정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

조혈모세포이식 환자에서 발생한 Cytomegalovirus 질환의 특징 : 일개 대학변원에서 최근 10년간의 경험

최수미,이동건,박선희,김시현,김유진,민창기,김희제,이석,최정현,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Studies on cytomegalovirus (CMV) diseases in Korean hematopoietic stem cell transplant (HSCT) recipients are lacking and do not reflect the recent trends of advances and changes. Therefore, we tried to analyze the clinical features of CMV diseases in HSCT recipients over the past 10 years at a tertiary university hospital in Korea. Methods : Retrospective review of medical records was done for all adult HSCT patients who received transplant at the Catholic HSCT Center from January 1998 to January 2008. Results : Forty-four cases (2.2%) of CMV diseases were identified. CMV pneumonia was diagnosed in 17 patients, retinitis in 16 patients, enterocolitis in 7 patients, esophagitis 1 patient, gastritis in 1 patient, duodenitis in 1 patient, and hepatitis in 1 patient. The median onset of symptom was 90 days after transplantation. Late CMV diseases accounted for 47.7%. CMV related death varied from 0 to 58.8% according to the involved organ. CMV retinitis was diagnosed relatively later in the course of transplantation mostly in patients who had chronic graft versus host disease (GVHD). On the contrary, CMV enterocolitis mainly occurred in patients who suffered from acute GVHD. The overall concurrent CMV reactivation was documented to be 63.6%: the concurrent CMV reactivation was observed only in 37.5% of patients with retinitis. Conclusions : We observed some differences in the pattern of CMV disease manifestation according to the involved organ and reconfirmed the fact that CMV pneumonia is the most common and fatal disease in HSCT recipients. Additionally, CMV retinitis was not uncommon in HSCT recipients. Since specific marker does not exist in predicting retinitis, regular ocular examination should be done thoroughly, especially in patients with chronic GVHD.

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

Si-Schottky障壁型의 大陽電池 製作에 관한 硏究

李相潤,羅炳旭,朴德圭,李鍾德,金奎用,玄東杰,禹洪,盧景錫 慶北大學校 物理化學硏究所 1981 硏究論文集 Vol.1-2 No.-

The characteristics of these Si-schottky barrier type and Heterojunction type solar cells are as follows; 1. SnO_2/n-Si Heterojunction Solar Cells Fabricated by Spray Pyrolysis Method SnO_2 film were deposited on the (100) or (111) surface of Si single crystal by the spray pyrolysis method. The best SnO_2/n-Si solar cell has a good performance, with an open-circult voltage: Voc.=0.45V, short circuit current: Isc.=35.5㎃, fill factor: FF.=0.64, and conversion efficiency: η=10.2% under 98㎽/㎠ irradiation of AMl. The spray pyrolysis described in this paper is simple and suitable for mass production. One possibility for cost reduction lies in this method of junction fabrication, and the idea of simply deposited SnO_2/n-Si junction is, at first sight, very attractive. Hence the SnO_2/n-Si Solar Cell and the effectiveness of this method may be of great value in some future production of low-cost solar cells. 2. In_2O_3: Sn Heterojunction Solar Cells Fabricated by Spray Pyrolitic Method Highly conductive and transparent thin films of In_2O_3: Sn (ITO) are fabricated by spray pyrolytic method. The parameters of these thin films are as follows: resistivity ρ = 1.5×10 exp (-3) Ω·㎝, carrier concentration n = 7.5×10 exp (19) cm^-3, mobility μ = 55.5 ㎠/V·sec and transmission 85-90% over visible and long wave-length region. These thin films have simple cubic system with lattice constant 10.2Å. In_2O_3: Sn/n-Si heterojunction solar cells are fabricated, depositing In_2O_3: Sn (ITO) thin films on n-Si substrates with orientation(100) and resistively 2-3Ω, ㎝ by spray pyrolitic method. Under AMl sunlight simulator, the parameters of the excellent cell obtained has open-circuit voltage Voc=0.52V, short-circuit current I_sc=39.0㎃, fill factor: F.F=0.60 and conversion efficiencyη=12.1%. 3. Al/p-Si MOS Solar Cells Fabricated by Vacuum Evaporation Method Al/p-Si MOS solar cells, consisting of Al on P-tupe silicon with a thin interfacial layer of SiO_2 have been found to have good light conversion efficiency for solar radiation. The effects of the oxide layer thickness between metal and substrate were investigated. Under AMl simulated sunlight illumination the best cell has open circuit voltage Voc=0.50V, short-circuit current I_sc=26.3㎃/㎠, fill-factor FF=0.70 and conversion efficiency η=9.2%. 4. Cr-Cu/P-Si MOS Solar Cells Fabricated by Vacuum Evaporation Method Cr-Cu/p-Si MOS Solar cells, consisting of Cr-Cu on p-type silicon with a thin interfacial layer of SiO_2 have been found to have good light conversion efficiency for solar radiation. The effects of the oxide layer thickness between metal and substrate were investigated. Under AMl simulated sunlight illumination the best cell has open circuit voltage Voc=0.49V, short-circuit current I_sc=26.4㎃, fill-factor: FF=0.72 and conversion efficiency η=9.3%.

조건부수급자의 자활사업 참여와 불참간 의사결정 요인분석

이성희,원종욱 한국사회복지정책학회 2004 사회복지정책 Vol.20 No.-

본 연구는 조건부수급자증 자활사업 불참자의 특성을 자활사업 참여자와 비교하여 분석함으로써 어떠한 요인들이 이 두 집단을 구분짓게 마는지 실증적으로 규명하는데 그 목적이 있다. 조건부수급자중 정당한 사유 없이 자활사업에 불참한 사람들의 특성에 대한 과학적인 분석은 자활사업이 안고 있는 참여율 저조 문제에 대한 원인을 이해하고, 향후 성공적인 자활사업 시행을 위한 정책수립에 기초자료가 될 것으로 사료된다. 이를 위해 『2003 자활정책평가와 개선과제 실태조사』 의 자료를 이용하여 조건 부수급자증 자활사업 참여자와 불참자에 대찬 설문분석과 함께 자활사업 참여결정에 영향을 미치는 요인을 계량적으로 분석하였다. 설문분석 결과 자활사업 불참자는 참여자에 비해 상대적으로 남성의 비율이 높고, 연령은 낮고, 동거 가구원수가 많으며, 학력이 높고, 소득수준이 놓으며, 담당공무원이 자신의 소득수준을 정확히 파악하지 못한다고 생각하는 편으로 나타났다. 자활사업 참여결정에 영창을 미치는 요인을 probit model로 추정한 결과 역시 설문분석 결과의 타당성을 뒷받침하였다. 그리고 자활사업 불참자의 소득 추정식을 분석한 결과 수급자 가구가 근근이 생활하는데 필요하다고 생각하는 금액이 클수록, 즉 기본적인 생활수준을 높이고 싶은 욕구가 강할수록 민간 노동시장에서 얻는 소득수준도 높아지는 것으로 나타났다. The main purpose of the study is to identify the differences in socio-economic variables between participants and non-participants of the public self-reliant program. Under the 『Law of the Guaranteeing Basic Livelihood』, those who are physically fit to work, are classified as conditional recipients. One of the condition applied to them is to participate in the public self-reliant program when they can't find job. By analyzing the survey data of 2003, we found out that there are differences in socio-economic variables between two groups. Other things controlled, men are more likely to not to participate in public self-reliant program rather they chose to work in private labor market. Age is another factor influencing decision on participation of the program. The younger recipients are more likely to work in private labor market rather than public self-reliance program. We also found out that those who believe that real incomes are less likely to be revealed by government social workers are more likely to participate private labor market rather than government program. Finally, we predicted income level that non-participants could earn in the private labor market by utilizing Heckman selection model(two-stage). Even though average income of the non-participants' of the public program was about to 420,000 Won the predicted private market income of the total conditional recipients are close to only 200,000 Won. It implies that public self-reliant program is vital source of income for the recipients who possess labor capacity but are unfit to competitive private labor market.

UHF 대역 수동형 RFID 태그 Analog Front-end 분석 및 설계

이종욱 경희-다반 ASIC 설계교육센터 2005 경희-다반 ASIC센터 논문집 Vol.6 No.-

We investigated the design trade-off in the development of UHF-band RFID tag for increased reading range. Using the quality factors of the tag antenna and tag chip as design parameters, the effects of the quality factors on the turn-on voltage of the tag chip and the backscattered power from the tag were examined. The design equations from the analysis indicate two regions of good impedances, one forproviding high tum-on voltage forthe tag chip, and the other resulting in increased radar cross section (RCS) for the antenna. An optimum quality factor which provides the best compromise of the two designs is provided. Based on the analysis, an example of the tag chip and tag antenna was designed, and the reading range test in anechoic chamber resulted in a detection distance of 5.2 m for-75 dBm reader sensitivity.

Dual-Gate GaN HEMT의 고출력 RF 특성에 대한 연구

이종욱 경희-다반 ASIC 설계교육센터 2004 경희-다반 ASIC센터 논문집 Vol.5 No.-

Dual-gate AlGaN/GaN high electron-mobility transistors (HEMTs) having a 0.35 gm gate length with 1.0 mm (8×125㎛) periphery were examined for applications requiring high power and high frequency operation. A typical device exhibited a maximum drain current density of 500 mA/mm, a device unity gain cut-off frequency (f_(τ)) of 30.5 GHz, and a maximum frequency of oscillation (f_(MAX)) of 43.7 GHz. Reduced feedback capacitance through the dual-gate cascode configuration allows a larger gate periphery for a given input capacitance, thus higher microwave power can be generated. A monolithic non-uniform distributed amplifier has been designed which offers increased efficiency and broad-band operation by removal of the drain line dummy load and dual-gate cascode gain cell arrangement.

방사선 조사 후 대뇌결질에 분포한 Neuropeptide-Y 양성신경세포에 관한 면역조직화학적 연구

이상욱,김종중,정윤영,정종달,오윤경 조선대학교 2000 The Medical Journal of Chosun University Vol.25 No.2

Background and Objectives : Severe irradiation on the cerebral cortex of the human and animals may result in functional alterations of central nervous system. The purpose of this study, the irradiation effects on the cerebral cortex of the rats after brain irradiation was to investigate the change of distribution and morphology of neuropeptide-Y(NPY) neurons. Materials and Methods : Radiation was produced by the linear accelerator 6MV X-ray, and the animals were categorized into control and experimental groups and we use 45 Sprague-Dawley rats weighing about 200~250gm. The head areas of the animals were positioned within the radiation field of 12㎝ × 20㎝ and with the radiation depth of 1.5㎝. Sodium chloral hydrate-anesthetized rats were exposed to the radiation with the dose rate of 240 cGy/min. The total dose was 1800 cGy. Animals were sacrificed on 2 hours, 5 hours, 1 day, 3 days, 7days after brain irradiation. Under anesthesia, animals were perfused with 4% paraformaldehyde-1% glutaraldehyde solution. On one or two hours after the perfusion, brain were taken out and refixed over night in the same fixative. Using ABC immunohistochemistry, morphology and distribution of neuropeptide-Y immunoractive(NPY-IR) neurons were studied on the cerebral cortex of the control and brain-irradiated rats. We used light, transmission electron and confocal laser scanning microscope. Results : The following results were obtained : 1. On control group, NPY-IR neurons were found in all layers of the primary sensory and motor cerebral cortex, and the NPY-IR neurons were concentrated within the layer II, III, IV, V and VI. The typical NPY-IR perikarya was bipolar and multipolar shape. 2. On 2 hours, 5 hours, 1 day after X-irradiation, decreased number of NPY-IR neurons were detected in the primary sensory and motor cerebral cortex of the rats. Also shrunken and transformed NPY-IR neurons were detected in the primary sensory and motor cerebral cortex of the rats. 3. On 3 days and 7 days after X-irradiation, morphology and distribution of NPY-IR neurons in the primary sensory and motor cerebral cortex was generally restored. 4. In optical serial section analysis of NPY-IR neurons, high fluorescence intensity were observed in a part of the 8~11 sections of the control and all irradiated groups. In optical single section analysis of NPY-IR neurons, red color(high fluorescence intensity) was observed in a part of 6, 7 sections of the control and all irradiated groups. 5. By electron microscopy, NPY-IR neurons on 2 hours, 5 hours, 1 day after X-irradiation rats exhibited severe alterations of their organelles concerning intracellular material transport ; such as disappearance of microvilli and basal infoldings, reduction of invaginating pits on the basal and apical plasma membranes, reduction of transformed vesicles and shrunken Golgi complexes, etc. Conclusion : From the above results, it was concluded that the release of neurotransmitters and transcapillary leakage of blood substance were occurred on 2 hours, 5 hours, 1 day after X-irradiation, but the condition was generally restored on 3 days and 7 days following X-irradiation.

『삼국사기』에 나타난 초기 백제와 풍납토성

이종욱 西江大學校 人文科學硏究所 2000 서강인문논총 Vol.12 No.-