들깨 자엽으로부터 Callus 의 유기와 재분화에 따른 단백질 및 Peroxidase 의 변화

정상훈,양선경,김현경,정대수,김도훈 한국생명과학회 1998 한국생명과학회 학술발표회 Vol.20 No.-

Controlled Antimicrobial Peptide Delivery Supramolecular Injectable Hydrogels for Diabetic Chronic Wound Healing

정상훈,한세광 한국고분자학회 2023 한국고분자학회 학술대회 연구논문 초록집 Vol.48 No.1

Solvent - water - 2 - Propanol 삼성분계의 액 - 액평형

정상훈,이진우,박동원 ( Sang Hoon Jeong,Jin Woo Lee,Dong Won Park ) 한국공업화학회 1997 공업화학 Vol.8 No.4

에너지 비용의 상승에 따라 추출에 기본원리를 둔 새로운 분리공정에 대한 연구가 많이 진행되고 있으며, 이에 따라 액-액평형 조성의 계산 및 예측에 대한 필요성이 매우 증가하고 있다. 본 연구에서는 공비혼합물을 형성하는 2-propanol 수용액에 용매로서 methyl ethyl ketone, methyl isobutyl ketone, ethylacetate, butylacetate, toluene 및 o-xylene을 첨가한 삼성분계에 대하여 25℃에서 용해도곡선, tie line, plait point, 분배계수와 선택도를 실험을 통해 구하였다. Tie line 데이터의 열역학적 건전성을 확인하였으며 실험값을 NRTL 및 UNIQUAC 모델식으로 구한 계산값과 비교하였다. Due to the rising cost of energy, new separation processes based on extraction are becoming more attractive than before. Thus, the need for calculating and predicting liquid-liquid equilibria(LLE) compositions has very much increased. The purpose of this study is to determine the binodal curves, tie lines, plait point, distribution and selectivity for the ternary systems of 2-propanol-water with methyl ethyl ketone, methyl isobutyl ketone, ethylacetate, butylacetate, toluene and o-xylene as solvents at 25℃. And those tie line data were used to examine thermodynamic consistency. The experimental tie line data were correlated with NRTL and UNIQUAC models.

아름다운 동행

정상훈 고시계사 2019 考試界 Vol.65 No.1

『阿彌陀經諺解』에 대하여

정상훈 한국불교어문학회 1996 불교어문논집 Vol.1 No.-

광대역 펄스감마선 탐지센서 최적화 설계 및 제작

정상훈,이남호,Jeong, Sang-hun,Lee, Nam-ho 한국정보통신학회 2017 한국정보통신학회논문지 Vol.21 No.1

In this paper, we are proposing an optimal design of wideband pulsed type gamma-ray sensors. These sensors were manufactured based on the design results and after word electrical properties were analyzed. The sensor input parameters were derived on the basis of pulsed gamma-ray spectrum and time-dependent energy rate, and the output current which were derived on the basis of the sensor sensitivity control circuit. Pulsed gamma-ray sensors were designed using the TCAD simulators. The design results show that the optimal Epi layer thickness is 45um with the applied voltage 3.3V and the diameter is 2.0mm. The doping concentrations are as follows : N-type is an Arsenic as $1{\times}10^{19}/cm^3$, P-type is a Boron as $1{\times}10^{19}/cm^3$ and Epi layer is Phosphorus as $3.4{\times}10^{12}/cm^3$. The fabricated sensor was a leakage current, 12pA at voltage -3.3V and fully depleted mode at voltage -5V. A test result of pulsed radiation shows that the sensor gives out the optimal photocurrent. 본 연구에서는 광대역 펄스감마선 탐지센서 최적화 설계를 수행하고 설계결과를 기반으로 탐지센서를 제작하여 전기적 특성을 분석하였다. 탐지센서의 최적화 설계를 위해 펄스감마선의 시간에 따른 에너지 프로파일로 부터 입력 변수를 도출하고 탐지감도 제어회로를 통하여 출력전류 범위를 결정하였다. 도출된 변수를 바탕으로 N-type Epi Wafer 및 TCAD(Technology Computer Aided Design)로 설계하고 제작하였다. 제작된 탐지센서의 전기적 특성 분석 결과 -3.3V 전압에서 12pA의 누설전류와 -5V의 전압에서 완전 공핍화 되는 특성을 가짐을 확인하였다. 제작된 센서의 포항가속기연구소 TEST LINAC 시험결과 감마선 설정 선율의 펄스방사선에 대해 고감도의 광전류를 생성시킴을 확인하였다.

대한민국 유도탄의 세계 최고 품질구현을 위한 제언

정상훈,이승호,함범식,홍석진 한국방위산업진흥회 2016 國防과 技術 Vol.- No.450

Comparative Study of Postoperative Complications in Patients With and Without an Obstruction Who Had Left-Sided Colorectal Cancer and Underwent a Single-Stage Operation After Mechanical Bowel Preparation

정상훈,김재황 대한대장항문학회 2014 Annals of Coloproctolgy Vol.30 No.6

Purpose: The purpose of this study is to compare postoperative complications for single-stage surgery after mechanical bowel preparation in patients who experienced obstruction and those who did not. Methods: From 2000 to 2011, 1,224 patients underwent a single-stage operation for left colorectal cancer after bowel preparation. Nonobstruction (NOB) and obstruction (OB) colorectal cancer patients were 1,053 (86.0%) and 171 (14.0%), respectively. Postoperative morbidity and mortality were compared between groups. Results: The OB group had poor preoperative conditions (age, white blood cell, hemoglobin, albumin level, and advanced tumor stage) compared with the NOB group (P < 0.05). Mean on-table lavage time for the OB group was 17.5 minutes (range, 14–60 minutes). Mean operation time for the OB group was statistically longer than that of the NOB group (OB: 210 minutes; range, 120–480 minutes vs. NOB: 180 minutes; range, 60–420 minutes; P < 0.001). Overall morbidity was similar between groups (NOB: 19.7% vs. OB: 23.4%, P = 0.259). Major morbidity was more common in the OB group than in the NOB group, but the difference was without significance (OB: 11.7% vs. NOB: 7.6%, P = 0.070). Postoperative death occurred in 16 patients (1.3%), and death in the OB group (n = 7) was significantly higher than it was in the NOB group (n = 9) (4.1% vs. 0.9%, P = 0.001). Twelve patients had surgical complications, which were the leading cause of postoperative death: postoperative bleeding in five patients and leakage in seven patients. Conclusion: Postoperative morbidity for a single-stage operation for obstructive left colorectal cancer is comparable to that for NOB, regardless of poor conditions of the patient.

A feasibility study evaluating the relationship between dose and focal liver reaction in stereotactic ablative radiotherapy for liver cancer based on intensity change of Gd-EOB-DTPA-enhanced magnetic resonance images

정상훈,유정일,박희철,임도훈,한영이 대한방사선종양학회 2016 Radiation Oncology Journal Vol.34 No.1

Purpose: In order to evaluate the relationship between the dose to the liver parenchyma and focal liver reaction (FLR) after stereotactic ablative body radiotherapy (SABR), we suggest a novel method using a three-dimensional dose distribution and change in signal intensity of gadoxetate disodium-gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) hepatobiliary phase images. Materials and Methods: In our method, change of the signal intensity between the pretreatment and follow-up hepatobiliary phase images of Gd-EOB-DTPA-enhanced MRI was calculated and then threshold dose (TD) for developing FLR was obtained from correlation of dose with the change of the signal intensity. For validation of the method, TDs for six patients, who had been treated for liver cancer with SABR with 45–60 Gy in 3 fractions, were calculated using the method, and we evaluated concordance between volume enclosed by isodose of TD by the method and volume identified as FLR by a physician. Results: The dose to normal liver was correlated with change in signal intensity between pretreatment and follow-up MRI with a median R2 of 0.935 (range, 0.748 to 0.985). The median TD by the method was 23.5 Gy (range, 18.3 to 39.4 Gy). The median value of concordance was 84.5% (range, 44.7% to 95.9%). Conclusion: Our method is capable of providing a quantitative evaluation of the relationship between dose and intensity changes on follow-up MRI, as well as determining individual TD for developing FLR. We expect our method to provide better information about the individual relationship between dose and FLR in radiotherapy for liver cancer.

Prognostic Impact of Microsatellite Instability in Colorectal Cancer Presenting With Mucinous, Signet-Ring, and Poorly Differentiated Cells

정상훈,김소현,김재황 대한대장항문학회 2016 Annals of Coloproctolgy Vol.32 No.2

Purpose: Mucinous cells (MUCs), signet-ring cells (SRCs), and poorly differentiated cells (PDCs) are uncommon histologic types and have been associated with advanced tumor stage and poor prognosis. However, MUCs, SRCs, and PDCs are commonly observed in cancers with high microsatellite instability (MSI), which have favorable outcomes compared with cancers with microsatellite stability (MSS). The purpose of this study was to evaluate the prognostic impact of high-MSI in patients with sporadic colorectal cancer presenting with MUCs, SRCs, and/or PDCs. Methods: Between January 2006 and December 2012, 176 with proven microsatellite status who also presented with MUCs, SRCs, and PDCs were selected for this study and were divided into 2 groups, high-MSI and MSS; their outcomes were analyzed. Results: Of the 176 patients, 56 and 120, respectively, had high-MSI and MSS cancers. High-MSI cancers had larger tumors, proximal tumor location, and a lower TNM stage. The recurrence rate was lower in the high-MSI group (13.7% vs. 35.4%, P = 0.006). Common patterns of distant metastasis for MUC, SRC, PDC cancers were peritoneal spread (46.9%) and hematogenous metastasis (46.4%). The 5-year CSS rates were 88.2% and 61.2% for patients with high-MSI and MSS cancers, respectively (P < 0.0001). In the multivariate analysis, except for stage-IV cancer, MSI status was an independent risk factor for cancer-specific survival (MSS: hazard ratio, 4.34; 95% confidence interval, 1.68–11.21). Conclusion: In patients with colorectal cancer presenting with MUCs, SRCs, and/or PDCs, those with high-MSI cancers had better outcomes.