정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

배추 시스테인 단백질 분해 효소 억제 유전자 BCPI-1의 발현과 종자 발아 및 유묘 생장과의 연관성

홍준기,이은영,김정률,양경애,최영주,정우식,김호일,윤대진,이상열,조무제,임체오 Plant molecular biology and biotechnology research 2003 Plant molecular biology and biotechnology research Vol.2003 No.-

Phytocystatins are protein inhibitors of cysteine proteinases of the papain family that have been identified in both monocot and dicot plants. A cDNA encoding a phytocystatin, BCPI-1 (Brassica Cysteine Proteinase Inhibitor-1) has been isolated from Chinese cabbage (Brassica campestris L. ssp. pekinensis) flower buds. Here, we tested whether BCPI-1 transcription is regulated by hormones, and could be involved in regulating cysteine proteinases during and after germination. BCPI-1 was sensitive to exogenous GA_(3) and ABA, which are important factors controlling seed germination, suggesting that the expression of BCPI-1 is hormonally regulated. We introduced a recombinant plasmid containing the full-length BCPI-1 cDNA under the control of cauliflower mosaic virus 35S promoter into rice embryogenic calli using the particle delivery method, and regenerated a number of transgenic rice plants. Constitutively over-expressed BCPI-1 caused changes in overall plant growth and development, including reduced germination and seedling growth. These data support the role of the BCPI-1 in the regulation of endogenous proteinases during both seed germination and subsequent seedling development. Phylocystatins은 papain계열의 cysteine 단백질 분해 효소 활성을 특이적으로 억제하는 억제자로 다양한 식물 종으로부터 분리되었다. 본고에서는, 배추 화아 cDNA library로부터 분리된 phytocystatin인 BCPI-1(Brassica Cysteine Proteinase Inhibitor-1)의 생체 내 기능에 대해 연구하였다. 먼저, BCPI-1 전사체는 발아 조절에 중요한 영향을 미치는 GA₃와 ABA에 의해 예민하게 증가, 혹은 감소되는 반응을 보임으로써, BCPI-1이 식물 호르몬의 영향을 받으며, 특히 발아나 유묘의 생장 조절에 관련이 있음을 알 수 있었다. Particle bombardment 방법을 통하여 BCPI-1을 벼의 배 형성 세포 내에 도입, 재분화 시켜 형질 전환 벼를 생성하였다. CaMV 35S promoter의 조절에 의해 지속적인 BCPI-1 발현을 보이는 형질 전환 벼의 경우, 발아와 유묘 생장이 현저히 지연되었다. 위의 결과들을 바탕으로, BCPI-1이 식물체 내에서 생성되는 cysteine 계열의 단밸질 분해 효소 활성을 조절하여 종자의 발아와 유묘의 생장에 영향을 미치는 것으로 추측한다.

외식프랜차이즈 가맹점의 갈등과 분쟁해결 사례연구

김기홍,정웅용,변준영 韓國仲裁學會 2005 중재연구 Vol.15 No.3

This study is for an example of arbitration of a dining out franchise company in Korea and frachise system currently is expanding and developing to international trade. The main reason for that is franchising has some benefits compared to the existing trades. Korean dining-out industry has largely developed for the past 20 years, but there are little world-class company of the industry, because dining-out industry should go for qualitative as well as quantitative growth at the same time. Korean dining-out industry has adopted licensing and joint-venture among growth strategies, but the franchise system among them seems to have taken its place as a representative strategy for management to develop dining-out industry. The history of Korean dining-out franchise industry is very short and it is true that we have no a management philosophy of accompanying growth with franchise due to a short experiences and recognition of top management or managers and short-term strategy for branch expansion. For a brilliant growth of dininig-out franchise industry, to settle disputes through arbitration, in case of disputes taking place, is very important, because the franchise industry is a frequent-trading sector, requires expert-level knowledge, favors a closed examination and also needs a fast solution. As the franchise industry has been sharply growing around the world, there is more possibility of disputes, and various and complicated laws of the industry are related to disputes as well, so much more expert-level knowledge is required to solve disputes. Therefore, affiliated headquarters hope a disclosed settlement of their disputes and their any disputes should be fast settled for the benefits of affiliated members.

하수 2차 처리수 재이용을 위한 저압 및 중압 고도산화시스템의 성능평가

안규홍,안석,맹승규,김기팔,홍준석,정민우,권지향,Ahmed, Zubair 대한상하수도학회 2003 상하수도학회지 Vol.17 No.4

In the present study, the feasibility of UV/H₂O₂ systems was investigated using low and medium-pres sure lamps on biologically treated wastewater effluents for secondary effluent reclamation. Two types of UV lamps were used as the light sources (a 33W lowpressure mercury lamp and a 350-W mediumpressure mercury lamp). The results from these UV systems showed that the removal of organic compounds could be achieved in the contact time of longer than 30min (i.e., low UV doses). Efficiencies of color removal and disinfection were far better than those of organic matters measured as TOC, DOC and TCOD_(cr). In the low pressure lamp UV system, it has been found that DOC and color removals were 60.9 and 86.2% with 50㎎/L of H₂O₂ and contact times of 30 minute, respectively. Whereas, with the mediumpressure lamp UV system, TOC, DOC and color removal were 27.1, 5.6 and 95% with 14.3㎎/L of H₂O₂ and 14 minute of contact times, respectively. Both systems could be applied for the reclamation of secondary effluent treated with biological treatment processes.

콘크리트내의 철근 및 공동탐사를 위한 측정과 분석

임홍철,박기준,이숭재 한국비파괴검사학회 2000 한국비파괴검사학회지 Vol.20 No.4

콘크리트 내부에 위치한 철근과 공동의 탐사 성능을 파악하기 위해, 상용 비파괴 검사 장비를 이용한 측정과 이론적 모델링을 실시하고, 향상된 신호처리 결과의 예를 제시하였다. 실측에 사용된 장비는 레이더 장비 2종과 전자기법 철근 참사 장비 2종이다. 철근 참사에는 직경 19mm의 철근을, 그리고 공동 탐사에는 두께 50mm의 스티로폼을 콘크리트 시험체 안에 각기 다른 피복 두께로 매립하여 측정하였다. 또한, 철근의 수평 배근 간격 탐사를 위해 두개의 철근을 매립 측정하였다. 실험과 함께 전자기파 모델링 방법을 소개하여, 레이더를 이용한 경우, 철근과 공동이 탐지되는 과정을 이론적으로 보여주었다. 탐사능을 향상시키기 위해, 상용 레이더 장비의 측정 결과를 신호처리 과정을 통해 개선하였다.

준 열원의 강도분포에 관한 연구

도시홍,정세민,배세환,성상기,박흥준 釜山水産大學校 1985 釜山水産大學 硏究報告 Vol.25 No.1

실험결과 다음과 같은 결론을 얻을 수 있었다. q=3,q=30일때 최대치의 확율은 각각 0.08, 및 0.029이었다. 이것은 Pearl과 Troup의 결과 (q=1.9106, q=5.6904 및 q=34.7657 일때 최대치의 확율은 각각 0.09, 0.06 및 0.02)와 아주 유사했으며, 관측시간의 증가에 따라 분포의 천이경향도 이론적 결과와 잘 일치 되었다. 또한 준열원에서 방출된 광자들이 공간내의 유한한 영역에서 고르게 분포되어 있을때 그 광원을 coherence time보다도 더 긴 시간동안 관찰한다면 그 관원을 gaussian으로 취급할 수 있으며, 광자에 대한 Bose-Einstein 통계의 적용이 타당함과 Mandel의 근사공식(q>>1, q<<1인 경우)이 잘 성립될 것임을 실험으로 예상할 수 있었다. Light emitted from a source fluctuates both spatially and temporally. The spatial fluctuations are due to the finite size of the source and the spatial incoherence of the photons emitted from various parts of the source. Temporal fluctuation are due to the wide blackbody spectrum emitted by such a source. It is a direct result of the Bose-Einstein statistics obeyed by photons. Actual measurements on the statistical behavior of thermal light are conducted by pseudothermal light source. In the experiment, we examined the probability density f(I) that the intensity I associated with one or pore coherence volumes is between I and I+dI and the deviation for q<1, which is given by G. Bedad et al. The derivation of f(1) for the case of more than one coherence volume has been given in an approximate form by Mandel and by Troup. As a result, we obtain p(n,T)=0.08 at q=3 and p(n,T)=0.029 at q=30. These are very similar to pearl and Troup's [p(n,T)=0.09 at q=1.9106, p(n,T)=0.06 at q=5. 690, p(n,T)=0.02 at q=34.7657]. So we can conclude that when we observerse pseudo-thermal source for a long time (compared with its coherent time), the source can be treated as a gaussian light source and Mandel's approximation is good fit for photon counting.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

개심술후 정신의학적 합병증

임기영,조범구,민성길,이홍식,유계준 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.1

Pre-and post operative psychiatric evaluations were done using semi-structured interview with Hamilton scales for anxiety and depression in 57 open heart surgery receipients to assess post-operative psychiatric complications. Conspicuous post-operative psychiatric complications were observed in 16 (23%) of 57 patients after open heart surgery. Postcardiotomy delirium occurred in seven patients; acute psychotic reaction with paranoid ideation in one; and neurotic reaction in eight. Factors that tended to influence postoperative psychiatric complications were older age, unempolyment, previous medical/psychiatric history, and high level of preoperative anxiety. By analysis of the preoperative psychiatric evaluation, patients could be largely divided in 3 groups; anxiety group, denial group, and adjusted group. Excessive anxiety and massive denial seemed to be signficant in the postoperative psychiatric compliactions. With these findings, the author's impression was that the consultation psychiatrist should give comprehensive psychiatric evaluation and psychiatric preparation in pre-and post-open heart surgery for the possible prevention of postopertive psychiatric complications.

구조화 표본추출을 이용한 핀의 최적설계에 관한 연구

박홍준,김기형 朝鮮大學校 機械技術硏究所 2001 機械技術硏究 Vol.4 No.2

The Taguchi method by orthogonal array, one of the structured sampling methods, has many advantages which are row cost and time saving for experiments and researches. But this method has applied limited area especially about mechanical problems. So, we experimented whether the structured sampling is useful to apply optimal design of mechanical elements. First, we made a mechanical problem to determine optimal parameters of a pin with a hole. The second, we calculated combination of optimal parameters by simulation. At the same time, we seeked optimal combination by structured sampling using orthogonal array and ANOVA. The last, we compared these two results. The experimental result have shown that the structured sampling method seeked optimal parameters exactly. So, we see some possibility in this application.