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안상건,윤정훈 대한구강악안면병리학회 2005 대한구강악안면병리학회지 Vol.29 No.4
The dentigerous cyst(DC) and giant cell granuloma(GCG) in the jaws are well known entities that have been extensively reviewed. However, a search of the literature failed to reveal simulataneous occurrence of these two lesions. We describe a case of DC displaying foci of GCG-like lesion of a 11-year-old Korean girl. The lesion exhibited the characteristic histologic features of DC, which included a lining epithelium with underlying fibromyxoid stroma. The most intersting aspect of this lesion, however, was the presence of a prominant histologic component that resembled GCG. The most probable diagnosis was GCG-like lesion in association with a DC.
안상건,윤정훈 대한구강악안면병리학회 2005 대한구강악안면병리학회지 Vol.29 No.4
The dentigerous cyst(DC) and giant cell granuloma(GCG) in the jaws are well known entities that have been extensively reviewed. However, a search of the literature failed to reveal simulataneous occurrence of these two lesions. We describe a case of DC displaying foci of GCG-like lesion of a 11-year-old Korean girl. The lesion exhibited the characteristic histologic features of DC, which included a lining epithelium with underlying fibromyxoid stroma. The most intersting aspect of this lesion, however, was the presence of a prominant histologic component that resembled GCG. The most probable diagnosis was GCG-like lesion in association with a DC.
안상건,윤정훈 대한구강악안면병리학회 2007 대한구강악안면병리학회지 Vol.31 No.3
Oral fo cal mucinosis(OFM) is a tumor-Iike mass which is considered to be the oral counterpart of cutaneous focal mucinos is 01' a cutaneous myxoid cyst. Although all OFM havebeen reported to appear in the oral soft tissues, we describe a case of OFM with alveo lar bone involvement and review of thc prcvious reports. Histology revealed a localized area of myxomatous connective tissue surrounded by dense fibrous tlssue 8tromal mucins (alcian blue pH 2.5) and met achromasia( toluidine bl Lle pH 3) were obserγed in the tissue sectlOns Neither periodic acid-8chiff reaction nor retic Ll lin fiber nor 8-100 protein was observed. It is unclear whether the primary soft tissue lesion exte11ded into the cent1'al le Si011 or primari ly the lesion arose in the alveolar b011e 01' periodontal ligament.
백종필,안상건,윤정훈 대한구강악안면병리학회 2010 대한구강악안면병리학회지 Vol.34 No.2
The organotypic raft culture model has been shown to be a useful method for examining the effects of biochemical manipulation on various epithelial cell types, using in vitro conditions that simulate the in vivo environment of the tissue of origin. To investigate this method as a model for photodynamic therapy (PDT), we cultures the oral squamous carcinoma cell line YD-10B on fibroblast-containing collagen gels at the air-liquid interface and assessed the efficacy of PDT using a photosensitiser 5-ALA-hexenyl ester. PDT effect on YD-10B organotypic raft cultures after twenty- four hours was determined. The number of residual cells was significantly reduced in comparison to control at all four different conditions. PCNA immunostaining and TUNEL assay revealed that PDT inhibited cell proliferation and increased apoptosis. These findings suggest that the organotypic raft culture model provides an effective and rapid laboratory method of investigating strategies for PDT on oral precancerous lesions and squamous cell carcinomas
4-NQO 유도 백서 혀암 발생과정에서 L-type Amino Acid Transporter 1 (LAT1)과 4F2 Hea vy Cha in (4F2hc)의 발현
윤정훈,안상건 대한구강악안면병리학회 2009 대한구강악안면병리학회지 Vol.33 No.5
Amino acid transporters play an important role in supplying organic nutrient to cells. The expression profile of L-type amino acid transporter 1 (LAT1) and its subunit 4F2 heavy chain (4F2hc) on different differentiation stages in 4-NQO induced rat tongue carcinogenesis was examined using immunohistochemical analysis. The gradually increasing LAT1 and 4F2hc expression detected during the multistep progressive change shows that the protein may have an important role i n the multistep tongue c arcinogenesis. Conclusively, LAT1 and 4F2 hc c an b e a useful b iomarker f or a better understanding of multistep tongue carcinogenesis, while the specific inhibition o f LAT1 and 4F2 hc would be a new rationale for suppressing tumor cell growth in tongue cancer.
5'-Nitro-Indirubinoxime이 타액선 암세포의 제1형 교원질 부착 및이동에 미치는 영향
윤정훈,안상건 대한구강악안면병리학회 2009 대한구강악안면병리학회지 Vol.33 No.6
We have previously shown that 5’-nitro-indirubinoxime (5’-NIO) has potent anti-tumor effect in various human cancer cells. But the potential anti-invasive effect of 5’-NIO in salivary gland cancer has not been studied yet. The goal of this study is to evaluate the effect of 5'-NIO on salivary gland adenocarcinoma SGT cell adhesion and migration to Type I collagen treatment. Western blot, adhesion and migration assay were performed to evaluate the impacts of 5’-NIO on the expression of MMP-2/-9 and its upstream signaling molecules after treatment of type І collagen. SGT cell adhesion to type I collagen is significantly suppressed by 5’-NIO. 5’-NIO decreased expression of β1 integrin, phosphorylation of FAK, MMP-2/ -9 compared with type I collagen treatment. In addition, 5’-NIO inhibited the migration of SGT cells treated with type I collagen. These results suggest that 5’-NIO could effectively inhibit the invasion and migration of human SGT cells by downregulating the expression of β1 integrin and MMP-2/-9 and phosphorylation of FAK, Akt, and Erk. Adhesion and migration to type I collagen of SGT cells can be influenced through 5’-NIO..