동종 조혈모세포이식 후 발생한 치명적 홍역 폐렴 1예

백창렬,이동건,최정현,정현화,조유경,박훈준,이승훈,박윤희,이교영,민우성,김춘추,신완식 대한감염학회 2001 감염 Vol.33 No.4

As a result of the enlarging pool of unvaccinated children and young adults, there has been an increase in measles in our countries. In these situation, it has been reported that measles associated pneumoinia is easily complicated with fatal respiratory failure, espycially in immunocompromised patients. Herein we report the case of lethal measles pneumonia after allogenic hematopoietic stem cell transplantation in adults proven by autopsy. Recently, one case of measles was encountered in 39-year-old female patients after allogenic bone marrow transplanted case (chronic myelogenous leukemia), who progressed into interstitial pneumonia pattern, despite treatment including antibiotics, immunoglobulin. The patient died of giant cell pneumonia compatible with that of measles which was comfirmed in the section of necropsy lung specimen. (Korean J Infect Dis 33:301∼309, 2001)

히스타민 및 항히스타민제가 L_(1210)백혈병세포계증식에 미치는 영향에 관한 실험적 연구

염범우,이대일,백승룡 고려대학교 의과대학 1986 고려대 의대 잡지 Vol.23 No.1

There is close relationship between growth of tumor cell and immunologic function of the host. And growth of tumor cell also partially depends on histamine which indirectly modulate degree of immunologic response of the host. However, there is no report on direct effect of histamine on the growth of tumor cell. Therefore, to evaluate direct effect of histamine on growth of tumor cell, histamine and Hz-receptor antagonist (cimetidine) were added in Fischer's culture media in concentration of 10^(-3)M , 10^(-4)M and 10^(-5)M and cultured L1:10 leukemic cell for 24,72 and 96 hours. The results are as followings; 1. Histamine iii high concentration(10^(-3)M) inhibited the proliferation of L_(1210) cell lines. 2. H2-receptor antagonist showed no inhibitory activity on the proliferation of L_(1210) leukemic cell lines a t each concentration and (10^(-3), 10^(-4) and 10^(-5)). 3. The combination of histamine and H2-receptor antagonist showed temporary inhibitory effect on the L(1210) leukemic cell lines at 24 hours culture. Above results suggest that histamine show inhibitory activity to growth of L_(1210) leukemic cell lines through H2-receptor.

Helicobacter pylori와 대장균의 Shuttle Vector 개발

조명제,이우곤,이상룡,김경희,안영숙,김성희,김현주,류복덕,최여정,윤영혜,백승철,전영석,이광호 경상대학교 유전공학연구소 1997 遺傳工學硏究所報 Vol.16 No.-

In this study, a vehicle vector using cryptic plasmids was constructed for gene transfer in Helicobacter pylori. pHP51(3.9 kb) and pHP489(1.2 kb) were selected for constructing vectors from cryptic plasmid of H. pylori isolates in Korea. The HindⅢ-digestedDNA fragment(1.2kb) of pHP489 and 1.6kb DNA fragment of pHP51 were ligated with a kanamycin resistance gene(aph3'-Ⅲ) from C. jejuni to produce the recombinant plasmids pHP489K and pHP51K, respectively. Transformation frequency of pHP51K by electroporation was low. But pHP489K could be effectively transformed into various H. pylori strains. In order to design an intermdiate vehicle vector for gene transfer into H. pylori, pBlueHP489K was prepared by recloning pHP489K DNA into pBluescript and pTZ19R vector. This vector permitted the DNA fragment containing pHP489 sequence, aph3'-Ⅲ, and cloned DNA to be cut and self-ligated in the SacⅠ site after cloning. ureA and ureB gene were inserted into pBlueHP489K, resulting in pBlueHP489K/AB. The DNA fragment containing pHP489, kanamycin resistance gene(aph3'-Ⅲ), and urease structural gene was cut away from pBlueHP489K/AB and self-ligated to generate pBlueHP489K/AB. pBlueHP489K/AB made urease-negative H. pylori strains restore their urease activity. By this experiment, pBlueHP489K was confirmed to be the vehicle system for transferring H. pylori genes.

알코올 사용 장애 환자의 스트레스와 대처 양식 및 부적응에 관한 연구

박민철,오상우,이귀행,노승호,백영석,이상열,김재현 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.2

Background: This study was explored the influences of perceived stress, coping style on maladaptation of patients with alcohol use disorders. Methods: To investigate these objects, 66 patients with alcohol use disorders were completed scales for the perceived stress, coping style, dysfunctional attitude, alcohol expectancy, self-efficacy, social support, state-trait anxiety, quantity of alcohol use, problems of alcohol use and BDI. The data were analyzed by t-test, correlation and multiple regression analysis. Results: First, the results showed the significant difference between long term group and short term group on the problem-related alcohol use and trait anxiety. Second, the results showed the significant difference between severe problem related alcohol use group and mild problem related alcohol use group on cognitive coping, negative expectancy, quantity of alcohol use. Third, among each variables of patients with alcohol use disorders, quantity of alcohol use had significantly high correlation with quantity of alcohol by family, quantity of alcohol by friends, perceived stress, negative expectancy. Problems of alcohol use had significantly high correlation with negative expectancy, cognitive coping, percieved stress, social support and self efficacy. Finally, vulnerability-stress model predicted 26.1% of variances of quantity of alcohol use, 48.9% of variances of problems of alcohol use and 13.9% variances of depression. Conclusions: The results of the study indicated the superiority of vulnerability stress model to predict quantity of alcohol use, problems of alcohol use and depression.

다형성교아세포종을 동반한 Von Recklinghausen氏 병 1예

이현개,이종수,백민우,이승재,박효일,지제근 인제대학교 1981 仁濟醫學 Vol.2 No.4

가족성으로 신경섬유종증에 동반되는 중추신경계의 종양으로 수막종, 신경교종, 신경초종 등이 있으며 이들은 드물지 않게 보고되었다. 그러나 신경교세포에 생기는 종양 중 신경섬유종증에 동반되어 대뇌에 생긴 다형성교아세포종은 매우 드물다. 본 교실에서 가족성으로 발생한 신경섬유종증의 환자에 동반된 다형성교아세포종을 경험하였으며 가족중 부친은 von Recklinghausen씨 병을, 또 두 자녀는 다발성 cafe´ au lait spots를 가지고 있었다. The tumors of the central nervous system associated with familial neurofibromatosis are meningioma, glioma, and neurilemmoma, which are not uncommon. Of the glial tumors of the central nervous system, the association of cerebral glioblastoma multiforme with neurofibro matosis is very rare. We have experienced the unusual coincidence of neurofibromatosis and glioblastoma multiforme in a 33 year old man, whose father was afflicted with von Recklinghausen's disease and whose son and daughter had also multiple cafe´ au lait spots on their bodies.

찰옥수수연구 XVIII 시설하우스에서 2기작 찰옥수수 교잡종의 주요 생육특성 비교

나웅현,복태규,고혁수,백승우,조양희,이희봉 충남대학교 농업과학연구소 2013 농업과학연구 Vol.40 No.2

The major characteristics of the developed corn hybrids were compared at each different planting time; 1st time(April 28) and 2nd time(August 20), respectively. Among traits surveyed, stem height showed highly at 1st time than 2nd, while ear height, stem diameter and ear length were similar at two times. Sugar content of the used hybrids showed highly at 2nd planting time than 1st. Pericarp thickness was also high at 2nd planting time. Especially, among hybrids CNU99 was the highest in stem height and ear length, CNU11 and CNU56 were high in sugar content, and CNU51 and CNU124 were thiner than other hybrids in pericarp thickness. Accordingly, these hybrids will be planted and recognized in 2nd yield trial for superior corn hybrid selection.

圓光醫大 附屬 第2病院 神經精神科 患者에 對한 統計的 考察(Ⅱ)

박민철,장광철,김상원,김한주,유미경,김훈,유용진,김현정,박남진,오상우,이귀행,노승호,백영석 圓光大學校 醫科大學 神經精神科學敎室 1992 圓光精神醫學 Vol.8 No.1

본 연구는 1986년 7월 11일부터 1991년 7월 10일까지 원광의대 부속 제2병원 신경정신과에서 의래 및 입원치료를 받았던 6,072명의 환자를 대상으로 병원 역학조사를 실시하고 그 결과를 1차조사 (박민철 등1986)와 비교했다. 1.전체 환자 중 남자가 54.4%로 여자보다 많았고, 이리와 이리 인접지역이 84.0%로 대부분의 지역을 나타났다. 의료보장상태는 보험환자가 57.1%, 의료보호환자21.8%, 일반환자 21.1%였으며 연령별로는 20대 24.6%, 30대 22.8%로 20대 30대가 절반정도를 차지했다. 2.외래환자에서는 신경중성장애가 46.0%로 가장 많고 정동장애, 경련성장애 순이며, 입원환자에서는 정신분열증이 30.5%로 가장 많고 기질성정신장애, 정동장애의 순이었다. 3.남자는 신경증성쟝애(23.4%), 정신분열증, 기질성정신장애 순이고 여자는 신경증성장애(39.9%), 정동장애, 정신분열증의 순이었다. 남자가 여자보다 많은 진단은 알코올정신장애(94.6%), 기질성정신장애, 소아정신장애 순이고, 여자가 남자보다 많은 진단은 정동장애(64.5%), 신경증성장애였다. 4.진단별 연령분포에서 신경증성장에는 30대(25.3%), 20대, 40대 순이고, 정신분열증은 20대(40.5%), 30대, 40대 순이며, 정동장애는 20대, 30대, 50대 순이나 비교적 비슷한 융이었다. 5.진단별 발병연령에서 신경증성장에는 20대, 30대가 절반이고,정신분열증은 20대(51.3%), 10대, 30대 순이며 정동장애는 20대(30.7%), 30대, 50대 순이었다. 진단별 평균 발병연령은 신경증성장애 32.7세, 정동장애 36.1세, 정신분열증 23.6세였다. 6.진단별 이병기간은 2년이상이 신경증성장에 28.3%, 정신분열증 68.5% 정동장애 43.9%인데 전체적으로 41.0%였다. 진단별 평균 이병기간은 정신분열증 73.2개월, 정동장애 45.5개월, 신경증성장애 29.5개월이었다. We examined epidemiologic study of 6,072 patients who visited Wonkwang Neuropsychiatric hospital since July 11 of 1986 until July 10 of 1991 and compared this results with previous study(Park et al 1986). The study revealed as follows:1. Of total patients males visited this hosptial more than females as 57.1%, Most of them(84.0%) resided Iri and neighbouring Iri. In the point of insurance, insured patients, medicaid patients and uninsured patients were 57.1%, 21.8% and 21.1% respectively. On the distribution of age, the twenties, the thirties were 24.6%, 22.8% respectively and twenties and thirties were about half of total patients. 2. Of outpatients neurotic disorder was the most as 46.0%, secondly mood disorder and thirdly convulsive disorder, but of inpatients schizophrenia was the most as 30.5%, secondly organic mental disorder and thirdly mood disorder. 3. Of males neurotic disorder was the most as 23.4%, secondly schizophrenia, and thirdly organic mental disorder, but of females neurotic disorder was the most as 39.9%, secondly mood disorder and thirdly schizophrenia. alcoholic mental disorder(94.6%), organic mental disorder, child mental disorder were mostly found in males,but mood disorder(64.5%) and neurotic disorder were mostly found in females. 4. On the distribution of age neurotic disorder was found the most in the thirties(25.3%), next in the twenties and in the forties, and schizophrenia was found the most in the twenties(40.5%), next in the thirties and in the forties, but mood disorder was found the most in the twenties, next in the thirties and in the forties but revealed similar rates relatively. 5. On the distribution of age of onset neurotic disorder developed nearly half during the twrnties and the thirties, schizophrenia developed mostly during the twenties (51.3%), secondly the teens and thirdly the thirties, but mood disorder developed firstly the twenties(30.7%), secondly the thirties and thirdly the fifties. on the average age of onset of illness neurotic disorder, mood disorder and schizophrenia were 32.7 years, 36.1 years and 23.6 years respectively. 6. On the duration of illness more than two years was 28.3% in neurotic disorder, 68.5% in schizophrenia and 3.9% in mood disorder and on the average duration of illness schizophrenia, mood disorder and neurotic disorder were 73.2 months, 45.5 months and 29.5 months respectively.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

A Case of Orbital Abscess following Porous Orbital Implant Infection

Seung Woo Hong,Ji-Sun Paik,So-Youl Kim,Suk-Woo Yang 대한안과학회 2006 Korean Journal of Ophthalmology Vol.20 No.3

Purpose: We present a case of orbital abscess following porous orbital implant infection in a 73-year-old woman with rheumatoid arthritis. Methods: Just one month after a seemingly uncomplicated enucleation and porous polyethylene (MedporⓇ) orbital implant surgery, implant exposure developed with profuse pus discharge. The patient was unresponsive to implant removal and MRI confirmed the presence of an orbital pus pocket. Despite extirpation of the four rectus muscles, inflammatory granulation debridement and abscess drainage, another new pus pocket developed. Results: After partial orbital exenteration, the wound finally healed well without any additional abscess formation. Conclusions: A patient who has risk factors for delayed wound healing must be examined thoroughly and extreme care such as exenteration must be taken if there is persistent infection. Korean Journal of Ophthalmology 20(4):234-237, 2006

Study on the Development of an Adaptable Shape of the Handy Type Harvesting Machine to Expand the Expansion of the Cultivation Area of Boxthorn

Seung Woo Paik(백승우),Tug Sang Yun(윤덕상),Seung Wan Son(손승완),Young Chun Park(박영춘),Min Sik In(인민식),Hyun Ho Kim(김현호) 한국약용작물학회 2018 한국약용작물학회 학술대회논문집 Vol.2018 No.2