서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

관상동맥내 스텐트 시술시 Aspirin과 Cilostazol 2개월 병합요법

윤명호,탁승제,염철훈,장혁재,최소연,유상용,안성균,고종훈,신준한,김한수,최병일 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

住民運動參與의 決定要因에 관한 硏究

尹晙相,申尹澈 公州大學校 産業開發硏究所 1993 産業開發硏究 Vol.1 No.-

The objectives of the study were 1) to determine related variables of people's participation in collective action against three public community development administration projects, 2) to draw implications for development of democratic community development administration. To collect data, three areas in South Chung-Chong Province where such collective action took place were selected and a total of 261 residents were sampled as final subjects of survey. The degree of people's participation as dependent variable was measured mainly by Likert style ranging from 6-30 points on average. The independent variables were divided into two : individual attributes(sex, age, schooling, job, income, perceived level of living, period of living) and attitude valuables(community satisfaction, community cohesiveness, community leadership, political efficacy, political reliability, interest in community development project, benefit in community development project, wills of participation in community development project) Interview and/or questionnaire method was the main method of data collection. The statistics to determine related variables used in this study were analysis of variance and multiple regression analysis with a .01 significance level. The major findings of this study were as follows; 1. Five personal characteristics out of 5 associated with the degree of people's participation in collective action by analysis of variance were selected: sex, age, schooling, income, perceived level of living. 2. As a result of multiple regression analysis, seven variables of affecting people's participation in collective action, were determined: (1) interest in community development project, (2) income, (3) sex (4) age (5) community leadership, (6) benefit in community development project (7) political efficacy. Out of those seven variables the interest in community development project had the highest influence on the people's participation in collective action(10.9%). 3. Therefore, four implication were drawn for more efficient democratic community development administration: (1) planning of community development projects from below, (2) widening people's participation in community development administration, (3) openness information system from community development administration, (4) acclimatization of social movement through adult/continuing education.

다발성 신경 섬유종증 제 1형에서 발생한 뇌출혈 1예

정상욱,배희준,이승훈,윤병우 대한신경과학회 1998 대한신경과학회지 Vol.16 No.5

Chlamydia Pneumoniae에 대한 헌혈자, 혈액화학검사자 및 Mycoplasma Pneumoniae 항체 검사자의 혈청 항체 보유율

윤갑준,조상래,권오헌,이경원,정윤섭,김현숙 대한감염학회 1993 감염 Vol.25 No.2

Chlamydia pneumoniae infections, known to be very prevalent in many countries, are not reported in Korea to the best of our knowelege. Prevalence of antibodies against C. pneumoniae was determined by the micro-immunofluorescence test. The proportion of sera with antibody titers of ≥16,tested by polyvalent conjugate of IgG, IgM, and IgA (poly-Ig) were blood donor 76.8%, blood chemistry-tested patients 58.0% and Mycoplasma Pneumoniae antibody-tested patients 22.0%. The positive rates by age groups were ≤years 13.5%, 10-19 years 66.7% and over all 49.6%. Only three sera showed IgM antibody titer of ≥, which became negative after absorption with RF-absorbent. Poly-Ig against C. trachomatis was less prevalent and that against Legionella pneumophila rare. None of the sera at 1:8 dilution were positive for the poly-Ig against Coxiella burnetii. It is concluded that the poly-Ig antibody against C. pneumoniae are highly prevalent in the sera of Koreans suggesting the existance of the infection, and for the diagnosis of the infection, the same interpretation criteria of the MIF titer, which is used in other countries, can also be applied in Korea.

地域經濟活性化를 위한 農村市場開發에 관한 硏究 : 忠南 禮山地域市場을 中心으로

尹畯相,李武鉉,申尹撤,洪性贊,朴奉圭 公州大學校 産業開發硏究所 1994 産業開發硏究 Vol.2 No.-

Since the first year economic development plan, imblanced development of national territory during the economic development process has aggravated remarkable disparity between urban and rural areas. For this reason, this study introduced the development of rural market as one of the development strategies of regional economic to correct the imblance and relieve regional disparity. The purpose of this study were to look into the present situation of traditional rural market and to analyze the problems for the rural development in view of the current road situations in the rural areas and status of marketing facilities in market center and to measure the degree of rural area people's satisfaction to the rural market and to suggest the development plan of activating for rural market center. To collect data, the Yesan Gun rural market were selected and a total of 591 residents and 178 merchants were sampled as final subjects of survey. Interview and/or questionnaire method was the main method of data collection. The major findings of this study were as follows: 1) The population of Yesan Gun has decreased 2.85 persons per year from in 1984, but the number of vehicles were increased 2.85 times than in 1989. And the parking capacity of Yesan Eup was only 129 vehicles which were below of the total vehicles of Yesan Gun area (14,352). The number of Yesan area markets were 8 markets which consisted of 1 permanent market and 7 periodic markets. But as the economy has been developed, the conditions of rural markets have been changing. That is, the role of periodic market tends to be weakened with the growth of large cities, reinforcement of permanent markets, development of traffic facilities, large production, preferring high quality goods. 3) Generally, the people of Yesan Gun were attached for purchasing the necessaries of life and comodities and farming materials to ① Yesan Eup ② Seoul ③ Chonan Shi ④ Hongsung gun ⑤ Daejeon Shi. 4) The degree of community people's satisfaction to the town market presented 26.6% which meaned higher than dissatisfaction(9.5%). And the degree of people's inconvenience of accessibility to market center by transferring of bus terminal presented 64.2% which meaned higher than average. 5) The degree of people's dissatisfaction of traffic system in Yesan gun area presented followings: the road networks(61.5%), parking facility(68%), bus route(54%). 6) By the survey of merchants of Yesan gun area, on the average, it showed followings: the size of store was 6-10 pyeong(40%), the type of enterprise was retail dealer(70.9%), and purchasing place was wholesale dealer from Seoul(51.8%). 7) And they thought that Yesan town market were too small(70.8%), and the diversifying of goods was not enough(35.5%). 8) The merchants of Yesan area showed that the degree of into venience to traffic system was 72.7% and its to parking facility was 83.3%. And they complained that community administration agency have not tried to activate market(79.1%). Based on the results of this study, the following recommendation were made for activating regional economy and community market. That is, it is to strengthen the economic function in community market so as to suffice the economic and social activities for settlement area as their living space. And it is necessary to improve the interrelationship of the central functions. 1) So, the accessibility between market center and its surrounding areas must be rised. ① the enforcing preferentially to pave the bus terminal and market center to link two place. ② the running of shuttle-bus two place every regular market day. ③ the widening and connecting the road to rise accessibility between market center and its surrounding area. ④ the enforcement of parking facility around market center. ⑤ the constructing marketing centered area as intergrated body of various marketing facilities in the adjacent site is the centered area planned to achieve efficient marketing. 2) The modernization and specialization market center facilities. 3) The strengthening of drawing surrounding area people into Yesan market center. So, the following recommended: ① the development of special products market ② inducing special projects ③ the development tour and leisure course drawing industrial facilities. 4) And it needs to enforce community people's local patriotism and to support community markets by administration agency.

STI571 (Glivec^(�))에 의하여 빠른 치료 반응을 보인 불응성 Gastrointestinal stromal tumor

윤경원,이제중,김여경,황호인,이병환,조상희,정익주,김형준 全南大醫大 2001 전남의대학술지 Vol.37 No.4

성균관대학교 물리학과 방음실의 음향특성

尹錫旺,朴興秀,朴光俊,李聖壽,金成春 성균관대학교 기초과학연구소 1986 論文集 Vol.37 No.1

The acoustical properties of the chamber at the Department of Physics, Sung Kyun Kwan University are investigated. By using the least square method based on pressure inverse law each reference sound pressure level is determined. The free field data are collected at both outdoor and indoor measurements. The deviations from the free field condition show that a reference sound pressure level plays a critical role in evaluating the performance of anechoic chamber. The cutoff frequency of the anechoic chamber is found to be in the range of 150Hz-170Hz.

흉부 둔상 후 전종격동 출혈에 의한 종격동 압전 1예

윤상규,박종석,조준필 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Sternal fractures are most common in drivers of motor vehicles whose anterior chest hits the steering wheel during sudden deceleration. Sternal fractures may result in mediastinal hematoma secondary to bone marrow oozing. The hematoma usually resolves itself without complications, so an anterior mediastinal hematoma causing tamponade is rarely reported. We describe a case of blunt chest trauma resulting in a sternal fracture with a resultant anterior mediastinal hematoma and mediastinal tamponade.