여름철 계룡산국립공원 탐방로의 열쾌적성 및 어메니티 관리 연구

안시옥(Siok An),송도윤(Doyun Song),정다워(Dawou Joung),박범진(Bum-Jin Park),심규원(Kyu-Won Sim),박준효(Jun-Hyo Park) 국립공원연구원 2022 국립공원연구지 Vol.13 No.2

본 연구는 산악환경의 기상 특징과 계룡산국립공원 탐방로의 열쾌적성을 파악하고 열쾌적성이 높은 활동 시간 정보, 활동 공간 정보, 활동량 정보를 제공하기 위해 시행되었다. 탐방로의 열쾌적성 분석을 위해 여름철 도심 기온, 국립공원 방재기상관측장비(AWS, Automatic Weather System), 탐방로인 숲길의 평균 기온을 비교하였다. 또한, 계룡산 국립공원의 주요 탐방로 4개 구간의 미기후 요소와 수관울폐도 측정을 위해 총 240개 지점을 조사 후 열쾌적성을 파악 하였다. 도심과 국립공원AWS, 탐방로의 평균 기온을 비교하였을 때, 도심, 갑사AWS, 동학사AWS, 갑사 탐방로, 동학사 탐방로 순으로 평균 기온이 높게 나타났다. 이 결과, 탐방객이 직접 체감하는 탐방로의 열쾌적성을 고려해야 함을 의미한다. 주요 탐방로 4개 구간 조사 결과, 평균 수관울폐도는 동학사~남매탑 구간, 동학사~관음봉 구간, 갑사~연천봉 구간, 갑사~금잔디고개 구간 순으로 높았다. PMV(예상평균온열감)는 활동량이 2.8MET 일 때, 갑사~금잔디고개 구간, 갑사~연천봉 구간, 동학사~남매탑, 동학사~관음봉구간 순으로 높았다. 조사를 통하여, 열쾌적성이 높은 시간 정보, 공간 정보, 활동량 정보를 제시할 수 있었다. 탐방로의 열쾌적성 특성을 파악하여, 탐방로의 어메니티를 높일 수 있는 숲길 관리 방안의 기초를 마련하고자 한다. This study was conducted to understand the weather characteristics of the mountain environment and the thermal comfort of Gyeryongsan National Park trail and to provide information on activity time, activity space, and activity amount. For the analysis of the thermal comfort of the trail, the temperature of the city center in summer, the average temperature of the National Park Disaster Prevention Weather System (AWS), and the trail. Also, Microclimate elements and canopy closure were also measured in four major trails in Gyeryongsan National Park. After investigating a total of 240 points, thermal comfort was identified. When comparing the average temperature of the city center, National Park AWS, and trail, the average temperature was higher in the order of the city center, Gabsa AWS, Donghaksa AWS, Gabsa Trail, and Donghaksa Trail. As a result, it means that the thermal pleasure experienced by visitors should be considered. According to a survey of four major trails, the average canopy closure is Donghaksa~nammaetop route was high in the order of Donghaksa~Gwaneumbong route, Gabsa~Yeoncheonbong route and Gabsa~Geumjandigogae route. When PMV(Predicted Mean Vote) is 2.8MET, The PMV was highter in the order of Gabsa~Geumjandigogae route, Gabsa~ Yeoncheonbong route, Donghaksa~nammaetop route, Donghaksa~Gwaneumbong route. Through the survey, time information, spatial information, and activity information with high thermal comfort could be presented. By grasping the thermal comfort characteristics of the trail, we intend to lay the foundation for forest trail management measures that can increase the amenity of the trail.

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

조기 대장암

이재범,박영진,박군주,김선회,박재갑,이건욱,박용현,최국진,김진복 대한대장항문학회 1998 Annals of Coloproctolgy Vol.14 No.3

Elevated TRAF2/6 expression in Parkinson's disease is caused by the loss of Parkin E3 ligase activity.

Chung, Ji-Yun,Park, Hee Ra,Lee, Su-Jin,Lee, Sun-Hye,Kim, Jin Sik,Jung, Youn-Sang,Hwang, Sang Hyun,Ha, Nam-Chul,Seol, Won-Gi,Lee, Jaewon,Park, Bum-Joon United States and Canadian Academy of Pathology [e 2013 Laboratory investigation Vol.93 No.6

<P>Parkinson's disease (PD) is the second leading neurodegenerative disease, and is known to be induced by environmental factors or genetic mutations. Among the verified genetic mutations of PD, Parkin, isolated from the PARK2 locus, shows an autosomal recessive inheritance pattern and is known to be an E3 ligase. However, the physiological target of Parkin and the molecular mechanism of Parkin-deficiency-induced PD have not been clearly demonstrated until now. It has recently been proposed that inflammation, suggesting as a causal factor for PD, is enhanced by Parkin deficiency. Thus, we examined the relationship between inflammation-related factors and Parkin. Here, we provide the evidence that Parkin suppresses inflammation and cytokine-induced cell death by promoting the proteasomal degradation of TRAF2/6 (TNF-α receptor-associated factor 2/6). Overexpression of Parkin can reduce the half-lives of TRAF2 and TRAF6, whereas si-Parkin can extend them. However, mutant Parkins did not alter the expression of TRAF2/6. Thus, loss of Parkin enhances sensitivity to TNF-α- or IL-1β-induced JNK activation and NF-κB activation. Indeed, si-Parkin-induced apoptosis is suppressed by the knockdown of TRAF6 or TRAF2. We also observed elevated expression levels of TRAF6 and a reduction of IκB in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced PD mouse model. Moreover, elevated expression levels or aggregation of TRAF6 were detected in approximately half of the human PD tissues (7/15 cases) and 2 cases, respectively. In addition, TRAF6 and Parkin expression levels show a reverse relationship in human PD tissues. Our results strongly suggest that the reduction of Parkin or overexpression of TRAF2/6 by chronic inflammation would be the reason for occurrence of PD.</P>

운동강도 평가를 이용한 국립공원 등산로의 관리대책 -설악산국립공원과 계룡산국립공원을 대상으로-

이준우 ( Joon Woo Lee ),박범진 ( Bum Jin Park ) 한국환경생태학회 1998 한국환경생태학회지 Vol.11 No.4

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

생물학에 있어서의 취보적 성질에 대한 연구

진범순,박지현 순천향대학교 기초과학연구소 2002 순천향자연과학연구 논문집 Vol.8 No.1

Molecules, subcelluar organelles, and cells 과 같이 운동성을 갖고 있는 particles의 행동에 대한 묘사나 particles 이 평균적으로 얼마만큼 움직이는지를 확률의 성질을 이용하여 수학적인 방법으로 어떻게 묘사할 수 있는지에 대하여 연구하였다. 특히, 운동성이 있는 bacteria의 행동을 random walk와 관련지어 연구하였다.

이중형질전환에 의한 웅성불임유기유전자의 발현억제

박영두,김현욱,박범석,진용문,정태영 慶熙大學校 1997 論文集 Vol.26 No.-

This study was carried out with the purpose of looking into the regulation of gene related to anther development, and applying their promoter to induce male sterile plants and restore their fertility. Progenies of transgenic male sterile tobacco plants containing anther specific promoter (BAN215) and diphteria toxin A (DTx-A) gene were analyzed by danamycin screening and pollen observation. DTx-A gene in male sterile plants was confirmed by PCR with the two synthetic primers, 5'-AACTTTTCTTCGTACCAC-3' and 5'-GCTTTCGCCTGTTCCCAG-3', from the sequence of DTx-A genes. The fragment of 350bp was appeared when the PCR product of 428 bp was digested with Rsal. pDTx-2 containing DTx-A gene was used as a control (DTx). Some of them were double transformed with the construct of BAN215 promoter and antisense DTxA (pKDA215b) to test restoration of fertility.

회전근 개 병변에서 골 단일광자방출전산화 단층촬영과 단순 방사선 사진의 비교

박진영,박선건,김승철,임종범 단국대학교 2000 論文集 Vol.35 No.-

purpose : The increased uptake on the bone scan represents the zone of increased bon metabolism. Single photon emission computerized tomography(SPECT) is more precise in detecting lesions of increased uptake than planar bone scan. The purpose of this study is to examine applicability of bone SPECT to shoulder lesions and to analyze the efficacy of SPECT compared with simple X-ray in rotator cuff lesion. Materials and Methods : Subjects were 21 patients with of rotator cuff lesion confirmed by surgical(arthroscopic or open) procedure. Increased uptake(bone SPECT) and sclerosis of greater tuberosity and anterior acromion on X-ray were considered positive. Results : For acromion, sensitivity of the bone SPECT was 90.9% and specificity was 50.0%. For greater tuberosity, sensitivity was 92.3% and specificity 37.5%. For acromioclavicular joint, sensitivity was 80.0% and specificity 81.3%. Conclusion : This study demonstrates that the uptake of radioisotope in shoulder is increased in patients with painful partial or total rotator cuff tear. And extrinsic mechanical pressure seems to be the cause of rotator cuff lesion of the shoulder.