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양병환,김석현,이영호 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.2
About 150 years have passed since genetics introduced into the psychiatric fields. Nowadays, due to the development of biological psychiatry, psychiatric genetics become a very important section of the psychiatry, contributing to the research for genetic components of psychiatric disorders. But genetic studies of psychiatric disorders have many problems. One reason of the difficulty is that psychiatric disorders do not follow Mendelian inheritance. Instead, psychiatric disorders seems that they have polygenic and multifactorial inheritance characteristics. The authors reviewed the research methods of psychiatric genetics such as family study, twin and adoption study, segregation analysis, linkage and association studies. Also the problems and issues of the research methods were discussed.
양병환,황혜순,Yang, Byung-Hwan,Hwang, Hey-Soon 한국정신신체의학회 2000 정신신체의학 Vol.8 No.1
With Cartesian dichotomy, a person's behavior and illness distinguished sharply between "biologically based" phenomena and "psychologically based" phenomena in western country. But a more balanced view that considers both concepts swept into psychiatry in the 1960s and 1970s. And ironically, the revolution of neurosicience and genetics have now reached a level of sophistication that allow it to serve as a bridge between biology and psychosocial environment. So, even subtle changes in the environment can produce biological changes in the brain. We review the history of definitions and relationship of mind and body. And we provide a selective survey of the recent 3 conceptual models of mind-body relationships in general-biopsychosocial model, mental-physical identity theory, organic unity theory-, the relationships of genetic and environment, and stress-diathesis model.
양병환,백기청,Yang, Byung-Hwan,Paik, Ki-Chung 한국정신신체의학회 2001 정신신체의학 Vol.9 No.1
오늘날 '기억(memory) '이라는 용어는 일반적인 의미 이외에도, 컴퓨터공학의 메모리, 유전자생물학에서 쓰이는 메모리 등의 예에서 보듯 여러 분야에서 광범위한 의미로도 쓰이고 있다. 영어의 'memory' 라는 용어는 어원적으로는 앵글로-색슨어 'gemund' 에서 유래된 말로 gemund은 원래 mind(마음)의 의미라고 한다. 어떻든 전형적인 의미에서 기억이란 과거에 경험한 일들을 회상하고, 이러한 일들에서 학습된 여러 사실과 관념을 마음속으로 다시 가져와 상기시킬 수 있는 능력을 뜻하는데, 다시 말해 기억이란 현재의 도움으로 과거를 일깨워 주는 것이라고 정의될 수 있겠다. 최근에 이루어진 신경생물학적 연구의 발전은 이런 기억이나 학습이 뇌의 어떤 활동 또는 기능과 관련이 있는가를 어느 정도 밝힐 수 있는 단계로까지 이를 수 있게 해주었는데, 그 결과 기억은 단순히 기계적인 기억을 하는 기능만이 아닌 여러 뇌기능에 작용하는 다양한 인지기능의 핵심적인 요소라는 사실이 밝혀졌다. 오늘날 기억은 진화론적 입장에서 인간존재 자체나, 지(智) 정(情) 의(意)로 대별되는 인간정신세계의 가장 핵심적인 요소로서 관심의 대상이 되고 있다. 본 논문에서는 기억 및 기억연구의 개념, 역사, 그리고 신경생물학적 기억연구를 비롯한 최근의 연구경향을 총괄적으로 살펴보고, 향후 이루어져야 할 기억연구의 과제나 방향을 제시하고자 한다.
양병환,김자윤,Yang, Byung-Hwan,Kim, Ja-Yoon 대한생물정신의학회 2000 생물정신의학 Vol.7 No.2
The development of inexpensive high throughput methods to identify individual DNA sequences is important to the future growth of medical genetics. This has become increasingly apparent as psychiatric geneticists focus more attention on the molecular basis of complex multifactorial diseases at which most of psychiatric disease is estimated. Furthermore, candidate gene approaches used in identifying disease associated genes necessitate screening large sequence blocks for changes tracking with the disease state. Even after such genes are isolated, large scale mutational analysis will often be needed for risk assessment studies to define the likely medical consequences of carrying a mutated gene. This review provide basic knowledge of up-to-date technology, cDNA microarray which enables above mentioned various research themes.
전기경련충격시 경쟁적 역전사 중합효소연쇄반응(CRT-PCR)을 이용한 흰쥐 뇌 c-fos 유전자의 발현 양식 분석
양병환,이제욱,박응철,유재학,조광원,양보기,채영규,Yang, Byung-Hwan,Lee, Jei-Wook,Park, Eung-Chul,Yu, Jae-Hak,Cho, Goang-Won,Yang, Bo-Gee,Chai, Young-Gyu 대한생물정신의학회 1996 생물정신의학 Vol.3 No.2
To clarify the mechanism of action of electroconvulsive shack(ECS) in respect to molecular biology, and to detect the quantitative amount of change of c-fos gene expression after ECS in the rat's brain, the authors obtained brain specimens from the striatum, cerebral cortex, hippocampus, and cerebellum. Each brain was removed within 30min. after ECS(130V, 0.5sec) and ECS-sham. Then we performed RT-PCR. The results are 1) ECS was found to affect the expression of immediate early genes. 2) the cerebral cortex and hippocampus was more influenced by ECS thon in the cerebellum and striatum. From these results, we can suggest that ECS is related to the mechanism of cognition, mood, memory which is correlated to cerebral cortex and hippocampus.