서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

고빌리루빈혈증을 동반한 자가면역성 간염 1례

서영범,김성욱,장재식,강혁주,이중현,윤병구,김욱년,이광헌,이구,유석동,양창헌,이정호,이영현,이창우,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

자가면역성 간염은 대개 만성 경과를 가지며, 혈중 자가면역항체와 혈청 글로불린치의 상승, 그리고 조직학적으로 괴사 염증성 변화를 특징으로 하는 질환으로 아직 정확한 병인이 밝혀져 있지 않은 상태이다. 발병연령은 대개 젊은 영자(15-25세)에서 호발한다. 이 질환은 급성 간염의 임상경과를 보일 수 있으나, 심한 급성 간염이나 전격성 간염으로도 나타날 수 있는데, 이 경우 아주 나쁜 예후를 보인다고 한다. 치료는 자가면역성 간염 임상 경과의 다양성이나 병인, 병리기전의 불확실성에도 불구하고 대개 steroid 치료에 반응하는 것으로 알려져 있으며 대개 80%의 관해율을 나타내며 궁극적으로 간경변으로의 진행을 막을 수 있는 것으로 보인다. 저자들은 58세 남자에서 발생한 급성의 경과를 가지고 심한 황달을 동반한 자가면역성 간염을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Autoimmune hepatitis (AIH) is a chronic necroinflammatory liver disorder of unknown cause associated with circulating autoantibodies and a high serum globulin level. The age of onset of AIH show a peak between the age of 15 and 25 years. AIH can develop and be manifested as acute hepatitis, but severe form of acute hepatitis or fulminant hepatic failure has a poor prognosis. Although AIH is likely to progress from chronic active hepatitis to cirrhosis, steroid therapy can control the disease activity, prolong survival, improve the quality of life , and defer liver transplantation. In the present report we describe a 58-year-old man who admitted because of progressive jaundice and fatigue. He was diagnosed with AIH from laboratory test result showing positivity for antinuclear antibodies, anti-smooth muscle antibodies, and negativity for hepatitis viral markers and from liver biopsy. Steroid therapy, oral administration of prednisolone, was effective in improving the liver function test. Following liver biopsy 6 months after onset shows markedly improved necroinflammatory activity.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

3차원 지그 설계 시스템의 도면 작성 지원 기능의 개발

이상헌,김석렬 국민대학교 생산기술연구소 2004 공학기술논문집 Vol.27 No.-

Modeling and simulation are emerging as key technologies to support manufacturing, which offer great potential for improving products, perfecting processes, reducing design-to-manufacturing cycle time, and reducing product realization costs. Especially 3-D shape modeling and simulation is a very effective tool for the design and production of automotive body assembly lines. Therefore, 3-D CAD systems have been widely adopted in the design of welding jig systems that are the main components of body assembly lines. However, the production process of a jig system still requires 2-D drawings. Therefore, it is necessary to create drawings from 3-D jig models. However, commercial 3-D CAD systems do not provide as convenient tools as 2-D CAD systems, nor specialized functionalities for the jig drawings. To solve this problem, we customized Unigraphics, a commercial CAD system, for the specific jig drafting process. Several drafting utilities have been developed in this project, which are balloon creation, car-line creation, symbol creation, parts list generation, and check sheet generation utilities. By introducing these drafting utilities, a jig system can be drafted more efficiently and reduce the time and cost of the jig design and production.

UWB용 모노콘 안테나 설계

이성훈,최석호,박종권 한밭대학교 정보통신전문대학원 2004 정보통신전문대학원 논문집 Vol.2 No.1

본 논문에서는 UWB 응용을 위한 변형된 모노콘 형태의 안테나를 제안하였다. 안테나의 크기를 줄이기 위해서 사용된 기술은 슬리브를 이용한 것이다. 제안된 안테나는 UWB응용에 좋은 특성(초 광대역폭, 무지향성 패턴, 작은 그룹 딜레이)을 가진다. We have proposed a modified-monocone antenna for UWB applications(3.1∼10.6GHz). The Sleeve technique is used to decrease the antenna size. The proposed antenna have a good characteristics(ultra-wide bandwidth, omni-directional pattern, and low group delay) for UWB applications.

생쥐 대장 평활근 세포에서 내향 정류성 칼륨 전류의 특성 연구

이은주,김명,정명섭,조향훈,김기훈,하현철,김준수,최석,전제열 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Objectives: K^(+) channels play an important role in regulating cellular excitability. The aim of this study was to know whether or not inward rectifier K^(+) channel exists in colonic smooth muscle cells. Methods: Mouse colonic smooth muscle cells were isolated using collagenase, and then we recorded their membrane currents using a whole-cell patch clamp technique. Results: With 90 mM K^(+) in bath, hyperpolarization-induced inward currents from -120 mV to 20 mV with 400 ms duration at a holding potential of -10 mV showed rapid activation, inactivation and inward rectification. The inactivation showed single exponential time course. Reduction of external K^(+) to 60 mM decreased the amplitudes of the currents in whole test voltage range and shifted the reversal potential to more negative potential. The inactivation process and peak currents of hyperpolarization-induced inward currents were not affected by removing external Na^(+). External Ba^(+) blocked hyperpolarization-induced inward currents by dose-dependent manner and pure Ba^(+)-sensitive currents showed strong inward rectification. Cs^(+) also suppressed hyper- polarization-induced inward currents. Ba^(+) and Cs^(+)-induced inhibitiOn of hyperpolarization-induced inward currents was voltage-dependent, and the extent of inhibition increasing with membrane hyperpolarization. Conclusions: These results suggest that inward rectifier KU channels may exist in proximal colonic smooth muscle and may play an important role in regulating membrane potential.

살모사 교상 후에 발생한 뇌간 경색

권석범,이병철,배재천,황성희,김대훈 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

ESPI 기법을 이용한 폴더식 정보 통신기기의 힌지부 내구 수명 평가

이태훈,장석원,장경영 한국비파괴검사학회 2004 학술대회 논문집 Vol.- No.-

Folder type electronic devices have hinge to support the rotational motion of folder. This hinge is stressed by the rotational inertia moment of folder at the maximum open limit position of folder. This stress is repeated whenever the folder is open, and it is a cause of hinge fracture. In this paper, the reliability evaluation for the hinge fracture in the folder type cellular phone is discussed. For this, the durability testing machine using crack-rocker mechanism is developed to evaluate the life cycle of the hinge, and the degradation after repetitions of opening and shutting is evaluated from the deformation around the hinge, where the deformation is measured by ESPI (electronic speckle pattern interferometer). Experimental results showed that ESPI was able to measure the deformation of hinge precisely, so we could monitor the change of deformation around the hinge as the repetition number of folder open is increased.

CPW급전을 이용한 UWB 안테나 설계

최석호,이성훈,김학선,박종권 한밭대학교 정보통신전문대학원 2004 정보통신전문대학원 논문집 Vol.2 No.1

본 논문은 CPW급전 구조와 CST사의 Microwave Studio 사용하여 UWB 안테나를 설계하였다. 시물레이션 결과 제안된 안테나의 대역폭은 3.O5-13GHz를 가지고 방사패턴은 무지향성의 형태를 갖는 것을 보였다. In this paper, we have designed a UWB antenna using CPW feed line and used the Microwave Studio of CST to simulate the UWB antenna. Simulated results show that antenna bandwidth is 3.05-13GHz and radiation pattern is omni-directional.

응급실에서 급성 췌장염 환자의 선별을 위한 actim pancreatitisR검사의 유용성

송석훈,도병수,이삼범 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Background: Acute pancreatitis is a fairly common abdominal disorder that can be easily confronted in the emergency department(ED) and is one of the most complex and clinically challenging of all abdominal disorders. Currently, there is no gold standard for the diagnosis of acute pancreatitis. We evaluated the usefulness of the actim Pancreatitis□ rapid test, which has been recently developed in Europe, as a screening test of acute pancreatitis in our emergency department. Methods: We prospectively studied the urinary trypsinogen-2 dipstick tests(actim Pancreatitis□, Medix Biochemica, Kauniainen, Finland) of 200 patients with acute abdominal pain who were treated at our ED. All urine samples were collected from the patients within 12 hours of arrival at ED. We also measured serum amylase assay in the laboratory and compared the sensitivities and the specificities of the two test. Acute pancreatitis was diagnosed by authors according to standardized criteria. Abdominal USG or CT was performed when a patient with a normal serum amylase level had a typical clinical presentation. Results: The actim Pancreatitis□ rapid test was positive in 22 of the 25 patients with acute pancreatitis(sensitivity, 88.0 percent). The test was also positive in 6 of 175 patients without pancreatitis(specificity, 96.6 percent). The serum amylase assay had a sensitivity of 68.0 percent(with a cutoff value of 300 U per liter for the upper reference limit) and a specificity of 90.9 percent. But there were no statistical differences between the correlation coefficients of the two tests as diagnostic tool Conclusion: In patients with acute abdominal pain who are seen in the emergency department, the actim Pancreatitis□ urinary dipstick test has a high degree of probability as a screening test for acute pancreatitis. Also it can easily and rapidly be use at the bedside.