홍씨 앞방각측정법의 임상적 유용성

강신희,박기호,홍철,김동명,Shin Hee Kang,M,D,Ki Ho Park,M,D,Chul Hong,M,D,Dong Myoung Kim,M,D 대한안과학회 2007 대한안과학회지 Vol.48 No.3

Purpose: To compare the Hong`s grading method, utilized for slit-lamp grading of the mid-peripheral angle, with other conventional grading methods. Actual angle was measured by ultrasound biomicroscopy (UBM) for comparison. Methods: Fifteen eyes with narrow angles and eighteen eyes with wide angles were studied. The average age of thirty-three subjects was 46.8±19.2, and the male to female ratio was 1:3.7. The mid-peripheral angle was graded by Hong`s, van Herick`s and Spaeth`s grading system. The actual anterior chamber angle was evaluated by UBM and the correlation between each grading system and actual angle was investigated. Results: The results from the Hong`s grading (r=0.802, R2=0.643, p<0.01), Spaeth`s grading (r=0.728, R2=0.530, p<0.01) and van Herick`s grading (r=0.618, R2=0.382, p<0.01) methods correlated significantly with the actual angles. Conclusions: The Hong`s grading method was an easy and effective tool to evaluate anterior chamber angle. In addition, the results of the Hong`s grading method were closer to the actual angle than the other methods.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

경피적 겸자 정복 및 골수강내 금속핀 고정을 이용한 쇄골 골절의 치료

홍기도,하성식,정남식,심재천,김경호 대한골절학회 2004 대한골절학회지 Vol.17 No.4

목적 : 경피적 겸자 정복 및 골수강내 금속판 고정술을 이용한 쇄골 간부 골절의 치료에 대해 유용성을 규명해 보고자 하였다. 대상 및 방법 : 2002년 1월부터 2003년 7월까지 본원에서 쇄골 간부 골절 환자 중 신경 및 혈관 손상이 없었고, 골절의 분쇄상이 비교적 적었던 총 16례를 대상으로 겸자를 이용한 경피적 정복 후에 골수강에 금속판을 삽입하여 고정하였다. 술 후 유합 정도 및 결과를 임상적, 방사선학적으로 분석하였다. 결과 : 방사선학적으로 골유합을 보인 경우가 총 15례였으며, 술 후 평균 9.1주에 유합 소견을 관찰하였다, 임상적으로 강 등의 기준에 따라 구분한 결과, 우수 이상이 14례로 나타났다. 1례에서 1주 만에 K-강선의 내측전위로 골절부위가 재전위되어 관혈적 정복 및 금속판 내 고정을 시행한 이외에 다른 주요 합병증은 없었다. 결론 : 저자들의 방법은 수술시간이 짧고 간단하며, 연부조직의 추가적 손상이 적어 골유합율이 높고, 수술 반흔을 남기지 않아 수술적 적응을 신중히 고려한다면 쇄골 간부 골절의 치료법의 하나로 유용할 것으로 사료된다. Purpose: To investigate the utility of surgical treatment of clavicle shan fracture using a percutaneous towel clip reduction and intramedullary fixation. Materials and Methods : This study was conducted for total 16 case of patients who had no neurovascular injury and a few comminuted bone fragment among patients with clavicle shaft fracture from January 2002 to July 2003. The method of operation was percutaneous towel clip reduction and intramedullary fixation. The clinical and radiological results were evaluated. Results : Radiologically, 15 cases showed bone unions and the avenge time was 9.1 weeks. According to Kang's criteria clinically, there were 14 cases which were more than an excellence. One case substituted open reduction and nailing fixation due to a medial migration of K-wire and re-displacement of fracture even in 1 week. However, there wasn't any other major complication. Conclusion : Due to its having no additional injury to soft tissues, no scar formations, and its short operation time, percutaneous towel clip reduction and intramedullary fixation will be very useful as one of the treatments of clavicular shaft fracture if it follows correct surgical indications.

리눅스 클러스터 서버 상에서 RTSP 기반의 VOD 스트리밍 시스템의 설계 및 구현

홍기호,김영진,최황규 江原大學校 産業技術硏究所 2001 産業技術硏究 Vol.21 No.A

Linux cluster Server makes a high performance PC cluster system, and provides scalablity and availability as compared with an expensive single server. In this paper, we design and implement a VOD streaming service system to serve video and audio streaming services on the Linux cluster serve. Our Streaming server supports the MS Window Media Format based on the RTSP streaming protocol.

수영-스트레스에 의한 腦 Catecholamine 代謝의 變動에 있어서 甲狀腺-機能의 役割에 關한 硏究

洪起男,申炅浩,金炯健,全普權 고려대학교 의과대학 1989 고려대 의대 잡지 Vol.26 No.3

Effects of hyper-and hypothyroidism in the swim-stress(SS) induced changes of plasma corticosterone(CS) level and brain norepinephrine(NE) metabolism were studied in male mice pretreated with 1-thyroxine sodium(4㎎/㎏, i.p. inj. once a day for 5 days; T₄) and propylthiouracil (fed ad lib in 0.01% drinking water for 5 weeks : PTU). The circadian rhythm of spotaneous motor activity was not significantly altered by T₄ and PTU, respectively. The plasma thyroxine level was markedly increased by T₄ but reduced by PTU and the plasma thyrotropin level was markedly increased by PTU but decreased by T₄. The plasma CS level was not changed by PTU but moderately increased by T₄ Clonidine slightly increased the plasma CS level, but the clonidine effect was significantly enhanced by T₄-pretreatment. The brain NE and 3-methoxy-4-hydroxyphenylglycol(MHPG) contents were little affected by T₄ but significantly decreased by PTU. ThE SS-induced increase of plasma CS level was moderately decreased by PTU but increased by T₄. However, clonidine significantly inhibited the SS-induced increase, and the inhibitory effect of clonidine was little significantly affected by PTU and T₄ respectively. The brain MHPG content and MHPG/NE ratio were significantly decreased by clonidine bur increased by SS. THe clonidine-induced decrease of brain MHPG/NE ratio were not altered by PYTU or T₄. The SS-induced, and the inhibitory effect of clonidine was not affected by PTU and T₄ respectively. These results suggest 1) that the alteration of thyroidal function little affects the changes of brain NE in responses to swim-stress, but the stress-induced change of plasma corticosterone level may be somewhat modulated by the thyroidal function, and 2) that the hypothalamo-pituitary-adrenocortical stimulation in response to swim-stress seems to be mediated via hypothalamic noradrenergic activation, and the stress response may inhibited by the agonistic activity of clonidine on the presynaptic α₂-adrenoceptor.

인터넷 액세스 라우터 시스템 설계에 관한 연구 : 통합 액세스 노드 시스템에서

홍록기,음호식 공주영상정보대학 2001 논문집 Vol.8 No.-

본 논문에서는 다양한 형태의 액세스 기술을 통하여 접속하는 인터넷 트래픽을 효과적으로 NSP까지 전달하기 위한 인터넷 액세스 서비스 제공 방안을 제시하였다. 제시된 방안은 PPP세션을 이용자 단말에서 NSP까지 안전하게 전달하는 방안으로 AR와 NSP간에 다수의 PPP세션을 전달하기 위하여 터널링 방식을 사용하는 방식이다. 제안된 방식은 PPP세션 과정을 통하여 이용자의 인증과 연결할 NSP를 선택할 수 있다. 또한, 본 논문에서는 통합 액세스 노드에서 인터넷 액세스 라우터 시스템을 설계하였다. 액세스 라우터 시스템은 다수의 Access Concentrator와 개방 인터페이스를 통하여 접속하여 제안된 인터넷 액세스 서비스를 지원할 수 있을 뿐 아니라 시스템의 용도에 따라 다양한 인터넷 액세스를 지원할 수 있도록 설계하였다.

Critical role of bile acid (BA) in the cellular entry and permissiveness of Hepatitis B virus in vitro

Hong‑Jai Lee,Bo‑Young Shin,Jae‑Seung Moon,Ailyn Fadriquela,Selikem Abla Nuwormegbe,Chun‑Chang Ho,Jin‑Su Shin,Jee‑Sang Yoon,Sang‑Kyou Lee,Soo‑Ki Kim 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3

Background Lack of universal replication system for hepatitis B virus with narrow host range and organ tropism has hampered to uncover the pathogenesis of HBV. Previously, we reported the essentiality of humoral milieu and its components toward HBV and hepatitis C virus survival/viability in vitro. Of these components, the precise role of enterohepatic humoral milieu such as bile acid (BA) on HBV cultivation in vitro and in vivo is unknown. Objective We explored whether BA, specifically taurochenodeoxycholic acid (tCDCA) would directly regulate the viral DNA and surface antigen expression of HBV in vitro, consequently rendering HBV to enter into human or murine immortalized hepatocytes, and non-hepatocytes. Result We found that higher concentration of taurochenodeoxycholic acid (tCDCA) is able to preserve the genomic stability of HBV in cell-free DMEM, showing higher the surface antigenicity than taurocholic acid (tCA). In line, we found that in vitro cell culture condition (100 μmol/L of tCDCA coupled with 1 × 108 g e/mL HBV) would be optimal for HBV entry into target cells. Using this, human (HepG2, Huh7), and rodent (Hepa1c1c7, H4-II-E) hepatoma cell lines were infected by HBV, as evidenced by the presence of HBV biomarkers (HBsAg, and HBV DNA in culture supernatant, as well as HBcAg in cell). Further, cellular entry test revealed that HBV is able to infect 12 different non-hepatic cell lines regardless of species, and organ/tissue, consequently reproducing progeny as confirmed by HBV biomarkers. Last, reinfection test showed that the progenies of HBV from immortalized HepG2, and Hepa1c1c7 cells are able to enter into each or vice versa naïve HepG2, and Hepa1c1c7 cells with or without BA. Conclusion This study demonstrates that enterohepatic humoral milieu such as BA, specifically tCDCA would directly regulate HBV DNA and its surface antigen expression in vitro, consequently rendering HBV to enter into human or murine immortalized hepatocytes, and non-hepatocytes. This is the first note to render HBV permissive to human or rodent hepatic and non-hepatic cells via sole manipulation of humoral milieu, thus establishing the platform for in vitro robust replication system of HBV.

대장암환자에서 자연살해세포의 변화

김광호,심강섭,박응범,강은숙,홍기숙 대한대장항문학회 1998 Annals of Coloproctolgy Vol.14 No.3