서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

확장성 심근증의 임상적 특성에 대한 연구

정상만,문언수,정시전 건국대학교 의과학연구소 1993 건국의과학학술지 Vol.3 No.-

Dilated cardiomyopathy is a heart muscle disease in which one or both ventricles are dilated, resulting in decreasing left ventricular contractility and pump failure. Complex arrhythmias are frequent in this disorder and are often associated with poor prognosis. We analysis the clinical parameter, electrocardiographic and echocardiographic findings of the 15 patients who were diagnosed as dilated cardiomyopathy between Aug. 1978 and Dec. 1992 in Kon-Kuk University Minjoog Hospital. The results were as follows: 1) 9 male and 6 female patients with mean age of 56.6 were included in this study. 2) In decreasing order of frequency, the clinical findings were dyspnea on exertion(93.3%) ; fatigue or weakness(46.7%) ; orthopnea(26.7%) ; cough(26.7%) ; edema(20.0%) ; chest pain(20.0%) and palpitation(13.3%). 3) In decreasing order of frequency, the findings of physical examination were apical systolic murmur(53.3%) ; hepatomegaly(33.3%) ; S3 gallop(26.7%) : pretibial pitting edema(7%) ; rales or wheezing(20.0%) and peripheral cyanosis (20.0%). 4) The most common finding of electrocardiography was LVH(33.3%) and atrial fibrillation(33.3%). NSIVCD(26.7%), PVC(20.0%), LBBB(6.7%), atrial flutter(6.7%) were also noted in this study. 5)The echocardiographic study showed markedly increased LVEDD(65.3±11.1mm), LVESD(56.8±10.7mm), LAD(42.9±7.4mm), EPSS(23.3±6.1mm) and decreased EF(28.8±11.0%), IVST(7.6±1.1mm) and LVPWT(7.5±1.3mm). This data showed that congestive heart failure was the major clinical feature and the left ventricular performance was markedly decreased in the patients with dilated cardiomyopathy. Electrocardiographic abnormalities were frequently associated with this disorder. Adequate therapeutic modality and proper follow up were necessary to improve the prognosis of the patients with dilated cardiomyopathy.

수도수중 염소 소독부산물로 인한 건강위해성 평가에 관한 연구 : 서울시 수도수중 Trihalomethanes 및 Haloaceticnitriles을 중심으로

정용,신동천,양지연,박연신,김준성 한국환경독성학회 1997 환경독성보건학회지 Vol.12 No.2

Public concerns about hazardous health effect from the exposure to organic by-products of the chlorination have been increased. There are numerous studies reporting that chlorination of drinking water produces numerous chlorinated organic by -products including THMs, HAAS, HANs. Some of these products are known to be animal carcinogens. The purpose of this study was to estimate health risk of DBPs by chlorinated drinking water ingestion in Seoul based on methodologies that have been developed for conducting risk assessment of complex-chemical-mixture. The drinking water sample was collected seperately at six water treatment plant in Seoul at March, April, 1996. In tap water of households in Seoul, DBPs were measured with the mean value of 36.6 μg/L. Risk assessment processes, which include processes for the estimation of human cancer potency using animal bioassay data and calculation of human exposure, entail uncertainties. In the exposure assessment process, exposure scenarios with various assumptions could affect the exposure amount and excess cancer risk. The reference dose of haloacetonitriles was estimated to be 0.0023 mg/kg/day by applying dibromoacetonitrile NOAEL and uncertainty factor to the mean concentration. In the first case, human excess cancer risk was estimated by the US EPA method used to set the MCL (maximum contaminant level). In the second and third case, the risk was estimated for multi-route exposure with and without adopting Monte-Carlo simulation, respectively. In the second case, exposure input parameters and cancer potencies used probability distributions, and in the third case, those values used point estimates (mean, and maximum or 951!!i) upper-bound value). As a result, while the excess cancer risk estimated by US EPA method considering only direct ingestion tended to be underestimated, the -risk which was estimated by considering multi-route exposure without Monte-Carlo simulation and then using the maximum or 95% upper-bound value as input parameters tended to be overestimated. In risk assessment for Trihalomethanes, considering multi-route exposure with adopting Monte-Carlo analysis seems to provide the most reasonable estimations.

농촌인의 체격 및 체력 실태에 관한 연구

정성태,장창현,전태원 師範大學 體育硏究所 1993 서울大學校 體育硏究所論集 Vol.14 No.2

The purpose of this study was to investigate the physique and physical fitness of the rural area adults. To accomplish this purpose 202 adults were drawn from 4 different rural areas such as Chungnam, Junbook, Kyoungbook, and Chungbook, and their physique and physical fitness were measured. The data from these people were compared with those of 114 Seoul residents. The findings of this study were as followings; physique 1. The heights of rural area adults were shorter than those of urban area adults by about 4cm, and their heights tended to reduce by 2cm every 10 year as they got older. 2. The weights of rural area male adults were lighter that those of their urban counterparts by about 6kg ; rural area female adults were also lighter than their urban counterparts by 10kg. 3. The sizes of waist girths of both the rural area adults and urban area adults tended to increase after their 40s. physical fitness 1. There was no significant difference of grip strengh between rural and urban area male adults; rural area female adults exhibited stronger grip strengh than their urban area counterparts by about 4kg. 2. There was no significant difference of sit-up performance between rural and urban area male adults; rural area female adults showed weaker sit-up performance than their urban counterparts. 3. There was no significant difference of trunk bending performance between rural and urban area male adults; rural area female adults showed more flexible trunk bending performance than their urban counterparts.

소나무-참나무 천연혼효림에 있어서의 수분 경쟁에 관한 연구

정동준,전상근,김영채 경희대학교 생명자원과학연구원 2000 硏究論文集 Vol.21 No.-

This study is to rationalize the forest management practice based upon the growth and water competition of pine-oak natural mixed forest stands in central part of South Korea. Average volume is 259.3 m^(3)/ha for pine stands and 150 m^(3)/ha for mixed pine stands, whereas 206.5 m^(3)/ha for pure oak stands, and 71.7 m^(3)/ha for mixed oak stands. Quadratic mean diameter and quadratic mean height, basal area, and volume decrease as the direction moves from north to south, whereas the values peak at south slope and hit the lowest at the north for oak stands. The maximum water potentials measured between 12 and 14 oclock was analyzed by stand and altitude, and by direction in case of mixed stand. Water potential of pine showed higher in both pure stands and mixed stands than oak. Especially the water potential of oak in muted stands was 3 MPa, which was lower than that of pines, -2.7 MPa. The value of two species increased as the altitude gets lower. Pine has 3.2 MPa at higher altitude, -2.4 MPa at lower altitude, which are much higher than those of oak, 3.4 MPa and 2.9 MPa at higher and lower altitudes. Soil water content was high m oak pure stands than pine pure stands or mixed stands Soil water content for each direction in mixed stands tended to decrease as slope goes from north to south. Interspecific water potential and the soil moisture content turned out to be highly correlated. Under the same soil moisture content, water potential of oak was lower that that of pine. Therefore, it seems that both pine and oak have high moisture requirement in the highly competitive southern slope and oak has higher moisture requirement than pine. It is concluded that, oak is in much competitive position than pine in terms of water competition.

농촌인의 건강실태에 관한 연구

정동춘,정성태,장창현,전태원 師範大學 體育硏究所 1993 서울大學校 體育硏究所論集 Vol.14 No.2

The purpose of this study was to investigate the health condition of rural area adults. To accomplish this purpose 98 adults were drawn from 2 different rural areas such as Chungnam and Junbook, and their health condition were examined. The data from these people were compared with those of 108 Seoul residents. The main findings of this study were as followings; 1. Neuralgia was the commonest disease in rural area adults, followed by Rheumatism, waist pain, and heart problem. 2. About 62% of rural area adults indicated that their average sleeping time was less than 7 hours per day. 3. About 48% of rural area male adults indicated that their daily labor was generally “severe,”while 61.3% of female adults said in the same way. 4. The blood pressure value of rural area males was 124/73 ㎜Hg, while that of urban area males was 114/77 ㎜Hg. 5. The values of GOT and GPT were higher in rural area males than in rural area females. 6. the value of cholestrol was lower in rural area adults than in urban area adults.

다발성 골수종으로 이행한 단일형질세포종 1예

정재용,모성환,기장도,문철호,김창욱,전용준,박유환,정춘해,오윤경 조선의대 1995 The Medical Journal of Chosun University Vol.20 No.2

한우 Band 3 및 CHS 유전병의 분자유전학적 기초연구

정행진,유성란,상병찬,이준헌 충남대학교 농업과학연구소 2005 농업과학연구 Vol.32 No.1

Many bovine genetic diseases are currently unidentified in Korea because of the relatively low monitoring systems in the livestock farms. The molecular detection system using PCR-RFLP of two genetic diseases, namely Band 3 (Erythrocyte Membrane Protein Band Ⅲ) and CHS (Chediak-Higashi Syndrome), have been identified in Japan and used for screening large number of cattle whether each individual has the genetic disease or not. Using the 22 unrelated Korean cattle (Hanwoo) individuals, molecular detection system based on PCR-RFLP have been investigated, which can be distinguishable carriers for the genetic diseases. Even though we could not found the causative mutations for two genetic diseases, the PCR-RFLP techniques used in this study are very valuable for the screening the genetics diseases in Korean cattle, especially for the proven or candidate bulls.

마이크로 가스센서의 열해석

정완영,이상윤,임준우,이덕동 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

Thermal analyses for typical stack-type and newly proposed planar-type micro-gas sensors were accomplished. The thermal analyses for the proposed planar structure including temperature distribution over the sensing layer and power consumption of the heater were carried by finite element method and well compared with those of typical stack-type micro-gas sensor. The thermal properties of the microsensor from thermal simulation were tested to investigate the applicability of the heater to a real device.