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      • KCI등재

        Lorazepam 남용 6례

        민성길 大韓神經精神醫學會 1982 신경정신의학 Vol.21 No.1

        With brief review of literatures on abuse of benzodiazepines, the author reported 6 cases of lorazepam abuse and discussed their characteristic clinical features. Of 6 cases, 5 were females and daily dosages of lorazepam were 20 to 150mg and durations of abuse were 6 months to 7 years. Their premorbid personality was characterized by dependence, introversion, social isolation and sensitivity. They had begun to abuse the drug mainly due to anxiety, insomnia and neurotic somatic symptoms soon after object loss such as death of significant persons. Accordingly, it seemed that abuse resulted from defense against object loss and from oral gratification. As combined substances, alcohol, analgesics, diuretics and psychostimulants were reported in some of the patients. All the patients said that they had to take the drug and had to increase the dosage to relieve anxiety, insomnia, and neurotic somatic symptoms, but some of the patients expected or experienced some euphoric effect from lorazepam. Though the dosage was very heavy and the duration of abuse wa??? extended, no significant physical side effects or complications were found in any of them except drowsiness and weakness that could be found with therapeutic dose. Tolerance seemed to develop in relatively short time and the main reason seemed to be strong oral craving, culminating to psychological dependence rather than physical dependence. On withdrawal, severe anxiety, insomnia and somatic symptoms as headache and agitation have developed in all patients, which were considered as rebound phenomena. In addition, rigidity and tremor around mouth and extremities, paresthesia, perspiration, impulsive destructive behavior, depression, and psychosis-like menifestations which could be considered as true withdrawal symptoms have developed in some patients who had taken larger does of about 100mg a day. Most of them have been treated in hospital with medically supportive treatment, complete discontinuation of lorazepam and medication of tricyclic antidepressants and phenothiazines against possible withdrawal symptoms The treatment result was succeseful on a short term but in long term perspective, prognosis may be less favourable. The clinical feature of lorazepam abuse seems not to be so different from general feature of other benzodiazdpine abuses.

      • KCI등재

        Benzodiazepine계 약물의 사용과 의존성

        민성길 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.3

        The world-wide use of benzodiazepine increased steadily until the late 1970's. Since then. as the abuse of and dependence on benzodiazepine became public knowledge. the prescription of benzodiazepine by physicians has become conservative. In Korea. however. the number of prescriptions seems to be continuously increasing. Recently, the dependence and withdrawal symptoms with the therapeutic dose of benzodiazepion has been noted to be as severe and dangerous as those in chronic abuse with larger doses. The severity of benzodiazepine dependence and withdrawal symptoms seems to be related to the pharmacokinetic characteristics of the drug. The previously most popular one was diazepam. and lorazepam is most popular these days. Author has also described the nature of benzodiazepine dependence and withdrawal symptoms. the techniques for withdrawing benzodiazepine and guidelines recommended by experts for the prevention of benzodiazepine dependence. i.e., avoiding unnecessary chronic treatment.

      • KCI등재

        홧병(火病)의 개념에 대한 연구

        민성길 大韓神經精神醫學會 1989 신경정신의학 Vol.28 No.4

        Hwabyung(fire disease) is the term which has long been used by lay people in Korea for a clinical disease. This study was conducted in an attempt to define the concept of hwabyung through semistructured interviews with 100 patients complaining of hwabyung who presented at the Department of Psychiatry, Yonsei University Hospital in Seoul. The majority of patients with hwabyung were married women in middle or past middle age and of lower social, economic and educational classes. Any etiologically related factors in family history and past history were not apparent. Hwabyung was found to be a chronic disease with a duration of about 10 years. Many of the patients had received treatment from a number of specialists, herb doctors and even a faith healer and shaman. This was indicative of the fact that they were reluctant to be seen as psychiatric patients but were aware that their illness was of psychogenic origin, suggesting that Korean lay people are already familiar with concept of psychogenic or neurotic disorders. The etiologically related life experiences reported by patients included chronic marital conflict with husband and in-laws, financial loss, poverty, a difficult life, other unfair social suffering and personality characteristics of themselves. These life experiences caused complex emotional reactions characterized by annoyance, mortification, anger and hate. These emotional complexes had been incompletely suppressed as they were of real external origin in the patients' conscious level. Hwabyung seems to develop as these life experiences, characteristic emotional reactions and related adjustment problems are repeated and accumulate over a long period of time. Hwabyung or hwa seems to be named for a combined state of those incompletely suppressed dynamic emotional reactions and their somatized physical states. These seem to symbolize the nature of fire, from which the term of Hwabyung is derived, and the partial suppression of it. Accordingly, in addition to general neurotic symptoms such as anxiety, depressive syndrome, insomnia, indigestion, headache and other physical pains, the symptoms of hwabyung are also characterized by somatic symptoms such as chest oppression, sighs, heat or hot sensations, dry mouth, something pushing-up in chest, palpitation, epigastric mass, talkativeness, loss of mind, and an impulsive wish to quickly get out of the house. Diagnostically, depressive, anxiety and somatization disorders were most frequently observed. Many patients had two or more diagnoses. The prognosis seemed to be chronic and poor. The possible relationship between the psychopathology of hwabyung and so called hahn, which is known to be the unique traditional affective expression of Koreans, and the possibility that hwabyung can be a culture-bound syndrome in korea was discussed.

      • KCI등재후보

        Symptoms to Use for Diagnostic Criteria of Hwa-Byung, an Anger Syndrome

        민성길,서신영,송기준 대한신경정신의학회 2009 PSYCHIATRY INVESTIGATION Vol.6 No.1

        Objective: The aim of this study was to identify the characteristic symptoms which can be used for the diagnosis of hwa-byung, a culture-related anger syndrome in Korea. Methods: The symptoms of the Hwa-byung Scale were correlated with the Korean versions of the Hamilton Depression Rating Scale (K-HDRS) and the State and Trait Anger Inventory (K-STAXI) in 89 patients, who were diagnosed as having major depressive disorder, dysthymic disorder, anxiety disorders, somatoform disorders, or adjustment disorder according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSMIV) criteria and who had self-labeled hwa-byung. Also, the symptoms of the Hwa-byung Scale were correlated with each other. Results: The symptoms of the Hwa-byung Scale which were significantly correlated with the state anger of the K-STAXI but not with the depressive mood (item 1 of K-HDRS) included feelings of unfairness, subjective anger, external anger, heat sensation, pushing-up in the chest, dry mouth, and sighing. The symptoms which were significantly correlated with state anger and depressed mood included respiratory stuffiness, “haan” and hate. The symptoms which were not significantly correlated with depressed mood and state anger included going-out, epigastric mass, palpitation, headache/pain, frightening easily, many thoughts, and much pleading. These symptoms also showed higher correlation with each other in the correlation matrix. Conclusion: Our findings suggest that hwa-byung is different from depressive syndrome in terms of its symptom profile, and suggest what symptoms should be included in the diagnostic criteria of hwa-byung, an anger disorder. Objective: The aim of this study was to identify the characteristic symptoms which can be used for the diagnosis of hwa-byung, a culture-related anger syndrome in Korea. Methods: The symptoms of the Hwa-byung Scale were correlated with the Korean versions of the Hamilton Depression Rating Scale (K-HDRS) and the State and Trait Anger Inventory (K-STAXI) in 89 patients, who were diagnosed as having major depressive disorder, dysthymic disorder, anxiety disorders, somatoform disorders, or adjustment disorder according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSMIV) criteria and who had self-labeled hwa-byung. Also, the symptoms of the Hwa-byung Scale were correlated with each other. Results: The symptoms of the Hwa-byung Scale which were significantly correlated with the state anger of the K-STAXI but not with the depressive mood (item 1 of K-HDRS) included feelings of unfairness, subjective anger, external anger, heat sensation, pushing-up in the chest, dry mouth, and sighing. The symptoms which were significantly correlated with state anger and depressed mood included respiratory stuffiness, “haan” and hate. The symptoms which were not significantly correlated with depressed mood and state anger included going-out, epigastric mass, palpitation, headache/pain, frightening easily, many thoughts, and much pleading. These symptoms also showed higher correlation with each other in the correlation matrix. Conclusion: Our findings suggest that hwa-byung is different from depressive syndrome in terms of its symptom profile, and suggest what symptoms should be included in the diagnostic criteria of hwa-byung, an anger disorder.

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