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양병환,김석현,이영호 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.2
About 150 years have passed since genetics introduced into the psychiatric fields. Nowadays, due to the development of biological psychiatry, psychiatric genetics become a very important section of the psychiatry, contributing to the research for genetic components of psychiatric disorders. But genetic studies of psychiatric disorders have many problems. One reason of the difficulty is that psychiatric disorders do not follow Mendelian inheritance. Instead, psychiatric disorders seems that they have polygenic and multifactorial inheritance characteristics. The authors reviewed the research methods of psychiatric genetics such as family study, twin and adoption study, segregation analysis, linkage and association studies. Also the problems and issues of the research methods were discussed.
Methamphetamine과 Chlorpromazine이 白鼠腦의 Norepinephrine 含量에 미치는 影響에 關한 實驗的 硏究
楊秉煥 大韓神經精神醫學會 1978 신경정신의학 Vol.17 No.1
This experimental study was aimed at the effects of methamphetamine and chlorpromazine on brain norepinephrine levels and their interaction on central norepinephrine in Fischer albino rats. Drugs were injected twice daily by intraperitoneal routs to groups of rats weighing 150-250g for 5 days. Groups of rats were 25 control rats, 6 rats treated with methamphetamine in low does (3.5㎎/㎏ twice daily), 6rats treated with methamphetamine in low does(7㎎/㎏ twice daily), 13 rats treated with methamphetamine in high does(10㎎/㎏ twice daily), 15 rats treated with chlorpromazine (8㎎/㎏ twice daily) and 14 rats treated with combined drugs. The rats were sacrificed by decapitation one hour after last injection and brain levels of norepinephrine were assayed fluorometrically by the method of Bertler, Carlsson and Rosengren. The average value of norepinephrine in control rats was 0.235㎍/1g brain and had no sexual difference. Low doses methamphetamine had little or no effect on brain norepinephrine levels but norpinephrine level was depleted to 50~60% of the control level after large does of methamphetamine for 2 days. Generally, rats treated with chlorpromazine did not significantly alter norepinephrine levels. Rats treated with methamphetamine (10㎎/㎏ twice daily) and chlorpromazine (8㎎/㎏ twice daily) had higher norepinephrine level than methamphetamine-treated rats, but lower than chlorpromazine-treated rats. Norepinephrine level was depleted after combined treatment for 5 days. The results were discussed in terms of implication for several mechanisms of methamphetamine interaction with chlorpromazine, primarily mediated by cyclic AMP and calcium ion on release of central norepinephrine.