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鄭時銓 순천향대학교 1980 논문집 Vol.3 No.1
The attention has been directed at acute hepatic injury due to the various kinds of drugs. These drugs are those for the therapeutics or abused ones for those many nontherapeutic purposes. Percutaneous Vim-Silverman needle biopsy of the liver was performed on the six inpatients both at National Veterans Hospital and Soon Chun Hyang College Hospital during 2 year period from December, 1977 until December, 1979 Four of the six biopsied patients were all Korean war veterans who had been fairly extensively and broadly exposured to various kinds of pharmacologic agents over last 1 decade including very frequent use of alcoholic beverages because of their poor psychosociologic adjustments. Two other patients were female and they were civillian housewives. Five out of 6 cases showed positive liver biopsy findings compatible with the clinical impressions. One case with 10 year history of dilantin ingestion showed the morphologic evidence of hepatic damage which is compatible with the drug-induced chronic active hepatitis showing piecemeal necrosis. One case with acute D.D.S. poisoning showed only a slight degree of hepatic damage. One patient having acute morphine poisoning with its addiction who was found comatous revealed only a minimal degree of pathologic change in its morphological appearance. Two other patients showed very obscure morphological findings probably caused by various kinds of drug abuses and prolonged alcohol ingestion over 2 decades. One housewife with 9 year history of"Neusin"〔acetoaminophen〕 ingestion, showed no hepatic abnormality in its biopsy finding. All cases showed negative hepatitis B surface antigenemia. In regard to the hepatic damage caused by the drug introduction by oral or parentheral route, author had a conclusion that the most beneficial way for its correct interpretation and judgement for assessing clinical policy is only by the correct morphological observation of the injured or uninjured hepatic cells and its architecture directly obtained by the needle biopsy.
체성-심장반사에 의한 혈압변화가 심장 미주신경의 임펄스발사에 미치는 영향
정시전,홍승길,남숙현 고려대학교 의과대학 1985 고려대 의대 잡지 Vol.22 No.1
Somato-cardiac and somato-vagal reflex responses were studied by recording simultaneously the change of the arterial blood pressure and impulse discharge of the cardiac vagal afferents following electrical excitation of radial nerve in nembutal and alpha-chloralose anesthetized cats. The stimulation of the radial nerve has been done in group Ⅱ, Ⅲ, and Ⅳ fibers and the results are summarized as follows; 1. The stimulation of group Ⅱ radial afferents lowered arterial blood pressure and diminished the impulse discharge of the cardiac vagal afferents. 2. Simultaneous activation of group Ⅱ and Ⅲ of radial nerve resulted lowering blood piessure and diminishing impulse discharge of cardiac vagal afferents followed by immediate increase. 3. The electrical stimulation of group Ⅳ radial afferents increased arterial blood pressure and the impulse discharge of cardiac vagal afferents. To summarize above results, it was presumed that radial nerve, same as the other somatic nerve, has the effects on the cardiac function and especially group Ⅱ muscle afferents are related to lowering the arterial blood pressure. Also, ir was noticed that the change of impulse discharge of cardiac vagal afferents after electrical stimulation of radial nerve was the secondary effects of reflex reaction between the radial nerve and the heart.