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Treatment outcomes of imported Plasmodium falciparum malaria with intravenous artesunate
이승욱,박태진,정성구,조원진,이강의,고정인 대한응급의학회 2022 대한응급의학회지 Vol.33 No.1
Objective: There has been a consistent import of Plasmodium falciparum malaria into South Korea. As artesunate has been shown to reduce malaria related mortality in other countries, we sought to evaluate the treatment outcomes of P. falciparum malaria with artesunate. Methods: We retrospectively reviewed demographic (age, sex, travel history, and year of admission) and clinical data (sign and symptoms, laboratory findings, complications, treatment outcome) of patients with imported P. falciparum malaria diagnosed between 2014 and 2019. Results: A total of 55 patients with P. falciparum malaria were included, of which 36.4% had severe P. falciparum malaria. Their mean (±standard deviation) age was 42.6 (±12.8) years. Overall, the median length of hospital stay was 6 days (interquartile range, 4-9; range, 3-36) and 21.8% of the patients needed intensive care unit (ICU) care. The overall mortality rate was 3.6%. In patients with severe P. falciparum malaria, half of the patients (50.0%) needed ICU care and the mortality rate was 10.0%. Conclusion: This is the first study to report the outcomes of imported P. falciparum malaria treated with artesunate. The mortality rate for severe P. falciparum malaria in this study was higher than that in other non-endemic countries. Further studies are needed to evaluate the effect of treatment of P. falciparum malaria with artesunate.
임신간격에 관한 분석연구 : 한국농촌 일가 임여성을 대상으로
이승욱,김정근 한국보건통계학회 1976 한국보건정보통계학회지 Vol.2 No.1
This is one part of "Community Pregnancy Study" which has been carried out at three Myons of Chunseong Gun area, Kangwon Province over the period covering from May 1973 to April 1976 with financial assistance from UNFPA. In order to increase the sample size the author has included retrospective information for the period from May 1971 through April 1973. Among the three Myons where the study was actually done, one Myon, called Shindong Myon, has been a demonstration area of the Community Health Program by the School of public Health, Seoul National University since 1972. The intensive health care program is being carried out there for the purpose of field training for students, demonstration model for comprehensive health services, and health research activities. In the present analysis, the pregnancy interval is defined as the period between the end of a certain pregnancy and the beginning of next one, and is assumed to be made of two components: Ⅰ) Infecundable period including post·partum amenorrhoea and anovulatory period, Ⅱ) Fecundable period including ovulatory period. Since the pregnancy interval is the elementary basis for the enhancement of MCH, the author attempted to analyze from these data how the types of previous pregnancy terminations affected the following closed pregnancy intervals. This study attempted to compare by Myons Ⅰ) how the family planning programs prolong pregnancy intervals, Ⅱ) the differences among different types of previous pregnancy terminations, and Ⅲ) the impact of pregnancy interval to MCH. The results are summarized as follows. Ⅰ. The number born between 1935-1954 amounted to 655(91.9%) in total, which is reasonable when compared with the distribution of the married women of child-bearing age in general (Table 1). Ⅱ. By the number of women 543(76.4%) experienced one interval, 149(20.7%) two, and others over three (Table 2). Ⅲ. There were 912 cases in total and among them 735(80. 6%) did not practice contraception during the interval (Table 3). Ⅳ.The increase in the number of living children resulted in the lengthening of the pregnancy interval regardless of contraception (Table 4). Ⅴ. The mean of all the intervals was 20.8 months with the use of contraception and 13.4 without it (Table 5). Ⅵ. The pregnancy interval after live birth was 23.3 months with the use of contraception, and 6.3 without it (Table 5). Ⅶ. The interval after fetal death was 13.7 months with contraception and 6. 3 without it. Also the interval after spontaneous abortion was 11. 6 with contraception and 6. 1 without it after induced abortion 14. 5 with contraception and 6. 4 without it (Table 5). Ⅷ. It was observed that as the mothers' age at the beginning & end of interval increased, so did the length of interval regardless of contraception (Table 6). Ⅸ. The regression & correlation analyses were performed on the pregnancy interval by the mothers' age as shown in the end of Chapter Ⅲ. The findings from the results are as follows; Ⅰ. When the contraception is used, the pregnancy interval after live birth is very similar to the one medically recommended. Ⅱ. The longer pregnancy intervals are observed for the higher brackets of mothers' age. Ⅲ. The experience of contraception prolonged the pregnancy interval by 7. 4 months. Ⅳ. It may be desirable to concentrate on the practice of contraception, which is found to be very effective method of family planning, rather than the induced abortions.
이승욱,Yu Zhou,Tie Zhou,Ming Jiang,김종률,안치원,Alfred K. Louis 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.11
Visibility is a crucial figure of merit for grating-based neutron phase contrast and dark-fieldimaging, and estimating it is important for imaging system design. In this paper, we study thevisibility under polychromatic illumination by using partial coherence theory. Theoretically, weestablish a model to predict the visibility for various cases. Experimental data are also measuredby using polychromatic thermal neutron beam line to generate the visibility. Comparisons betweenthe two show that our theoretical predictions and the experimental results agree with a probabilityhigher than 70%.
이승욱,전영권,권오열 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.58 No.4
A neutron grating interferometer has been developed and implemented for phase-contrast and dark-field imaging experiments on a thermal neutron beamline at the Ex-core Neutron irradiation Facility (ENF) at High-flux Advanced Neutron Application Reactor (HANARO), a 30 MW multipurpose research reactor. The gratings were designed and fabricated to function optimally at a neutron wavelength of 4.4 Å while Beryllium filters were used to shape the beam spectrum by cutting off wavelengths below 4 Å. The average visibility over the grating area was measured at 10%. Neutron dark-field imaging experiments were performed to visualize magnetic domains in a Fe-3% Si sheet in a variety of orientations.
이승욱,이범하,이민희,최서연,이지은 대한영상의학회 2021 대한영상의학회지 Vol.82 No.1
신세포암의 회음부 전이는 매우 드물고 영상 소견은 거의 보고되지 않았다. 저자들은 투명세포 신세포암의 회음부 전이에 의한 회음부 통증을 주소로 내원한 76세 여자 환자의 표적 치료 전후의 영상 소견을 보고하고자 한다. Perineal involvement by metastatic renal cell carcinoma (RCC) is very rare, and there are only few reports on its radiological findings in the literature. Here, we present a case of a 76-year old female who presented with perineal pain caused by metastatic clear cell RCC. We discuss the radiological changes of the tumor before and after targeted therapy.