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노인의 우울감과 자아존중감이 생활만족도에 미치는 영향: 독거노인과 비독거노인의 비교를 중심으로
최정현,최소연 중소기업융합학회 2021 융합정보논문지 Vol.11 No.12
This study examined the effects of antecedent variables on life satisfaction of elderly people who live alone and who live with others by comparing the levels of depression, self-esteem, and life satisfaction. Using the 15th data of the Korean Welfare Panel held in 2020, independent sample t-test and hierarchical regression analysis were conducted. Elderly people who live alone had a high sense of depression, low self-esteem, and low life satisfaction. For both of them, the older the age and the higher the income level, the higher the life satisfaction. The regression model, which added depression and self-esteem, had a significant effect on both of them, but the effect of self-esteem was higher (β=.40, .41) than that of depression (β=-.28, -.29). The effects of depression and self-esteem on life satisfaction were higher in elderly people who live alone (R2=.409) than in elderly people who live with others (R2=.398). Based on the research results, this study suggested appropriate policies and practice directions to enhance self-esteem and improve life satisfaction of elderly people who live alone. 본 연구는 독거노인의 우울감, 자아존중감, 생활만족도의 수준을 비독거노인과 비교하면서 선행변수가 생활만족에 미치는 영향을 고찰하였다. 2020년에 진행된 한국복지패널 15차 데이터를 활용하여 독거노인 1,533세대와 비독거노인 3,130세대를 대상으로 t-검증과 위계적 회귀분석을 실시하였다. 연구 결과, 독거노인은 비독거노인에 비해 우울감은 높고 자아존중감과 생활만족도가 낮았다. 독거노인은 여성의 생활만족도가 높은 반면, 비독거노인은 남성의 생활만족도가 높았으며, 독거, 비독거노인 모두 나이가 많고 소득수준이 높을수록 생활만족도가 높았다. 우울과 자아존중감은 독거노인과 비독거노인 모두 유의미하게 영향을 미쳤으나 자아존중감 (β=.40, .41)의 영향이 우울 (β=-.28, -.29)의 영향보다 큰 것으로 나타났다. 우울과 자아존중감이 생활만족도에 미치는 영향은 독거노인 (R2 =.409)이 비독거노인 (R2=.398)보다 큰 것으로 확인되었다. 연구 결과를 토대로 독거노인의 자아존중감을 제고하며 생활만족을 증진하기 위한 정책 및 실천의 방향을 제시하였다.
몇 가지 항균제가 시험관내에서 내독소와 TNF-α, IL-6 분비에 미치는 영향
최정현,문건웅,김명훈,이동건,박윤희,김상일,김태연,유진홍,김양리,신완식,강문원 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.2
To evaluate antibiotic-induced endotoxin release(AIER) and its correlation with some cytokines, we measured endotoxin level and tumor necrosis factor alpha(TNF-α) and interleukin6(IL-6) production in mononuclear cells in vitro after exposure of Pseudomonas aeruginosa to antibiotics belonging to different class with two extreme concentrations. The tested concetration of antibiotics were set up according to peak serum level. The low concetration of ceftazidirne and low concentration of imiperiem increased AIER, but high concentration of ceftazideme, high concentration of ciprofloxacin, high concentration of cefoperazone/sulbactam, high concentration of amikacin, and high concentration of meropenem reduced AIER.Interestingly, combined treatment of these antibiotics markedly reduced AIER, But the major cyotkines, TNF-α and IL-6 were not affect by type and concettration of antibiotics, combined treatment of antibiotics, and level of endotoxin released by antiboitics. In this study, we observed AIER was different according to type of antibiotics, concentration of antibiotics, and combination of antibiotics, But AIER had poor correlation with TNF-α and IL-6 in Pseudomonas aeruginosa. It suggests that cytokine release is not solely dependent to endotoxin, but more complex cascade is needed. More invesfigations, such as endotoxin induced cytokine mRNA expression, relationship with penicillin-binding proteins and endotoxin-neutralizing effect of antibiotic itself, must be performed.