부당경량아에서 발생하는 대사 장애의 기전

김은영,박상기 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.33 No.S

일 고등학교 학생들의 건강증진행위와 관련요인

유상학,김진선 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

Background and Objectives: Little is known about the health promoting behaviors of adolescence. The purposes of this study were to identify healthUpromoting behaviors of high school students and to explore the predictors of their health-promoting behaviors. Method: A crossUsectional study was conducted. Data were collected from 751 students in a technical high school located in G city using a structured questionnaire. Results: High school students in this study practice health promoting behaviors relatively well. Among 6 dimensions, students reported the highest score on the interpersonal relationship dimension and the lowest score on the health responsibility dimension. Of 751 respondents, 26.2% was current smokers and 64.6% was current drinkers. Health-promoting behaviors were predicted by selfUeff'icacy, family support, school life adaptation, and gender. Students who reported higher self-efficacy, higher family support, and higher school life adaptation practice more health promoting behaviors than their counterparts. Moreover, boys reported higher health promoting behavior scores than girls, Conclusion: Health promotion programs to increase health responsibility of high school students are need to be developed. There were great needs to develops tobacco cessation and drink control programs. More studies are needed to identify predictors of high school students' health promoting behaviors.

담낭종양에서 CD24의 역할

임성철,이용,김동출,강길,변익건,박정희,최석민 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.2

CD24 is a small heavily glycosylated glycosylphosphatidylinosito-linked cell surface protein, which is expressed in hematologic malignancies as well as in a large variety of solid tumors, It appears to function as a ligand of PUselectin, an adhesion molecule that is present in activated platelets and endothelial cells. The authors aimed to evaluate CD24 protein expression in adenoma and adenocarcinoma of gallbladder to correlate to clinicopathologic data. The staining- was evaluated as stainability (negative, weak-, moderate-, strong-positive) and staining' patterns (membranous vs. intracytoplasmic) for statistical analysis. A highly significant association of cytoplasmic CD24 expression with adenocarcinoma compared to the adenoma of gallbladder was demonstrated. The present study demonstrates that CD24 was abundantly expressed on adenocarcinoma rather than on adenoma, but it was not statistically significant, Interrelation between the stainability or intracytoplasmic staining of CD24 and lymph node metastasis was not statistically significant. The authors conclude that CD24 is involved in tumorigenesis of gallbladder mucosa and intracytoplasmic expression of CD24 is an important molecular marker for malignant transformation.

소아 두통의 진단과 치료

노영일 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

족저건 보강법을 이용한 아킬레스건 파열의 치료

이준영,하상호 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

Background and Objectives : We try to evaluate the result of the operative treatment ofAchilles tendon rupture using plantaris tendon augmentation and the functional outcomes related to the cause of injury and rehabilitation methods. Materials and Methods : We studied retrospectively, 28 patients of Achilles tendon rupture treated and followed over l-year, from Januaiy 1995 to August 2001. There were 24 men and 4 women, mean age was 38 years. The repair method of ruptured tendon was pirmary repair with plantahs tendon augmentation. We used Leppilahti method for the clinical evaluation and analyzed patient's satisfaction and subjective strength deficit. Results : In clinical results, we had 11 excellent cases(39%), 10 good cases(36%), 4 fair cases(14%) and 3 poor cases(11%). Nonsports-related rupture had worse result than sports related rupture due to old age and degenerative changes of tendon. The result of short leg cast was similar to that of long leg cast in rehabilitation method, especially, the group starting the weight bearing ambulation within 8 weeks obtained excellent results. Conclusion : We had good result for Achilles tendon rupture treated by primary repair with planths tendon augmentation. This study shows plantahs tendon augmentation was recommended method for primary repair and early rehabilization of Achilles tendon rupture.

청소년기 특발성 척추 측만증의 원인 및 자연사

유재원,손홍문 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

Adolescent idiopathic scoliosis(AIS) is a structural lateral curvature of the spine in the adolescent period in otherwise normal children. The diagnosis is obtained through evidence of a lO-degree lateral curvature with vertebral rotation on a standing upright radiograph of the spine, Prevalence studies indicate that 2% to 3% of children have idiopathic scoliosis. The exact etiology of idiopathic scoliosis, however, remains unknown at this time. The general consensus is that there is a hereditary predisposition and its actual cause is multifactohal. Approphate decisions for AIS require thorough knowledge of natural history, Understanding the natural history enables physicians to make thoughtful and appropriate management decisions that will alter the course of the disease in a positive way. The main concerns in the natural history are curve progression, back pain, Pulmonary function, mortality, Psychosocial effects and pregnancy, Previous natural history studies claimed an exaggerated results. Many recent results, however, are comparable to general population other than back pain and cosmetic concerns. 척추 측만증에 대한 원인과 자연사에 대하여 많은 보고가 있지만 아직까지 확실한 단일 원인은 밝혀지지 않았고 원인으로 생각되는 요소가 측만증의 원인인지 아니면 측만증에 의한 이차적인 변화인지 확실하지 않은 경우가 많다. 자연사는 과거의 보고는 요통, 폐기능, 사망률, 임신 등에서 정상인에 비해 좋지 않은 결과를 보인다는 보고가 많았으나 최근 보고는 정상인과 비슷하거나 약간 나쁜 정도의 결과를 보고하고 있다. 앞에서 언급한 내용틀은 일반적인 내용이며 측만증 환자에 대한 치료에 임할때는 측만증의 자연사에 대한 지식과 만곡의 크기, 골격 성숙도, 성 성숙도, 나이 등에 기초한 만곡의 진행 가능성을 충분히 고려하여 각각의 환자에 맞는 치료를 시행하여야 할 것이다.

165 rDNA PCR을 이용한 양수내 세균 검출

이성현,장숙진,최상준,김영숙,한호림,문대수,박영진 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.1

Background and Objectives : Microbial invasion of the amniotic cavity is a significant clinical problem in obstetrics leading to infectious morbidity of both the mother and the newborn. So rapid and reliable test to detect bacteria in amniotic fluid is urgently needed. The purpose of this investigation was to determine the feasibility of using the 16S rDNA PCR to detect bacteria in amniotic fluid. Material and Method : Amniotic fluid samples from 15 pregnant women with hydramnios, preterm labor, or old age pregnancy were analysed with universal bacterial PCR. We used universal primers which amplify a DNA fragment of 16s rDNA from all known bacteria and sequenced the positive samples to identify the bacterial species, In some cases, routine bacterial culture, WBC, and CRP were studied also. Result : Three of 15 pregnant women were positive in the PCR. DNA sequencing of the PCR product detected Staphylococcus epidermidis in one case, and Streptococcus anginosus in two cases. Conclusion : The broad-spectrum bacterial 16S rDNA PCR assay, in properly controlled conditions, may provide a fast and reliable means for the detection of bacteria in amniotic fluid. 배경 및 목적 : 양수강의 미생물 침습은 산모와 신생아 양자에게 감염성 질환을 야기할 수 있어 산과학에 있어 중요한 임상적 문제이다. 따라서 양수에서 세균을 검출할 수 있는 신속하고 믿을 만한 검사가 절실히 필요하다. 이 연구의 목적은 16S rDNA PCR을 이용하여 양수에서 세균을 검출할 수 있는지 그 실행가능성을 검사하는데 있다. 대상 및 방법 : 양수과다증이나 조기 분만, 노산 등이 있는 임산부 15인의 양수 검체를 16S rDNA PCR로 분석하였다. 모든 알려진 세균의 16S rDNA 분절을 중폭할 수 있는 보편적인 시동물질을 사용하여 증폭하였고, 양성 검체를 염기순서분석하여 세균 균종을 동정하였다. 일부 환자들에서는 세균 배양검사와 WBC, CRP 검사도 함께 시행하였다. 결과 : 15명중 3명의 임산부가 PCR에 양성이었고 PCR 산물을 DNA 염기순서분석한 결과 한 환자에서 Staphylococcus edidermidis가 다른 두 환자에서 Streptococcus anginosus가 검출되었다. 결론 : 광범위 세균 16S rDNA PCR 분석은 적절히 관리된 조건 하에서 양수내 세균 검출을 위한 신속하고 믿을 만한 방법을 제공해 줄 수도 있다고 생각되었다.

열성 경련의 최신 치료와 예후

노영일 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.1

Febrile seizures, the most common form of childhood seizures, have an excellent prognosis but may also signify a serious underlying acute infectious disease such as sepsis or bacterial meningitis. The incidence approaches 3-5% of young children. Febrile seizures are age dependant and usually occur between the ages of 3 months to 5 years. The cause of febrile seizures is uncertain. Male are affected more often than females. A strong family history of febrile seizures in siblings and parents suggests a genetic predisposition. An autosomal dominant inheritance pattern is demonstrated in some families. Usually the degree of the child's fever and the speed in which the temperature rises seem to be important factors. Most febrile seizures are considered simple, although those with prolonged duration (> 15 minutes), focal onset, or that occur more than once within the same febrile illness are considered complex. Recurrence is possible, but only 2%~10% of children whose first seizure is associated with fever will go on to develop epilepsy. Although antiepileptic drugs can prevent recurrent febrile seizures, they do not alter the risk of subsequent epilepsy. Most children outgrow febrile seizures. This article reviews the current understanding of the management and prognosis of febrile seizures.

장관골 간부골절 치료의 원칙

하상호,손홍문,이준영 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.1

1세대 Northgate SD-3와 3세대 Donier Compact Delta를 이용한 체외충격파쇄석술의 비교 : 상부 및 중부요관석 243례

고영록,노준,소영석 朝鮮大學校 附設 醫學硏究所 2003 The Medical Journal of Chosun University Vol.28 No.2

Objectives: To compare the efficacy of the Dornier Compact Delta lithotriptor with the Northgate SD-3 lithotriptor in the treatment of upper and mid-ureteral stones. Materials and Methods: A total of 243 patients without any previous experience of ESWL were treated for upper and mid-ureteral stones. 121 patients were managed with the Northgate SD-3 lithotriptor which had ultrasonography targeting system and electro hydraulic shock wave source. The other 122 patients were treated with the Dornier Compact Delta equipped with a fluoroscopic focusing system and electromagnetic shock wave source. The locations and sizes of stones, sessions, stone-free rates, auxiliary procedures, and complications of ESWL were reviewed retrospectively. In each group stone-free results were determined by KUB 1 month after the last ESWL and then efficacy quotients (EQ) were obtained. Results: Baseline characteristics were equivalent, including patient ages, sex ratio, stone numbers and locations. Using the Northgate SD-3 lithotriptor, the average sessions and stone-free rates were 1.53 and 86.8%, respectively. Using the Dornier Compact Delta lithotriptor, average sessions and stone-free rate were 1.38 and 92.6 %, respectively. Effectiveness quotient(EQ) in the Northgate SD-3 and the Dornier Compact Delta was 61 and 65, the rates of the auxiliary procedure were 9.1% and 18%. Conclusions: The Dornier Compact Delta lithotripsy resulted in a higher stone-free rate and EQ, although it was associated with a higher rate of pre-ESWL auxiliary procedures than the Northgate SD-3 Lithotripsy.