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수종의 표피종양에서 p53단백발현에 관한 면역조직화학적 연구
이성열,부태성,이종석,김의한 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2
This study was carried out to evaluate the aberrant expression of P 53 protein using immunohistochemical method in 28 basal cell carcinoma, 24 squamous cell carcinoma, 7 keratoacanthoma, and 4 Bowen's disease. Eighteen out of 28(64.3%) and twenty one out of 24(87.5%) showed positive reaction in the nucleus of basal cell carcinoma and squamous cell carcinoma, respectively. Five out of 7(71.4%) and three out of 4(75%) showed positive reaction in the nucleus of keratoacanthoma and Bowen's disease. In conclusion, our results suggest that the aberrant expression of P53 protein is a common and an important part of the pathogenetic sequence in a majority of cases of epidermal neoplasms.