서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

緯度와 地形에 따른 溫帶中部 溪谷植生의 種多樣性 및 群集構造에 關한 硏究

尹相旭,辛壽哲,郭東勳,金昌浩 동국대학교 농림과학연구소 1994 農林科學 論文集 Vol.18 No.-

This study was Carried out to analyse species composition, species diversity and structure and variation trends of vegetation, of Mt. Odae, Mt. Sobaek, and Mt. Juwang following various latitudes and topographies which were in middle temperate zone in Korea. Obtained results are as follows : 1. As a result of the simple discriminant analysis, soil texture Showed the highest high percent contribution of each environmental factor to the discriminant of Studred area. And Mt. Odae showed high content of sand while Mt. Juwang Showed silt. 2. Mean stem density showed highest value in Mt. Juwang and mean D. B. H. was Mt. Odae, and on phisiographic locations showd high values of stem density and mean D. B. H in slow slope area, nothern aspect area, and high elevation area, in order. 3. Species that showed the highest importance value in each canopy-subtree-shrub layer in study area were Quercus mongolica-Acer pseudo-sieboldianum-Lindera obtusiloba were in Mt. Odae, Betula platyphylla var. japonica-Styrax obassia-Deutzia parviflora were in Mt. Sobaek, and Pinus densiflora-Acer pseudo-sieboldianum-Lindera obrusiloba were in Mt. Juwang. 4. Species that showed the highest importance value in each canopy-subtree-shrub layer on the physiographic location were Quercus mongolica-Acer pseudo-sieboldianum-Lindera obtusiloba in high elevation and southern aspect, Carpinus laxiflora-Acer pseudo-sieboldianum-Lindera obtusiloba in high elevation and southern aspect, Carpinus laxiflora-Acer pseudo-sieboldianum-Lindera obtusiloba in nothern slope, Carpinus laxiflora-Styrax obassia-Lindera obtusiloba in low elevation, and Betula platyphylla var. japonica-Styrax obassia-Deutzia parviflora in high elevation. 5. According to decrease of latitudes with going down from Mt. Odae to Mt. Juwang, the more Number of species and individuals were increased, and the deversity index was the highest value in Mt. Sobaek, the evenness was in southern aspect, and the dominance was in high elevation. 6. As a result of Cluster analysis, the study area were divided into 4 groups, Carpinus laxiflora community, Styurax obassia community, Deutzia parviflora community, and Quercus mongolica community. 7. As a result of COA analysis, communities of the study area were divided into Betula platyphylla var. japonica community, Deutzia parviflora community, Quercus mongolica-Acer pseudo-sieboldianum community, and species were divided into 4 groups as the major, the disturbed, the waterside, and the fertile. 8. As results of the simple discriminant analysis and the linear regression, sand and silt content, slope aspect, total nitrogen content, and elevation among environmental factors had high percent contribution to classification and ordination of vegetation communities of the study area. 9. Major tree species had the unstable layer structure due to lower importance values of canopies and subtrees than those of shrubs, and Pinus laxiflora and Betula platyphylla var. japonica were on the decline phase due to very low dominance and absence of next generation. while, Styrax obassia and Acer pseudo-sieboldianum were sustanable layer structure as being distributed on all the crown layer.

악골 외상성 골 낭의 임상 및 병리조직학적 분석

윤정훈,김도경,안상건,김수관 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.1

We reviewed a series of 22 traumatic bone cysts of the jaws experienced during the 21-year period between 1982 and 2002 at the Chosum University Dental Hospital. The study group consisted of 13 females (59.1%) and 9 males (40.9%). The patient's mean age was 25.2 years, with peak incidence occuring in the first and second decade. Most traumatic bone cyst was located in the posterior mandible. Radiographically, well-defined round radiolucent (9 cases) or scalloped appearance (8 cases) were the predominant type, whereas 2 cases were ill-defined. A provisional clinical diagnosis was varied, only 9 of which were correct. Histopathologically, all the biopsy specimen composed of loose fibrous connective tissue accompanied by inflammatory reaction (13 cases), giant cells (9 cases). In addition, calcifications (6 cases) and new bone formation (5 cases) in the cyst wall were also observed. Taken together, correlative analysis of histopathologic and clinico-radiographic features is essential for definitive diagnosis and management.

전자상점의 성과모형에 관한 실증적 분석

윤철호,김상훈 한국경영과학회 2004 한국경영과학회지 Vol.29 No.3

This paper focused on empirically testing the ESM(Electronic-Store Success Model). The model was developed by basing upon the 'Updated D&M(DeLone and McLean) IS Success Model(2003)' and reflecting the characteristics of marketing and e-business, and composed of the six dimensions including system quality, information quality, service quality, trust, customer loyalty and financial performance. The research model consisting of five dimensions. excluding financial performance, was proposed and empirically verified by structural equation model with respect to data from 224 customers on 69 Electronic-Stores. The results show that system quality and information quality significantly influence service quality, and that service quality also significantly Influence trust and customer loyalty, and that trust has significant Influence on customer loyalty.

이중 산화구 시스템에서 HRT에 따른 유기물 및 영양염류의 처리성 평가

윤조희,김승현,이상훈,정기홍 경남대학교 환경문제연구소 1999 환경연구 Vol.22 No.-

This study was conducted to estimate treatability of organics and nutrients at new developed double oxidation ditch system when the ratio of anoxic/oxic basin volume was 1. An internal recycle pump did not need because of using with port and baffle in this system. The results obtained from this study were as follows. The removal efficiency for TOC was over 93%, and the removal rate was 1215.3 g/㎥/day when the HRT was over 8hr. The removal efficiency for TIN was over 85%, and the maximum removal rate was 110.6 g/㎥/day when the HRT was over 16hr. The removal efficiency for PO₄^(3-)-P was 83%, and the maximum removal rate was 25.4 g/㎥/day when the HRT was 16hr.

관상동맥내 스텐트 시술시 Aspirin과 Cilostazol 2개월 병합요법

윤명호,탁승제,염철훈,장혁재,최소연,유상용,안성균,고종훈,신준한,김한수,최병일 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

다발성 신경 섬유종증 제 1형에서 발생한 뇌출혈 1예

정상욱,배희준,이승훈,윤병우 대한신경과학회 1998 대한신경과학회지 Vol.16 No.5

콩에서 발생하는 강낭콩일반모자이크바이러스(BCMV)와 땅콩위축바이러스(PSV)의 저항성 평가

이영훈, 윤영남, 강범규, 김현영, 최만수, 구성철, 김현태, 윤홍태, 이수헌, 백인열 忠北大學校 農業科學硏究所 2014 農業科學硏究 Vol.30 No.2

It has been reported several viral diseases in soybean. The occurrence of Bean common mosaic virus and Peanut stunt virus are able to induce severe problem because the main breeding target for viral disease was focused on Soybean mosaic virus. BCMV is a spcies of the genus Potyvirus of the family Potyviridae. BCMV reduces yield by as much as 80% and also adversely affects seed quality in common bean. BCMV has a worldwide distribution because of its high rates 35% of transmission via seeds produced by plants systemically infected prior to bloom. PSV is a species of the genus Cucumovirus of the family Bromoviridae. PSV has been reported to be economically damaging on beans worldwide. Although the virus is reportedly seed transmissible at very low rates, infected plants rarely produce pods with normal viable seeds. The most satisfactory management method of viral diseases such as BCMV and PSV is the use of resistant cultivars and healthy seed. For the overcome of genetic resistance by new virus such as BCMV and PSV, virus diseases monitoring and researches need to study deeply and continually. In this study, we conducted the resistance screen on BCMV and PSV for selection of resistance cultivars. We inoculated on 128 cultivars with PSV and BCMV respectively. These cultivars were classified through pathogenic response such as resistance, necrosis and susceptibility. In addition, 99 and 66 resistant cultivars were confirmed against PSV and BCMV respectively.

충북 남부지역 중소 제조기업의 경쟁력 제고를 위한 경영 및 애로기술 실태조사 연구

윤상원,구경완,정성진,백기영,김선훈,서용성,이근복 호서대학교 반도체제조장비국산화연구센터 2001 반도체장비학술심포지움 Vol.2001 No.-

본 연구에서는 충북 남부 3개군 지역(옥천 · 보은 · 영동)의 중소 제조기업의 경영실태 및 애로기술을 대상으로 실증조사 되었다.·지역의 특정상황의 전제하에 지방 중소기업들의 실질적인 문제점들을 발견하고, 그 개선 방안을 탐색함은 물론 산 · 학 · 연 컨소시엄 사업의 성공적인 수행을 위해 시도되었다.세부적으로는 중소 제조기업의 경영 및 애로기술 특성을 일반적 사항, 경영애로요인, 경영전략, 현장개선기법, 정보화, 제품 및 공정 기술상의 애로기술 현황파악의 6개 영역으로 조사되었다. 조사결과들은 추후 산 · 학 · 연 공동기술개발 사업에 있어 창의적, 틈새적 과제발굴 및 신제품 기술개발의 토대마련이 될 뿐 아니라, 지역경제 발전을 위한 산 · 학 관의 지원 전략 수립에 적극 활용 될 것으로 판단된다.