형질전환을 위한 청치마의 재분화 체계확립

박태성(Tae Sung Park),조동욱(Dong Wook Cho),진명호(Myung Ho Jean),정규환(Kyu Hwan Chung) 한국원예학회 2000 원예과학기술지 Vol.18 No.5

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

정신분열병 환자의 살인행동과 관련된 임상양상

정석훈,이태경,정재열,장정기,장상현,이미경,강시현,정혜윤,유한익,김창윤,홍진표 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.1

Objectives : Recent studies have shown that schizophrenic patients are at increased risk to commit acts of aggression, and aggressive behaviors have severe critical results for the patients and victims. The purpose of the present study is to assess the homicidal behaviors of schizophrenic patients as a extreme case of aggressiveness. Methods : 93 homicidal schizophrenic patients and 93 non-homicidal schizophrenic patients participated in this study. Diagnostic evaluation was made with SCID (Structured Clinical Interview for DSM-IV), and personality trait was evaluated with SIDP (Structured Interview for DSM-IV Personality Disorders). Symptom evaluation was done with PANSS (Positive And Negative Syndrome Scale), and violent behaviors were assessed with LHA (Life History of Aggression) and OAS (Overt Aggression Scale). Results : There were no significant differences in demographic vahables, schizotypal personality trait and antisocial Personality trait between two groups. Mean age at homicidal commitment was 34±8.9 years and 9.8±7.5 years after the onset of illness. The major criminal victims were the parents of the patients (N=49, 53.7%). The aggressiveness was higher in homicidal schizophrenic patients in LHA and OAS scales. There were statistical significances in separate items of the PANSS scale such as excitement (P4), Poor rapport (N3), lack of judgement and insight (G12), disturbance of volition (G13), Poor impulse control (G14) and active social avoidnance (G16), but not in the positive, negative, general subscales and the total scores of the PANSS scale. Conclusion : Excitement and poor impulse control persisted in homicidal schizophrenics, although overt psychotic Symptoms decline after proper treatment. Homicidal behavior can be preventive if proper treatment for excitement and poor impulse control are given.

운동생리학 연구의 역사와 과제

정성태,전태원 한국체육사학회 2000 체육사학회지 Vol.6 No.-

The reviews of the developmental history and issues of exercise Physiology have reached to following four suggestions. 1. For the development of exercise physiology, it is necessary to secure specialilst and research facilities and appratus. 2. It is necessary to establish research structures for an educational-industrial complex. 3. The creative academic atmosphere is need to be raised to develop our own unique exercise physiology and exercise science through development of new theories and basic science. 4. It is necessary to joint study with adjacent science for communication of exorcise physiology or exercise science in terms of domestic aspects. It is necessary to change our communication channels from America to Japan or other Europerian nations.

On the algebra and Einstein's connection in 2-dimensional *g-UFT

정경태,김성극 연세대학교 대학원 1980 延世論叢 Vol.16 No.2

Many types of solutions of Einstein's equation hove been obtained so far. They are, however, too complicated for the first class, probably due to the complexity of the 4-dimensional generalized Riemann space X4. The main purpose of the present paper is to study the algebraic and differential geometric peoperties of 2-dimensional *gλν-unified field theory in X2, reducing the dimension to 2. In particular, the solution of Einstein's equation will be obtained in a simple tensorial form using a particular recurrence relation.

검사시간의 경과에 따른 컴퓨터 신경행동검사 수행기능의 변화양상

정성태,전만중,사공준 大韓産業醫學會 2007 대한직업환경의학회지 Vol.19 No.4

목적: 컴퓨터 신경행동검사에서 검사시간의 경과에 따른 측정치들의 타당도 변화양상과 타당도에 영향을 미치는 요인들을 평가하고 수용할 만한 타당도가 나타나는 최소한의 검사시간을 제시하여 컴퓨터 선경행동검사의 결과 해석의 정확성을 높이고 검사시간 설정의 기준으로 활용 하고자 수행되었다. 방법: 자동차공장 근로자 중 혼합 유기용제에 만성적으로 노출되는 도장공 118명과 연령을 짝지은 대조군 113명으로 총 231명을 대상으로 하였다. 대상자 전원은 고등학교졸업의 학력을 가진 남자 근로자였으며,연령,작업부서,근무년수,주야간 교대작업 여부,음주 및 흡연 습관을 자기기입식 설문지를 통하여 조사하고 SPES를 이용한 컴퓨터 신경행동검사를 시행하였다. 신경행동검사는 연습수행을 포함하여 단순반응시간 6분,부호숫자짝짓기 10회,손가락두드리기 5회를 수행하였다. 단순반응시간은 1분 단위로, 부호숫자짝짓기와 손가락두드리기는 수행단위(session)마다의 평균반응시간,표준편차 및 두드린 횟수에 대한 검사시간의 경과에 따른 변화양상을 관찰하고 t 통계량과 반복측정분산분석을 이용하여 타당도의 변화양상을 관찰하였다. 결과: 단순반응시간은 도장공과 대조군 모두에서 검사에 대한 미숙함은 적은 반면 시도가 반복됨에 따라 학습 효과에 비해 지루함 혹은 흥미의 감소 등의 영향이 더 큰 것으로 나타났다. 도장공과 대조군의 평균반응시간 차이의 타당도는 연습수행 후 1분의 검사시간에서 높았다. 부호숫자짝짓기의 초기에는 검사에 대한 미숙함 등이 많이 개입되며,시도의 횟수가 증가함에 따라 학습효과의 개입이 증가하였다. 5∼7번째 시도의 평균반응시간에 대한 t 동계량이 가장 컸다 손가락두드리기의 경우 우수는 학습 효과에 의해 시도가 반복될수록 두드린 횟수가 증가하는 경향이 있었고 열수는 피로에 의해 두드린 횟수가 점차 감소하는 경향이 있었다. 결론: 따라서 단순반응시간은 연습수행 1회 후 1분(1회째)의 검사를 분석에 이용하고,부호숫자짝짓기는 검사 시작 후 4번의 시도들을 연습수행으로 하며 ,이후 연속적인 3번의 시도에 대한 평균반응시간을 대표값으로 이용하고,손가락두드리기는 연습수행 1회 후 1,2번째 시도의 평균 두드린 횟수를 분석에 이용하면 타당도를 높이고 시간을 절약할 수 있을 것이다. Objective: A cross-sectional study was performed to assess changes in computerized neurobehavioral performance across multiple test sessions for developing a valid performance level and reducing test time. Methods: The study was conducted on 118 male car painters exposed to low-dose, mixed organic solvents. The study controls were 113 unexposed reference workers matched for age and educational year from different sections of the same factory. Each worker completed a medical and occupational exam and questionnaire. Three tests of the Swedish Performance Evaluation System (5 minutes of Simple Reaction Time, 9 sessions of Symbol Digit, and 4 sessions of Finger Tapping Speed) were administered to each group. Results: The mean age, mean duration of employment, and mean years of education were 33 years, 6.7 years, and 12 years in both groups, respectively. The mean reaction times of the Simple Reaction Time increased with the lapse of time. The known group difference between the exposed and control groups was larger for the first minute than for the successive 3 minutes. Both groups showed improved performance across the first to the seventh sessions on Symbol Digit. Following the seventh session, the performance levels of Symbol Digit had worsened. The t statistic of the two groups was the largest when the two mean reaction times were calculated from the sessions of the fifth to the seventh, In the dominant and non-dominant hands, the number of taps increased and decreased, respectively, across the sessions on Finger Tapping Speed. The known group difference was the largest when comparing the performances from the first to the second sessions. Conclusions: For valid interpretation and timesaving in computerized neurobehavioral tests, the following is recommended: one practice and one test session for Simple Reaction Time, four practice and three test sessions for Symbol Digit, and one practice and two test sessions for Finger Tapping Speed.

선반 주축대 결합부가 주축계의 동특성에 미치는 영향

정인성,홍동표,박대원,유성기 全北大學校 1989 論文集 Vol.31 No.-

Generally machine tool has a lot of blocks and contact surfaces for the reason of easiness to manufacture, repair and transport. Even though B.B.S(Building Block System) has lower static stiffness than solid system, B.B.S has advantages of vibration reduction and dynamic stability. In this study, the column model was fixed to the bed by means of inserting thin metallic sheets or gilding on contact surface and obtained the interesting result-these bolted joints improve dynamic characteristics as well as static stiffness-. The result of the model test was applied at the actual lathe by inserting 0.3mm metallic sheets between headstock and bed among the cycle of workpiece-headstock-bed-tool. Similar conclusion was obtained in the actual lathe, that is, dynamic characteristics of spindle system and surface roughness of workpiece are improved according to the hardness of inserted materials.

저 지연시간 CELP 음성 부호화기 성능 개선에 관한 연구

鄭昌京,張泰成,李乃仁 明知大學校 産業技術硏究所 1994 産業技術硏究所論文集 Vol.13 No.-

This paper presents a good-quality 8 kb/s speech coder which has one-way coding delay less than 5 ms. The coder achieves one-way coding delay of less than 5 ms by masking both the LPC predictor and the excitation gain backward-adaptive, and by using a small excitation vector size of eleven samples. We propose a low delay excitation reconstruction algorithm based on a vector quantized multi-tap adaptive codebook or a single gain fixed codebook in producing a good quality speech signal operating at 8 kb/s.

온실의 환기제어를 위한 PID제어 시뮬레이션

정태상,김태규,김명규,문성동 진주산업대학교 1998 산업과학기술연구소보 Vol.- No.5

본 연구는 소형 모형 온실에 환경계측제어 장치를 설치하여 환기 냉방제어계의 온도 예측 수식모형 동정에 필요한 파라미터 식별을 실행하였고, 그 결과를 기초로 하여 비례적분미분제어법을 이용한 환기 냉방제어 시뮬레이션을 실시하였다. 그 결과 가장 우수한 제어성능을 나타내는 PID게인은 kp=1, ki=5, kd=1로 나타났다. 또한 PID제어법은 작은 환경의 변화, 제어방법, 계절변화 등에 적응하기 위해서는 게인의 변동은 필수적이라 생각된다. In this paper, parameters of mathematical model of temperature prediction for the ventilating cooling system were identified in a model greenhouse built for this study. With results from the parameter identification, operation simulations on ventilating cooling systems were carried out by proportional integrated derivative(PID) control. And them most efficient PID gains were verified, that is kp=1, ki=5, kd=1. The PID control was superior in temperature control, altough it needed to adjust gains according to daily variation, vent control methods, seasonal variations, and etc.