홍씨 앞방각측정법의 임상적 유용성

강신희,박기호,홍철,김동명,Shin Hee Kang,M,D,Ki Ho Park,M,D,Chul Hong,M,D,Dong Myoung Kim,M,D 대한안과학회 2007 대한안과학회지 Vol.48 No.3

Purpose: To compare the Hong`s grading method, utilized for slit-lamp grading of the mid-peripheral angle, with other conventional grading methods. Actual angle was measured by ultrasound biomicroscopy (UBM) for comparison. Methods: Fifteen eyes with narrow angles and eighteen eyes with wide angles were studied. The average age of thirty-three subjects was 46.8±19.2, and the male to female ratio was 1:3.7. The mid-peripheral angle was graded by Hong`s, van Herick`s and Spaeth`s grading system. The actual anterior chamber angle was evaluated by UBM and the correlation between each grading system and actual angle was investigated. Results: The results from the Hong`s grading (r=0.802, R2=0.643, p<0.01), Spaeth`s grading (r=0.728, R2=0.530, p<0.01) and van Herick`s grading (r=0.618, R2=0.382, p<0.01) methods correlated significantly with the actual angles. Conclusions: The Hong`s grading method was an easy and effective tool to evaluate anterior chamber angle. In addition, the results of the Hong`s grading method were closer to the actual angle than the other methods.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

대학생들의 안전교육 및 안전의식에 관한 연구

홍기헌 ; 윤석호 김천대학교 2014 김천대학교 논문집 Vol.35 No.-

The purpose of this study is to figure out current status of safety education until today and safety consciousness of university students. For this study, the 300 university students were taken among freshmen and sophomores in gimcheon university. Furthermore it is try to realize the necessity of additional safety education in universi-ty and the unification of emergency call numbers. The results are as follows: 1. It was showed that the most students prefer unified emergency call number not divided. 2. Marine accident safety education was lowered compared with other life safety ducations such as fire, earthquake, and traffic safety educations. 3. It was showed that many university students wish additional actual safety educa- tion in university as academic subjects. 4. University students consider that Sewol passenger ship accident was caused by eficient of vocation and safety frigidity of crew and company staffs. And in order to revent this kind of accident, crew vocation should be built up, students safety duca-tion should be strengthened and government agency should watch severely the hip remodelling

配水管綱의 非線形 解釋

池洪基,朴埼鎬 嶺南大學校 工業技術硏究所 1993 工業技術硏究所論文集 Vol.21 No.2

This study deals with the analysis of pipe networks. The analysis of pipe network is normally done by computer programming. And the system are composed of as follows; elements, the pipes, connected with specified number of nodes. The pipe network system should be solved for the network system's solution. The element level, head losses for each elements are calculated from the head losses. From this process, the network solutions are completed. The critical step in this analysis is the determination of individual element behaviour. For this the method which is based on the Hazen-Williams formula and used Newton-Rapson technique is chosen. This non-linear analysis leads precise results.

자동차 사고의 한 사회심리락적 분석(I) : 골목길 사고와 추돌 사고 Back-ally Accidents and Rear-end Collisions

홍기원,차재호,김수영 서울大學校 社會科學大學 心理科學硏究所 1995 心理科學 Vol.4 No.2

서울과 지방 도시에서 1993년에 발생한 자동차 운전사고 240사례의 기록을 토대로 가장 흔히 발생하는 사고 유형을 서울에서 7개, 그리고 지방 도시에서 8개 선정해서 각각의 유형 안에서 사고가 발생하는 원인을 사회심리학적 입장에서 분석했다. 사고의 의미 있는 심리학적인 이해와 효과적인 방지책 설립을 위해서는 사고를 사고 빈발 상황 별로 분석할 필요성을 역설하고 실제 사례 분석으로 틀을 고찰했다. 이어 서울에서 확인된 사고유형중 (1)골목길 사고와 (2)정지선에서의 차-차 추돌사고를 분석했다. 골목길 사고는 주로 어린 피해자의 충동적 횡단이 그리고 추돌 사고에서는 운전자의 운전경력부족이 사고의 원인으로 밝혀졌다. . A random sample of 240 auto accidents which occurred in 1993 in a Seoul district and a small city outside Seoul have been classified according to the similarity of the situation. A total of 7 categories in Seoul(N=120) and 9 categories for the small city(N=120) were identified in terms of high frequency of occurrence. The present paper first argued for the usefulness of combinining an interdependency analysis and a cause-effect analysis of auto accidents. The present report then presented an analysis of two specific categories from Seoul, namely (1) backally car-person accidents and (2)rear-end collision accidents. It was found that in the back-ally accidents yound children's impulsive act was a decisive factor while in the rear-end contacts a lack of driving experience on the part of the driver making the hit was

β-Lactamase생성균주에 대한 새로운 β-Lactamase Inbitating Compound와 β-lactam항생제와의 병용시 항균효과

홍인표,김홍진,임채욱,김기호 중앙대학교 약학연구소 1996 약학 논총 Vol.10 No.-

The in vitro and in vivo activities of CH1250, a new β-lactamase inhibiting compound, were compared with the activities of clavulanic acid and sulbactam against 30 β-lactamase-producing bacteria. Broth microdilution susceptibility testing was performed to compare the activities of β-lactamase inhibitors. Serial two fold dilutions of β-lactams were tested alone and in two combinations with β-lactamase inhibitor. CH1250 was more active than clavulanic acid against Acinetobacter calcoaceticus S21, Pseudomonas aerug-nosa GN918, Proteus vulgaris 20, Staphylococcus aureus MS15009/1258, Serratia marcescens 1 when combined with cefotaxime. When combined with amoxicillin, CH1250 was more effective against Citrobacter diversus 2046E. Staphylococcus aureus MS25009/1258, Proteus vulgaris GN76. With ampicillin, CH1250 had an better or simillar activities against Escherichia coli 3455E, Klebsiella aerogenes 1976E, Serratia marcescens 1, Staphylococcus aureus MS15009/1258. The efficacy of ampicillin-CH1250 in treatment of mice with systemic infections produced by Klebsiella aerogenes 1976E, a β-lactamase-producing bacteria, was compared with that of ampicillin, ampicillin-sulbactam. Acute systemic infections in mice were produced by i.p. inoculation of bacterial cultures suspended in 6% mucin. Mice were treated s.c. 1hr after challenge. PD50s of the ampicillin, ampicillin-sulbactam. ampicillin-CH1250 were 334.32, 170.58, 250.5mg/kg, respectively. CH1250 was not more effective than sulbactam in reducing ampicillin doses required to protect mice from infection produced with Klebsiella aerogenes 1976E. The reduction in the 50% protective dose of ampicillin by CH1250 was 23% better than those effected by sulbactam for Klebsiella aerogenes 1976E infection.

배추 시스테인 단백질 분해 효소 억제 유전자 BCPI-1의 발현과 종자 발아 및 유묘 생장과의 연관성

홍준기,이은영,김정률,양경애,최영주,정우식,김호일,윤대진,이상열,조무제,임체오 Plant molecular biology and biotechnology research 2003 Plant molecular biology and biotechnology research Vol.2003 No.-

Phytocystatins are protein inhibitors of cysteine proteinases of the papain family that have been identified in both monocot and dicot plants. A cDNA encoding a phytocystatin, BCPI-1 (Brassica Cysteine Proteinase Inhibitor-1) has been isolated from Chinese cabbage (Brassica campestris L. ssp. pekinensis) flower buds. Here, we tested whether BCPI-1 transcription is regulated by hormones, and could be involved in regulating cysteine proteinases during and after germination. BCPI-1 was sensitive to exogenous GA_(3) and ABA, which are important factors controlling seed germination, suggesting that the expression of BCPI-1 is hormonally regulated. We introduced a recombinant plasmid containing the full-length BCPI-1 cDNA under the control of cauliflower mosaic virus 35S promoter into rice embryogenic calli using the particle delivery method, and regenerated a number of transgenic rice plants. Constitutively over-expressed BCPI-1 caused changes in overall plant growth and development, including reduced germination and seedling growth. These data support the role of the BCPI-1 in the regulation of endogenous proteinases during both seed germination and subsequent seedling development. Phylocystatins은 papain계열의 cysteine 단백질 분해 효소 활성을 특이적으로 억제하는 억제자로 다양한 식물 종으로부터 분리되었다. 본고에서는, 배추 화아 cDNA library로부터 분리된 phytocystatin인 BCPI-1(Brassica Cysteine Proteinase Inhibitor-1)의 생체 내 기능에 대해 연구하였다. 먼저, BCPI-1 전사체는 발아 조절에 중요한 영향을 미치는 GA₃와 ABA에 의해 예민하게 증가, 혹은 감소되는 반응을 보임으로써, BCPI-1이 식물 호르몬의 영향을 받으며, 특히 발아나 유묘의 생장 조절에 관련이 있음을 알 수 있었다. Particle bombardment 방법을 통하여 BCPI-1을 벼의 배 형성 세포 내에 도입, 재분화 시켜 형질 전환 벼를 생성하였다. CaMV 35S promoter의 조절에 의해 지속적인 BCPI-1 발현을 보이는 형질 전환 벼의 경우, 발아와 유묘 생장이 현저히 지연되었다. 위의 결과들을 바탕으로, BCPI-1이 식물체 내에서 생성되는 cysteine 계열의 단밸질 분해 효소 활성을 조절하여 종자의 발아와 유묘의 생장에 영향을 미치는 것으로 추측한다.

리눅스 클러스터 서버 상에서 RTSP 기반의 VOD 스트리밍 시스템의 설계 및 구현

홍기호,김영진,최황규 江原大學校 産業技術硏究所 2001 産業技術硏究 Vol.21 No.A

Linux cluster Server makes a high performance PC cluster system, and provides scalablity and availability as compared with an expensive single server. In this paper, we design and implement a VOD streaming service system to serve video and audio streaming services on the Linux cluster serve. Our Streaming server supports the MS Window Media Format based on the RTSP streaming protocol.