서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Ethylenediaminetetraacetic acid (EDTA)항응고제에 의한 Mean Corpusculaar Volume(MCV)변화

홍승민,박영진,최하여,임진,정옥연,이호준,이호영,장숙진,문대수 조선의대 1996 The Medical Journal of Chosun University Vol.21 No.2

배추 시스테인 단백질 분해 효소 억제 유전자 BCPI-1의 발현과 종자 발아 및 유묘 생장과의 연관성

홍준기,이은영,김정률,양경애,최영주,정우식,김호일,윤대진,이상열,조무제,임체오 Plant molecular biology and biotechnology research 2003 Plant molecular biology and biotechnology research Vol.2003 No.-

Phytocystatins are protein inhibitors of cysteine proteinases of the papain family that have been identified in both monocot and dicot plants. A cDNA encoding a phytocystatin, BCPI-1 (Brassica Cysteine Proteinase Inhibitor-1) has been isolated from Chinese cabbage (Brassica campestris L. ssp. pekinensis) flower buds. Here, we tested whether BCPI-1 transcription is regulated by hormones, and could be involved in regulating cysteine proteinases during and after germination. BCPI-1 was sensitive to exogenous GA_(3) and ABA, which are important factors controlling seed germination, suggesting that the expression of BCPI-1 is hormonally regulated. We introduced a recombinant plasmid containing the full-length BCPI-1 cDNA under the control of cauliflower mosaic virus 35S promoter into rice embryogenic calli using the particle delivery method, and regenerated a number of transgenic rice plants. Constitutively over-expressed BCPI-1 caused changes in overall plant growth and development, including reduced germination and seedling growth. These data support the role of the BCPI-1 in the regulation of endogenous proteinases during both seed germination and subsequent seedling development. Phylocystatins은 papain계열의 cysteine 단백질 분해 효소 활성을 특이적으로 억제하는 억제자로 다양한 식물 종으로부터 분리되었다. 본고에서는, 배추 화아 cDNA library로부터 분리된 phytocystatin인 BCPI-1(Brassica Cysteine Proteinase Inhibitor-1)의 생체 내 기능에 대해 연구하였다. 먼저, BCPI-1 전사체는 발아 조절에 중요한 영향을 미치는 GA₃와 ABA에 의해 예민하게 증가, 혹은 감소되는 반응을 보임으로써, BCPI-1이 식물 호르몬의 영향을 받으며, 특히 발아나 유묘의 생장 조절에 관련이 있음을 알 수 있었다. Particle bombardment 방법을 통하여 BCPI-1을 벼의 배 형성 세포 내에 도입, 재분화 시켜 형질 전환 벼를 생성하였다. CaMV 35S promoter의 조절에 의해 지속적인 BCPI-1 발현을 보이는 형질 전환 벼의 경우, 발아와 유묘 생장이 현저히 지연되었다. 위의 결과들을 바탕으로, BCPI-1이 식물체 내에서 생성되는 cysteine 계열의 단밸질 분해 효소 활성을 조절하여 종자의 발아와 유묘의 생장에 영향을 미치는 것으로 추측한다.

나노 세리아 슬러리를 이용한 Stainless steel 304의 MR Polishing 특성에 관한 연구

홍광표,신봉철,김동준,조명우,신영재 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

An finishing process using magnetorheological fluid has been developed as a new precision finishing technique to obtain a fine metal surface. Therefore, magnetorheological fluids has been used for micro polishing and micro part. The applied material is 304 stainless steel. It is widely used in the semiconductor machinery and aerospace industries because of high corrosion resistance. For MR polishing process, MR fluids was consisted of carbonyl iron, DI-water and nano slurry ceria(Celexis cx 94s slurry). The wheel speed and electric current were chosen as the variables for analyzing the characteristics of MR polishing process. In the results, the surface roughness according to the variation of wheel speed was analyzed , and it was obtained 1.393nm surface roughness.

Ethylenediaminetetraacetic acid(EDTA)항응고제에 의한 Mean Corpuscular Volume(MCV)변화

홍승민,박영진,최하영,임진,정옥연,이호준,이호영,장숙진,문대수 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.2

It is essential that we put the anticoagulant into the blood specimen of the CBC test. However, the value of some parameters in the CBC test can be changed whenever using some anticoagulants. EDTA anticoagulant is mostly used these days. There are 3 kinds of EDTA, that is K_(2-), K_(3-), and Na_(2-) EDTA. The author studies how many effects each the EDTA gets into the true value of blood specimen for MCV of RBCs. Especially we compared the MCV effect of different concentrations of 3 EDTA anticoagulants on the bias with time and instrument. Some results are gotten. In our results, K_(3-)EDTA anticoagulant shows more satisfactory MCV value than K_(2) or Na_(2-)EDTA. On using concentration of EDTA, 1.5㎎ EDTA/㎖ of blood show more satisfactory MCV value than 7.5㎎ EDTA/㎖ of blood. However, the choice of anticoagulant may be dependant on the different instruments.

디지털 이미지 보호를 위한 효과적인 웨이브릿 변환

홍성표,박영옥,송기범,배일호,이준 조선대학교 전자정보통신연구소 2002 電子情報通信硏究所論文誌 Vol.5 No.2

The use of digital imaging technique and digital contents based on internet has grown rapidly for last several years, and the needs of digital image protection become more important. For the purpose of copyright protection on digital image, the verification of authentication techniques like content authentication, ownership authentication, illegal copy and etc are needed. Digital watermarking, the invisible encryption technique to insert digital watermark into image, the sophisticated perceptual information should be used for providing transparency and robustness of images on watermarking process. In this paper, we implement the algorithm for preventing forged attack, ownership protection and authentication by transforming the wavelet algorithms in frequency domain in terms of human visual system.

어트랙터 해석을 이용한 AISI 304강 열화 신호의 카오스성 평가

고준빈,오상균,김홍배,이성구,이영호 韓國工作機械學會 2000 한국생산제조학회지 Vol.9 No.2

This study proposes the analysis and evaluation method of time series ultrasonic signal using the chaotic feature extraction for degradation extent. Features extracted from time series data using the chaotic time series signal analyze quantitatively material degradation extent. For this purpose, analysis objective, in this study, is fractal dimension, lyapunov exponent and strange attractor on hyperspace. The lyapunov exponent is a measure of the rate at which nearby trajectories in phase space diverge. Chaotic trajectories have at least one positive lyapunov exponent. The fractal dimension appears as a metric space such as the phase space trajectory of a dynamical system. In experiment, fractal(correlation) dimensions and lyapunov exponents showed values of mean 3.837∼4.211 and 0.054∼0.078 in case of degradation material. The proposed chaotic feature extraction in this study can enhances ultrasonic pattern recognition results from degradation signals.

中學校 科學科의 實驗實習敎材의 開發硏究Ⅱ

朴泳喆,韓麟傳,李春雨,權寧駿,朴弘緖 공주대학교 사범대학 과학교육연구소 1982 과학교육연구 Vol.14 No.1

In this study a few laboratory teaching materials have been developed to be available for the effective performance of experiments and practices- a heart of inquiry learning-as a continuance of 'A study on the Development of Laboratory Teaching Materials for Middle School Science Course I' The present condition of science education has been investigated by means of questionaires, interviews and literature, the results of the present condition and problems in junior high schools are as follows: 1. The hours for science classes are considerably little for the teaching contents of science textbooks. 2. The level of teaching is beyond the student's capability in terms of their experience and intellectual development. 3. Science teachers are overburdened with much tasks, and laboratories and laboratory facilities are too insufficient and furthermore teaching is mainly conducted on the lecture method as a preperation for various entrance exams. 4. Teachers' eagerness and desirable attitude for teaching are required. In this study, materials for every branch of science have been developed to be available for the effective performance of experiments and practices through inquiries. The materials developed in this study are as follows: 1. In physics, measure apparatus of extremely small masses, length, and very little time intervals are developed. 2. In chemistry, new methods for gas generating apparatus and materials. are developed. 3. In biology, the size of quadrate and the method to decide the time in facilitating for the purpose of survey of botany community are introduced. The results of the investigation of natural enemy on Hyphantria cunea, and the study on collecting, breeding of Planaria are also shown. 4. In earth science, the laboratory teaching materials are developed for observing continuous spectrum and line spectrum. Putting the above results of study together, the suggestions are made to the effect as follows: 1. The quantity of learning should be reduced and the levels lowered in the new textbooks. 2. The development and distribution of various teaching materials(film, T,P., cassettes film, supplementary, textbook, program teaching material, individual learning material) is required. 3. The experimental instruments should be timely manufactured and distributed on the basis of effective administrative support to ensure their solidity and accuracy. 4. The concrete design to eliminate the teacher's burden should be contrived and the system for senion teachers in charge of science teaching in secondary schools, should be improved. 5. Teacher's research activities should be encouraged through various research institutes(Institute of science education , graduate school of education and the other research institutes.) 6. The disposition of laboratory assistant should be considered. 7. More positive supports from other societies relevant with education are much expected to be made.

여성 골프 스타 모델의 이미지 속성차원에 따른 광고모델의 차별화 분석 : Focused on Golf Stars

천영일,홍준기 中央大學校 韓國敎育問題硏究所 2000 韓國敎育問題硏究所論文集 Vol.- No.15

The purpose of this research is to find the factors (image elements and image levels) that mostly influence the endorsement power by power measurement of sports stars as advertisement endorsers through their image analysis. For this purpose, we chose golf as an advertisement sport and golf club as an advertising product, selected sports stars(Seri Pak, Mihyun Kim, Jiyun Park) for golf club advertisement model, and investigated a model selection method which we designed by applying the method, 'measurement of the endoresement power factors of sports stars by their image analysis'. Concrete research objectives are as follows: 1) to ascertain the sub factors of image construction 2) to identify image levels of factors that affect the attitude toward advertisements and advertising products. We conducted a questionnaire survey of 313 students(151 men and 162 women) in C university and reached the following conclusions: 1) Seri Pak has familiar and popular image and appeals to purchasers by her powerful image, so when we apply her to advertisement, we should consider these facts. 2) Mihyun Kin is characterized by her cheerfulness, social image, and familiarity, so we need a marketing strategy that emphasizes these points. 3) Jiyun Park is a player worthy of utilization in marketing by her western image such as generous and active characteristics.