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Won, Kyung-Jong,Park, Sung-Won,Lee, Seunghoon,Kong, Il-Keun,Chae, Jung-Il,Kim, Bokyung,Lee, Eun-Jong,Kim, Dong-Ku 한국조명·전기설비학회 2015 한국조명·전기설비학회 학술대회논문집 Vol. No.
<P>The triggering receptor expressed on myeloid cells (TREM) family, which is abundantly expressed in myeloid lineage cells, plays a pivotal role in innate and adaptive immune response. In this study, we aimed to identify a novel receptor expressed on hematopoietic stem cells (HSCs) by using <I>in silico</I> bioinformatics and to characterize the identified receptor. We thus found the TREM-like transcript (TLT)-6, a new member of TREM family. TLT-6 has a single immunoglobulin domain in the extracellular region and a long cytoplasmic region containing 2 immunoreceptor tyrosine-based inhibitory motif-like domains. TLT-6 transcript was expressed in HSCs, monocytes and macrophages. TLT-6 protein was up-regulated on the surface of bone marrow-derived and peritoneal macrophages by lipopolysaccharide stimulation. TLT-6 exerted anti-proliferative effects in macrophages. Our results demonstrate that TLT-6 may regulate the activation and proliferation of macrophages.</P>
( Won Ku Lee ),( Jeong Min Kim ),( Gun Wook Kim ),( Margaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ),( Je Ho Mun ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Choristoma is a tumor-like mass composed of histologically normal cells or tissues occurring in an abnormal location. Cartilaginous choristoma, composed of ectopic cartilaginous tissue, is mostly located in the hands and feet and very rare in the oral mucosa. Lip involvement is extremely rare and only two cases are reported worldwide. We describe a 53-year-old manpresented with a 6-month history of an asymptomatic mass on the lower lip. Intraoral examination revealed a firm, well-circumscribed, and mobile submucosal mass (15x8x15 mm) within normal mucosa. Ultrasonography showed ovoid, heterogeneous echoic nodule with hypoechoic rim in the lower lip. The patient underwent surgical excision of the mass and the whitish mass covered with a thin membrane was removed easily. Histopathologic examination revealed a cartilaginous lesion surrounded by fibrous connective tissue and well-circumscribed aggregation of hyaline cartilage tissue arranged in a lobular pattern. Because no tumorous characteristics or malignant changes were evident microscopically in the lesion, the pathologic diagnosis was confirmed as cartilaginous choristoma. The patient’s postoperative course was uneventful, and there has been no recurrence for 10 months after surgery. We describe a rare case of cartilaginous choristoma with clinical, histopathologic, and ultrasonographic findings of which is the first reported case in dermatology literature.
Diurnal variation of default mode network in patients with restless legs syndrome
Ku, Jeonghun,Lee, Yeong Seon,Chang, Hyuk Won,Earley, Christopher J.,Allen, Richard P.,Cho, Yong Won Elsevier 2018 SLEEP MEDICINE Vol.41 No.-
<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>Restless legs syndrome (RLS) patients compared to controls have been found to have abnormal patterns in the default mode network (DMN) in the morning when symptom threshold is the highest and symptoms are least likely to occur. If these morning abnormalities in DMN are pertinent to disease expression, then similar or further detectable differences may be expected on a nighttime assessment when RLS symptom threshold is at its lowest. The purpose of this study was to elucidate the potential neural mechanisms underlying the circadian aspect of RLS symptom expression by assessing diurnal changes in DMN.</P> <P><B>Methods</B></P> <P>Fifteen drug-naïve subjects with idiopathic RLS and 15 age- and gender-matched healthy subjects had fMRI scans in the morning and evening. The DMN patterns were compared both for differences between morning and evening and between RLS and controls.</P> <P><B>Results</B></P> <P>RLS patients compared to the healthy controls showed significant differences in morning and evening DMN. In particular, RLS patients showed consistent increased connectivity in the parietal lobule in both the morning and evening. In contrast, connectivity in the thalamus was increased in the morning and reduced in the evening. In addition, there were negative correlations between thalamic connectivity and the Korean versions of the international RLS scale and the quality-of-life subscore.</P> <P><B>Conclusions</B></P> <P>The results indicated diurnal disturbances of the DMN in RLS subjects are consistent with both the circadian rhythm and severity of RLS. The circadian expression of RLS may relate to changes in arousal cortical-activation thresholds occurring with diurnal changes in the thalamic circuits of the DMN.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Diurnal changes in the brain with RLS symptoms could elucidate symptom dynamics. </LI> <LI> Daytime DMN, thalamic, and sensorimotor networks suggest solutions for RLS symptoms. </LI> <LI> Evening thalamic reduction with sustained sensorimotor activation controls symptom emergence. </LI> <LI> The results suggest RLS is a disorder of the disturbed sensory activation/threshold. </LI> <LI> The results could provide clinical provision for symptom emergence and treatment. </LI> </UL> </P>
Ku, Bonsu,Yun, Hye-Yeoung,Lee, Kyung Won,Shin, Ho-Chul,Lee, Sang-Rae,Kim, Chang Hyen,Park, Hwangseo,Yi, Kyu Yang,Lee, Chang Hoon,Kim, Seung Jun Elsevier 2018 Bioorganic & medicinal chemistry Vol.26 No.18
<P><B>Abstract</B></P> <P>Cytosolic protein tyrosine phosphatase epsilon (cyt-PTPε) plays a central role in controlling differentiation and function of osteoclasts, whose overactivation causes osteoporosis. Based on our previous study reporting a number of cyt-PTPε inhibitory chemical compounds, we carried out a further and extended analysis of our compounds to examine their effects on cyt-PTPε-mediated dephosphorylation and on osteoclast organization and differentiation. Among five compounds showing target selectivity to cyt-PTPε over three other phosphatases <I>in vitro</I>, two compounds exhibited an inhibitory effect against the dephosphorylation of cellular Src protein, the cyt-PTPε substrate. Moreover, these two compounds caused destabilization of the podosome structure that is necessary for the bone-resorbing activity of osteoclasts, and also attenuated cellular differentiation of monocytes into osteoclasts, without affecting cell viability. Therefore, these findings not only verified anti-osteoclastic effects of our cyt-PTPε inhibitory compounds, but also showed that cyt-PTPε expressed in osteoclasts could be a putative therapeutic target worth considering.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Role of Glutathione Conjugation in 1-Bromobutane-induced Immunotoxicity in Mice
Lee, Sang-Kyu,Lee, Dong-Ju,Jeon, Tae-Won,Ko, Gyu-Sub,Yoo, Se-Hyun,Ha, Hyun-Woo,Kang, Mi-Jeong,Kang, Won-Ku,Kim, Sang-Kyum,Jeong, Tae-Cheon Korean Society of ToxicologyKorea Environmental Mu 2010 Toxicological Research Vol.27 No.2
Halogenated organic compounds, such as 1-bromobutane (1-BB), have been used as cleaning agents, agents for chemical syntheses or extraction solvents in workplace. In the present study, immunotoxic effects of 1-BB and its conjugation with glutathione (GSH) were investigated in female BALB/c mice. Animals were treated orally with 1-BB at 375, 750 and 1500 mg/kg in corn oil once for dose response or treated orally with 1-BB at 1500 mg/kg for 6, 12, 24 and 48 hr for time course. S-Butyl GSH was identified in spleen by liquid chromatography-electrospray ionization tandem mass spectrometry. Splenic GSH levels were significantly reduced by single treatment with 1-BB. S-Butyl GSH conjugates were detected in spleen from 6 hr after treatment. Oral 1-BB significantly suppressed the antibody response to a T-dependent antigen and the production of splenic intracellular interlukin-2 in response to Con A. Our present results suggest that 1-BB could cause immunotoxicity as well as reduction of splenic GSH content, due to the formation of GSH conjugates in mice. The present results would be useful to understand molecular toxic mechanism of low molecular weight haloalkanes and to develop biological markers for exposure to haloalkanes.
SiC Single Crystal Growth on Dual Seed with Different Surface Properties
Lee, Sang Il,Jung, Jung Young,Park, Mi Seon,Lee, Hee Tae,Lee, Doe Hyung,Lee, Won Jae,Hong, Soon Ku,Yeo, Im Gyu,Kim, Heung Rak,Chun, Myong Chuel Trans Tech Publications, Ltd. 2013 Materials science forum Vol.740 No.-
<P>SiC crystal ingots were grown on 6H-SiC dual-seed crystal with different surface properties by a PVT (Physical Vapor Transport) technique. And then SiC crystal wafers sliced from the SiC ingots were systematically investigated in order to find out the dependence of surface properties for seed on the polytype formation. While n-type SiC crystals exhibiting the 4H polytype were grown on seed crystal having high root-mean-square (rms) value, 6H-SiC crystals were grown on seed having lower rms value. However, 6H polytype was maintained on on-axis and off-axis seeds during the entire growth period. The crystal quality of 6H-SiC single crystals grown on on-axis seed were revealed to be slightly better than that of 6H-SiC crystal grown on off-axis seed.</P>
Efficient Labeling of Porcine Hematopoietic Cells by Fluorescence-Conjugated Nanoparticles
Lee, Hyun-Joo,Park, Eun-Ji,Lee, Yong-Soo,Park, Sung-Won,Kim, Jae-Hwan,Kim, Dong-Ku The Korean Society of Animal Reproduction 2010 Reproductive & developmental biology Vol.34 No.3
Nanotechnology is currently receiving considerable attention in various fields of biotechnology. The uptake of nanoparticles by cells for labeling and tracking is a critical process for many biomedical therapeutic applications. However, nanoparticle labeling of porcine hematopoietic cells has not been demonstrated so far. In the present study, silica-coated nanoparticles conjugated with rhodamine B isothiocyanate (SR-RITC) were used to investigate the uptake of nanoparticles by porcine hematopoietic cells. Flow cytometric and confocal microscopic analyses reveled that the cells were efficiently internalized by the silica-coated nanoparticles. Furthermore, biocompatibility tests demonstrated that the SR nanoparticles were not cytotoxic, and they had no impact on proliferation. Our study demonstrates that silica-coated nanoparticles are taken up very rapidly and with high efficiency into porcine hematopoietic cells, with no apparent deleterious effects. Therefore, silica-coated nanoparticles appear to be a promising tool for tracking porcine hematopoietic cells.