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정경태,박병수,최호순,고정희,박강서,조병석,이현상,최덕례 대한소화기내시경학회 1994 Clinical Endoscopy Vol.14 No.3
Endoscopic infection sclerotherapy(EIS) has been shown to be the most effective simple method for control of bleeding and eradication of varices. This method has been accepted widely as a standard treatment of bleeding esophageal varices. However, EIS may be associated with undesirable local and systemic complications. Endoscopic variceal ligation(EVL) was first described in 1986 by Stiegmann et al, which consists of mechanical ligation and thrombosis of varices using elastic $quot;0$quot;-ring. EVL has been shown to control active bleeding and to eradicate varices when sessions are repeated. The purpose of this study was to compare with change of esophageal variceal form, with respect to safety, efficacy and complications of EVL in the each sessions. We performed EVL in 43 patients who had recently bled from esophageal varices. Total 679 variceal ligations were performed during 174 separyte EVL sessians. Eighteen(94.7%) of those actively bleeding(19 patients) at initial treatment had bleeding controlled at initial session. During the study period two patients died after 1st and 3rd session, one who died from aggravation of concomitant hepatoma with rebleeding, the other died from early massive rebleeding after 3rd session. Rebleeding, before eradicates varices, occured in 7 patients(16.3%) two patients had bled from varices with aggravation of concomitant hepatoma, other 2 patients had bled from early varices ligation, other 3 patients had bled from re-varices formation in fundus of the stomach. Varices were eradicated or reduced to F₁ in 36 patients(87.8%) of the 41 follow up patients. Each patient received mean 15.8 ligations and 4.1 sessions during the 1st to 6th sessions. Eradication rate of varices(F_0) has increased from the 3rd to the 4th session periods. Improvement rate of varices(F₁) has increased from the 1st to the 3rd session periods. During the 5th or the 6h EVL sessions, eradication and improvement rate of esaphageal varices has been shown to decreased. During or after EVL, there were no major complications, except mild chest discomfort in 6 patients, early bleeding in 2 gatients, mild dysphagia in one patient of 43 patients. According to this study, EVL appears to control active variceal bleeding and eradicate varices with repeat treatments. It is a safe and effective treatment for esophageal varices bleeding. We recommended EVL as an alternative to EIS over the 5th sessions.
정경태,Tae Ho Lee,Gyong Suk Kan 한국생물공학회 2003 Biotechnology and Bioprocess Engineering Vol.8 No.3
BiP, immunoglobulin binding protein, is an ER homologue of Hsp70. However, unlike other Hsp70 proteins, regulatory protein(s) for BiP has not been identified. Here, we demonstrated the presence of potential regulatory proteins for BiP using a pull-down assay. Since BiP can bind any unfolded protein, only the ATPase domain of BiP was used for the pull-down assay in order to minimize nonspecific binding. The ATPase domain was cloned to produce recombinant protein, which was then conjugated to CNBr-activated agarose. The structural conformation and ATP hydrolysis activity of the recombinant AT-Pase domain were similar to those of the native protein. Eight proteins from metabolically labeled mouse plasmacytoma cells specifically bound to the recombinant ATPase protein. The binding of these proteins was inhibited by excess amounts of free ATPase protein, and was dependent on the presence of ATP. These proteins were eluted by ADP. Of these proteins, Grp170 and BiP where identified, while the others were not identified as known ER proteins, from Western blot analyses. The presence of the ATPase-binding proteins for BiP was first demonstrated in this study, and our data suggest similar regulatory machinery for BiP may exist in the ER, as found in prokaryotes and other cellular compartments.
X_n에서의 통일장론 기하학과 시공간 다양체에 관한 연구
정경태 연세대학교 자연과학연구소 1982 學術論文集 Vol.9 No.-
본 논문에서는, 일반화된 n차원 리이만공간 X_n에서, n차원 ^*g-통일장론 기하학의 공리계를 세워 이 기하학의 수학적 기초를 제시하고 이 공리계에서 얻어지는 결과를 연구한다. 마지막장에서는 n=2,3,4되는 낮은 차원의 통일장론 기하학 가운데서 본 저자가 얻은 결과의 개요를 간단히 소개한다. This paper present a mathematical foundation of the geometry of n-dimensional ^*g-unified feld theory (n-^*g-UFT) in a generalized n-dimensional Riemannian space X_n. In this paper we introduce an axiomatic system of the geometry of n-^*g-UFT and investigate its results. In the last Chapter of the present paper, the author's previous results for the lower dimensional cases will be briefly introduced.
공리계와 기하학 : Ⅰ. 결합공리 Ⅰ. INCIDENCE AXIOMS
정경태 연세대학교 교육대학원 1977 연세교육과학 Vol.12 No.-
The extension of the mathematical curriculum in Korean colleges has not infrequently been at the expense of some of the most valuable fields of more "old-fashioned" mathematics. Among the victims we find elementary, projective, and algebraic geometry, fields which used to stir the enthusiasm of an older generation. This decline into relative neglect not only means that mathematicians grow up poorly acquainted with one of the most attractive fields of their science, elegant in form and in results, but also means a loss of more fundamental values. This "modern" geometry of the nineteenth centry was to a considerable extent responsible for the whole revolution in mathematical thinking typical of that period ; out of it came the concepts of non·Euclidean geometry and geometry of more than three dimensions. Moreover, it has profoundly influenced axiomatics. Neglect of this part of mathematics therefore tends to stile the understanding of some of the most important notions of modern mathematics, physics, and engineering. Hence one of our main tasks of these days is to find the legitimate place for this field inside our present mathematical curriculum and to stress those fundamentals which are most vital for the understanding of our science as a whole. In the first part of this article, historical background of modern geometry such as its discovery, rise, and development is investigated. In the second, axiomatic systems of geometry are introduced. Euclidean geometry is perhaps one of the most famous examples of an axiomatic system, hut there are simpler ones which show the interrelation of the various parts without the added complications of this classical system. Chapter IV illustrates and analyzes one of the most simple examples of axiomatic systems. Finally axioms of incidence are introduced and analyzed in the last chapter of the present article.
방사성동위원소옥소(131I)에 의한 갑상선질환의 임상적연구
정경태,이문호,이범홍,김목현,장고창,김명재,이장규 대한핵의학회 1967 핵의학 분자영상 Vol.1 No.1
$quot;서울대학교 의과대학 부속병원 방사성동위원소진료실에서 1960년 5월부터 1966년 6월까지 진료한 1,716명의 각종 갑상선 질환 환자에 대하여 131I에 의한 각종 갑상선기능검사를 실시하는 동시에 갑상선 기능항진증에 대한 131I의 치료성적을 종합검토하여 아래와 같은 결론을 얻었다. 1) 1,716예의 갑상선질환중 중독성미만성선종이 596명 (34.7%)으로 가장 많았으며 비중독성결절성선종이 412명 (24.0%), 정상기능이 278명 (16.2%), 비중독성미만성선종이 236명 (13.8%), 기능저하가 89명 (5.2%), 중독성결절성선종이 53명 (3.1%), 갑상선염이 32명 (1.9%), dyshormonogenesis가 20명 (1.2%)이었다. 2) 갑상선질환의 성별 발생빈도는 남자 218명 (12.7%), 여자 1,498명 (87.3%)로 그 비는 1:6.9이었다. 3) 연령별 발생빈도는 20∼40대가 1,365명으로 가장 많았으며 이는 전예의 79.6%이었다. 4) 각종 갑상선기능검사중 131I 갑상선섭취율, 131I 혈청내방사능, T3 시험, PB131I 전화율, BMR 등의 진단적가치를 논하고 각 검사의 정상범위에 대하여 고찰하였다. 5) 갑상선 기능항진증예 545명에 대한 131I의 완치율은 초회에 68.3%, 2회에 92.3%이었으며 1회 투여량은 6mC가 가장 많았다. 6) 131I 투여$quot; Over the past 6 years, from May 1960 to June 1966, 1,716 patients with various diseases of thyroid were examined and thyroid function tests with 131I were done. Among them, 545 patients with hyperthyroidism were treated with (131)^I. A summary of the clinical data of the (131)^I-thyroid function tests and the therapeutic results of (131)^I were presented and discussed. 1) The patients examined consisted of;596 cases (34.7%) with toxic diffuse goiter, 412 cases (24.0%) with non-toxic nodular goiter, 278 cases (16.2%) with euthyroidism, 236 cases (13.8%) with non-toxic diffuse goiter, 89 cases (5.2%) with hypothyroidism, 53 cases (3.1%) with toxic nodular goiter, 32 cases (1.9%) with thyroiditis and 20 cases (1.2%) with dyshormonogenesis. 2) There were 218 (12.7%) male patients and 1,498 (87.3%) female patients, showing a ratio of 1:6.9, female predominantly. 3) The majority of patients (79.6%) were in the 3rd through 5th decades of their lives showing the peak in the 4th decades (35.9%). 4) The diagnostic values and normal ranges of (131)^I uptake test, 48 hour serum activity, T3 red blood cell uptake and PB131I conversion ratio were discussed. 5) An attention was given to dyshormonogenesis, a qualitative hypothyroidism, due to its characteristic findings of clinical and (131)^I thyroid function tests, and its pathogenesis was briefly reviewed. 6) Among 545 patients with hyperthyroidism treated with (131)^I, 68.3% was cured after single therapeutic dose and another 24.0% was cured after second dose. 7) The complications of (131)^I therapy were discussed in some details and myxedema had developed in 3.9% of our cases. No thyroid cancer was found after (131)^I therapy.