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이동원,곽임수,이수봉,송상헌,양병윤,설미영,성은영,이민영 대한의학회 2009 Journal of Korean medical science Vol.24 No.-
5-Lipoxygenase inhibitor and human recombinant erythropoietin might accelerate renal recovery in cisplatin-induced acute renal failure rats. Male Sprague-Dawley rats were randomized into four groups: 1) normal controls; 2) Cisplatin group-cisplatin induced acute renal failure (ARF) plus vehicle treatment; 3) Cisplatin+nordihydroguaiaretic acid (NDGA) group-cisplatin induced ARF plus 5-lipoxygenase inhibitor treatment; 4) Cisplatin+erythropoietin (EPO) group-cisplatin induced ARF plus erythropoietin treatment. On day 10 (after 7 daily injections of NDGA or EPO), urea nitrogen and serum Cr concentrations were significantly lower in the Cisplatin+NDGA and Cisplatin+EPO groups than in the Cisplatin group, and 24 hr urine Cr clearances were significantly higher in the Cisplatin+EPO group than in the Cisplatin group. Semiquantitative assessments of histological lesions did not produce any significant differences between the three treatment groups. Numbers of PCNA(+) cells were significantly higher in Cisplatin, Cisplatin+NDGA, and Cisplatin+EPO groups than in normal controls. Those PCNA(+) cells were significantly increased in Cisplatin+NDGA group. These results suggest that EPO and also NDGA accelerate renal function recovery by stimulating tubular epithelial cell regeneration.
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이동원,곽임수,이수봉,송상헌,양병윤,설미영,성은영,정현철,이민영 대한의학회 2009 Journal of Korean medical science Vol.24 No.-
The selective cyclooxygenase-2 (COX-2) and 5-lipoxygenase (LOX) inhibitors might inhibit prostaglandin synthesis and reduce proteinuria. The present study was designed to investigate the anti-proteinuric effects of nordihydroguaiaretic acid (NDGA) as compared with celecoxib in puromycin aminonucleoside (PAN) nephrosis rats. Fifty five male Sprague-Dawley rats were divided into 4 groups; A, normal control; B, PAN group; C, PAN+COX-2 inhibitor (celecoxib) group; and D, PAN+5-LOX inhibitor (NDGA) group. After induction of PAN nephrosis through repeated injections of PAN (7.5 and 15 ㎎/100 g body weight), rats were treated with celecoxib, NDGA, or vehicle for 2 weeks. Twenty four hour urine protein excretions were significantly lower in PAN+celecoxib and PAN+NDGA groups than in PAN group. Serum creatinine (SCr) concentrations and 24 hr urine creatinine clearances (CCr) were not significantly different in the four groups. Electron microscopy showed that podocyte morphology was changed after the induction of PAN nephrosis and was recovered after celecoxib or NDGA administration. Celecoxib significantly recovered the expressions of nephrin, CD2AP, COX-2, and TGF-β. NDGA also recovered TGF-βexpression, but did not alter the expressions of nephrin, CD2AP and COX-2. The present study suggested that celecoxib and NDGA might effectively reduce proteinuria in nephrotic syndrome without impairing renal function.
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연결납세제도의 도입방안 : 일본의 연결납세제도를 중심으로
李東原 한국기업법학회 2002 企業法硏究 Vol.10 No.-
This paper is intended to study the needs for introducing fiscal unity system of Japan to design that system and to draft the relevant tax laws for implementation in Korea. Today, because of the increasing competition of corporations, they want to change their structures in various forms to earn more money, as is holding company, division system and company system and so on. In carrying out the corporations, the financial tax burden should be fair and neutral by adjusting tax distortion. So, this paper mainly examines why we should adopt the fiscal unity system and introduce the information of that system of several countries. This paper also deals with the effect of the fiscal unity system, especially in holding company and the relevance of double taxations. This paper mainly examines the history and contents of fiscal unity system implemented in Japan in 2002, April, containing the structure of that system, proceeding to implement that system, requirements to apply, and relevant financial effect. Japan has studied this fiscal unity system for several years since the lifting of the ban of holding companies. So, the system can be the appropriate tax model of Korea and represent the real equity ratio of corporation tax. On the model of Japan, we can find the appropriate one of fiscal unity system just and fair.
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이동원,Hyun Kyu Jeong,박정용,Jong Hyuk Lee,Son Jeong Wang,Yong Hwan Jeong,Young Duk Bae,Bong Guen Hong 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.51 No.3
In order to investigate the manufacturing and qualification methods for the first wall (FW) of the International Thermonuclear Experimental Reactor (ITER), we fabricated several mock-ups with various shapes through the hot isostatic pressing (HIP) bonding method for joining the Cu-alloy with Be armor and the Cu-alloy with stainless steel (SS). Non-destructive test (NDT) methods currently being developed for the ITER FW were applied to these mock-ups to find the defects. Ultrasonic test (UT) showed that a probe of 10 MHz and 0.25 inch in diameter could detect defects up to 3 mm in diameter. The eddy current test (ECT) for the SS tube was simulated with a numerical code and showed the feasibility of detecting defects in the SS tube. Thermography was simulated with a numerical code, CFX-10, and preliminary tests were performed. Also, a high heat flux (HHF) test was performed up to 1000 cycles at 5.0 MW/m2 for the Cu/SS mock-up in Japan (JEBIS, JAEA Electron Beam Irradiation Stand), and it is being prepared for the Be/Cu mock-up in Russia. .
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