獻仙桃에 대한 考察 : 文獻을 中心으로

孫貞姬 한국무용연구회 1982 한국무용연구 Vol.1 No.-

The purpose of this study is to establish a clear concept on “Dong-Ak-Jung-Jae” (Chinese music-styled court singing and dancing) by comparatively analyzing contents, forms and various elements of “HEON SUN DO” which belongs to “Dang-Ak-Jung-Jae” among traditional court dances, and also to examine the possibility of the revival of old court singing and dancing which has been handed down only through document, by resorting “Heon Sun Do” to it’s original form through reviewing of it’s general forms and characteristics. In the changing process and structure of “Goong-Joong-Jung-Jae” (court singing and dancing), it is considered that each work of court singing and dancing has a racial character rising above an unique expression of feeling, and oriental thought of philosophy of “Eum Yang Five Elements” dwells in the ceremonial procedures and framework itself, and that form of dance is characterized by it’s courtesy, slow tempo and it’s meaningful, free use. The “Goong-Joong- Jung-Jae” is classified into two parts of “Hyang-Ak-Jung-Jae” (Korean traditional music style) and “Dang-Ak-Jung-Jae” (Chinese music-styled singing and dancing). The contents of “Heon-Sun-Do”, a typical dance of “Dang-Ak-Jung-Jae are that Wang-Mo comes down from the fairy land to present the fairy land’s pcaches to the King to pray for long living of the King. In the form of dancing motion, the first KuHo of the ceremony is announced by 2 Bongjuk- Kanja (ceremony processors who are playing a role of guide for dancing), then stands facing inward each other. Then, 1 Kisaeng (youth or juniors are preferrable) gives fairy land's peach tray to Wang-Mo, and Wang-Mo faces westward, singing words of song in Chinese characters. Thus, all procedures for ceremony to announce the beginning of dance are just finished. Now, they start dancing in full scale. First, all of dancers return to their original form, performing various dances, such as “Sasu-Mu”, “SuboRock-Mu”, “Hyupsu-Mu”, etc, and singing words of other songs between some intervals of dancing. After that, facing forward, Bongjuk-Kanja announce “after-KuHo” by saluting that the dancing was finished, and all of dancers move backward. In the comparative analysis of music journal “Koryo-Sa-Ak-Chi”, “Ak-Hak-Kwe-Bom” and “Goong-Joong-Jung-Jae-Mu-Do-Hol-Gi” (at the end of Yi Dynasty), some music used for the subject dancing is found to be of the same name of melody (or tune) and some others are found to be of different name of tune. However, the details on the forms and contents of music are unknown, because it was not shown in old documents. Therefore, the forms and contents of music used depend upon common name and pen name which were established by the National Classical Music Institute. Moreover, “KuHo-Chio” and “Chio” of “Koryo-Sa-Ak-Chi” were divided into “before- KuHo" and “after-KuHo” since “Music Standard”, and the “Jakkan-Ja” announced it in such way, and sang it in the abridged form of contents. “Won-Mu” (dancing team consists of 3 dancers), 1 “Wang-Mo” (Sun-Mo shown in “Goong-Joong-Jung-Jae-Mu-Do-Hol-Gi”), 2 “Hyup- Mu”, and “Bongwi-Eui” consists of 18 members. Moreover, we can easily understand that costumes and ceremonial things for them are found to be the same one as in other “Jung-Jae” in most cases. However, many changes for dancing motion and forms had been made due to the contemporary performance situation, especially in it’s contents. Moreover, we are unable to compare such changes in detail because there are not records in documents for it. As commented above, it is well concluded that, some changes has been made for “Heon Sun Do” during the period from “Koryo-Dynasty” to “Chosun-Dynasty”, including changing of names, singing it in the abridged form of song words and changing of music, especially in con¬tents and forms. However, it is considered that “Heon-Sun-Do” is a typical “Dong-Ak-Jung-Jae” which preserves it’s original form without being much changed both in it’s contents and forms.

공동주택내 이산화질소(NO2) 및 휘발성유기화합물(VOCs) 노출에 따른 건강 위해성 평가

Jung,Soon-Won,Yang,Won-Ho,Son,Bu-Soon 한국환경보건학회 2007 한국환경보건학회지 Vol.33 No.4

Indoor air quality has become a topic of interest and concern. Especially changes in construction design and the increased use of synthetic products may result in an increasing of complaints and health effects about the quality of indoor air at home. In this study, nitrogen dioxide(NO2) and volatile organic compounds(VOCs) within new and established apartments on the basis of 4 years of building year were measured every 3 days consecutively during 60 days. We selected each 10 house in Seoul, Asan and Daegu, respectively, and produced risk numbers for hazard quotients, and predicted increases in incidence of cancer. The calculations were made for the adult with default exposure values and also made for a worst case scenario using Monte-Carlo simulation as describing the reasonable exposure(RME). Mean of Monte carlo analysis by benzene, in the construction under 4 years (male: 9.2105, female: 1.0×104) and over 4years (male: 6.8×105, female: 8.3×105) exceeded 106 of permitted standards in US EPA, RME of Monte carlo analysis. In construction under 4 years (male: 9.9×103, female: 9.6×103) and over 4years (male: 9.8×103, female: 7.8×103) exceeded 104 of maximum permitted standards in US EPA. The hazard index of non-carcinogenic pollutants by nitrogen dioxide, toluene, m,p-xylene and o-xylene, both male and female in apartment constructed under 4 years and over 4 years was found less than the permitted standards of hazardous health effects in CTE. Significant cancer risks and non-cancer hazard quotients were predicted in under 4 years of building year.

Methylation Status and Expression of E-cadherin in Oral Squamous Cell Carcinomas Compared to Benign Oral Epithelial Lesions

Son, Hyun-Jin,Chu, Jung-Youb,Cho, Eui-Sic,Lee, Dong-Geun,Min, Myung-Gee,Lee, Suk-Keun,Cho, Nam-Pyo The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2

Expression of invasion/metastasis suppressor, E-cadherin, is reduced in many types of human carcinomas. Although somatic and germline utations in the CDH1, which encodes the human E-cadherin, have frequently been reported in cases with diffuse gastric and lobular breast ancers, irreversible genetic inactivations are rare in other human carcinomas. Recently, it has been well documented that some genes in human cancers may be inactivated by altered CpG methylation. Herein, we determined the expression and methylation status of E-cadherin in oral squamous cell carcinoma (SCC) by immunohistochemistry and methylation-specific PCR. The expression of E-cadherin was significantly higher in the well-differentiated oral SCCs than the moderately or poorly differentiated ones. None of eight tested benign pithelial hyperplasias showed aberrant methylation, whereas five of 12 oral squamous cell carcinomas showed aberrant methylation. When we compared E-cadherin expression with methylation status, oral SCCs with normal methylation showed a higher expression of E-cadherin than those with methylation. These findings suggest that aberrant CpG methylation of CDH1 promoter region is closely associated with transcriptional inactivation and might be involved in tumor progression of the oral mucosa.

현대음악 앙상블의 리허설 담론 분석

손민정(Son, Min-Jung) 한국교원대학교 교육연구원 2020 敎員敎育 Vol.36 No.2

본 연구는 2012년에 결성된 한국 현대음악 단체 project21AND의 제4회-제6회 정기연주회(2016-2018년) 리허설 담론을 분석함으로써 한국 현대음악의 의미생성 과정의 현장을 질적으로탐구하고자 하였다. 연구의 목적은 한국 현대 음악 전반의 흐름을 분석하는 것이 아니라, 일부일지라도 현재 활발하게 작품 활동을 하고 있는 음악인들의 역동적인 음악 만들기 과정을 심층적으로해석하는 것이다. 연구에서 취했던 방법론은 현장중심의 인류학적 연구이며, 본 논문에서는project21AND의 상임 작곡가 김정훈의 <Chorus (2016)>와 공모 작곡가 전현석의 <De Tuin derLusten (2018)> 리허설 담론을 집중적으로 분석하였다. <Chorus>는 제4회 정기연주회(2016년)를위한 작품으로서 project21AND의 설립자이자 상임 음악감독인 김승림과 김정훈이 지휘자와 작곡가의 역할로 음악 만들기에 공조했는가 하면, <De Tuin der Lusten>의 경우는 제6회 정기연주회(2018년)를 위한 공모에서 선정된 작품이었기에 project21AND의 내재적인 특성을 드러내기에 적합하였다. 분석의 틀은 긴스보르와 킹의 리허설 담론 연구와 고든의 현대음악 리허설 논의를 기본으로 했으며, 질적연구 소프트웨어 <NVivo12>를 활용하여 코딩하였다. 이 때, 제4회-제6회 정기연주회에 참가한 총 13인의 작곡가와의 개별면담을 통해 ‘음악적 실험’을 추구하고자 하는 공통적인 인지적 맥락을 도출하였으며 이를 리허설 담론 분석의 근거로 삼았다. 실제로 리허설은 연습리허설과 공연 리허설로 구분되었으며, 연구자는 리허설 내내 작곡가, 연주자, 지휘자 간의 대화를녹취 및 녹화를 실시했다. 두 경우의 리허설에서 기록된 대화를 전사하여 코딩한 결과로 도출된코드는 ‘작곡가의 작품에 대한 성찰’, ‘악보 보완 및 수정’, ‘악기 주법’, ‘연주자의 물리적 배치’, ‘공연에 대한 설명’ 등이었다. 이는 작곡가 면담에서 도출되었던 ‘음악적 실험’에 관한 가치관과 일맥상통한 것을 확인했으며, 작곡가, 지휘자, 그리고 연주자 간의 민주적인 상호관계가 형성되어 있음을 알 수 있었다. The purpose of this study was to qualitatively explore the musical meaning generation process of Korean contemporary music by interpreting the rehearsal discourse of a Korean contemporary musicgroup project21AND (est. 2012), focusing on the 4th~6th periodical concert (2016~2018). This research was not geared to analyze the entire spectrum of Korean contemporary music, but to interpret the dynamic music-making process of certain active a vant-garde musicians. The researcher has not only been participating in their music-making process as a music critic since the foundation of the organization, but also established a strong rapport with the members. The method ologyutilized in this study is field-oriented anthropological research, and the analyzed pieces in this article include Kim Jung-hoon s <Chorus (2016)> and Jeon Hyun-suk s <De Tuin der Lusten (2018)>. KimSeung Lim and Kim Chunghoon, the two key members of project21AND collaboratively worked as a conductor and a compsoer respectively in the music-making of <Chorus>, while Chun as anofficially chosen composer by the group realized his work, <De Tuin der Lusten>. The framework of the analysis was based on Ginsborg and King s research on rehearsal discourse and Gordon s discussion on contemporary music rehearsal, with the help of the qualitative research software NVivo12. In addition, 13 composers were interviewed who participated in the 4th to 6th regular concerts, and this research found their common cognitive ground, ‘musical experiment’ to contextualize the rehearsal discourse of the two exemplary cases. Rehearsals were divided intopractice-rehearsals and performance-rehearsals, and conversations were recorded between composers, performers, and a conductor throughout the rehearsals. The codes resulted from the interpretation of the dialogue recorded in the rehearsals in both cases include the following:‘composers contemplations on their works; ‘editing and changing the acoustic details; ‘instrumental renditions; and ‘physical arrangement of the performers. In conclusion, the rehearsal discourses of project21AND emphasized the search for new sounds and unveiled the values of the ‘musical experiment derived from the composer interview, and the discourses that were produced through the dynamic interrelationships between the composers, the conductor, and the performers.

Whole-genome resequencing analysis of 20 Micro-pigs

Da‑Hye Son,Nam‑Hyun Hwang,Won‑Hyong Chung,Ha‑Seung Seong,Hyungbum Lim,Eun‑Seok Cho,Jung‑Woo Choi,Kyung‑Soo Kang,Yong‑Min Kim 한국유전학회 2020 Genes & Genomics Vol.42 No.3

Background Miniature pigs have been increasingly used as mammalian model animals for biomedical research because of their similarity to human beings in terms of their metabolic features and proportional organ sizes. However, despite their importance, there is a severe lack of genome-wide studies on miniature pigs. Objective In this study, we performed whole-genome sequencing analysis of 20 Micro-pigs obtained from Medi Kinetics to elucidate their genomic characteristics. Results Approximately 595 gigabase pairs (Gb) of sequence reads were generated to be mapped to the swine reference genome assembly (Sus scrofa 10.2); on average, the sequence reads covered 99.15% of the reference genome at an average of 9.6-fold coverage. We detected a total of 19,518,548 SNPs, of which 8.7% were found to be novel. With further annotation of all of the SNPs, we retrieved 144,507 nonsynonymous SNPs (nsSNPs); of these, 5968 were found in all 20 individuals used in this study. SIFT prediction for these SNPs identified that 812 nsSNPs in 402 genes were deleterious. Among these 402 genes, we identified some genes that could potentially affect traits of interest in Micro-pigs, such as RHEB and FRAS1. Furthermore, we performed runs of homozygosity analysis to locate potential selection signatures in the genome, detecting several loci that might be involved in phenotypic characteristics in Micro-pigs, such as MSTN, GDF5, and GDF11. Conclusion In this study, we identified numerous nsSNPs that could be used as candidate genetic markers with involvement in traits of interest. Furthermore, we detected putative selection footprints that might be associated with recent selection applied to miniature pigs.

우리나라 일부 석면사업장의 석면폐 유병률

백도명,백남원,최정근,손미아,임정기,이원진,문영한,박정선,최병순 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.1

Asbestos industry has been in operation over 60 years in Korea. However, the prevalence of asbestosis has not been yet reported. With rapid turn-over of workers, previous cross-sectional studies of current workers on the job could not find cases with exposures long enough for the development of asbestosis. This study was done to evaluate asbestosis prevalence of those worksites with operation history of more than 20 years. In total, 139 workers from 5 worksites were examined. Asbestos industries covered in the study include 2 asbestos textile, 1 brake lining, and 2 ship repairing worksites. Chest x-ray was taken from all workers and read by two experts familiar with pneumoconiosis classification according to 1980 ILO guidelines. Those with findings compatible with asbestosis were further ckecked with high resolution computerized tomography (HRCT). Pulmonary function tests were done according to ATS guidelines, and occupational and previous medical history was taken through a standardized interview. Air-borne asbestos was measured according to NIOSH method 7400. The air-borne asbestos concentrations ranged from 0.2-1.3 f/cc for asbestos textile, from 0.7-1.0 f/cc for brake lining, and from 6.3-7.8 f/cc during asbestos removal at ship repairing worksite. Of the 139 workers 25 had abnormal chest radiographic findings, and 10 of them had findings compatible with pneumoconiosis. When work history and current asbestos measurements were accounted, 9 workers who had more than 10 years of asbestos exposure history showed chest radiographic findings of pneumoconiosis with Finally, 4 workers showed finding of pulmonary fibrosis and/or pleural thickening at HRCT, and 2 of them had restrictive lung function changes. The study results showed that, among 139 subjects, there were 4(3%) definite asbestosis cases confirmed with HRCT. The prevalence of probable asbestosis was 7% for 10-14 years of exposure, 13% for 15-19 years of exposure, and 23% for 20 or more years of exposure. The prevalence of compensable asbestosis with abnormal lung function was 4-6% for those with 15 or more years of exposure.

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

천안시 도로변의 NO₂및 SO₂오염도 측정에 관한 연구

손부순,염윤기,김종오,문정숙 한양대학교 환경및산업의학연구소 2000 環境과 産業醫學 Vol.9 No.1

This study's goale to find out the degree of the air pollution caused by vehicle emissions and to collect basic data for alternative plan in the improvement of the quality of the air by searching for the quality of the air around the road(in front of Chunan station, Terminal intersection, at Bangiugan five forked road, Chunanro intersection) in Chunan. NO2 and SO2 were measured as a object for this study in winter time and in summer time respectively. There has been an rapid increase in population and industrial complex has been built up in Chunan area. Therefore an increase in the number of vehicles and the use of domestic fuel has followed by that. So more studies of that and the effort for the improvement in the quality of the air will have to be made.