하악골에 발생한 골막 골육종

김태우,김승범,권혁찬,문선재,윤정훈,김형준,차인호,육종인,김진 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.1

Periosteal osteosarcoma is a distinct entity of malignant bone tumor with characteristic clinical, morphological, and histological features within the group of juxtacortical osteosarcoma. Periosteal osteosarcoma is predominantly located in the tubular long bones, and extremely rarely involving the jaws. A case of periosteal osteosarcoma of the right mandible is presented. A 27-year-old woman complained of the gingival swelling and bleeding tendency of the right posterior mandible. Clinical examination revealed a reddish brown strawberry-like swelling on the affected mucosa, which measured 1.5㎝×1.5㎝. The tumor was located on the lingual cortex of the mandible and extended into the surrounding soft tissues. Microscopically, the tumor consisted exclusively of atypical chondroblastic cells with a small osteoblastic area. A minimal bone marrow involvement was noted and the adjacent cortex was free of tumor. These findings suggested that the tumor originated from the periosteal cambium layer, which lies between the periosteal fibrous layer and the cortex of mandible.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

老齡者의 建康을 위한 生活習慣 實態調査

申東敏,長鳳愚,李揆文,金賢俊,金昌範,崔宗洙,崔鍾晥,李鍾珏,金圭碩,趙庚旭,金鍾聲,朴鍾振 平生體育硏究所 論文集 1987 平生體育硏究所 論文集 Vol.2 No.-

With a view to examining the habit and method in which old people maintain and improve their health, we consulted 551 men and 444 women who were over 65 years old, and concluded as follows: 1. Habit of eating It's been revealed that most of the old people keep a regular eating hour, control the quantity of meal or eat a little food, and prefer vegetables to meat. 2. Mental health Old people feel the necessity for mental health and most of them (about 80%) keep good mental health without becoming pessimistic. Their chief concenrs have turned out to be about their sons and daughters and their own health and finance. 3. Managing Good Health It has been revelaed that old people do not possess any special kind of secret to keep good health but taking plenty of rest, regular meal, and proper exercise, and many of them (about 60%) have been shown to eat invigorant food that they can easily get around their living area. 4. Physical Functions It has been revealed that many old people are conscious of some symptoms about their parts of body and about to percent of them suffers from neuralgia. Some measures like medical aid especially for old people need to be taken as soon as possible. As we have found that the health-keeping method of old people consists plenty of rest, proper exercise, and appropriate nutrition, we can conclude that the recreatonal and culture facilities and programs for keeping old people in good health should be developed. It is also necessary to study food that contribute to their health and develop ways to get rid of the stresses to which they are exposed in their daily life. Presides, it is natural that government found an administrative department to deal with these matters effectively.

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

고속도로 휴게소 오수의 특성(I)

김종오,서성규,김상채,이우범 木浦大學校 沿岸環境硏究所 1999 沿岸環境硏究 Vol.16 No.1

The sewage characteristics in the highway service area were investigated according to an interval of 2hrs for 24hrs. and seasonal variation to use them as the basic data for operating and maintaining those sewage treatment units. The range of temperature, pH and DO as physical characteristics were 15.1 ∼ 23.6℃, 6.6 ∼7.4 and 1.1 ∼ 2.2 mg/L, respectively, and found to be appropriate to the biological treatment. The sewage concentrations were larger than those of the general domestic sewage but analogous to those of shopping center and office. Specially, BOD and SS concentraions among them were analogous to those of Japan. The variation of sewage characteristics for 24hrs were insignificant except at high-demand time. It was observed that those concentrations were insignificantly changed with seasonal variation(spring, summer, autumn, winter) except temperature.

마우스에서 전기자극 스트레스의 면역조절 효과

김정범,박종욱,배재훈 대한생물치료정신의학회 1996 생물치료정신의학 Vol.2 No.2

전기자극 스트레스가 마우스의 면역계에 미치는 영향을 조사하기 위해 체액성과 세포성 면역반응을 조사하고, 이 면역반응 결과에 대한 면역조절 기전을 이해하기 위해 전기자극 스트레스가 사이토카인의 유전자 발현에 미치는 영향을 조사하였다. 생체내 면역반응을 평가하기 위하여 흰쥐 적혈구에 대한 특이항체생성반응은 스트레스군에서 대조군보다 항체생성반응이 감소하였다. DNFB에 대한 접촉성 과민반응 실험에서 T24는 스트레스군과 대조군 간에 차이가 없었으나 T48는 T24에 비해 스트레스군에서 증가를 보였다. Phytohemagglutinin으로 자극된 비장 단핵구의 증식에 미치는 영향을 알아보기 위해 ³H-thymidine incorporation 검사를 실시한 결과 스트레스군에서 대조군보다 세포증식반응이 증가되었다. 전기자극 스트레스에 의한 면역조절 기전을 이해하기 위하여 사이토카인의 유전자 발현을 조사한 결과 스트레스군에서 대조군에 비해 IL-2, IL-6의 유전자 발현이 억제되고 IL-1, IL-12,GM-CSF,MIF등의 유전자 발현에는 대조군과 차이가 없음을 보였다. 이상의 결과를 볼 때 전기자극 스트레스에 의해 체액성 면역반응이 저하된 현상은 면역반응 활성화와 항체 생성에 중요한 IL-2및 IL-6 유전자 발현의 억제와 연관이 있을 것으로 생각되며, 스트레스군에서 IL-2 유전자 발현의 억제에도 불구하고 mitogen에 의한 세포증식반응이 증가한 현상을 해명하기 위해서는 보다 다양한 실험조건의 적용이 필요하며 더 나아가 스트레스에 의한 동물의 행동반응 또는 신경내분비계에서 나타날 수 있는 변화들과의 연관성에 대한 계속적인 연구가 필요할 것으로 생각된다. To explore the molecular mechanisms by which electric footshock has immunomodulatory effects, the effects of electric footshock, on the humoral and cell-mediated immune responses of ICR mice and then the gene expression of cytokines in splenocytes, including interleukin-1(IL-1), IL-2, IL-6, IL-12, the migration inhibitory factor(MIF), and the granulocyte macrophage-colony stimulating factor(GM-CSF), were investigated. Mice were subjected to electric footshock for 3 days(two sessions a day, 11 footshocks a 31-min session). The humoral response was measured using ICR mice immunized with rat RBC. The cell-mediated immune response was evaluated by contact. hypersensitivity to 2,4-dinitrofluorobenzene(DNFB) and by phytohemagglutin(PHA)-stimulated splenocytes proliferation assay. In the stressed group, electric footshock suppressed significantly the anti-rat RBC antibody(P<0.05), but enhanced significantly T48 relative to T24 in contact hypersensitivity(P<0.01) and T-cell proliferation response(P<0.05) by PHA stimulation relative to the control group. The gene expression of IL-2 and IL-6 were suppressed significantly in PHA-stimulated splenocytes, but that of IL-1, IL-12, GM-CSF and MIF were not. In conclusion, suppressed IL-6 gene expression seems to account for suppressed humoral immune response. In spite of enhanced cell-mediated immune response, the result is that IL-2 gene expression was suppressed, which suggests the two putative mechanisms. Firstly, while in the stressed group production of IL-2 occurs rapidly and thereafter declines abruptly, in the control group that of IL-2 occurs slowly and thereafter declines gradually. Secondly, there may be certain detouring circuits extending the signal conduction system by IL-2 except the usual signal conduction system.

폐쇄성 황달로 내원한 담관내 증식을 동반한 간세포암 1예

김승범,김태년,이호찬,박재현,은종렬,장병익,이헌주,윤성수,배영경 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

The incidence of hepatocellular carcinoma presenting as obstructive jaundice is 0.7 -9% The mechanisms of obstructive jaundice include bile duct invasion by tumor, tumor thrombi, blood clots, direct bile duct compression by tumor, and intraductal tumor growth. We report a rare case of hepatocellular carcinoma with intraductal growth A 46-year-o1d woman was admitted due to colicky right upper abdominal pain and jaundice for 4 days Computed tomography showed dilatation of the left intrahepatic duct, and endoscopic retrograde cholangiography showed a filhng defect in the left main intrahepatic duct. We performed a left lobectomy with a Roux-en-Y hepaticojejunostomy. The tumor was diagnosed as a hepatocellular carcinoma with intraductal growth.

소나무와 잣나무 원목에서 변재변색 발생

김규혁,김재진,나종범 한국목재공학회 2002 목재공학 Vol.30 No.2

본 연구는 동절기 (1월 중순)에 벌채된 후 목재집하장으로 운반되어 야적장에 저목 중인 소나무와 잣나무 원목을 대상으로 변재변색의 발생시기와 변색 특성을 조사하기 위하여 수행되었다. 벌채 후 3, 4, 5, 6, 8개월 경과시 변색 평가를 실시하였는데, 매 평가시 원목 3개를 임의로 선정하여 원목당 수축방향에 대해 일정 간격으로 7∼9개의 두께 3 ㎝ 원판을 채취하여 변색 원인균을 분리한 후 변재변색의 방사방향 최대 침투깊이와 % 변색율을 측정하였다. 변재변색은 전적으로 층형변색이었으며, 주요 변색원인균인 Ophiostomatoid 균을 매개하는 수피천공충은 소나무좀으로 확인되었다. 소나무와 잣나무 원목은 5월 이전까지는 변재변색의 위험없이 저목할 수 있으나 5월 이후부터는 원목의 변재변색이 급속하게 증가하였다. 변색의 정도는 소나무보다 잣나무에서 심하였으며, 장마철 저목 중에 소나무 원목에서 개떡버섯과 치마버섯의 자실체를 다수 관찰할 수 있었다. 본 연구를 통해 밝혀진 결과들은 앞으로 동절기에 벌채되어 저목 중인 소나무와 잣나무 원목에 발생하는 변재변색을 예방하기 위한 제반 조치를 취하는데 매우 중요한 자료로 사용될 것이다. This study was conducted to investigate the influence of storage time on the sapstain development of Japanese red pine and Korean pine logs during storage in log yard, and their stain characteristics. Japanese red pine and Korean pine trees were harvested and cut into logs in mid January of 2001. These logs were transported to the two local sawmills where they were closely stacked in remote parts of log yard. The logs were then sampled destructively by cutting seven to nine 3-㎝ long discs along the length of each log at intervals of 3, 4, 5, 6, and 8 month after felling. The stain coverage and maximal radial penetration of stain were measured from the discs of the sampled logs after the isolation of causal staining fungi. The sapstain was primarily infested by the attack of bark beetles and the species of bark beetle was identified as Tomicus piniperda. The main fungal species isolated from stained wood was Ophiostoma species. Based on the present study, the logs could be stored in log yard until May without stain; but stain development was rapid after May and the severity of stain increased proportionally with storage time. Korean pine was more susceptible to fungal stain than Japanese red pine. During summer storage, decay started to develop in logs and the main species were identified as Tyromyces sp. and Schizophyllum commune. Information provided in this paper would be very useful to develop more effective control strategies for sapstain prevention in Japanese red pine and Korean pine logs.

전리수에서의 STS304의 부식

이종권,박소연,김범식 순천향대학교 산업기술연구소 2006 순천향 산업기술연구소논문집 Vol.12 No.1

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成人 排球選手들의 Sports 傷害에 關한 硏究

金昌範,金顯俊,朴鍾振 忠北大學校 平生體育硏究所 1991 平生體育硏究所 論文集 Vol.5 No.-

After I investgated the matters about the sprots injuries of the one hundred and twenty-nine men and women volleyball players who belonged to a business volleyball league and played in the volleyball game of President Cup in 1992, I got the following results. 1. It was found that many player suffered from sports injuries between one and three years after they began the sport, the time when the injuries happened was the middle of the main sport, and the season when the injuries happened is almost winter. 2. It was found that the most state when the injuries happened was in the middle of exericise, the part of body where the injuries happened was mainly hand or ankle, and when the injuries happened, the used sport technique was mainly when the player made a blocking, trained their bodies, made a landing , and so on. 3. It was found that the first aid which was needed when the sport injuries happened was mainly given by the coach, director, or colleague, and after the first aid the players were treated at the hospital or went to the herb doctor. 4. It was found that the length of the time when the players could not take part in the game was mainly below a month and after about seventy of eighty percent recovery, they took part in the game again. 5. It was found that the main causes of injuries accurrences were the carelessness of the players', the lack of warming-up, and so on, and the ways by which injuries could be reduced were the cultivation of the power of concentration and mental power, and the sufficient warming-up.