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신질환을 동반한 고혈압 환자에서 Lisinopril의 임상 효과
신영태,오선미,나기량,김종섭,빈기태,김성숙,이강욱 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.1
The antihypertensive efficacy and safety of lisinopril, a long-acting angiotensin-converting enzyme inhibitor, was assessed in 15 patients with hypertension assocciated with impaired renal function (creatinine clearance rate 60 ml/min or less) in an open study of 8 weeks duration. The starting dose was 2.5 mg in patient with creatinine clearance rate of less than 30 ml/min and 5 mg in all other patients. Mean blood pressure was significantly reduced by lisinopril treatment(163 ±25 mmHg at baseline, 137 ±19 mmHg after 8 weeks of treatment). The mean dose of lisinopril tiken was 14.0 mg daily (range 10-30 mg). The mean creatinine clearance rate and 24 hour urinary protein were unchanged during the study (30 ±10.7 ml/min and 5.9 ±7.5 gm at baseline, 26 + 8.9 ml/min and 4.5 ±5.8 gm after 8 weeks of treatment, respectively). No clinically significant hematological or biochemical changes were observed. All patients had hyperkalemic tendency but not siginificant statistically. Two patients had mild coughing and other two patients had postural dizziness but tolerable. In conclusion, lisinopril provided effective blood pressure control and was well tolerated. Significant hyperkalemia may compromise in patient with advanced renal impairment, leading to potentially dangerous hyperkalemia.
신영태,신승훈,이순구,이정호,이강욱 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2
A clinical retrospective study was undertaken in 81 patients with acute pyelonephritis admitted to the Department of Internal Medicine, Chungnam National University Hospital from January 1983 to December 1989. The results were as follows : 1. Total number of patients studied was 81(M/F ratio, 1 : 4.4). The M/F ratio of 22 complicated patients (27.2%) was 1 : 2.7 2. The predisposing factors associated with complicated patients were as follows : 7 cases of urinary tract stone, 7 cases of pregnancy, 4 cases of neurogenic bladder and each one case of prostatic hypertrophy, ureter cancer, bladder diverticulum and polycystic kidney disease. 3. The common subjective symptoms on admission were fever and chills, frank pain, nausea and vomiting. High body temperature and CVA tenderness were noted in 61% and 95% of patients respectively. And 50.6% of patients revealed right CVA tenderness and 28.4% in left, 16% in both respectively. There was no difference in symptoms and signs between complicated and uncomplicated groups 4. In 50 patients(61.7%) microorganisms were isolated on the urine culture specimens. The most common organism was E. coli(80%), and followed by Staphylococcus aureus and Serratia odorifera. E coli was the most frequent pathogen in both female and male patients, and in complicated and uncomplicated groups. (In sensitivity test of complicated and uncomplicated groups). In sensitivity test of causative pathogens to antibiotics, E coli was sensitive to amikacin(93%), tobramycin(83.3%) and gentamycin(79.4%) and 88.9 percent of E coli were ressistant to ampicillin 5. In urinary examination on admission, pyuria was noted in 81% of patients, and proteinuria and microscopic hematuria were noted in 68% and 44% of patients respectively. 6. Within 3 days after antibiotics treatment deference was occured in 73.5% of total patients, and complicated patients revealed delayed defeverence compared to uncomplicated ones.
辛榮泰 충남대학교 의과대학 지역사회의학연구소 1984 충남의대잡지 Vol.11 No.2
Arterial blood gas analysis was performed on 28 cases of Korean Hemorragic Fever who were admitted to Chungnam National University Hospital from July 1982 to June 1984. The results were as follows. 1. In oliguric phase, 13 cases(81.2%) out of 16 patients showed metabolic acidosis with compensatory respiratory alkalosis. In 4 clinically severe oliguric cases, metabolic acidosis was severer than that of mild oliguric cases. 2. In diuretic phase, 8 cases (80%) out of 10 patients showed persistent metabolic acidosis whi was slightly improved compared to that of oliguric phase. 3. In non-oliguric patients, 4 cases(50%) out of 8 patients showed primary respiratory alkalosis complicated with metabolic acidosis. 4. Inverse correlation between serum creatinine and plasma HCO_3- concentration was noticed (r=0.808, P<0.001)
신영태,김경곤,황인철 대한가정의학회 2009 Korean Journal of Family Medicine Vol.30 No.9
The debate over the clinical meaning of plasma uric acid level is still a very hot issue. As the interest in health grows larger in the general public, the number of having a regular health check-up is increasing rapidly. Most of the health care centers routinely check the plasma uric acid level but it is not simple to interpret and explain the appropriate meaning of that. Over the past decade, there have been several studies on clinical implication of plasma uric acid level but the question still remains. However the clinical signifi cance of the results might be different according to the severity of cardiovascular risk among subjects studied, and the fi ndings for correlation with the established risks have enough proof to be applied to clinical practice. Additionally, the uric acid-lowering agents should not be used in general population even though it has reason to be prescribed in a specifi c high risk patient. Thus, this review seeks to be helpful in clinical practice by examining the preexisting related studies in a different perspective. 혈중 요산 수치의 해석에 대한 논란이 뜨겁다. 해를 거듭할수 록 건강에 대한 관심이 늘어나면서 건강검진 수진율이 급격 히 증가하고 있고, 대부분의 검진기관에서 혈중 요산 수치를 일률적으로 측정하고 있으나 그 결과에 대해 적절하게 해석 하고 설명하는 것은 결코 쉬운 일이 아니다. 최근 10년 동안 요 산의 임상적 의의에 대한 수많은 연구가 발표되었지만, 아직 까지는 이에 대한 명쾌한 해답을 제시하지 못하고 있다. 그러 나 연구대상자의 심혈관 위험도에 따라 그 결과가 제시하는 의미가 다르고, 몇 가지 고식적인 심혈관 위험인자와의 관계 규명에서는 지금까지의 증거만으로도 실제 임상에 적용할 수 있는 실마리를 제공하고 있다. 또한, 혈중 요산 수치를 낮추는 약제의 일률적 사용은 현재로써는 지양되어야 하겠으나, 특 정 고 위험군에서는 그 사용이 어느 정도의 명분을 가질 수 있 을 것이다. 이에 본고에서는 요산의 대사와 그것의 작용을 살 펴보고, 현재까지 진행된 요산관련 연구들을 약간은 다른 관 점에서 고찰함으로써, 향후 검진결과의 해석이나 임상에서의 환자진료에 도움이 되고자 한다.
암호화폐 서비스 특성이 사용자 이용의도에 미치는 영향 - 페이코인 결제 서비스를 중심으로
신영태,김정욱 한국인터넷전자상거래학회 2022 인터넷전자상거래연구 Vol.22 No.2
The purpose of this study is how cryptocurrency service characteristics personal affect the continued intention to use. ETAM (Extended Technical Acceptance Model) model is validated as a theoretical background, selecting personal characteristics, system characteristics, cryptocurrency service characteristics, perceived usefulness, perceived ease of use, continued intention to use. The method of this study used questionnaire survey to collect 473 data on user's perception on cryptocurrency services, and also performed a structural equation modeling method using by AMOS 23. The result of this paper shows that 7 hypotheses are accepted statistically significant except 5 hypothesis among 12 hypotheses. This research is concluded that innovation, convenience, security risk, and economic feasibility is affected on statistically positive impact on perceived ease of use, not statistically social impact reliability. In addition to this, convenience, reliability, economic feasibility is affected on statistically positive impact on perceived usefulness, not statistically innovation, social impact, security risk.