정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

김치유래 젖산균의 균체지방산 분석을 이용한 분류학적 연구

이정숙,정민철,김우식,이근철,김홍중,박찬선,이헌주,주윤정,이근종,안종석,박완,박용하,민태익 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.2

표준균주를 포함한 230여개의 김치유래 젖산균에 대한 균체지방산(FAMEs)을 분석하였다. FAMEs profiles는 Euclidian Distance 17.5에 의해 7개의 Major Cluster와 1개의 Single Cluster로 나뉘어졌다. 이중 A, B, C 및 Cluster는 Leuconostoc속으로 분석되어졌고, F는 Lactobacillus속으로 분석되어졌다. 그리고 E와 G cluster는 두개의 Genus가 혼재되어 나타났으며 보충적인 연구가 필요하다. 앞으로 김치유래 젖산균의 균체지방산 분석결과를 기반으로 한 데이타베이스에 95가지 탄소원을 이용하는 수치분류학적 접근방법 및 Pyrolysis Mass Spectrometry 등의 화학적 분석 방법과 분자친화적 연구를 통한 종합적 분류정보 체계가 갖추어지면 젖산균의 신속, 정확한 동정 및 연구에 활발히 이용되어질 것이다. Two hundreds and thirty lactic acid bacteria, mostly isolated from Kimchi, including type strains were sued for analysis of cellular fatty acids. The 230 test strains were recoverd in 7 major and 1 single clusters defined a Euclidian distance of 17.5. These aggregate taxa were equivalent to the genus Leuconostoc (aggregate group A, B, C and D), and the genera Leuconostoc and Lactobacillus (aggregate group G). It is concluded as evident that FAMEs (Fatty Acid Methyl Esters) profile of cell can be used as a criterion in classification of lactic acid bacterial from kimchi. Additional comparative taxonomic studies need to be carried out on well chosen representative strains to determine the most appropriate methods of value.

Adamkiewicz 동맥의 폐색에 의한 척수경색 1례

이광훈,이종걸,이태연,신동익,이성현,이상수,한설희,차상훈 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

정신분열병환자에서 Haloperidol 투여에 따른 치료반응과 혈장 Homovanillic Acid 농도 및 혈장 Haloperidol과 Reduced Haloperidol농도와의 관계에 대한 연구

이상익,권준수,우종인 大韓神經精神醫學會 1992 신경정신의학 Vol.31 No.3

In order to develop a more effective therapeutic guidelines for haloperidol treatment, the authors measured plasma haloperidol(HP), reduced haloperidol (RH) and homovanillic acid (HVA) levels in 14 schizophrenic patients and analyzed their relationship to therapeutic response. The plasma homovanillic acid levels were further evaluated to see whether it can be adopted as a predictive biological marker reflecting therapeutic response of haloperidol. The measurement of plasma haloperidol, reduced haloperidol and HVA levels were carried out with high performance liquid chromatography(HPLC) and the therapeutic reponses were assessed with Brief Psychiatric Rating Scale(BPRS) every week before and during the administration of haloperidol for 5 weeks. The results of this study are as follows. 1) There was no significant changes on the plasma HVA levels after haloperidol administration as a whole. But in higher pHVA group(baseline plasma HVA level≥4.5ng/ml), the plasma HVA levels were significantly decreased after haloperidol administration, and in lower pHVA group(baseline plasma HVA level〈4.5ng/ml), the plasma HVA levels were significantly increased compared to baseline plasma HVA levels. 2) Total BPRS scores were continuouly and significantly decreased from 1st week to 3rd week after haloperidol administration not only in total subject, but also in higher pHVA group and lower pHVA group. 3) There was significant correlation between baseline plasma HVA levels and clinical improvement(percentile improvement) at 3rd week in higher pHVA group. But no significant correlation was found between baseline plasma HVA levels and clinical improvement in total subject or in lower pHVA group. 4) Hyperbolic correlation was observed between plasma haloperidol level and plasma RH level(Km=33.11ng/ml). 5) There were no statistically significant correlations between clinical improvement and plasma haloperidol level, plasma RH level and RH/HP ratio in any of the total subject, higher pHVA group and lower pHVA group. 6) The changes of plasma HVA levels after haloperidol administration were not significantly correlated with plasma haloperidol level, plasma RH leel and RH/HP ratio in any of the total subject, higher pHVA group and lower pHVA group.

정신분열병 환자의 인식유발전위에 관한 연구

이상익,김종성,김용식 大韓神經精神醫學會 1989 신경정신의학 Vol.28 No.6

To investigate the characteristic features and the diagnostic meaning of the cognitive evoked potential in schizophrenics, the authors performed the auditory evoked potential to the schizophrenic patients(n=34) who were admitted to Seoul National University Hospital and the normal controls(n= 19) from the 15th, Feb. 1988 to the 24th, Aug. 1989. The latency and peak-to-peak amplitudes of the cognitive evoked potentials were compared with student t-test between schizophrenic group (n=19) and control group who was age-and sex-matched by one to one. Also, the correlations between 12 items of clinical characteristics, and latency and peak-to-peak amplitudes were studied in schizophrenic group(n=34). The schizophrenic group showed longer latencies in N₂and P₃and smaller amplitude in P₃-N₃than the control group, and there were the statistically significant correlations between age of onset and P₂-N₁amplitude, between number of the electroconvulsive therapy and P₃-N₃amplitude, between the presence of the auditory hallucination and the P₁-N₁amplitude, between the medication dosage at test and amplitudes of P₃-N₂, P₃-N₃ and N₁latency, and between years of education and amplitudes of P₁-N₁, P₂-N₂and P₂-N₁. We confirmed that there were some differences of the cognitive evoked potentials between schizophrenic patients and normal controls. Also there were some clinical characteristics which had influences on the cognitive evoked potentials. We discussed the possibility of cognitive evoked potentials as diagnostic utility For that, study condition needs to be controlled and standardized, and the basic psychophysiological study of cognitive evoked potentials should be preceded.

Fe-17%Cr 페라이트계 나노사이즈-산화물 분산강화합금의 인장성질과 고온산화에 미치는 산화물종의 영향

김익수,강창룡,이종문,이병우,정상훈,이원희 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.12

In order to develop mechanically alloyed nano-sized ferritic ODS alloys, we have investigated the effect of three kinds of oxide such as Y₂O₃, Al₂O₃ and TiO₂, on the high temperature tensile properties, high temperature oxidation behavior and corrosion resistance. Due to the most distribution of fine and spherical particles, ODS alloys containing Y₂O₃ raise yield strength and tensile strength at high temperatures considerably. The results of high temperature oxidation tests indicate that the ODS alloys containing Y₂O₃, Al₂O₃ and TiO₂ are resistant to oxidation between 823K and 1023K. The ODS alloy containing Y2O3 by attributed by to thermal safety of Y₂O₃ showed an ecellent characteristics in oxidation and corrosion.

마이크로머시닝을 이용한 Bump형 Probe Card의 제조

최원익,김용대,심준환,이종현 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

Probe card is the most important part of testing IC chips. This work was related to silicon vertical probe card which enabled to simultaneously test multiple semiconductor chips. We presented Bump-type vertical probe card. It was fabricated by dry etching using RIE technique, isotropic etching, and bulk-micromachining on SDB wafer. The process used in this work was very simple and reproducible, which had good controllability in the probe card dimension and spacing. It is expected that the fabricated probe card can reduce testing time, can promote productivity and enables bum-in test.

한국과 러시아(구소련) 마라톤 선수들의 스포츠 성과에 관한 비교 분석

김익겸,이종희,김복현 경희대학교 체육과학연구소 1999 體育學論文集 Vol.27 No.-

According to the result of sport achievement of Korean and Russian marathoners(Soviet Union) through regression analysis, it can be concluded following this: 1.Korean marathoners have more good result than Russian marathoners, and Success of Korea marathon is classified by three stages First, in 1930's under Japanese colony Korea marathon had succeeded in LA Olympics(1932) and Berlin Olympics(1936). Second, From 1947 to 1957 Korean marathon had succeeded in commercial marathon race. Third, In 1990's the succession of Barcelona(1992) and Atlanta(1996) Olympics and succession of Asian Games(1990,1994,1998). 2.The succession of Russian marathon is classified by two stages. First, from 1946 to 1962 and 1978, the succession of European Championship. Second, the succession of Moscow Olympics.

소디움 루프 운전지원시스템

황종선,남호윤,문성익,이광형,조충호 한국경영과학회 1996 한국경영과학회 학술대회논문집 Vol.- No.1

본 연구에서는 액체금속로의 핵심구조인 소디움루프를 위한 운전지원 전문가시스템을 개발한다. 소대움루프는 현재 원자력연구소에서 연구 개발 단계에 있으며, 안전 운전을 위한 운전 지식을 연구하고 있는 중이다. 본 논문에서는 이러한 연구 상황에 맞추어 개발되는 전문가시스템에게 요구되는 특징을 정리하고, 소디움루프 운전의 효과적 지원과 운전원의 편의에 중점을 둔 전문가시스템의 개발을 설명한다.

분자유전학 검사로 확진된 Hereditary Neuropathy with Liability to Pressure Palsy 환자 1 례

변재환,이원영,박성익,기창석,공선영,김종원,김선희 대한근전도전기진단의학회 2003 대한근전도 전기진단의학회지 Vol.5 No.1