식도정맥류 출혈의 내시경적 결찰요법의 임상적고찰

정경태,박병수,최호순,고정희,박강서,조병석,이현상,최덕례 대한소화기내시경학회 1994 Clinical Endoscopy Vol.14 No.3

Endoscopic infection sclerotherapy(EIS) has been shown to be the most effective simple method for control of bleeding and eradication of varices. This method has been accepted widely as a standard treatment of bleeding esophageal varices. However, EIS may be associated with undesirable local and systemic complications. Endoscopic variceal ligation(EVL) was first described in 1986 by Stiegmann et al, which consists of mechanical ligation and thrombosis of varices using elastic $quot;0$quot;-ring. EVL has been shown to control active bleeding and to eradicate varices when sessions are repeated. The purpose of this study was to compare with change of esophageal variceal form, with respect to safety, efficacy and complications of EVL in the each sessions. We performed EVL in 43 patients who had recently bled from esophageal varices. Total 679 variceal ligations were performed during 174 separyte EVL sessians. Eighteen(94.7%) of those actively bleeding(19 patients) at initial treatment had bleeding controlled at initial session. During the study period two patients died after 1st and 3rd session, one who died from aggravation of concomitant hepatoma with rebleeding, the other died from early massive rebleeding after 3rd session. Rebleeding, before eradicates varices, occured in 7 patients(16.3%) two patients had bled from varices with aggravation of concomitant hepatoma, other 2 patients had bled from early varices ligation, other 3 patients had bled from re-varices formation in fundus of the stomach. Varices were eradicated or reduced to F₁ in 36 patients(87.8%) of the 41 follow up patients. Each patient received mean 15.8 ligations and 4.1 sessions during the 1st to 6th sessions. Eradication rate of varices(F_0) has increased from the 3rd to the 4th session periods. Improvement rate of varices(F₁) has increased from the 1st to the 3rd session periods. During the 5th or the 6h EVL sessions, eradication and improvement rate of esaphageal varices has been shown to decreased. During or after EVL, there were no major complications, except mild chest discomfort in 6 patients, early bleeding in 2 gatients, mild dysphagia in one patient of 43 patients. According to this study, EVL appears to control active variceal bleeding and eradicate varices with repeat treatments. It is a safe and effective treatment for esophageal varices bleeding. We recommended EVL as an alternative to EIS over the 5th sessions.

초고층 건축물의 비정형 입면디자인 요소 및 구조시스템

정경태 대한건축학회지회연합회 2023 대한건축학회연합논문집 Vol.25 No.4

As the demand for high-rise buildings increased, the standardized box shape was converted into a new trend of atypical shape. In this study, 50 cases of atypical skyscrapers with a scale of 200m or more were selected as research subjects in order to explore the design trends of future atypical skyscrapers through various cases of atypical skyscrapers constructed around the world. In addition, the application status of the structural system according to the atypical form of the high-rise building was analyzed. As a result of the analysis, atypical forms of current high-rise buildings appeared to have the highest frequency of application in the order of Taper, Curve, Twist, Free-Shape, and Folding elements. In addition, as a result of analyzing the application frequency of the structural system, it was found that the Outrigger Frame, Shear Walled Frame, and Diagrid Frame systems were applied in the order. As a result of the study, it is judged that it will be possible to identify the tendency of structural systems with relatively high application frequency from atypical facade design elements. 초고층 빌딩의 수요가 높아질수록 획일화된 박스형태는 비정형 형상이라는 새로운 경향으로 전환되었다. 이러한 경향은 국내에서도 뚜렷하게 나타나고 있으나 해외 사례에 비해 초기단계에 머물고 있다. 본 연구에서는 전 세계적으로 활발히 건설되는 다양한 비정형 초고층 빌딩 사례를 통해 향후 비정형 초고층 건축물의 디자인 경향을 모색하고자 200m 이상의 규모를 갖는 비정형 초고층 건축물을 50건을 연구대상으로 선정하였다. 또한, 초고층 건축물의 비정형 형태에 따른 구조시스템 적용현황을 분석하였다. 분석결과, 현재 초고층 건축물의 비정형 형상은 Taper, Curve, Twist, Free- Shape, Folding 요소 순으로 적용빈도가 가장 높게 나타났다. 또한, 비정형 형태 요소별 구조시스템의 적용빈도를 분석한 결과, Outrigger frame, Shear Walled Frame, Diagrid Frame 시스템 순으로 적용된 것으로 나타났다. 연구결과, 비정형 입면디자인 요소로부터 상대적으로 적용빈도가 높은 구조시스템 경향을 파악할 수 있을 것으로 판단된다.

방사성동위원소옥소(131I)에 의한 갑상선질환의 임상적연구

정경태,이문호,이범홍,김목현,장고창,김명재,이장규 대한핵의학회 1967 핵의학 분자영상 Vol.1 No.1

$quot;서울대학교 의과대학 부속병원 방사성동위원소진료실에서 1960년 5월부터 1966년 6월까지 진료한 1,716명의 각종 갑상선 질환 환자에 대하여 131I에 의한 각종 갑상선기능검사를 실시하는 동시에 갑상선 기능항진증에 대한 131I의 치료성적을 종합검토하여 아래와 같은 결론을 얻었다. 1) 1,716예의 갑상선질환중 중독성미만성선종이 596명 (34.7%)으로 가장 많았으며 비중독성결절성선종이 412명 (24.0%), 정상기능이 278명 (16.2%), 비중독성미만성선종이 236명 (13.8%), 기능저하가 89명 (5.2%), 중독성결절성선종이 53명 (3.1%), 갑상선염이 32명 (1.9%), dyshormonogenesis가 20명 (1.2%)이었다. 2) 갑상선질환의 성별 발생빈도는 남자 218명 (12.7%), 여자 1,498명 (87.3%)로 그 비는 1:6.9이었다. 3) 연령별 발생빈도는 20∼40대가 1,365명으로 가장 많았으며 이는 전예의 79.6%이었다. 4) 각종 갑상선기능검사중 131I 갑상선섭취율, 131I 혈청내방사능, T3 시험, PB131I 전화율, BMR 등의 진단적가치를 논하고 각 검사의 정상범위에 대하여 고찰하였다. 5) 갑상선 기능항진증예 545명에 대한 131I의 완치율은 초회에 68.3%, 2회에 92.3%이었으며 1회 투여량은 6mC가 가장 많았다. 6) 131I 투여$quot; Over the past 6 years, from May 1960 to June 1966, 1,716 patients with various diseases of thyroid were examined and thyroid function tests with 131I were done. Among them, 545 patients with hyperthyroidism were treated with (131)^I. A summary of the clinical data of the (131)^I-thyroid function tests and the therapeutic results of (131)^I were presented and discussed. 1) The patients examined consisted of;596 cases (34.7%) with toxic diffuse goiter, 412 cases (24.0%) with non-toxic nodular goiter, 278 cases (16.2%) with euthyroidism, 236 cases (13.8%) with non-toxic diffuse goiter, 89 cases (5.2%) with hypothyroidism, 53 cases (3.1%) with toxic nodular goiter, 32 cases (1.9%) with thyroiditis and 20 cases (1.2%) with dyshormonogenesis. 2) There were 218 (12.7%) male patients and 1,498 (87.3%) female patients, showing a ratio of 1:6.9, female predominantly. 3) The majority of patients (79.6%) were in the 3rd through 5th decades of their lives showing the peak in the 4th decades (35.9%). 4) The diagnostic values and normal ranges of (131)^I uptake test, 48 hour serum activity, T3 red blood cell uptake and PB131I conversion ratio were discussed. 5) An attention was given to dyshormonogenesis, a qualitative hypothyroidism, due to its characteristic findings of clinical and (131)^I thyroid function tests, and its pathogenesis was briefly reviewed. 6) Among 545 patients with hyperthyroidism treated with (131)^I, 68.3% was cured after single therapeutic dose and another 24.0% was cured after second dose. 7) The complications of (131)^I therapy were discussed in some details and myxedema had developed in 3.9% of our cases. No thyroid cancer was found after (131)^I therapy.

후쿠시마 방사능 오염수의 거동 및 해양생물에의 영향

정경태,김경옥,김미경,Chang, Z,Qiao, F,Maderich, V,Brovchenko, I,Bezhenar, R 한국해양환경·에너지학회 2014 한국해양환경·에너지학회 학술대회논문집 Vol.2014 No.5

역의 관점에서 바라보는 신명사도의 구조론적 분석

정경태,정승안 한국사회학회 2023 한국사회학회 사회학대회 논문집 Vol.2023 No.12

Salmonella typhimurium lipid A를 처리한 식세포 존재 조건에서 mitogen에 유도되는 이자 세포의 증식억제

정경태,강경숙 한국생명과학회 2007 생명과학회지 Vol.17 No.2

사람의 장티푸스 연구는 생쥐에 감염되는 Salmonella typhimurium를 모델로 연구되고 있으며, 생쥐에 있어서 S. typhimurium의 감염은 이자세포의 증식반응을 감소시키는 것으로 알려져 있다. S. typhimurium lipid A의 처리가 T 세포 mitogen에 의한 이자 세포의 증식에 어떤 영향을 주는 가를 in vitro와 ex vivo 조건에서 알아 보았다. Lipid A 단독 처리는 이자 세포의 증식을 보였으나, lipid A 처리 후 T 세포 mitogen인 concanavalin A (Con A)와 phytohemagglutinin (PHA)에 의한 in vitro와 ex vivo 조건에서의 이차 처리는 오히려 세포증식이 억제되었다. Lipid A를 주사한 생쥐로부터 분리한 이자 세포에서 대식세포를 제거하였을 조건에서는 T 세포 mitogen에 의한 증식 효과가 유지되었으나 대식세포를 제거하지 않았을 경우에는 T 세포 mitogen에 의한 증식 효과가 억제되었다. Lipid A를 주사한 생쥐에서 얻은 대식세포를 포함한 이자세포의 숫자를 증가하면서 Lipid A를 주사하지 않은 생쥐에서 얻은 이자세포와 혼합 배양하였을 때 Lipid A를 주사한 생쥐에서 얻은 대식세포를 포함한 이자세포의 숫자가 높을수록 Con A와 PHA에 의한 증식억제가 높게 측정되었다. 이러한 결과는 Con A와 PHA의 이자세포 증식 기능이 lipid A의 전처리에 의해 활성화된 대식세포의 직접적인 접촉 작용으로 억제된 것으로 생각된다. 본 연구의 결과를 바탕으로 억제에 관여하는 대식세포 표면분자를 밝히는 것이 사람의 장티푸스 연구에 도움이 되리라 생각된다. Infection with virulent or attenuated Salmonella typhimuriumhas known to induce reduction in proliferative responses of spleen cells. We investigated a role of lipid A from S. typhimurium, a B cell mitogen, on proliferation of spleen cells by T cell mitogens such as concanavaline A and phytohemagglutinin under in vitro and ex vivo conditions. Lipid A alone induced proliferation of spleen cells in vitroin a dose-dependent manner. However, subsequent treatment of concanavaline A or phytohemagglutin in after lipid A treatment induced proliferation suppression of murine spleen cells in vitro and ex vivo. Removal of macrophages from spleen cells, which were obtained from a lipid A-injected mouse, restored proliferation by concanavaline A and phytohemagglutinin, indicating that macrophages appeared to play a role in lipid A-induced suppression. Secreted molecules from macrophages did not accounted for the suppression because suppressive effect was not achieved when the supernatant from macrophage-containing spleen cell culture was conditioned to macrophage-depleted spleen cell culture. Co-culture of spleen cells from lipid A-treated and –untreated mice showed proliferation suppression as increasing cell numbers of lipid A-treated mouse. These data suggested that the cell-to-cell contact of macrophage with splenic lymphocyte cells is responsible for immune responses against lipid A, which is applicable to the case of human S. typhi infection.

국내 최초 보툴리누스 중독증 발생 1예

정경태,강도현,유천권,최종현,성원근 대한임상미샐물학회 2003 Annals of clinical microbiology Vol.6 No.2

학술발표(學術發表) 연제(演題) 및 초록(抄錄) 제사부(第四部): 공중위생(公衆衛生),생리(生理),어병(魚病),법령(法令),분야(分野) : 24. 시험동물에서 설파제 투여에 의한 체내잔류량 조사

정경태,조헌호,이강록,김근규 한국동물위생학회 1997 학술대회논문집 Vol.1997 No.-

Isolation of Proteins that Specifically Interact with the ATPase Domain of Mammalian ER Chaperone, BiP

정경태,Tae Ho Lee,Gyong Suk Kan 한국생물공학회 2003 Biotechnology and Bioprocess Engineering Vol.8 No.3

BiP, immunoglobulin binding protein, is an ER homologue of Hsp70. However, unlike other Hsp70 proteins, regulatory protein(s) for BiP has not been identified. Here, we demonstrated the presence of potential regulatory proteins for BiP using a pull-down assay. Since BiP can bind any unfolded protein, only the ATPase domain of BiP was used for the pull-down assay in order to minimize nonspecific binding. The ATPase domain was cloned to produce recombinant protein, which was then conjugated to CNBr-activated agarose. The structural conformation and ATP hydrolysis activity of the recombinant AT-Pase domain were similar to those of the native protein. Eight proteins from metabolically labeled mouse plasmacytoma cells specifically bound to the recombinant ATPase protein. The binding of these proteins was inhibited by excess amounts of free ATPase protein, and was dependent on the presence of ATP. These proteins were eluted by ADP. Of these proteins, Grp170 and BiP where identified, while the others were not identified as known ER proteins, from Western blot analyses. The presence of the ATPase-binding proteins for BiP was first demonstrated in this study, and our data suggest similar regulatory machinery for BiP may exist in the ER, as found in prokaryotes and other cellular compartments.

바커코드에 대한 최적 평균 자승 부엽 억제 필터설계 ( DESIGN of OPTIMUM MEAN SQUARE SIDELOBE SUPPRESSION FILTERS FOR BARKER CODES )

정경태,김창주,임창헌,이황수,곽영길 대한전자공학회 1992 대한전자공학회 학술대회 Vol.1992 No.1