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Lee, Kyunghoon,Kim, Ji-Eun,Kwon, Jihyun,Kim, Inho,Yoon, Sung-Soo,Park, Seonyang,Han, Kyou-Sup,Kim, Hyun Kyung Rapid Communications of Oxford Ltd 2014 Blood coagulation & fibrinolysis Vol.25 No.3
Overall assessment of the hemostatic system including procoagulant and anticoagulant changes may help assess the clinical status and prognosis of disseminated intravascular coagulation (DIC). The thrombin generation assay provides useful information about the global hemostatic status. Therefore, we measured several parameters of global hemostatic potential by the thrombin generation assay in patients suspected of having DIC. A total of 114 patients with suspected DIC were included. The thrombin generation assay was performed on the calibrated automated thrombogram using tissue factor with or without the addition of thrombomodulin, showing three parameters: lag time, endogenous thrombin potential (ETP), and peak thrombin. Both 1 and 5 pmol/l tissue factor-stimulated ETP and peak thrombin were well correlated with DIC severity. Interestingly, antithrombin level greatly affected ETP, whereas protein C influenced lag time. Prognostic analysis revealed that the area under the curve of peak thrombin stimulated by 1 pmol/l tissue factor was superior to that of D-dimer. Moreover, multivariate Cox analysis showed that the lag time and time to peak with both 1 and 5 pmol/l tissue factor were independent prognostic markers. ETP and peak thrombin well reflect DIC severity. Hypocoagulability manifesting as prolonged lag time and time to peak is expected to be an independent prognostic marker in DIC.
Structural Origin for the Transcriptional Activity of Human p53
Lee, Si-Hyung,Park, Kyu-Hwan,Kim, Do-Hyung,Choung, Dong-Ho,Suk, Jae-Eun,Kim, Do-Hyung,Chang, Jun,Sung, Young-Chul,Choi, Kwan-Yong,Han, Kyou-Hoon Korean Society for Biochemistry and Molecular Biol 2001 Journal of biochemistry and molecular biology Vol.34 No.1
Transcriptional activation domains are known to be inherently "unstructured" with no tertiary structure. A recent NMR study, however, has shown that the transactivation domain in human p53 is populated with an amphipathic helix and two nascent turns. This suggests that the presence of such local secondary structures within the overall "unstructured" structural framework is a general feature of acidic transactivation domains. These pre-existing local structures in p53, formed selectively by positional conserved hydrophobic residues that are known to be critical for transcriptional activity, thus appear to constitute the specific structural motifs that regulate recognition of the p53 transactivation domain by target proteins. Here, we report the results of a NMR structural comparison between the native human p53 transactivation domain and an inactive mutant (22L,23W$\rightarrow$22R,23S). Results show that the mutant has an identical overall structural topology as the native protein, to the extent that the amphipathic helix formed by the residues 18T 26L within the native p53 transactivating domain is preserved in the double mutant. Therefore, the lack of transcriptional activity in the double mutant should be ascribed to the disruption of the essential hydrophobic contacts between the p53 transactivation domain and target proteins due to the (22L,23W$\rightarrow$22R,23S) mutation.
Free Vibrations of Continuous Curved Beams considering Rotatory Inertia and Shear Deformation
LEE, Byoung Koo,PARK, Kwang Kyou,OH, Sang Jin,MO, Jeong Man 圓光大學校 環境建設硏究所 1996 環境建設論文集 Vol.5 No.-
이 논문은 회전관성과 전단변형을 고려한 연속곡선보의 자유진동에 관한 연구이다. 곡선보 요소에 작용하는 합응력 및 관성력의 동적 평형방정식을 이용하여 원호형 곡선보의 면외 자유진동을 지배하는 미분방정식을 유도하였다. 이 미분방정식을 Heun's method를 이용하여 수치적분하고 미분방정식의 고유치인 고유진동수는 반분법을 이용하여 계산하였다. 수치해석예에서 힌지-힌지-힌지 보 및 고정-힌지-고정 보의 고유진동수를 제 4모드까지 산출하여 무차원양으로 나타내었다. 수치해석의 결과로 회전관성 및 전단변형이 고유진동수에 미치는 영향을 분석하였고, 고유진동수와 중심각, 세장비, 전단변수 및 강성변수와의 관계를 그림에 나타내었다. 또한 2조의 실험실 규모의 실험을 통하여 본 논문결과의 타당성을 보였다.