their business expenses and improve services for customers by offering convenient and fast banking services. It is also expected that the banks will expand and make up their weakness through increased profit and customers will be provided additional services. 요즘 시중의 은행들은 전국적으로 확산된 지점망으로 많은 고객에게 금융 서비스를 제공 하고 있으며, 관련 분야의 높은 경쟁으로 인해 서비스의 양과 질은 향상됨은 물론 고객의 돈을 다루는 업종의 특성상 높은 신뢰도를 바탕으로 고객을 유치하고 었다. 하지만, 이러한 발전에도 불구하고 소매금융을 주로 다루는 영업점에서의 은행창구 업무는 고객의 수요와 다양한 욕구를 충족시키지 못하고 있는 실정이다. 본 연구에서는 이러한 은행 창구의 문제점에 주목하고 은행 창구 업무를 프랜차이즈 사 업으로 확대하여 은행과 가맹점간의 협력적 이익을 형성하여 영업점에 대한 영업비용의 절 감을 추구하고, 점차 증가하는 고객 욕구에 대한 높은 수준의 만족을 제공하며, 사회적인 문제로 대두되고 있는 제 3 금융권에 대한 소비자의 인식을 재정립하는 등 소비자의 바람 직한 금융문화 인식의 향상에 기여하고자 다음과 같은 제안을 하였다. 본 제안을 통해 은행본사와 가맹점간의 상호 협력으로 은행은 창구에 대한 영업비용의 절감과 고객 서비스의 질 향상, 고객은 편리하고 신속한 금융 서비스를 제공받고, 소상인의 금융산업으로 진출의 기회, 서민층에 대한 제 3 금융권의 피해 축소 등 사회적인 이익도 고 려할 수 있으리라 기대된다. 또한 은행은 창구의 영업비용을 여유자금으로 전환하여 사업 범위를 확장하거나 기존의 약점을 보완할 수 있고, 고객은 현재 소매금융의 한정적인 부분 에 효율적인 요소를 가미한 서비스를 받을 수 있으리라 기대된다.