소속명탕(小續命湯)이 백서(白鼠)의 국소뇌혈류량(局所腦血流量)과 혈압(血壓)에 미치는 영향(影響)

김영균,권정남,김경민,조은희,박지은,Kim, Young-Kyun,Kwon, Jung-Nam,Kim, Kyung-Min,Cho, Eun-Hee,Park, Ji-Eun 대한한방내과학회 2000 대한한방내과학회지 Vol.21 No.5

SosokMyeongTang(SMT) have been used in oriental medicine for many centuries as a therapeutic agent for cerebral disease. The effects of SMT on the vascular system is not known. The purpose of this study was to investigate the effects of SMT on the changes in blood pressure(BP) and regional cerebral blood flow(rCBF) of rats. SMT consists of the following components : Radix Ledebouriellae(防風), Radix Cocculi or Stephaniae(防己), Semen Armeniacae(杏仁), Cortex Cinnamomi(肉桂), Radix Scutellariae(黃芩), Radix Paeoniae Lactiflorae(白芍藥), Radix Ginseng(人蔘), Rhizoma Cnidll(川芎), Herba Ephedrae(麻黃), Radix Glycyrrhizae(甘草), Radix Aconiti(附子?), Fructus Zizyphi Jujubae(大棗), Rhizoma Zingiberis(生薑) and the changes of BP and rCBF were tested Leser-Doppler Flowmetry(LDF) The experimental results were as follows ; BP was not affected by SMT in rats, but rCBF was increased significantly by SMT in a dose dependent manner. SMT increased previous decreasd rCBF due to pretreatment methylene blue, but did not increased previous decreasd rCBF due to pretreatment L-NNA, indomethacin. Pretreatment with indomethacin decreased BP compaired with control group. These results suggest that SMT causes a diverse response of blood pressure and regional cerebral blood flow(rCBF). The increased rCBF is mediated by nitric oxide synthease.

Effects of Sunghyangchungisan(SHCS) on Cellular Ion Contents and Metabolism in Cat Brain Cortical Slices under Hypoxic Insult

김영균,권정남,조수인,김나리,Kim, Young-Kyun,Kwon, Jeong-Nam,Cho, Su-In,Kim, Na-Ri The Society of Internal Korean Medicine 2001 대한한방내과학회지 Vol.22 No.4

목적: 고양이 대뇌피질 절편을 사용하여 저산소 발작을 유발한 뒤, 성향정기산이 세포의 이온 환경과 대사의 변화와 관련하여 어떤 영향을 미치는지 연구하였다. 방법: 고양이의 대뇌 피질 절편에 저산소 발작을 유발한 뒤 flame photometry scintillation, Spectrophotometry, method of Jorgensen and Skou, method of Fiske and Subbarow, oxygen monitor, luciferin-luciferase assay 등을 이용하여 세포내 이온함량과 세포대사를 측정하였다. 결과: 성향정기산은 저산소증으로 유발된 세포내의 $K^+$와 $Na^+$의 함량의 변화를 현저하게 지연시켰다. 성향정기산은 Na-K-ATPase의 억제제인 와바인 또는 대사억제제인 2.4-DNP로 유발된 세포내 $K^+$함량의 변화에 어떤 효과도 보이지 않았다. 또한, 정상 상태의 절편뿐만 아니라 저산소 상태의 절편에서 분리된 과립체의 분설에 있어서 Na-K-ATPase의 활동도에 영향을 미치지 않았다. 성향정기산은 저산소 발작하에서 산소 소비량과 세포의 ATP함량이 떨어지는 것을 현저하게 막았다. 또한 ATP를 생산하는 기능을 보호하는 저산소 조직의 사립체를 돕는데 효과적이었다. 결론: 성향정기산은 대뇌 조직의 저산소 발작하에서 세포의 이온 환경과 대사를 보호하는 유익한 효과가 있음을 알 수 있다.

초내식성 스테인리스강의 Hank 용액에서의 부식마모 거동에 관한 연구

김영균,박용수 한국표면공학회 1993 한국표면공학회 학술발표회 초록집 Vol.1993 No.-

성향정기산(星香正氣散)이 가토의 경동맥(頸動脈) 평활근(平滑筋) 긴장(緊張) 및 $Ca^{2+}$ 대사(代謝)에 미치는 영향(影響)

김영균,권정남,김종훈,Kim, Young-Gyun,Kweon, Jung-Nam,Kim, Jong-Hoon 대한한방내과학회 2000 대한한방내과학회지 Vol.21 No.3

Objective : This study was undertaken to evaluate the effect of Sunghyangchungisan (SHCS) on the regulation of vascular tone and $Ca^{2+}$ metabolism in arterial tissues. Vascular rings isolated from rabbit carotid artery were myographed isometrically in isolated organ baths and the effect of SHCS on contractile activities, endothelial function and $Ca^{2+}$ metabolism were determined. Methods : In phentobarbital sodium-anesthetized rabbits, SHCS administered through ear vein (100 mg/Kg body wt.) or intragastric dwelling tube (300 mg/Kg body wt.) attenuated phenylephrine (PE, 10 ${\mu}g$/Kg, i.v.)-induced increases in both systolic and diastolic cartoid arterial blood pressure. Results : In experiments with isolated arterial strips, SHCS relaxed arterial rings which were pre-contracted by phenylephrine (PE, 1 ${\mu}M$). The responses to SHCS were partially dose-dependent at concentrations lower than 0.5 mg/ml. When SHCS was applied prior to the exposure to PE, it inhibited the PE-induced contraction by a similar magnitude which was comparable to the relaxation of pre-contracted arterial rings. Washout of SHCS after observing its relaxant effect resulted in a full recovery of PE-induced contractions, indicating that the action mechanism is reversible. The observation that SHCS did not change the $ED_{50)$ of PE oh its dose-response curve ruled out the possible interaction of SHCS with ${\alpha}$-receptors. The relaxant effect of SHCS was not affected by removal of endothelium or a nitric oxide synthase inhibitor, L-NAME. Methylene blue, an inhibitor of the soluble guanylate cyclase, did not affect the relaxant effect of SHCS. These results suggest that the action of SHCS is not mediated by the endothelium nor soluble guanylate cyclase. Constant cGMP production determined in arterial strips in the presence or absence of SHCS is consistent with this conclusion. When contraction was induced by additive application of $Ca^{2+}$ in arterial rings which were pre-depolarized by high $K^+$ in a $Ca^{2+}$-free solution, the relaxant effect of SHCS was attenuated by increasing the $Ca^{2+}$ concentration. SHCS, when applied to the arterial rings pre-contracted by PE and then relaxed by nifedipine, a $Ca^{2+}$ channel blocker, did not show additive relaxation. SHCS partially blocked $Ca^{2+}$ influx stimulated by PE and high $K^+$ which was determined by 5-min ^{45}Ca$ uptake, while it did not affect $Ca^{2+}$ efflux. Conclusions : From above results, it is suggested that SHCS relax PE-induced contraction of rabbit carotid artery in an endothelium independent manner, andinhibition of $Ca^{2+}$ influx may contribute to the underling mechanism.

반흔 성형술의 임상적 고찰

김영균,여환호,변웅래,Kim, Young-Kyun,Yeo, Hwan-Ho,Beon, Ung-Rae 대한악안면성형재건외과학회 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.2

Inselecting scars for treatment, attention be paid not only to the features of the defect as seen objectively but also to the element of the defect most disturbing to the patient. We revised the scar tissues with simple elliptical excision, Z-plasty, modified Z-plasty, W-plasty and hand dermabrasion in varialbe pattern of scars and got the favorable results. The success rate of scar revision usually depends on the patient's subjective judgement. We must inform our patient the limitation of scar revision and importance of postoperative care. The oral and maxillofacial surgeons must resolve the variable scars which re involved in variable operations and traumas.

<어린이연극> 5월

김영균 공연과이론을위한모임 2005 공연과 이론 Vol.- No.18

고혈압(高血壓)의 원인(原因)에 관한 문헌적(文獻的) 고찰(考察)

김영균,권정남,박지은,김지웅,Kim, Young-Guen,Kwon, Jung-Nam,Park, Ji-Eun,Kim, Jee-Woong 대한한방내과학회 2000 대한한방내과학회지 Vol.21 No.5

xWe studied about the causes of hypertension in the occidental and oriental medical records and the results are as follows. 1. The causes of hypertension in oriental medicine can be divided into wind, fire, phlegm and deficiency of Qi in our body, and broadly into three categories as emotions in excess, improper diet and damages of endogenous etiological factors. 2. Hypertension is the disease of undermining of fundamental aspects while prevailing incidental aspects and liver, heart and kidneys are the organs mainly related to hypertension. 3. The main pathological factors of hypertension are as follows; the disorder of Yin and Yang makes the situation of the deficiency of the vital essence of kidneys and the exuberance of the vital essence of liver and they are the fundamentals to be taken hypertension and finally make the state of the deficiency of both Yin and Yang. 4. In the point of occidental medical view, the essential hypertension is a disease of unknown etiology and we think it occurs not on the only one factor but on the various factors and secondary hypertension occurs from the diseases of the substances and the vessels of kidneys.

폐쇄성수면무호흡증 환자의 하악전방이동장치 적용에 있어서 전방이동량이 미치는 영향

김영균,윤인영,김정훈,이철희,윤필영,Kim, Young-Kyun,Yoon, In-Young,Kim, Jeong-Whun,Lee, Chul-Hee,Yun, Pil-Young 대한수면의학회 2011 수면·정신생리 Vol.18 No.1

목 적: 본 연구의 목적은 폐쇄성수면무호흡증으로 하악 전방이동장치 치료를 시행한 환자들에게 하악전방이동장치의 유용성을 확인하고, 하악전방이동창치 치료시 하악의 전방이동량이 미치는 영향을 평가하고자 하였다. 방 법: 2007년 1월부터 2009년 2월까지 코골이 및 수면무호흡을 주소로 분당서울대학교병원에 내원하여 야간수면다원검사를 통해 폐쇄성수면무호흡증으로 진단받은 환자 중에서, 치료법으로 하악전방이동장치를 선택한 총 86명의 환자를 후향적으로 평가하였다. 임상기록과 수면다원검사를 포함한 모든 환자의 자료를 검토 및 분석하였다. 결 과: 총 86명의 환자 중 65명(75.6%)에게서 성공적인 결과를 얻었다. 경과관찰 기간 중에 28명의 환자에게서 경미한 전치부와 턱관절의 불편감이 보고되었으며, 특히 하악의 전방이동량에 따른 불편감은 7.0 mm 이상의 환자에게서 두드러지게 보고되었다. 하악의 전방이동량과 임상 결과와는 직접적인 관련은 없었다. 결 론: 중증도와 상관없이 하악전방이동장치는 폐쇄성 수면무호흡증 환자의 효과적인 치료방법의 하나로 선택될 수 있다. 잠재적인 치과적인 부작용을 방지하기 위하여 하악전방이동장치의 치료시에 하악의 전방이동량을 우선적으로 고려하여야 할 것이다.

웹 기반 리포팅 시스템 구현

김영균,Kim, Young-Kyun 한국컴퓨터산업학회 2006 컴퓨터産業敎育學會論文誌 Vol.7 No.5

This paper describes how to implement reporting system for web-based information system. Reporting system is the S/W module that user is able to produce output of data in formal format. In Client/Server system, remote user can make formal output with client-side reporting component module. This client reporting component is usually system dependent. With web based information system, intranet, evolving, this client/server system need to he migrated to web-based reporting system. Reporting system component support multi-processing and real-time text/graphic output of server data. Ant Client can save or pint web page of client module. Especially, for real test its function and user interface, this reporting component is adopted in real network management system. The result shows that this reporting system component is very smart and excellent for real time web based monitoring system.

[아시테지 겨울 축제] 아시테지가 변해야 한국 아동ㆍ청소년 연극이 변한다

김영균 공연과이론을위한모임 2011 공연과 이론 Vol.- No.41