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정재용,박진수 한국항해항만학회 1998 한국항해항만학회지 Vol.22 No.1
Traffic density has increased recently in Korean waters due to an expansion of the sea trade and the development of coastal fisheries. The enlargement of the coastal industrial belts and the development of coastal inslands further increases marine traffic. The rapid increase of marine traffic has often resulted in marine casualties with the attendant loss of life, damage to property, and marine pollution. Especially, tanker casualties may destroyed the food web and an untold amount of ocean resources. Un regard to the potential of tanker spills in Korean waters, systematic research in this field is lacking. In this paper, the data relating to a total of 261 tanker casualties in Korean waters has been compiled and statistically anlaysed. The result of this study describes the general trend of marine casualties in Korean waters, and describes the casualtiy database, from which their causes and consequences are derived and this results in the determination of the causal relationships connected to tanker casualties, and quantifies the effective level of causal factorsin Korean waters.
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광섬유의 선형복굴절 보상에 따른 170 kV GIS용 전류 센서의 출력 특성
정재용,김병태,Jeong Jae-Yong,Kim Byung-Tai 대한전기학회 2005 전기학회논문지C Vol.54 No.2
The optical CT was developed to use twisted fibers for 170 kV GIS. The fiber sensor optimized on the optical CT was wound 3 turns and twisted 4 times per a turn at the pipe with a diameter of 130 mm. The measurement error for the linearity which was satisfied the criterion of 'IEC Class-1.0' was less than ± 0.44 % at the transmission type and ± 0.82 % at the reflection type to 2,000 A. At a low current to 200 A, the measurement error was ± 0.69% at the transmission type and ± 1.38 % at the reflection type.
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UGT2B7 유전형이 발프로익산(Valproate)의 약동학에 미치는 영향
정재용 대한임상약리학회 2004 Translational and Clinical Pharmacology Vol.12 No.2
UDP-glucuronosyl transferases (UGT) mediate a conjugation reaction by glucuronidation of various clinically important drugs. The functional significance of genetic polymorphisms in these UGTs are main concern of the current researchers of UGTs. Valproate (valproic acid) is an antiepileptic drug glucuronidated mainly by UGT2B7. We investigated the effect of genetic polymorphism on pharmacokinetics of valproate in healthy normal volunteers. Before the clinical study, we screened genotype of UGT2B7-T801A (T:*1, A:*2). Twenty three healthy subjects were enrolled and grouped with regard to the UGT2B7 genotype. The pharmacokinetic profile of valproate was characterized after valproate administration (600 mg once daily for 5 days). The plasma concentrations of valproate were analyzed before and 1, 1.25, 1.5, 2, 2.5, 3, 5, 7, 9, 13, 25, 49 hours after 5th valproate administration by TDX with FPIA method. Although the pharmacokinetic profiles of valproate did not showed significant differences between the UGT2B7 genotype groups, a trend of decrease of clearance as increase of UGT2B7*2 allele was observed. Oral clearance of valproate in the UGT2B7*2/*2 group was 66% of that of the UGT2B7*1/*1 group. The results suggest that the UGT2B7*2/*2 genotype group possibly has a decreased clearance of valproate. Further study may be required to clarify the results.
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건강한 한국인 자원자에서 테가세로드(Tegaserod) 반복 투여에 의한 안전성 및 약동학 평가
정재용,임형석,홍경섭,배균섭,유경상,조주연,이소영,고재욱,장인진,신상구,Chung, Jae-Yong,Lim, Hyeong-Seok,Hong, Kyoung-Sup,Bae, Kyun-Seop,Yu, Kyung-Sang,Cho, Joo-Youn,Yi, So-Young,Ko, Jae-Wook,Jang, In-Jin,Shin, Sang-Goo 대한임상약리학회 2003 Translational and Clinical Pharmacology Vol.11 No.2
Background: Tegaserod is a selective partial agonist at the $5HT_4$ receptor. Tegaserod belongs to a new class of agents in development for the treatment of functional motility disorders of the gastrointestinal(GD tract. This Phase I clinical study was conducted to evaluate the safety and pharmacokinetics(PK) of tegaserod in Korean for bridging foreign clinical data. Methods: A randomized, double blind, placebo controlled, multiple oral dosing(2 mg, 6 mg, twice a day for 7 days) study was conducted in 32 healthy Korean volunteers(M:F=16:16). Serial blood samples for pharmacokinetic analysis were taken. Safety evaluation was performed by adverse event monitoring, physical examination including vital signs, ECG and clinical labororatory analysis. Results: Plasma concentration of tegaserod reached peak levels $1.0{\sim}1.5$ hours after single and multiple dose administration and declined with a terminal half life of about 12 hours. PK parameters of 2 mg group were not calculated well due to low plasma concentration. Tegaserod showed linear pharmacokinetic characteristics, and little accumulation occurred after multiple administrations. There were no gender differences in PK parameters. Neither serious nor dose-limiting adverse events were observed. PK of tegaserod in Koreans was comparable to Caucasian data. Conclusion: Tegaserod was found to be safe and showed similar PK characteristics to Caucasians. This study demonstrates comparability between Korean and Caucasian healthy subjects in the PK of tegaserod and supports the use of Caucasian data in the evaluation of PK, safety, and efficacy for Korean patients.
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