간질발작의 병리 생리학적 기전에 대한 문헌고찰 : A pathophysiologic correlation of clinical and EEG findings with a review of the recent literature

김윤범 대한신경외과학회 1975 Journal of Korean neurosurgical society Vol.4 No.1

To increase the understanding of the pathophysiologic mechanisms present in epileptic seizures, and to correlate the clinical features with the EEG findings, a review of the recent literature has been made. Epileptic seizures are classified into three types: focal (or partial), generalized and unilateral seizures. In the first type, the focal seizure, there are two sites which have been thought to have one or the other of an initial discharge. The first site is the cortical pole, and the second is the end pole of the interconnected subcortical nuclear system. the cortical pole is more accessible and vulnerable to seizures. the end pole of the interconnected subcortical nuclear system has two sectors which may be involved. the first sector, the cortico-thalamic system, includes filstly the specific cortico-thalamic system in which the focal stimulation is related to relatively simple somato-motor, sensory and autonomic nervous functions. Secondly, in this first sector, is the non-specific corticothalamic systems which includes the body integrative functions which underlie psychic elaboration of primary sense data. The second sector in the subcortical nuclear system is the amygdalo-brain stem sector. In this non-thalamic system there are the deep temporal structures of the brain such as the amygdala-hippocampal complex. These structures are involved in the regulation of emotions, in memory functions, and in the maintenance of consciousness. A schematic diagram is prepared to explain the mode of propagation of the epileptic discharge from the initial focus along pathways in the brain structures. This diagram is explained and discussed. The second type of seizureis the generalized seizure. This type is subdivided into two groups: convulsive and non-convulsive. The convulsive group of seizures includes tonic clonic (grand mal), tonic, clonic, infantile spastic, and bilateral myoclonic seizures. These are discussed. The non-convulsive group of seizures includes the following kinds: typical absence (petitmal), atypical absence (petitmal varient), absence status, and atonic seizures. In this group of seizures the initial discharge occurs at the centrencephalon (diencephalo-mesencephalo-rhombencephalon). The intricate mode of propagation of this type of discharge, which involve the recruiting and inhibitory systems, was discussed and also presented schematically. The third type of seizures is the unilateral type which is common in infants and young children. This type is discussed with special reference to the site of the original discharge, as well as the mode of propagation of the discharge and variations in this type of seizure.

3-MCA 유발(誘發) 상피종(上皮腫)에 대(對)한 향패양영탕(香貝養榮湯)과 패모단미제(貝母單味劑)가 면역반응(免疫反應)에 미치는 영향(影響)

김윤범,채병윤,Kim, Yun-Beom,Chae, Byeong-Yun 대한암한의학회 1997 大韓癌韓醫學會誌 Vol.3 No.1

Hyangpaeyangyeongtang, which was first prescribed in the book of Euijonggumgam (醫宗金鑑), has been widely applied to the treatment of scrofula and carbuncle in the neck and tumor as well in the oriental medicine. The Fritillariae roylei bulbus was also used as an anti-tumor medicine. In order to investigate the effect of Hyangpaeyangyeongtang and Fritillariae roylei bulbus extracts on the immune responses to the epithelioma induced by 3-methylcholanthrene and prostaglandin-$F_2{\alpha}$ in mice, the change of epithelioma size was observed and delayed type hypersensitivity, hemagglutinin titer, hemolysin titer, rosette forming cells, natural killer cell activity, lymphocyte transformation, productivity of interleukin-2 and phagocytic activity were also measured. The results were as follows; 1. The epithelioma size was decreased with statistical significance in the Hyangpaeyangyeongtang group at the 14th day, as compared with the control group. 2. Delayed type hypersensitivity was not shown any decrease in the Hyangpaeyangyeongtang group and the Fritillariae roylei bulbus group, as compared with the control group. 3. Hemagglutinin titer was increased with statistical significance in the Hyangpaeyangyeongtang group, but not in the Fritillariae roylei bulbus group as compared with the control group. 4. Hemolysin titer was increased with statistical significance in the Hyangpaeyangyeongtang group, but not in the Fritillariae roylei bulbus group as compared with the control group. 5. Rosette forming cells were not increased in the Hyangpaeyangyeong tang group, but increased with statistical significance in the Fritillariae roylei bulbus group as compared with the control group. 6. Natural killer cell activity at the ratio 100:1 of effector cells to target cells was increased with statistical significance in the Hyangpaeyayeongngtang group and the Fritillariae roylei bulbus group respectively, and the natural killer cell activity at the ratio of 50:1 and 10:1 of effector cells to target cells Hyangpaeyangyeongtang group was increased with statistical significance as compared with the control group. 7. Lymphocyte transformation was increased in the Hyangpaeyangyeong tang group and the Fritillariae roylei bulbus group respectively, as compared with the control group. 8. Productivity of interleukin-2 was increased in the Hyangpaeyangyecing tang group and the Fritillariae roylei bulbus group respectively, as compared with the control group. 9. Phagocytic activity was not shown any decrease in the Hyangpaeyangyeongtang group and the Fritillariae roylei bulbus group, as compared with the control group.

안이비인후피부 환자의 HRV 검사 : 자가 스트레스 인식자를 대상으로

김윤범,남혜정,Kim, Yoon-Bum,Nam, Hae-Jeong 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.3

Objective: Stress is one of the most important etiological factors in our lives. Human body makes effort to keep his homeostasis from stress by using autonomic nerve system. So we need markers which can evaluate autonomic nerve system easily. HRV represents such markers. Sympathetic and Parasympathetic nerve system are part of autonomic nerve system, related with cur body and diseases in ENT, Dermatology, Ophthalmology are also deeply related with stress, Sympathetic and Parasympathetic nerve system. So we can expect that it can help understanding patients to evaluate autonomic nerve system with HRV Research Methods and Procedures: Forty one patients who have seif-recognized stress in Dept. of Oph & Otolaryngo & Dermatology were selected. SDNN. RMSSD, LF, HF, norm-LF, norm-HF, LF/HF ratio, LnLF, LnHF were checked. Results: Men showed lower SDNN, HF, and LnHF than women(p<0.05). Age over-forty group showed significant lower SDNN, LF, HF, LnLF, LnH(p<0.01), and lower RMSSD(p<0.05) than age under-forty group. There's no big differences for age at norm-LF, norm-HF, and LF/HF ratio. Skin disease group showed higher SDNN, RMSSD, LF, HF, LnLF, LNHF than the others, facial palsy group showed higher norm-HF. LF/HF ratio, and mouth-throat group showed higher norm-LF, but there's no statically significant difference. Comparing skin disease group with the others, the others showed statically significant low SDNN(P<0.01), RMSSD, LF, HF, LnLF and LnHF(P<0.05).

피부요관창냄술 후 발생한 원발성 요관 편평세포암종

김윤범,이광염,박용설,이정기,정태영,곽철,심홍방 大韓泌尿器科學會 2003 Korean Journal of Urology Vol.44 No.4

척수 손상 환자의 신경인성 방광에서 방광확대성형술의 장기 성적

김윤범,박원희,심홍방 大韓泌尿器科學會 2003 Korean Journal of Urology Vol.44 No.6

接觸性 皮膚炎에 對한 韓方的 考察

김윤범,김중호,채병윤,Kim, Yun-Beom,Kim, Jung-Ho,Chae, Byeong-Yun 대한한방안이비인후피부과학회 1992 한방안이비인후피부과학회지 Vol.5 No.1

전통 한방처방을 이용한 기초 한방화장품에 대한 임상적 연구

김윤범,김호철,Kim, Yoon-Bum,Kim, Ho-Cheol 대한한방안이비인후피부과학회 2002 한방안이비인후피부과학회지 Vol.15 No.1

During a clinical test with Korean herbal cosmetics, significant data and related results are summarized as following: 1. The questionnaire resulted the subjects who used Korean herbal cosmetics showed significant subjective improvement. 2. $11{\%}$ of the subjects who used Korean herbal skin lotion replied "very good" , $60{\%}$ "good" , and $29{\%}$ "so so". 3. In the questionnaire about how often the subjects who used Korean herbal skin lotion experienced skin irritation, $91{\%}$ of the subjects replied they didn't experience any skin irritation 4. The subjects who used oily & combinational cosmetics showed more significant result than the placebo group in the questionnaire about how they feel when using emulsion. 5. In the questionnaire about how they feel when using emulsion. $11{\%}$ of all the subjects replied "very good" , 60{\%}$ "good" , and $29{\%}$ "so so". 6. In the questionnaire about how they feel when using essence $18{\%}$ of all the subjects replied "very good" , $56{\%}$ "good" , and $27{\%}$ "so so". 7. In the questionnaire about how often the subjects who used skin lotion experienced skin irritation, $100{\%}$ of the subjects replied there was no skin irritation. 8. the subjects who used Korean herbal cosmetics showed significant result in the questionnaire about how much moisture they feel when using cream. 9. The subjects who used neutral & dry cosmetics showed more significant result than the placebo group in the questionnaire about if the cosmetics spread well when using emulsion. 10. The subjects who used oily & combinational cosmetics showed more significant result than the placebo group in the questionnaire about how much moisture they feel when using cosmetics. 11. In the questionnaire about how they feel when using cream $13{\%}$ of all the subjects replied "very good", $49{\%}$ "good", and $2{\%}$ "so so". 12. In the questionnaire about how often the subjects who used cream lotion experienced skin irritation, $96{\%}$ of the subjects replied there was no skin irritation. 13. In the measurement of coreometer, the subjects who used oily & combinational cosmetics showed significant result(measurement area : indang). Especially in the area of sungjang there is significant difference between the subjects group and placebo group. 14. In the measurement of skin-ph-meter, there was no significant change in all group. 15. in the measurement of melanin-erythema index meter, the subjects who used cosmetics which doesn't contain Korean herbs showed significant change and made significant difference in comparison to the subjects who used Korean herbal cosmetics.

Extensive Systemic Sarcoidosis with Testicular Involvement Mimicking Metastatic Testicular Cancer

김윤범,정연구,김상진,김세중,안현수,주희재,김선일 대한비뇨의학회 2011 Investigative and Clinical Urology Vol.52 No.4

Sarcoidosis is an idiopathic, multisystem disease that rarely involves the genitourinary tract. Here we present an unusual case of testicular sarcoidosis with extensive lymphadenopathy that mimicked a metastatic testicular tumor. A 27-year-old male presented with a palpable right testicular mass accompanied by multiple palpable inguinal lymph nodes. The scrotal ultrasound showed a hypoechoic lesion at the inferior portion of the right testis. Extensive enlarged lymph nodes were noted in multiple areas on the abdominal computed tomography. Preoperative testicular tumor markers were within the normal range. Exploration of the right testis with a frozen section analysis of the right testicular mass and of a palpable right inguinal lymph node showed granulomatous inflammation. The testis was salvaged and the final pathological diagnosis was sarcoidosis. Treatment with high-dose corticosteroids resulted in complete resolution of the intratesticular mass and a significant decrease in the extent of the lymphadenopathy.

성인의 낭성 신종

김윤범,정연구,주희재,김선일,안현수,김세중 한국인지 및 생물심리학회 2008 한국심리학회지 인지 및 생물 Vol.20 No.4

Cystic nephroma (CN) is a rare benign cystic renal tumor, which only recently has been recognized as an exclusively adult lesion. CN presents after age 30 and affects primarily reproductive age to early menopausal women. Although an aggressive behavior has been reported in very few cases, CN is considered as a benign lesion and surgical excision is curative. We report on a case of CN in a 31-year-old woman who presented with an incidentally detected renal tumor. The patient has had no evidence of disease 5 years after radical nephrectomy.

비침이 비색증에 대한 영향

김윤범,윤상협,Kim, Yoon-bum,Yoon, Sang-hyub 대한한방안이비인후피부과학회 1999 한방안이비인후피부과학회지 Vol.12 No.2

We studied 32 patents, who had visited Kyung Hee downtown oriental hospital with nasal obstruction. They has been observed their nasal cavity through anterior rhinoscopy. We had paten't middle and inferior turbinte bleeding by acupuncture. This symptom had been disappeared after this treatment. The result were as follows. 1. Sex and age distribution: The males were 18($56.2\%) and Female were 14($43.8\%$). The most common occurrence was found between 1-5 years old. 2. The most common duration of disease was between 2-6 months. 3. In decreasing order, the common complication & past history of otolaryngologic or allergic disease were allergic rhinitis, atopic dermatitis, chronic sinusitis, adenoid or tonsil hypertrophy, otitis media with effusion and asthma. 4. In descending order, distribution of symptoms were rhinorrhea, sneezing, dry sensation, sputum, frontal headach, postnasal drip and cough. 5. The improvement rate in symptom were $31.3\%\;excellent\;and\;53.1\%$ good.