地震波를 받는 基礎-地盤 相互作用계에서의 波消散 效課

金宗周,孫榮浩,崔鎭旭,崔光圭 東亞大學校 海洋資源硏究所 1992 硏究論文集 Vol.5 No.2

In this study , the dynamic analysis procedure of foundation -soil interaction system subjected to seisemic wave is presented . The foundation is placed on a linear elastic , isotropic and homogeneous half space representing the soil medium. The boundary element model of half space and the finit element model of foundtion are coupled together by enforcing compatibility condition of displacements and equilibrium condition of traction on the contact surface. The acuuracy of the proposed method si vertified throough the conparison studies with results reported method is that it provides directly the transient response unlike the frequency domain techniques.

수출입 컨테이너 장치장 배정을 위한 소프트웨어의 개발

김갑환,김홍배,홍봉희,김기영,배종욱,최진오,김두열,이영기,박영만,박강태,손행대 한국경영과학회 1995 經營 科學 Vol.12 No.3

The Pusan Container Terminal faces a rapid increase in berthing time of container ships as well as in waiting time of external trucks, which is due to an absolute lack of yard space. This research is focused on the development of a decision support system for the planning of the container terminal yard assignment so that the yard space would be utilized most effectively. Efforts should be given to the reasonable assignment of the yard storage and the dynamic adaptation to the ever changing environment. The software introduced here is based o the know-how of the field exports and its framework takes the approach of the hierarchical decision making.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

신이식에서 이식신의 생존분석

오선미,김종학,황평주,구영선,강민규,나기량,김종섭,김성숙,이강욱,신영태,설종구,배진선,손기섭 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

To investigate the prognostic factors for the survival of transplanted kidney in patients with end-stage renal failure, 59 cases of renal transplantation from September 1986 to Feburary 1997 in Chungnam National University Hospital were analyzed retrospectively. The results were as follows: 1)The mean age of recipients was 33.8 years and that of doners was 38.9 years. The male to female ratio of recipients was 2.5:1, and that of donors was 1.03:1 2) Living related donore(LRD) were 79.6% and living non-related donors were 20.3%. The HLA-identical donors(ID) in LRD were 18.7% and HLA-haploidentical donors(HID) were 61.0%. In living non-related donors(LNRD), mean matched HLA-AB antigens were 1.56 and mean matched HLA-DR antigens were 0.56. 3) The average 5-year patient survival fate was 94%, and average 5-year graft survival rate was 70%. The 5-year graft survival fate of HLA-ID was 100%, and those HLA-HID and LNR were 70% and 36% respectively. 4) Total 33 episodes of acute rejection were found in 45.8% of transplanted patients. The number of acute rejection episode did not show significant difference between LRD and LNRD(P > 0.05). There was no significant difference in MLC between two groups(p > 0.05). 5) In comparison between the 18 patients who lost their graft function in 5 years and 17 patients who are maintaining graft function for more than 5 years, MLC was significantly lower in patients with functioning graft than of patients with non-functioning graft (p < 0.05). The number of rejection episode was also lower in patients with functioning graft than that of the patients with non-functioning graft(p < 0.05). However, there were no significant difference in recepient and donor age and history of pre-transplantation donor specific transfusion between two groups. With the results above, we can speculate that adequate donor selection according to good matched HLA typing and low MLC is very important for graft survival in renal transplantation. Prevention and treatment of acute rejection in renal transplantation is also na important factor for graft survival.

The comparison of two different intraarticular injections using a sonographic anterolateral approach in patients with osteoarthritic knee

( Jin Wook Choi ),( Jun Ho Lee ),( Minjong Ki ),( Myung Jong Kim ),( Sehrin Kang ),( Juhyung Lee ),( Jun-rae Lee ),( Young-jin Han ),( Ji-seon Son ) 대한통증학회 2018 The Korean Journal of Pain Vol.31 No.4

Background: The intraarticular (IA) injection has become popular for the management of the osteoarthritic knee without an effusion. The success rate of IA injection would be better if it was able to be visually confirmed. We hypothesized that an anterolateral approach, which targets the synovial membrane of the lateral condyle using ultrasound, would provide an equivalent alternative to the anterolateral approach, targeting the synovial membrane of the medial condyle for IA injection of the knee. Methods: A total of 96 knees with osteoarthritis were randomized placed into the two groups, which were group I (anterolateral approach to the medial condyle) and group II (anterolateral approach to the lateral condyle). The primary outcome was to compare the success rate of the two methods of IA injection. The required length of the needle for injection was also measured and compared. Pain intensity was assessed using the Numeric Rating Scale in order to evaluate the success of injection. Results: There were no significant differences in the success rate between both groups. The success rate of group I and group II were 87.8% (95%, CI 78.7-97.0) and 91.5% (95%, CI 83.6-99.5), respectively (P = 0.549). The needle depth was 5.0 ± 0.8 (3.0 to 6.1 cm) in group I, and 3.0 ± 0.8 (1.5 to 5 cm) in group II (P < 0.001). Conclusions: The anterolateral approach to the lateral femoral condyle, using ultrasound, is an alternative method to the approach targeting the medial femoral condyle, using shorter needle. (Korean J Pain 2018; 31: 289-95)

Five cases of phytophotodermatitis to fig leaves and a review of literature

( Jin Hwa Son ),( Hyunju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Gun Wook Kim ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Moon Bum Kim ),( Byung Soo Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Phytophotodermatitis is a dermatitis caused by sequential exposure to photosensitizing substance containing plants and then to ultraviolet light. Several plants (e.g., limes, celery, fig and wild parsnip) contain furocoumarin compounds (psoralens). It is important for a dermatologists to be aware of phytophotodermatitis because it may be misdiagnosed as cellulitis, tinea, and allergic contact dermatitis. We present 5 patients with sharply demarcated erythematous swollen patch with bullae on both feet. They reported that they soaked their feet in fig leaf decoction to treat their underlying dermatologic diseases. Within 24 hours, all had a burning sensation at both feet, and erythema and edema had developed on dorsum of feet except skin hidden below the sandal. Histopathologic examinations revealed subepithelial blister with intensive epidermal necrosis. Ultimately, a final diagnosis of a phytophotodermatitis was established and after several days, their skin lesions began to recover with treatment of systemic and topical corticosteroids. Unfortunately, as no study that provides sufficient evidence of the benefits of fig leaves, it should be used in caution.

Overlap syndrome of graft-versus-host disease presenting with diffuse palmoplantar keratoderma

( Jin-hwa Son ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Gun-wook Kim ),( Hoon-soo Kim ),( Byung-soo Kim ),( Moon-bum Kim ),( Hyun-chang K 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Recently, the National Institutes of Health Consensus Conference proposed the term “overlap syndrome” of chronic GVHD (cGVHD) to describe the situation when both acute and chronic GVHD appear together. A 3-year-old boy presented acute GVHD symptoms which were fever, diarrhea, and generalized erythematous patches on trunk after peripheral blood stem cell transplantation (PBSCT) for myelodysplastic syndrome. After four months HSCT, whitish reticulated patches on lip and oral mucosa and flat-topped papules on both wrists were observed, accompanied by diffuse scaly hyperkeratotic patches on both palms and soles. The histopathologic findings from the oral mucosa revealed focal interface change with apoptosis and vacuolar change in epidermal basal layer, compatible with lichen planus-like eruption in cGVHD. Marked hyperkeratosis and acanthosis with vacuolar change of basal layer were observed from hyperkeratotic patch of the left palm. He was diagnosed as overlap syndrome of cGVHD with diffuse palmoplantar keratoderma-like eruption. And then, he was treated with systemic corticosteroid and tacrolimus and showed improvement of cutaneous symptoms gradually. This is a rare case of overlap syndrome which shows acute and chronic GVHD symptoms at the same time. Although uncommon, in children who have undergone PBSCT, diffuse palmoplantar keratoderma like lesion could be considered atypical manifestation of overlap syndrome of cGVHD.

[P440] Acral acanthosis nigricans associated with diabetes.

( Jin-hwa Son ),( Sung-min Park ),( Hyun-joo Lee ),( Hyunju Jin ),( Hyang-suk You ),( Woo-haing Shim ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Moon-bum Kim ),( Byung-soo Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Acanthosis nigricans (AN) is a disorder characterized by skin hyperpigmentation and velvety thickening, especially on back, neck, axillae, inframammary areas and groins. It is categorized into eight types; benign, malignant, associated with obesity, syndromic, unilateral, drug induced, mixed and acral. In acral AN, the lesions are localized to the knee, ankle, phalangeal joints and tarsophalangeal joints. Since this type essentially occurs in healthy patients, evaluation for underlying disorders is usually unnecessary. However, there were many reports about the associations of acral AN with lymphoma, gastric adenocarcinoma and etc.. A 33-year-old man presented with velvety hyperpigmented patches on knuckles of both hands for 1 month. On examination, there was diffuse hyperpigmentation over both axillae and groins for about 1 year. Although he had diabetes since age of 13, he was not on treatment. Level of blood sugars were 363 mg/dl and HbA1c was 12.7%. Histopathologic examinations revealed epidermal hyperkeratosis and acanthosis. The diagnosis was confirmed to acral AN associated with diabetes. In the present case, acral AN may also be accompanied with underlying disease and necessitate a evaluation for a possible diagnosis of underlying disorder.

Segmental piloleiomyomas as Wolf`s isotopic response after herpes zoster

( Jin Hwa Son ),( Hyunju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Gun Wook Kim ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Wolf``s isotopic response implies that the development of a secondary dermatoses having no association with the primary dermatoses which are usually herpes zoster or simplex. The secondary dermatoses could be various with neoplastic (breast carcinoma, squamous cell carcinoma, basal cell carcinoma, leukemic or lymphomatous infiltration and etc.), infectioous (warts, dermatophytosis, molluscum contagiosum, and etc.) inflammatory (lichen planus, granuloma annulare, and etc.,) and other conditions (reactive perforating collagenosis and etc). Though piloleiomyoma, which is derived from arrector pili muscle, is not rare condition, its segmental form is quite rare. A 51-year-old man presented with a three-year history of multiple scattered erythematous papules on left middle back that developed in the healed site of herpes zoster which had occurred nine years before. The distribution was zosteriform at the dermatomes of T9-10. Histopathologically, well-defined bundles of smooth muscle were arranged in dermis. The bundles were stained as red in Masson``s trichrome and positivity in smooth muscle actin. The final diagnosis were segmental piloleiomyomas as Wolf``s isotopic response after herpes zoster. Various dermatoses as Wolf``s isotopic response after herpes zoster have been reported in the literature. However, to our best of knowledge, segmental piloleiomyomas as Wolf``s isotopic response has never been reported in the literature.