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김훈,김훈,김선경 한국의사학회 2025 한국의사학회지 Vol.38 No.1
본 연구는 『조선왕조실록』과 『승정원일기』에 기록된 의약 자료를 바탕으로 조선 제22대 왕 정조의 질병 양상을 분석하고, 그의 만성질환이 체질적 요인과 심리적 스트레스, 정치적 환경과 어떻게 상호작용했는지를 고찰했다. 정조에게 가장 빈번하게 나타난 병증은 격기(膈氣)와 열증(熱症)으로, 이는 위장 기능 저하와 정서적 긴장에서 비롯된 것으로 추정된다. 격기는 소화 장애, 복통, 흉부 답답함 등의 증세를 수반했으며, 열증은 번열감과 불면증, 감정 기복 등으로 표현되었다. 이러한 병증은 정조의 예민하고 조급한 성정, 부친 사도세자의 비극적 죽음, 왕권 강화를 위한 과도한 업무 부담 등 심리·정치적 요소와 밀접하게 연관된다. 또한 여름철마다 서증(暑症), 곽란(霍亂), 감기 등 외감성 질환이 반복되었으며, 이는 비위 허약과 면역력 저하로 설명될 수 있다. 말년에는 종기(癤候)의 악화로 인한 패혈증이 직접적인 사망 원인으로 작용한 것으로 보인다. This study analyzes the medical records found in the Annals of the Joseon Dynasty (朝鮮王朝實錄) and the Diary of the Royal Secretariat (承政院日記) to examine the chronic illnesses of King Jeongjo (正祖, 1752–1800), the 22nd monarch of the Joseon Dynasty. The analysis focuses on how his recurring diseases were shaped by a complex interplay of constitutional factors, psychological stress, and political circumstances. The most frequently documented conditions were gyeokgi (膈氣, chest qi stagnation) and fever syndromes (熱症), which are attributed to digestive weakness and emotional strain. Gyeokgi (膈氣) manifested through symptoms such as indigestion, abdominal pain, and chest tightness, while fever syndromes(熱症) included sensations of internal heat, insomnia, and emotional agitation. These were closely tied to Jeongjo’s sensitive and impatient temperament, the trauma of his father Crown Prince Sado’s unjust death, and the burdens of political leadership. Additionally, Jeongjo regularly suffered from seasonal disorders such as seojeung (暑症, heat illness), gastrointestinal distress (霍亂), and colds—symptoms likely linked to his chronic digestive frailty and lowered immunity. In his final years, the development and aggravation of boils ultimately led to sepsis, presumed to be the direct cause of death. This study illustrates how Jeongjo’s health was influenced by a convergence of hereditary constitution, mental and emotional strain, and the weight of kingship, offering a deeper understanding of disease and medicine in the late Joseon royal court.
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용접후열처리 조건이 용접열영향부의 균열진전에 미치는 영향
김훈 麗水水産大學校産業技術硏究所 1998 産業基術硏究所 論文集 Vol.7 No.-
It is important fact that the fatigue failure of the engineering structures and pressure vessels initiates from not the imbedded cracks but the surface cracks. A welded region in structures includes a incomplete beads deposits, and is existed the ununiformed residual stress triple-axiality, various micro-structures and micro-cracks by the welding heat. These are able to behave like the surface cracks occasionally, and to influence on the initiation and growth of cracks. In order to eliminate the welded residual stress and improve the various unuseful factors, therefore, the welded region is carried out a post weld heat treatment (PWHT). This study was done to investigate the effects of the post weld heat treatment(PWHT) on the fatigue behaviors of the surface crack of the multi-pass welded heat affected zone (HAZ) under the repetitive pure bending moment. The conditions of PWHT are followed : the heat treatment temperature of 650℃, the holding time of 1/4 and 10 hour and the uniaxial compressive stress of 15 ㎏f/㎟. The crack growth behaviors were dependent upon the heat treatment conditions, such as the holding time and the applied stress. The crack growth behaviour of PWHT specimens with 10 hour holding time is a little faster than that of 1/4 hour one. The crack growth rate of PWHT specimens subjected to the applied stress is faster than that of the specimen without any stress during PWHT at a constant △K.
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Feature of amenorrhea in postoperative tamoxifen users with breast cancer
김훈,한원식,구승엽,서창석,김석현,최영민 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.2
Objective: Tamoxifen has been used to prevent the recurrence of breast cancer. However, tamoxifen-users frequently experience amenorrhea and it can be confused from that caused by other hormonal abnormalities. In amenorrheic patients without breast cancer, clinicians usually measure the sex hormone levels that are known to be associated with ovarian or menstrual function. This study aimed to investigate the feature of female sex hormones in premenopausal breast cancer patients undergoing tamoxifen treatment. Methods: The medical records of fifty-nine premenopausal breast cancer patients who underwent tamoxifen treatment were reviewed retrospectively. The study population consisted of amenorrheic patients (n=36) and patients with menstruation (n=23). Serum hormone levels were measured either specifically between cycle days 2 and 5 in menstruating patients or at any time in amenorrheic participants. Results: Serum levels of lutenizing hormone and estradiol were not statistically different according to the presence of menstruation. Serum follicle stimulating hormone level was significantly higher in amenorrheic patients (8.1±5.7 mIU/mL) than those in menstruating subjects (5.1±2.2 mIU/mL) (p=0.01). Serum concentration of thyroid stimulating hormone was lower in patients with amenorrhea (1.5±0.9 vs. 2.3±2.2 μIU/mL, p=0.04), although the prevalence of hypo- or hyperthyroidism was not different according to the pattern of menstruation. Conclusion: Menstruation status and hormone levels can be influenced by tamoxifen use in reproductive age breast cancer patients. Physicians should be attentive to the alteration of pituitary hormone levels in addition to sex steroid hormones in this population.
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