서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

조혈모세포이식 환자에서 발생한 Cytomegalovirus 질환의 특징 : 일개 대학변원에서 최근 10년간의 경험

최수미,이동건,박선희,김시현,김유진,민창기,김희제,이석,최정현,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Studies on cytomegalovirus (CMV) diseases in Korean hematopoietic stem cell transplant (HSCT) recipients are lacking and do not reflect the recent trends of advances and changes. Therefore, we tried to analyze the clinical features of CMV diseases in HSCT recipients over the past 10 years at a tertiary university hospital in Korea. Methods : Retrospective review of medical records was done for all adult HSCT patients who received transplant at the Catholic HSCT Center from January 1998 to January 2008. Results : Forty-four cases (2.2%) of CMV diseases were identified. CMV pneumonia was diagnosed in 17 patients, retinitis in 16 patients, enterocolitis in 7 patients, esophagitis 1 patient, gastritis in 1 patient, duodenitis in 1 patient, and hepatitis in 1 patient. The median onset of symptom was 90 days after transplantation. Late CMV diseases accounted for 47.7%. CMV related death varied from 0 to 58.8% according to the involved organ. CMV retinitis was diagnosed relatively later in the course of transplantation mostly in patients who had chronic graft versus host disease (GVHD). On the contrary, CMV enterocolitis mainly occurred in patients who suffered from acute GVHD. The overall concurrent CMV reactivation was documented to be 63.6%: the concurrent CMV reactivation was observed only in 37.5% of patients with retinitis. Conclusions : We observed some differences in the pattern of CMV disease manifestation according to the involved organ and reconfirmed the fact that CMV pneumonia is the most common and fatal disease in HSCT recipients. Additionally, CMV retinitis was not uncommon in HSCT recipients. Since specific marker does not exist in predicting retinitis, regular ocular examination should be done thoroughly, especially in patients with chronic GVHD.

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

韓國傳統寺刹建築의 配置構成과 佛書의 構圖技法間의 關係硏究 : 구례 천은사의 사찰배치를 중심으로

李郁,崔武革,孔宗烈 경북대학교 산업기술연구소 1989 産業技術硏究誌 Vol.17 No.-

This study aims at revealing the building composition of Buddhist temples built in Chosun era from the compositional intention of Buddhist painting. A result of compare the building composition of Buddhist temples to the compositional intention of Buddhist painting are as follow: 1. A Buddhist temple are divided into three categories like a compositional method of Buddhist painting : building groups of gods, Buddhisttvas, and Buddhas. 2. The irregular layout of Buddhist architecture is resemblant with irregular composition of Buddhist painting. From the above results, the site layout of Buddhist temples could be concluded that the two dimensional composition of Buddhist painting were extended into three dimensional building compositon.

가락국의 소국형성과 가야연맹과 전개

이종욱 西江大學校 人文科學硏究所 1997 서강인문논총 Vol.7 No.-

한국산 나비목(Lepidoptera)의 발향린(Androconia)에 관한 주사 전자현미경적 연구 Ⅰ. 뱀눈나비과

이종욱,차진열,류성만 嶺南大學校附設 基礎科學硏究所 1988 基礎科學硏究 Vol.8 No.-

한국산 Satyridae 에서 보고된 35종 중 북한산 11종과 채집하지 못한 3종을 제외한 21종을 재료로 광학현미경으로 발향린의 유무 및 분포를 확인하였다. 이중 발향린이 관찰된 9종을 대상으로 주사전자현미경으로 그 형태를 비교 연구하였다. 1. 발향린이 관찰된 종은 Coenonympha ammaryllis Cramer, Erebia wanga Bremer, Eumenis antonoe Esper, Lopinga achine Scopoli, Minois dryas Scopoli, Pararge deidamia Eversmann, Ypthima argus Buttler, Ypthima amphithea Menetries, Ypthima mojschulsk Bremer et Grey 9종 이었다. 2. 발향린은 암컷에서는 발견되지 않았고 수컷의 앞·뒷날개 표면(dorsal surface)에서 관찰되었다. 3. 발향린의 분포는 주로 앞날개의 둔맥과 경맥사이, 뒷날개는 주맥을 중심으로 분포하였으며, 종에 따라서 상당한 차이를 보였다. 4. Satyridae 9종의 발향린은 나발막(fimbriae), neck, 잎새(laminar), 자루병반(foot stalk)등을 갖추었으나, 부속반(accessory disk)은 가지지 않았다. 5. Satyridae 9종의 발향린은 같은 종 내의 다른 개체간, 부위에 따른 변이는 관찰되지 않았다. 6. 발향린의 성유인 물질의 분비는 샘(gland)의 생성물이 자루병반의 강(cavity)내로 들어가서 잎새(laminar), neck, 나발막(fimbrae)의 말단개구부등 발향린 전면에 걸쳐있는 구멍(pore)을 통해 분산되는 것으로 여겨진다. This paper observed through microscope the existance and the distribution of the androconia of the 21 species of Satyride among 35 ones which have been reported in Korea, excluding 11 species in north Korea and 3 one's not in collection. 9 species which were observed the androconia among these were chifely compared and studied through Scanning Electron Microscope. 1. The species observing androconia are ? Coenonympha ammaryllis Cramer, Erebia wanga Bremer, Eumenis antonoe Esper, Lopinga achine Scopoli, Minois dryas Scopoli, Pararge deidamia Eversmann, Ypthima argus Buttler, Ypthima amphithea ? Menetries, Ypthima mojschulsk Bremer et Grey. 2. The androconia was not found at the females, but only at the dorsal surface of the fore and hind wings of males. 3. The androconia was mainly distributed between the anal vein and the radius of the fore wings and at the cubitus of the hind wings, and made differences among the species. 4. The androconia of 9 species Satyridae fimbriae, nack, laminar,foot stalk, but no accessory disk. 5. The androconia of 9 species Satyridae was observed no variation at the sections and among the inviduals of the same species. 6. The secretion of the sexual attractant at the androcnia was through to be diffused into the pores at the surface of the androconia of laminar, neck, and fimbriae through the cavirty of the foot stalk of the gland.

한국산 잠자리과(잠자리목) 5종의 세포분류학적 연구

李鐘郁,愼鏞直,朴元學,金德勳 嶺南大學校附設 基礎科學硏究所 1988 基礎科學硏究 Vol.8 No.-

The chromosome study was performed in some species on the Korean Libellulidae by using squash techniques and lactopropionic orcein stain in order to define species relationship between them. The numerical and morphological differences were shown in the chromsome between the species of the stages of spermatocyte metaphase. The results obtained were summarized as follows: 1. The pattern of standard chromosome number in these species is divided into two groups; Orthetrum albistylum speciosum (UHLER), Orthetrum triangrlare melanina (SELYS), Rhyothemis fulignosa HAGEN are 13 in the haploid chromosome number. But, Crocothemis servilia servilia DRURY and Synoetrum eroticum (SELYS) are 12. 2. The shape of chromosome in these specie in divided into two groups; O. albistylum, S. eroticum eroticum, R. fulignosa, O. triangulare melania are bar or clover in shape at the spermatocyte metaphase. These species seem to be holocentric chromosome. On the other hand, C. servilia servilia is gloval and this species has monocentric chromosome. 3. The sex chromosome of five species ( O. albistylum speciosum, O. Triangulare melania, R. fulignosa, C. servilla servilia, S. eroticum eroticum ) are XO type. 4. Three species ( O. albistylum speciosum, O. Triangulare melania, S. eroticum eroticum ) shows the fragment chromosome in the spermatocyte metaphase. As the results, five species on the Korean Libellulidae (O. albistylum speciosum, O. triangulare melania, R. fulignosa, C. servilla servilia, S. eroticum eroticum ) is similar to each other in the external morphology, But, in the analysis of chromosome, these species is different to some degree.

수중 가청음에 의한 쏨벵이의 청각능력 : 2. 청각 임계비

이창헌,박용석,문종욱,강창익,김고환,서두옥 제주대학교 해양연구소 1999 해양자원연구소연구보고 Vol.23 No.-

수중 가청음은 어군의 행동 제어와 해양목장화에서 음향 순치에 많이 이용되고 있다. 수중 가청음에 의한 어류반응 해석을 하기 위해서는 물고기의 청각능력을 정확히 파악할 필요가 있으며,오래전부터 여러물고기의 청각능력을 관련된 연구가 수행되었다.

군에서 값을 갖는 확률분포의 합성

이재원,박성욱,김종헌 金烏工科大學校 産業技術開發硏究院 1999 産業技術開發硏究 Vol.15 No.-

In [1] Bhattacharya has shown that the sequence of the n-fold convolution powers of a probability measure μon a compact connected group G converges in the norm exponentially fast to the normed Haar measure ?? if ?? has a nonzero ??-absolutely continuous part for some κ∈N. Our main purpose in this article is that ??=?? for a symmetirc ??-absolutely continuous probability measure on G.