정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1997)

김재홍,문득곤,김정수,김용준,임동진,박상훈,김희성,이민수,송기훈,김갑형,김형석,성소영,이인섭,김석우,황지환,조창근,김경문,부태성 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

Background : In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. Objective & Methods : For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1997. 99 strains of N. gonorrhoeae were isolated, among which 45(45.5%) were PPNG. Conclusion : The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 45.5% in 1997.

부산지역 수돗물과 지하수의 중금속 농도

김준연,손지언,김형수,김두희,원미숙,김인식,이혜령 동아대학교 산업의학연구소 2000 산업의학연구소 논총 Vol.- No.5

This study investigated mean airborne CO concention of 15 workplaces, suspected of CO exposure and conducted self-reported questionnaire completion and indirect COHb concentration measure using Micro II Smokerlyzer to healthy 702 adult subjects from 1999 May to 1999 September in order to find a relation of CO exposure and occupational factors, socioeconomic factors, and health related behaviors and confirm the related conditions in the screening test for CO exposure. The results of this study were summarized as follows : 1. In the CO exposed and non exposed group, COHb concentrations of the smokers were 2.55±0.96% and 2.21±0.97% and that got a statistically significant difference, There were not statistically significant differences in the age and total smoking index. Passed times after the last smoking, Working time/day, and working duration were statistically significant difference (p〈0.05). 2. In the CO exposed and non exposed group, COHb concentrations of non-smoking group were 0.94±0.35% and 0.68±0.47% and that got a statistically significant difference. There were not statistically significant differences in the age and working duration but Working time/day was a statistically significant difference(p〈0.05). 3. In the CO exposed group, r-square of multiple regression of the smokers was 38.5 % and passed time after the last smoking, working time/day, and job category were statistically significant differences (p〈0.05). And r-square in the CO non-exposed group was 38.3 % and age, passed time after the last smoking, and total smoking index were statistically significant difference. 4. In the CO exposed group, r-square of multiple repression of the non-smokers was 66.3% and job category and airborne CO concentration were statistically significant differences(p〈0.05). But r-square of non-smokers in the CO non-exposed group was 1.0% and there was not a statistically significant difference(p〈0.05). 5. In the smokers of CO exposed and non exposed groups, relation of COHb concentration and passed time after the last smoking was expressed as exponential function, Y = 2.9182e-0.0083x and r-square of this function was 37.4%. Therefore it was more than 150 minutes that passed time after the last smoking was when COHb concentrations were measured as less than 1%. In conclusion, variable, that was statistically significant to COHb concentraion in the both CO exposed and non-exposed smokers, was a passed time after the last smoking. We suggest that you have to restrict the smoking of smokers at least 150 minutes in the exposed and non exposed group before COHb concentration measure in order to exclude smoking effects

Associations of serotonergic genes with poststroke emotional incontinence

Kim, Jae‐,Min,Stewart, Robert,Kang, Hee‐,Ju,Bae, Kyung‐,Yeol,Kim, Sung‐,Wan,Shin, Il‐,Seon,Kim, Joon‐,Tae,Park, Man‐,Seok,Cho, Ki‐,Hyun,Yoon, Jin‐ John Wiley Sons, Ltd 2012 INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY Vol.27 No.8

<P><B>Objectives</B></P><P>Poststroke emotional incontinence (PSEI) has been associated with serotonergic dysfunction. Polymorphisms of serotonin transporter (5‐HTT) and serotonin 2a receptor (5‐HTR2a) genes may regulate serotonergic signaling at brain synapses, and this study was to investigate associations with PSEI in an East Asian population.</P><P><B>Methods</B></P><P>In 276 stroke cases, PSEI was diagnosed by Kim's criteria. Covariates included age, gender, education, history of depression or stroke, current depression, and stroke severity and location. Genotypes were ascertained for 5‐HTT gene‐linked promoter region (5‐HTTLPR), serotonin transporter intron 2 variable number tandem repeat, 5‐HTR2a 1438A/G, and 5‐HTR2a 102 T/C. Associations with PSEI were estimated by using logistic regression models, and gene–gene interactions were investigated by using the generalized multifactor dimensionality reduction method.</P><P><B>Results</B></P><P>PSEI was present in 37 (13.4%) patients. The 5‐HTT gene‐linked promoter region <I>s</I>/<I>s</I> genotype was independently associated with PSEI. No associations with STin2 VNTR and 5‐HTR2a genes were found, and no significant gene–gene interactions were identified.</P><P><B>Conclusions</B></P><P>Stroke patients with 5‐HTTLPR <I>s</I> allele had higher susceptibility to PSEI, which underlines the potential role of serotonergic pathways in its etiology. Copyright © 2011 John Wiley & Sons, Ltd.</P>

ELISA에 의한 뇌척수액내 Fibronectin의 측정과 임상적 의의

김숙희,박충서,이병헌,조준승 慶北大學校 醫科大學 1990 慶北醫大誌 Vol.31 No.3

신경계 질환의 진단은 임상 소견과 뇌척수액 검사소견 등을 기초로 하고 있다. 그러나 이들 소견이 각 질환간의 감별에 분명한 도움을 주고 있지는 못하고 있다. 이에 본 연구에서는 뇌척수액 fibronectin을 측정하여 여러 신경계 질환과의 관련을 조사하고 나아가 이들 질환의 감별에 도움을 얻고자 하였다. Fibronectin은 뇌척수액내 미량으로 존재하므로 이의 측정을 위하여 먼저 측정능이 좋은 ELISA를 개발하였다. 그 결과 농도가 10 ng/ml에서부터 100 ng/ml의 범위내에서 뇌척수액 fibronectin 농도를 측정할 수 있었다. 결핵성 뇌막염 9례, 바이러스성 뇌막염 5례, 세균성 뇌막염 2례를 포함한 기타 신경계 질환 8례 및 정상대조군 18례 등 총 40례를 대상으로 뇌척수액내 fibronectin농도를 조사한 결과, 결핵성 뇌막염군은 4.21±2.32 ㎍/㎖, 바이러스성 뇌막염군은 0.9±0.79 ㎍/㎖, 기타 질환군은 2.05±2.48 ㎍/㎖, 그리고 정상대조군은 1.35±0.84 ㎍/㎖의 평균값을 보여 결핵성 뇌막염군이 기타 질환군을 제외한 타 질환군들에 비해 통계적으로 유의하게 높은 값을 보였다(p<0.01). 결핵성 뇌막염의 경우 1례를 제외하고는 모두 2.9 ㎍/㎖ 이상이었고, 3례(38%)에서는 4.6 ㎍/㎖ 이상이었던 반면, 바이러스성 혹은 무균성 뇌막염에서는 1례에서만 2.2 ㎍/㎖이고 나머지는 모두 1 ㎍/㎖ 이하로 나타났다. 이상의 결과로 보아 뇌척수액내 fibronectin농도의 측정은 결핵성 뇌막염과 바이러스성 뇌막염의 감별진단에 유용하리라 생각된다. The diagnosis of neurologic diseases is based on the clinical symptoms and cerebrospinal fluid findings. These findings, however, are often ambiguous. This study aims to evaluate the diagnostic value of cerebrospinal concentration of fibronectin. Fibronectin level in cerebrospinal fuid was measured by ELISA which could detect fibronectin in the range from 10 ng/ml to 100 ng/ml. Nine cases of tuberculous menigitis, 5 cases of viral meningitis, 8 cases of miscellaneous neurologic conditions and 18 cases of normal controls were studied. The mean value of fibronectin level in cerebrospinal fluid in tuberculous meningitis was 4.21±2.32 ㎍/㎖, in viral meningitis 0.9±0.79 ㎍/㎖, in miscellaneous neurologic conditions 2.05±2.48 ㎍/㎖ and in controls 1.35±0.84 ㎍/㎖. The fibronectin level in tuberculous meningitis was significantly higher than in other groups except the miscellaneous neurologic conditon(p<0.01). Cerebrospinal fluid fibronectin level appeared to be useful to differentiate tuberculous meningitis fro viral meningitis. Those levels were higher than 2.9 ㎍/㎖ in all except one case and higher than 4.6 ㎍/㎖ in 38% of tuberculous meningitis cases, but, 2.2 ㎍/㎖ in only one case of viral meningitis and lower than 1.0 ㎍/㎖ in all except one case of viral meningitis. It is suggested that measurement of fibronectin level in cerebrospinal fluid is a useful test for diagnosis of tuberculous meningitis, especially for differential diagnosis between tuberculous and viral meningitis.

치과용 금합금과 상변태

김형일,백창준,이경희,이희경 大韓齒科器材學會 2000 대한치과재료학회지 Vol.27 No.3

GIS와 항공정사사진을 이용한 산림정보 관리시스템 구축

김준범,조명희,권태호,김인호,조윤원,신동호 한국지리정보학회 2004 한국지리정보학회지 Vol.7 No.2

우리나라 산림행정 업무의 대부분은 서류 및 대장에 의존하고 있는 실정으로 신속, 정확하고 다양한 업무 처리를 위해서는 첨단의 공잔정보기술을 이용한 과학적인 산림정보 관리시스템의 개발이 시급하다. 특히 지리정보시스템(GIS)과 항공사진 활용기술의 도입은 산림이용기본계획이나 산지개발, 산림자원 관리 및 산림보호 정책 등의 의사결정지원에 효율적으로 기여할 수 있을 것이다. 본 연구에서는 GIS와 항공사진(1998년도 촬영)을 기반으로 주요 산림정보인 수치지도, 수치임상도, 임야도 및 관련 속성데이터 둥을 가공하여 DBMS(data base management system) 내에 저장하였으며, 이를 기반으로 세부 응용시스템인 지번별 임야정보 검색, 산지이용개발 정보관리, 법정제한림 정보관리, 산림자원 정보검색 등의 인터페이스를 개발함으로써 산림 관련 실무자가 산림정보의 종합적인 공간분석 및 질의 검색이 가능한 산림정보 관리시스템을 구축하였다. 본 시스템의 구축으로 산림의 효율적 관리는 물론, 경제적인 산림자원 및 임산업 육성과 쾌적한 산림환경을 조성할 수 있을 뿐만 아니라 관련 부서들 간의 표준화된 공간 자료 공유와 과학적인 정보체계의 연동으로 산림자원 관리를 위한 집약된 공간 및 전자 정보화 인프라 구축의 기반을 마련할 것으로 사료된다. Recently in order to more effectively and scientifically process forest official tasks, which have been focused on documents and inventories, they should be applied with the up-to-date spatial information technologies. Especially, the forest resource information management based on GIS (geographic information system) and aerial orthophoto is expected not only to play an important role as DSS (decision support system) for domestic forest conservation policy and forestry development industry but also to service forest resource information toward people such as the owners of a mountain rapidly. In this study, the important forest information such as digital topography map, digital forest type map, digital forest cadastral map, digital aerial photographs and attribute data were first reprocessed and constructed in DBMS (data base management system). In addition, forest officials could analyze and retrieve forest information by using detail sub-application systems such as forest cadastral retrieval, forest land development information management, reserved forest information management and forest resource information retrieval. For this, the user interface is developed by using Visual Basic 6.0 and MapObjects 2. 1 of ESRI based on CBD (component based development) technology. The result of developing this system will not only perform constructing economical forest and better environment but also be the foundation of domestic spatial technology for forest resource management.

비만 펩티드 백신의 효능에 영향을 미치는 구조적 요소

김형진,이희종,김효준 한양대학교 이학기술연구소 2007 이학기술논문지 Vol.10 No.-

Apo B-100 is a constitutive component of low density lipoprotein (LDL) of which functions in packaging, transport, and absorption of lipids. Extortive binding of anti B4-antibody onto Apo B-100 should inhibited the functions of Apo B-100. Previously, we had showed that the peptide B4 induced antibodies recognized Apo B-100 and thus elicited anti-obesity effect. In this study, we compared the efficacy of peptide vaccine against obesity and of antibody inducing immune response by introducing additional peptides fused to B₄ Peptide. Previously, we had constructed B₄T, introducing additional peptides fused to the C-terminal of B₄ peptide, and BTB, fused to the middle of B₄ peptide, with preS2 of HBV. Then we manufactured vaccines, and vaccinated on C57BL/6 mouse. We measured weight of mice 3 days a week and, after vaccinating, we gathered blood and performed ELISA in interval 2 weeks for indicating antibody inducing immune response. Among these two artificial vaccines, B₄T was better Vaccine against obesity than another. But BTB was batter efficient inducer of the antibody against B₄. These result explains that B₄ tetramer is very crucial structural factor to operate as an obesity vaccine. Apo B-100은 low-density lipoprotein의 구성 요소로서 지방의 패키징, 운송, 흡수를 담당한다. App B-100에 anti B4-antibody의 인위적 결합은 이러한 Apo B-100의 기능을 저해할 것이다. 선행 연구에서 B4 펩티드에 의해 유도된 antibody가 Apo B-100을 인지하고 그에 따라 비만억제 효과를 나타내는 것을 확인하였다. 본 연구는 비만에 대한 B cell epitope을 4번 반복한 B4 펩티드에 추가적인 펩티드를 연결한 두 가지의 백신을 사용하여 효능을 비교하였다. HBV의 preS2를 B4의 C-terminal에 연결한 B₄T와 중간에 삽입시킨 BTB를 제조하여 C57BL/6 마우스에 주사하였다. 일주일에 3회 마우스의 체중을 측정하였고, 백신 주사는 2주 간격으로 4회 실시하였으며, 백신 주사 후 2주 간격으로 혈액을 채취하여 면역 반응에 의해 유도된 antibody를 indirect Enzyme -Linked Immunosorbent Assay에 의해 측정하였다. 두 가지 백신 사이에서 체중 증가 억제율로 본 비만에 대한 백신효과는 B₄T가 더 우수하였다. 그러나 B₄T에 비해 BTB가 유도된 antibody의 titer와 혈중 지속 시간이 더 우수했다. 이런 결과는 B펩티드가 항체유도에 있어서 중요하지만, 비만억제 기능에 있어서 B₄ tetramer가 매우 중요한 인자임을 입증하였다.

癩腫樣型癩의 血淸脂蛋白의 分劃

金澄賢,鄭泰浩,宋浚榮,徐正姬 大韓癩學會 1979 癩學 會誌 Vol.12 No.1

초기재령 R.C 라멘교의 균열에 관한 연구

김우중,이관희,박준용 진주산업대학교 산업과학기술연구소 2004 산업과학기술연구소보 Vol.- No.11

This paper propose a designing technique for crack controlling the early-aged reinforced concrete rahmen bridges based on measured temperature history, strength revelation model and shrinkage model. The temperature histories at the slabs and the hunches of the four early-aged reinforced concrete rahmen bridges are recorded by field measurement; base on them, the decent temperature loads are determined in terms of the curing time. It is proposed the analytical algorithm which can be applicable to the general finite elements analysis including effect of elastic modulus and temperature change by the curing time. Developed analytical algorithm is applied to the rahmen bridge and computed stress are compared to the field-measured stresses