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김성우,Ha Ra Jeon,Eun Ji Park,Hyo In Kim,Da Wa Jung,Mee Ryung Woo 대한재활의학회 2014 Annals of Rehabilitation Medicine Vol.38 No.3
Objective: To investigate the usefulness of MacArthur-Bates Communicative Development Inventories-Korean (M-B CDI-K) short form as a screening test in children with language developmental delay.Methods: From April 2010 to May 2012, a total of 87 patients visited the department of physical medicine and rehabilitation of National Health Insurance Service Ilsan Hospital with the complaint of language developmental delay and were enrolled in this study. All patients took M-B CDI-K short form and Sequenced Language Scale for Infants (SELSI) or Preschool Receptive-Expressive Language Scale (PRES) according to their age.Results: The study group consisted of 58 male patients and 29 female patients and the mean age was 25.9 months. The diagnosis are global developmental delay in 26 patients, selective language impairment in 31 patients, articulation disorder in 7 patients, cerebral palsy in 8 patients, autism spectrum disorder in 4 patients, motor developmental delay in 4 patients, and others in 7 patients. Seventy-one patients are diagnosed with language developmental delay in SELSI or PRES and of them showed 69 patients a high risk in the M-B CDI-K short form. Sixteen patients are normal in SELSI or PRES and of them showed 14 patients non-high risk in the M-B CDI-K short form. The M-B CDI-K short form has 97.2% sensitivity, 87.5% specificity, a positive predictive value of 0.97, and a negative predictive value of 0.88. Conclusion: The M-B CDI-K short form has a high sensitivity and specificity so it is considered as an useful screening tool in children with language developmental delay. Additional researches targeting normal children will be continued to supply the specificity of the M-B CDI-K short form.
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Neurodevelopmental Disorders of Children Screened by The Infantile Health Promotion System
김성우,Ha Ra Jeon,Zee-A Han,최자영,Hee Jung Chung,Young Key Kim,Yeo Hoon Yoon 대한재활의학회 2011 Annals of Rehabilitation Medicine Vol.35 No.6
Objective To perform an in depth evaluation of children, and thus provide a systematic method of managing children, who after infantile health screening, were categorized as suspected developmental delay. Method 78 children referred to the Developmental Delay Clinic of Ilsan Hospital after suspected development delay on infantile health examinations were enrolled. A team comprised of a physiatrist, pediatrician and pediatric psychiatrist examined the patients. Neurological examination, speech and cognitive evaluation were done. Hearing tests and chromosome studies were performed when needed clinically. All referred children completed K-ASQ questionnaires. Final diagnoses were categorized into specific language impairment (SLI),global developmental delay (GDD), intellectual disability (ID), cerebral palsy (CP), motor developmental delay (MD) or autism spectrum disorder (ASD). Results 72 of the 78 patients were abnormal in the final diagnosis, with a positive predictive value of 92.3%. Thirty (38.4%) of the 78 subjects were diagnosed as GDD, 28 (35.8%) as SLI, 5 (6.4%) as ASD, 9 (12.5%) as MD, and 6(7.6%) as normal. Forty five of the 78 patients had risk factors related to development, and 18 had a positive family history for developmental delay and/or autistic disorders. The mean number of abnormal domains on the K-ASQ questionnaires were 3.6 for ASD, 2.7 for GDD, 1.8 for SLI and 0.6 for MD. Differences between these numbers were statistically significant (p<0.05). Conclusion Because of the high predictive value of the K-ASQ, a detailed evaluation is necessary for children suspected of developmental delay in an infantile health promotion system.
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Visual-perceptual Function in Children with Spastic Cerebral Palsy
김성우,Myoung Sik Bae,Jung Bin Shin,Sung You,Ha Ra Jeon,Hye Jung Lee 대한재활의학회 2011 Annals of Rehabilitation Medicine Vol.35 No.1
Objective To compare visual-perceptual function between children with bilateral spastic cerebral palsy who have periventricular leukomalacia and unilateral spastic cerebral palsy without periventricular leukomalacia. Method Twenty-one children with spastic cerebral palsy (11 bilateral, 10 unilateral) were enrolled and their visual- perceptual function were assessed using K-DTVP-2 (Korean developmental test of visual perception 2). Results K-DTVP-2 in the bilateral group showed significant dysfunction when compared with the unilateral group. Among 6 sub-items of K-DTVP-2, scores related to visual closure and copying were particularly reduced in the bilateral group. There was discrepancy of verbal and performance IQ in the bilateral group which was not apparent in the unilateral group. Conclusion In children with spastic cerebral palsy, the bilaterally affected group had characteristic features of visual- perceptual dysfunction.
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A Survey on the Health Status of Population with Disability in Goyang City
김성우,Gwang Bok Park,Hyoung Seop Kim,Jung Bin Shin,김종문,Myoung Sik Bae 대한재활의학회 2011 Annals of Rehabilitation Medicine Vol.35 No.1
Objective To improve the quality of life of the disabled population by decreasing the incidence of complications and chronic diseases and improving self-care abilities according to individual diseases through health status evaluation and basic survey. Method The basic clinical information of 1,378 regional severely-disabled patients were collected along with information regarding functional level, activities of daily living, nutritional status, and management of complications which were distinguished into 3 stages (good, moderate, poor), which were correlated into scores (1-3 points) that were used to assess a collaborative score (5-15 points) that represented their health status. Health behavior and blood tests were also done. Results Health status were evaluated based on sex, grade of disability, age, frequency of exercise and type of disability, which revealed that female sex, brain disorder, 1st grade disability, total lack of exercise, old age disabled patients were relatively poor in terms of health status. Conclusion Health status of the severely-disabled showed differences according to sex, age, grade of disability, type of disability, and frequency of exercise, and health programs designed to screen and follow up the severely-disabled person with poor health status as well as manage their accompanying diseases and complications are needed.
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김성우,허원희,Tian Zhu Li,이영기,최정은,홍성우,류광수,유찬란,정은선,정찬권,박태선,엄수종,윤승규 생화학분자생물학회 2014 Experimental and molecular medicine Vol.46 No.-
Nonalcoholic steatohepatitis (NASH) is characterized by hepatocyte injury and inflammatory cell infiltration, which has been linked to peripheral insulin resistance and increased levels of triglycerides in the liver. The purposes of this study were to establish a mouse model of NASH by feeding mice a 60% high-fat diet (HFD) and to demonstrate the anti-fibrotic effects of oleuropein, which has been shown to have anti-oxidant and anti-inflammatory properties, in this HFD-induced mouse model of NASH. C57BL/6 mice were divided into three groups: a regular diet group (Chow), a HFD group and an oleuropeinsupplementedHFD group (OSD), which was fed a 0.05% OSD for 6 months. The effects of oleuropein in this model wereevaluated using biochemical, histological and molecular markers. The expression levels of alpha-smooth muscle actin (a-SMA)and collagen type I in the HFD and OSD groups were evaluated using real-time PCR and western blotting. The body weight, biochemical marker levels, nonalcoholic fatty liver disease activity score, homeostasis model of assessment-insulin resistance (HOMA-IR) and leptin levels observed in the HFD group at 9 and 12 months were higher than those observed in the Chow group. The HOMA-IR and leptin levels in the OSD group were decreased compared with the HFD group. In addition, a-SMA and collagen type I expression were decreased by oleuropein treatment. We established a NASH model induced by HFDand demonstrated that this model exhibits the histopathological features of NASH progressing to fibrosis. Our results suggest that oleuropein may be pharmacologically useful in preventing the progression of steatohepatitis and fibrosis and may be a promising agent for the treatment of NASH in humans.
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