한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

分散性染料의 染色性에 關한 硏究

鄭元圭,鄭斗鎭 嶺南大學校 工業技術硏究所 1974 연구보고 Vol.2 No.1

。The study was carried out to elucidate the dependence of diffusion coefficient on penetrant concentration of disperse dyes in poly ethyleneterephthalate (PET). 1. For the experiment in over the wide range of dye bath concentration, p-nitroaniline (PNA) which has high solubility in water was used as a model of disperse dyes, and diffused in various dye bath concentration at 70, 75, 80, 85, 90 and 95℃. The dependence of diffusion coefficient on penetrant concentration was clearly observed (Fig.2), and empirically represented by the equation (1), for the lower concentation (up to about 8x10-²mol/kg) and (2) for the higher concentration, D=D。Cⁿ (1) D=D。exp (δC) (2) where C is concentration of penetrantrant and n and δ are constants. PNA penetrated into an easily diffusible amorphous region at the lower concentration. At the higher concentration of PNA, the penetrant diffused into more closely packed amorphous part without changing the total amounts of amorphous region available for dyeing. It was suggested that the increase of diffusion coefficient was caused by the minute qualitative change of amorphous region of PET which could not be detected by the IR spectrum (Table 2), small angle X-ray scattering and dichroism of the dyed film. With increasing PNA concentration the decrease of relaxation modulus of the PET film was observed (Fig.6), and this tendency corresponded to the increase of diffusion coefficient mentioned above (Fig.2). 2. Purified disperse dyes (4-nitro-4'-amino azobenzene, 4-nitro-4'-oxy azobenzene, 2,4-dinitro diphenylamine, 1-amino-4-oxy anthraquinone) was diffused in PET, and diffusion coefficient was calculated by Matano's equation. The dependence of diffusion coefficient on penetrant concention was clearly observed, and it is represented by the equation (3). D=D。+kC (3) where k is constant. It was presumed that the dependence of diffusion coefficient on penetrant concentration was caused by the swelling of amorphous region. With increasing partition coefficient. as a result of this study , the decrease of diffusion coefficient was observed.

Polyethylene terephchalate의 溶劑處理에 따른 染色性의 變化에 關한 硏究

鄭元圭,鄭斗鎭 영남대학교 공업기술연구소 1985 연구보고 Vol.13 No.2

In order to investigate the changes in the fine structure and dyeing properties of TCE substrate treated with solvents, observations are made of the changes in crystallinity, and orientation of PET film treated with water, TCE and water/TCE emulsion(2%) at 60℃-140℃ for three hours, and of the dyeing properties of the film stabilized with slovents treatment for 3 hrs at 140℃ and dyed with disperse dyes. The following conclusions are drawn: 1. Changes in crystallinity increase when treated with water, TCE and water/TCE emulsion(2%) in the given order 2. The changes of crystallinity was considered to have contributed to increase in diffusion coefficients 3. The diffusion coefficients of dyes used increase in the order of water, TCE and water/TCE(2%), and the activation energy of diffusion decrease in the same order.

항진균제 알릴아민류의 합성과 생물학적 평가

정병호,조원제,천승훈,박면지,유진철,천문우 朝鮮大學校 1998 藥學硏究誌 Vol.19 No.2

For the development of antifungal agents. modification of naftifine which exhibits significant antimycotic activity was performed by replacing the naphthalene ring of it to hetero cyclic rings such as morpholine. benzothiazole. piperidine and pyridine derivatives. The synthesized compounds were tested in vitro antifungal activity against five different fungi with naftifine as a comparative antimycotic molecule. From the biological evaluation two compounds. (E)-N-(3-phenyl-2-propenyl)-N-(4-piperidinylmethyl)amine(3d) and (E)-N-(3-phenyl-2-propenyl)-N-(3-pyndylmethyl)amine(3D) showed relatively noticeable activity(MIC=50㎍/㎖). On the other hand. the other compounds had no activity.

한국 여성운동과 걸스카우트운동 : 과거·현재·미래 Yesterday, Present and Tomorrow

정세화,이동원,김미숙,박진숙,장화경,홍승아 이화여대 한국여성연구소 1988 여성학논집 Vol.5 No.-

One of the major implications of women's movements seems to lie in the fact that it tends to promote women's consciousness-raising and, thus, heighten social status of women in general. It would be very much the case when discussion centers around the emergence of Korean women's movements in modern sense. Due to the socio-political atmospheres of the lathe 19th century Korean society, its basic characteristics owe to strong tones of patriotic nationalism under the slogan of "learning is might enough to deal with the imperialistic foreign powers of the time." As such, ever since the introduction of women's enlightenment movements of the time, Korean women's movements have provided for the advancement of egalitarian society. However, assessing the effectiveness of programs that are practiced by the existing women's organizations in Korea, it deserves mention in that most programs are for the adult female members, assuming it would only be applicable to those adults. In this regard, it can be said that the Korean Girl Scout organization has worked a unique role to make up such voids in women's movements - most programs developed and exercised by the Girl Scout are reserved for those young girls. For instance, special activities like social services, field campaigns, and international gatherings would definitely work a profound impact in the formation of gender-role stereotypes of the youth. The present study tries to examine the Korean Girl Scout movement being the case of women's movement organization. Discussion will cover such topics as; historical reviews of Korean Girl Scout movement, principal organizational goals and its practice in real life, and internal dynamics of members between "staffs" and the ordinary members themselves-on perceptions of the movement, evaluation of leaderships, and the future orientations of the Girl Scout, etc. Various research methods are employed. Book reviews, in-depth interviews, questionnaires, and participant observations are utilized, when the respective measurement is required. Major findings of the study can be summarized as follows: (1) Numbers of Girl Scout membership have declined since 1980, while revealing its utmost pick upto mid-70s. In terms of regional distributions of the members, both Seoul and Kyung-Nam Branches are the most prosperous. Whereas commemoration ceremonies and camping works are considered most impressive programs, membership trainings and field works are the lowest. About 70 percent of the members show their length of activities in Girl Scout less than one year. Most members are involved in the activities based on self-decision in order to have social services, club memberships, or self actualizations. They are satisfied with most of the programs, especially when participating in the social service programs. (2) As for the staff members, about half of the leaders in the headquarters are newly appointed. Whereas majority of the 'field' staffs are young (in their 20s, or 30s), other leaders are considered old (most of them are in their 40s, 50s, or 60s). Half of the leaders are involved in the activities for less than 5 years. They are recruited by either colleagues' or office seniors' recommendations. Reasons to participate in the movement are to have self-actualized or to have opportunity for social services. All in all, leaders are satisfied with the Girl Scout activities mainly because they can see their youth members progressing and developing. (3) Several issues for the better organizational managements seem to be related. prevalence of aspirational differences between leaders and members tends to cause psychological burdens. Other problematics such as lack of free communication networks, tensions due to cohort differences, authoritarian leadership styles, and financial difficulties would hinder Girl Scout movement more promising and popular to all. Based on the research findings, two major suggestions might be in order. First, underlying rationales of the Girl Scout movement should be reoriented. A special emphasis on the creation of self-supportive 'androgynous individuals' would be the case (in this regard, an intensive program targeted for those pre-school-aged members would be the most effective). As a way to achieve the strategic reformulation, reliance on the interdisciplinary program (for example, coordination with the university) will be one possibility. Secondly, an organizational management should be sufficiently considered. provisions (tangible and intangible) for the 'field leaders' being the key leader group in the Girl Scout movement should be afforded enough to keep their participations voluntary and continuous.

Charles Jencks의 理論을 中心으로 한「포스트-모던」建築의 特性에 관한 硏究

鄭鎭元 경기대학교부설 산업기술종합연구소 1986 산업기술종합연구소 논문집 Vol.2 No.-

After the decadence of modern architecture, todays contemporary architecture has shown meaning of pluralism rather than a strong thread in theory and practice. But a chief feature of current architecture is overcoming the limitation of modern architecture and one of the alternatives is an approach through a Post-Modernism. The objectives of this report are precisely to analyze the ideas and characteristics of Post-Modern architecture which now has been frequently discussed in the aspects of theory and practice in Korea. This study consists of three major parts. The first part deals with the background of the appearance of the Post-Modern architecture. The second part covers the ideas of Post-Modernism, the general characteristics of Late-Modern and the Post-Modern Architecture, and the special features of a different kind of the Post-Modern architecture. And the last part deals with the trend of the Post-Modern Classicism in architecture.

국내 아파트 가변형 시스템 적용에 관한 연구

정진원,박진수 경기대학교 산업기술종합연구소 2006 산업기술종합연구소 논문집 Vol.31 No.-

고등학교 지구과학 실험·실습 요목 비교 분석

정원우,이윤종,기우항,김영호,양승영,강용희,안병호,임성규,윤일희,김중욱,윤성효,강동진 경북대학교 과학교육연구소 1997 科學敎育硏究誌 Vol.21 No.-

The purpose of this study is to investigate the status of the experimental and practical education in high school earth. The present status and reasonable management of the experimental and practical education in high school earth science have been grasped from the questionaires. To do this, eighty eight earth science teachers in Korea are administered questionaires. The frequency of the experimental and practical items in the seven kind of earth science text books were investigated. The problems and the reasonable management for experimental and practical education were proposed in this paper.