천자서평 1 : 약물남용 - 민성길 / 중앙문화사 / 1998 -

민성길 한국상담선교연구원 ( 구 한국상담선교학회 ) 2000 상담과 선교 Vol.8 No.4

Triazolam의 수면효과

민성길,오병훈 최신의학사 1988 最新醫學 Vol.31 No.10

한국 전통의약물로부터의 신경정신계 신약개발

민성길,홍창형 대한정신약물학회 2007 대한정신약물학회지 Vol.18 No.1

This paper reviews history of new drug development in Korea as well as the world and researchs on development of new psychotherapeutic drug from traditional medicines or natural products in Korea. Korea has a long history of traditional medicine and accumulated knowledge of natural resources. However, only a few new drug have been developed from those natural products. Now many researchers in Korea are devoting themselves to test the possibility of natural products as antipsychotic drugs, antidepressants, anxiolytic drugs and cognitive enhancers. However, only a few graduates from traditional medical schools in Korea are engaging in research on developing new drug from natural products and they are not familiar to research methods of western medicine and pharmacology. For research and development of new drug from natural products or traditional medicines, many researchers should be trained for methodology of basic medicine, pharmacology, pharmacognosy, and oriential pharmacy. Government and pharmaceutical companies need to provide more investment for R&D for new drug from natural products including establishment of data base for component of traditional medicines and natural products, system development integrating information technology, bio-technology and nanotechnology, and international collaboration with advanced countries which have common interest in new drug development from natural products. 외국 및 국내의 천연물 신약 개발의 역사와 현황과 그리고 신경정신질환을 대상으로 한 국내 천연물 신약 개발 현황에 대해 조사 기술하였다. 현재 우리나라는 오랜 전통의학의 역사와 풍부한 천연물 자원을 가지고 있으나 개발된 천연물신약은 많지 않은 편이다. 국내에서는 최근 한약재 및 전통의학에서 사용되어온 재료 또는 기타 천연물을 이용하여 신경정신질환을 대상으로 한 항불안, 항정신병, 항우울, 항치매 약효의 가능성을 연구 중에 있다. 그러나 한국전통의학을 연구하는 한의대에서 많은 인재를 배출하고 있지만 연구분야에 종사하는 경우가 드물 뿐 아니라 서양의학적 내지 약리학적 연구 방법에도 익숙치 않은 형편이다. 앞으로 한국전통의학에 기반을 둔 천연물 신약개발을 위해서는 서양의학, 약리학, 생약학 및 한약학 등에 익숙한 기초의약학 연구자들이 많이 배출되어야 할 것이다. 특히, 정부와 제약회사는 연구개발에 많은 투자를 해야 하며, 천연물과 한약재의 특성에 대한 데이터베이스 구축뿐 아니라 정보기술(information tech-nology), 생명공학기술(bio-technology), 나노기술(na -notechnology)를 통합할 수 있는 시스템구축과, 한국전통의약물을 이용한 천연물 신약개발에 관심이 있는 선진국과 국제적 협력 교류에도 많은 관심을 가져야 할 것이다.

한(恨)의 정신병리학(精神病理學)

민성길 한국라깡과현대정신분석학회 1998 코리안이마고 Vol.2 No.-

Lorazepam 남용 6례

민성길 大韓神經精神醫學會 1982 신경정신의학 Vol.21 No.1

With brief review of literatures on abuse of benzodiazepines, the author reported 6 cases of lorazepam abuse and discussed their characteristic clinical features. Of 6 cases, 5 were females and daily dosages of lorazepam were 20 to 150mg and durations of abuse were 6 months to 7 years. Their premorbid personality was characterized by dependence, introversion, social isolation and sensitivity. They had begun to abuse the drug mainly due to anxiety, insomnia and neurotic somatic symptoms soon after object loss such as death of significant persons. Accordingly, it seemed that abuse resulted from defense against object loss and from oral gratification. As combined substances, alcohol, analgesics, diuretics and psychostimulants were reported in some of the patients. All the patients said that they had to take the drug and had to increase the dosage to relieve anxiety, insomnia, and neurotic somatic symptoms, but some of the patients expected or experienced some euphoric effect from lorazepam. Though the dosage was very heavy and the duration of abuse wa??? extended, no significant physical side effects or complications were found in any of them except drowsiness and weakness that could be found with therapeutic dose. Tolerance seemed to develop in relatively short time and the main reason seemed to be strong oral craving, culminating to psychological dependence rather than physical dependence. On withdrawal, severe anxiety, insomnia and somatic symptoms as headache and agitation have developed in all patients, which were considered as rebound phenomena. In addition, rigidity and tremor around mouth and extremities, paresthesia, perspiration, impulsive destructive behavior, depression, and psychosis-like menifestations which could be considered as true withdrawal symptoms have developed in some patients who had taken larger does of about 100mg a day. Most of them have been treated in hospital with medically supportive treatment, complete discontinuation of lorazepam and medication of tricyclic antidepressants and phenothiazines against possible withdrawal symptoms The treatment result was succeseful on a short term but in long term perspective, prognosis may be less favourable. The clinical feature of lorazepam abuse seems not to be so different from general feature of other benzodiazdpine abuses.

뚜렛 장애의 임상적 연구

민성길,신동원,노경선 대한소아청소년정신의학회 1997 소아청소년정신의학 Vol.8 No.1

Benzodiazepine계 약물의 사용과 의존성

민성길 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.3

The world-wide use of benzodiazepine increased steadily until the late 1970's. Since then. as the abuse of and dependence on benzodiazepine became public knowledge. the prescription of benzodiazepine by physicians has become conservative. In Korea. however. the number of prescriptions seems to be continuously increasing. Recently, the dependence and withdrawal symptoms with the therapeutic dose of benzodiazepion has been noted to be as severe and dangerous as those in chronic abuse with larger doses. The severity of benzodiazepine dependence and withdrawal symptoms seems to be related to the pharmacokinetic characteristics of the drug. The previously most popular one was diazepam. and lorazepam is most popular these days. Author has also described the nature of benzodiazepine dependence and withdrawal symptoms. the techniques for withdrawing benzodiazepine and guidelines recommended by experts for the prevention of benzodiazepine dependence. i.e., avoiding unnecessary chronic treatment.

뇌기능과 정신건강

민성길 연세대학교 신과대학·연합신학대학원 1999 연세 목회전문화 세미나 Vol.1 No.-

향정신성약물과 그 작용

민성길 의학교육출판사 1988 Korean Journal of Family Medicine Vol.4 No.3

맥라렌 교수(2). 그의 정신의학 이론

민성길 대한신경정신의학회 2012 신경정신의학 Vol.51 No.1

Professor Dr. Charles I. McLaren (1882-1957) of the Department of Psychiatry, Severance Union School of Medicine in Seoul, Korea had introduced not only Christianity but medicine and psychiatry of his time with his own theories to Korea while he had served as a Christian missionary from Australia to Korea from 1911 to 1941. Based on his view of Christianity and knowledge of modern science and medicine, he tried to explore the etiology, symptoms, treatment and spiritual meaning of mental disorders including general paresis, dementia praecox, mania, melancholia, paranoia, neurasthnenia, hysteria, hypochondriasis, and even psychophysiological disorder. Though he accepted that mental disorders are related to disrupted functions of brain or neurons, he believed that fundamental causes of insanity is spiritual. Regarding etiology, he suggested that people’s choice not to follow God’s logos by their free-will and consequent disharmony with nature or human society or failure of self to adapt to reality causes mental disorders. And he explained psychotic phenomena in view of Christian spirituality. In addition, he argued “psychic” (psychological or spiritual) conflict, sensitivity and guilt feeling as a possible etiology of psycho-neurosis including neurasthenia, hysteria and hypochondria. Conflict includes not only sexual conflicts but social conflicts related to family, job, money, or guilt feeling. He also emphasized the meaning and purpose of life in relation to development of mental illness. Remarkably, he introduced idea of “spill-over” to explain how emotional problems influence autonomic dysfunction resulting in psycho-physiological symptoms. He can be recognized as a psychiatrist who integrated bio-medical descriptive psychiatry with psycho-social approach, dynamic psychotherapy and even spiritual approach as a fundamental one. Though many scientific criticism can be given to his theories of psychaitry, he is deserved to be rediscovered and recognized as a pioneer who had shown another apprach to mental disorders to present psychiatrists who are lost in confusion with so many uncertainties in regard to understanding and treating mental disorders. 끝으로 맥라렌은, 과학이 기독교와 상치되지 않는다는 주장과 더불어 인류의 과학적 미래에 낙관적 시각을 보여주고있다. 그는 미래에 과학이 발달하면, 정신병에 대한 영적 치료, 기적, 신유, 등 영적 이론들을 뇌과학적으로(현재의 예를들면, 도파민 가설이나 뇌영상연구, 유전자 연구, 등으로) 입증할 수 있을 것으로 보았다. 그의 이러한 언명은 최근 대두되고 있는 감정과 인지기능에 대한 뇌과학, 정신분석과 신경과학의 융합, 즉 neuro-psychoanalysis 등 새로운 연구 경향에서 바로 그 실현이 시작되고 있는 것 아닌가 한다. 이러한믿음을 따르든 말든 모든 의과학자들은, 맥라렌의 신념에 따르면, 하나님이 인간에게 주신 소명에 따라 결과적으로 영성을 입증하고자 노력할 것이며, 결국 언제인가 성공할 것이다.