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김형수 한국농화학회 1960 Applied Biological Chemistry (Appl Biol Chem) Vol.1 No.1
① Inorganic paper chromatography를 蔘根灰分의 系統分析에 應用했으며 少量의 灰分으로 一齊分析이 可能하였다. ② 系統分析에는 6族法으로 하였으며, Hg, Pb, Cd, Cu, As, Sb, Al, Fe, Co, Mn, Zn, Ca, Na, K, 등의 陽 ion이 蔘根灰分中에서 檢出되었다. (Ba^(++)는 試驗不求得으로 不實施) ③ 蔘根灰分의 陽ion中 Ce, Zn, Mn 등은 그들의 植物榮養學的 面에서 關心事가 될 것이다. (貴金屬과 陰 ion에 對해서는 次後 繼續豫定임)
Recipient Management before Lung Transplantation
김형수,박성훈 대한심장혈관흉부외과학회 2022 Journal of Chest Surgery (J Chest Surg) Vol.55 No.4
Lung transplantation is considered a viable treatment option for patients with end-stage lung disease. Recent decades have seen a gradual increase in the number of lung transplantation patients worldwide, and in South Korea, the case number has increased at least 3-fold during the last decade. Furthermore, the waiting list time is becoming longer, and more elderly patients (>65 years) are undergoing lung transplantation; that is, the patients placed on the waiting list are older and sicker than in the past. Hence, proper management during the pre-transplantation period, as well as careful selection of candidates, is a key factor for transplant success and patient survival. Although referring and transplant centers should address many issues, the main areas of focus should be the timing of referral, nutrition, pulmonary rehabilitation, critical care (including mechanical ventilation and extracorporeal membrane oxygenation), psychological support, and the management of preexisting comorbid conditions (coronary artery disease, diabetes mellitus, gastroesophageal reflux disease, osteoporosis, malignancy, viral infections, and chronic infections). In this context, the present article reviews and summarizes the pre-transplantation management strategies for adult patients listed for lung transplantation.
The transcription factor NFIL3 controls regulatory T-cell function and stability
김형수,Hyogon Sohn,Sung Woong Jang,이갑열 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Regulatory T (Treg) cells are a CD4 T-cell subset with an important role in immune tolerance; however, the mechanisms underlying Treg cell differentiation and function are incompletely understood. Here, we show that NFIL3/ E4BP4, a transcription factor, plays a key role in Treg cell differentiation and function. Microarray analysis showed that Treg cells had lower Nfil3 expression than all other CD4 T-cell subsets. Overexpression of Nfil3 in Treg cells led to diminished expression of Foxp3 and other signature Treg genes, including Il2ra, Icos, Tnfrsf18, and Ctla4. Furthermore, Nfil3-overexpressing Treg cells exhibited impaired immunosuppressive activity in vitro and in vivo. We discovered that NFIL3 directly binds to and negatively regulates the expression of Foxp3. In addition, bisulfite sequencing revealed that NFIL3 induces methylation at Foxp3 locus regulatory CpG sites, which contributes to the control of Treg cell stability. Together, these data indicate that NFIL3 impairs Treg cell function through the downregulation of Foxp3 expression.
김형수,이준식,강신형,Kim, Hyeong Soo,Lee, Joon Sik,Kang, Shin Hyung 대한기계학회 1999 大韓機械學會論文集B Vol.23 No.9
The effects of secondary flow on the structure of a turbulent wake generated by a flat plate was investigated experimentally. The secondary flow was induced In a $90^{\circ}$ curved duct in which the flat plate wake generator was installed. The wake generator was installed in such a way that the wake velocity gradient exists in the span wise direction of the curved duct. Measurements were made in the plane containing the mean radius of curvature where pressure gradient and curvature effects were small compared with the secondary flow effect. All six components of the Reynolds stresses were measured in the curved duct. Turbulence intensities in the curved wake are higher than those in the straight wake due to an increase of the turbulent kinetic energy production by the secondary flow. In the inner wake region, shear stress and strain in the plane containing the velocity gradient of the wake show opposite signs with respect to each other, so that eddy viscosity Is negative in this region. This indicates that gradient-diffusion type turbulence models are not appropriate to simulate this type of flow.