한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

고속도로 IC 및 JCT 주변 유휴부지의 물류시설 활용가능성 분석 : 수도권 및 지방광역시를 중심으로

양현지(Yang, Hyun-Ji),최재성(Choi, Jae-Sung) 한국물류학회 2021 물류학회지 Vol.31 No.2

최근 코로나 19 등의 감염병으로 인한 비대면 활동 증가로 인터넷, 모바일 등을 통한 이커머스 택배 이용건수가 증가하며 택배업체 등의 물류시설 부지 확보 수요가 점점 증가하는 추세이다. 업체별로 필요한 부지를 연도별 임계치 수준에서 수급하며 적게는1천 평에서 많게는 1만 평 이상의 부지가 추가적으로 필요하므로 부족한 부지를 현재와 같이 부동산업체 등을 통해 사적영역에서확보하는 것은 지속가능성의 한계에 직면할 것으로 보인다. 본 연구에서는 수도권(서울, 인천, 경기도) 및 지방광역시(대전, 대구, 광주, 울산, 부산)를 중심으로 공공 부문의 도시계획시설 측면에서 가장 넓은 유휴부지의 확보가 가능한 고속도로 IC/JCT 교통광장 유휴부지의 부지현황⋅활용가능성을 분석하였다. 분석방법 및 내용으로 다음 카카오맵의 로드뷰, 스카이뷰 등을 활용해 연구대상지의 유휴부지를 전수조사 후 사업지 내 이면도로 등의 존재 유무에 따라 단기 및 중⋅장기적 사업 우선순위화 분류, 국가물류통합정보센터 내 물류단지 건립계획을 이용해 택배업체의 허브 및 서브터미널 건설 시 예상 사업비 분석, 한국은행의 산업연관표를 적용해 경제적 파급효과 등의 결과를 도출하였다. 도출된 유휴부지를 택배업체 등에서 활용하기 위해서는 IC/JCT 교통광장대부분의 지역이 현재 ｢국토계획법 시행령 제71조｣에 의해 생산⋅자연녹지 용도지역인 상황을 고려하면 ｢건축법 시행령 별표1｣ 의 ‘18.창고시설 중 물류터미널’을 추가하는 방안, ｢도로법｣내 교통광장의 설치 및 관리에 관한 규정을 신설하거나 박성중 의원등 10인이 제안하여 위원회 심사 중인 ｢도로공간의 입체개발에 관한 법률안｣의 본회의 통과를 통한 입법화를 완료해 법적 근거마련이 필요한 상황으로 보인다. 향후 법제도 개선을 통해 고속도로 IC/JCT의 유휴부지(총 183만평-수도권 140만평, 지방광역시43만평) 중 수도권은 약 12%, 지방광역시는 약 10% 정도만이라도 활용 가능하다면‘19년 한국통합물류협회의 18개 택배사업자가제시한 물류시설 구축을 위한 유휴부지 마련 수요를 충족시켜 부지확보의 어려움이 일정 부분 해소될 수 있을 것으로 추정한다. As contact-free activities have increased due to infectious diseases such as COVID-19, the number of delivery-related services has also increased through the rise of e-commerce. As such, the demand for securing sites for logistics facilities is rising as well. Each delivery company keeps supply and demand in balance at the annual threshold level, which means that they require additional land ranging from 3,300m2 (1,000 pyeong) to as much as 33,000m2 (10,000 pyeong). However, it is unreasonable to continuously secure land to meet demands from private areas through real estate companies, as is the current standard procedure done by delivery companies. This study analyzes the feasibility of securing unused land in its current state, focusing on unused sites in expressways IC/JCT, where the widest unused land, in terms of urban planning facilities can be found, mainly in the capital region (Seoul, Incheon, Gyeonggi-do) and provincial metropolitan cities (Daejeon, Daegu, Gwangju, Ulsan, Busan). Full-scale inspection of unused land near expressways is first conducted using Kakao Map’s Road View and Sky View, and the results, such as short-term or mid to long term business priorities, are derived depending on whether backside roads exist or not. Estimated business expenses are calculated using information of logistics center from the National Logistics Integrated Information Center, and economic effects of building hubs and sub-terminals for delivery companies in the unused land are also drawn, applying the Leontief input-output table from the Bank of Korea. Most unused land such as those surrounding roundabouts near expressways IC/JCT is considered as productive green areas and natural green areas in accordance with Article 71 of ｢Enforcement Decree of the National Land Planning and Utilization Act｣, so clause 18, which states “logistics terminal amongst storage facility field”, of schedule 1 in ｢Enforcement Decree of Building Act｣ should be added to the Article to loosen restriction on construction in areas surrounding roundabouts. Also, regulations on the installation and management of roundabouts in the ｢Road Act｣ should be established to allow delivery company to utilize the unused land derived through this analysis. Preparation of a legal basis is deemed necessary by passing legislation through the plenary session for ｢The Bill on the Development of Three-dimensional Road Space｣ under examination made by 10 lawmakers, including Park Sung-joong. If approximately 12% of the total unused land in expressways IC/JCT in the capital region and approximately 10% in provincial metropolitan cities are made available by improving the legal system in the future, demand of 18 delivery companies from Korea Logistics Association will be met. Through this, it is estimated that the difficulty of securing sites for logistics facility construction would be partially resolved.

녹동균 세포외막 단백질 백신 CFC-1-101의 안정성 및 면역원성 검토 : 임상 제 Ⅰ/Ⅱa상 시험

장인진,김익상,유경상,임동석,김형기,신상구,장우현,박완제,이나경,정상보,안동호,조양제,안보영,이윤하,김영지,남성우,김현수 대한감염학회 1998 감염 Vol.30 No.3

목적 : 제일제당에서는 녹농균의 세포외막 단밸질을 유효성분으로 하는 백신인 CFC-101을 개발하였으며, 동물시험에서 이 백신의 안전성과 유효성을 입증하였다. 본 연구에서는 이 녹농균 백신의 인체에 대한 안전성과 면역원성을 평가하는 동시에 인체 접종시의 최적 투여 용량을 결정하기 위하여 제 I/Ⅱa상 임상시험을 수행하였다. 방법 : 건강한 성인 남자를 피험자로 선별하여 각 용량군에 백신투여자 6명, 위약투여자 2명을 배정하였다. 백신 투여군은 0.25mg, 0.5mg 또는 1.0mg 용량의 녹농균 백신을 7일 간격으로 3회에 걸쳐 근육주사 하였으며, 위약 투여군에게는 세포외막 단백질을 제외한 동일한 성분을 투여하였다. 백신접종 후 국소적 또는 전신적인 반응의 발생여부를 관찰하고, 혈액시료를 체취하여 백신의 역가와 유효성을 검정하였다. 결과 : 녹농균 백신 CFC-101은 모든 접종자에서 양호한 내약성을 보였다. 또한 0.5mg 과 1.0mg 백신 투여군에서는 100%의 항체양전율을 나타내었다. 생성된 항체는 녹농균 세포외막단백질에 특이성을 보였고, 녹농균 감염에 대해 방어효능이 있었다. 결론 : 이와같은 결과로부터 이 녹농균 백신은 인체에 안전하게 투여할 수 있으며, 높은 항체 생성능으로 감염방어 효능을 보이고 0.5mg과 1.0mg이 최적용량인 것으로 판단되었다. Background : We developed a Pseudomonas aeruginosa outer membrane protein(OMP) vaccine CFC-101, and the prophylactic efficacy of which has been demonstrated in animal models. In order to evaluate the safety and immunogenicity of the P. aeruginosa vaccine, we carried out a phase I/Ⅱa clinical trial in healthy male volunteers. Methods : Groups of eight volunteers, including two placebo subjects, were vaccinated intramuscularly with three doses of 0.25, 0.5 or 1.0 mg of the vaccine at one week intervals. Sings of systemic and local reactions observed after vaccination were recorded for each vaccinee for 5 days. Physical examinations were performed on days 0, 1, 7, 8, 14, 15, 21, and 42, and clinical laboratory tests were done on days 0, 3, and 21. Blood samples for assay of serum antibody levels were obtained up to 42 days after the first vaccination. Results : The vaccine was generally well tolerated by all vaccinees, showing no significant side effects. In the three dosage groups, all vaccinees, except one receiving the 0.25 mg dose, showed significant elevation in serum IgG antibody titers against the vaccine proteins, indicating 100% seroconversion in 0.5 and 1.0 mg groups. The human antibodies induced by the vaccine were specific for P. aeruginosa OMPs, as confirmed by western blot analysis and immunoprecipitation assays. The capacity of the human antisera to enhance opsonophagocytic killing activity by polymorphonuclear leukocytes and to confer protection against P. aeruginosa infections indicates that the antibodies elicited by the vaccine have protective efficacy. Conclusion : We conclude that the P. aeruginosa OMP vaccine is safe and effective for human use and its optimal dose to be 0.5 or 1.0 mg.

췌장염에 의한 가성낭종내에 생긴 가성동맥류 : 1례 보고

오연희,이채경,김승현,이성우,양창현,이정호,이영현 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

만성 췌장염의 합병증으로 생긴 가성동맥류는 드문질환으로, 반복적으로 다량의 출혈을 일으킬 수 있으며, 치료를 하지 않을 경우 사망율이 높기 때문에, 조기 진단과 치료가 필수적이다. 저자들은 38세 남자 환자에서 췌장염의 합병증으로 생긴 가성낭종내에서 발생한 가성동맥류 1예를 경험하였기에 보고하는 바이다. 가성 동맥류의 색혈류도플러상 낭종내에 양방향 흐름의 와류를 볼 수 있었다. Pancreatic Pseudoaneurysm within Pseudocyst from Pancreatitis: 1 Case Department of Diagnostic Radiology and Internal Medicine, College of Medicine,DongGuk University Yeon Hee OH M.D., Chae Kyeong Lee M.D., Seoung Hyeon Kim M.D., Sung Woo Lee M.D., Chang Heon Yang M.D., Jung Ho Lee M.D., Young Hyun Lee M.D. Pseudoaneurysm from pancreatitis is uncommon, but it can cause recurrent and massive hemorrhage. Because of high morbidity and mortality, early detection and treatment of the pseudoaneurysm is needed. We report a case of pseudoaneurysm within pseudocyst from pancreatitis. Color-flow Doppler sonography shows bidirectional flow and turbulent arterial flow, within anechoic mass.

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

다발성 내분비병증을 보이는 다중심성 Castleman씨병

양성현,김흥태 단국대학교 2000 論文集 Vol.35 No.-

Castleman's disease, giant lymph node hyperplasia, is rate disease that is subdivided into hyaline-vascular and plasma cell histopathological patterns, with intermediate variants. Hyaline-vascular type is asymptomatic and usually detected on chest X-ray as an incidental finding. On a single involvement, it is curable with excision. Plasma cell type involves lymph nodes separately or in aggregations and often displays multicentricity with systemic symptoms including autoimmune phenomena and aggressive course. Infections are the most frequent causes of patient demise in these cases, followed by malignancies such as Kaposi's sarcoma , malignant lymphoma or epithelial neoplasia. The frequent concomitance of the hyaline-vascular and plasma cell types at separate sites, together with transient morphological patterns from one type to the other and from the localized to multicentric form during the course of the disease. The responses to treatment were variable. More effective therapy for multicentric type needs to be developed. We report a case of case of multicentric Castleman's disease with multiple systemic abnormalities.

1-Di-butylaminonaphthalene-5-Sulfonyl Chloride와 Pyridine 置換體와의 反應

成大東,李鍾八,朴現錫,金良姬 東亞大學校 大學院 1989 大學院論文集 Vol.14 No.-

Nucleophilic substitution reaction of bansyl chloride with mathyl substituted pyridines have been studied kinetically at 0℃ in methanol-acetonitrile binary solvent mixtures. The order of magnitude of reactivity is γ-picoline>β-picoline>pyridine to react with bansyl chloride. The Bronsted βand Hammett ??values indicated that the bond formation is advanced more than the bond breaking at the transition state. The reactivity of nucleophiles is in accord with charge controlled and the reactivity of substrate has shown an orbital controlled reaction.

인체 유방암종에서 Cyclic-Dependent Kinase Inhibitor, p27^Kip1 발현의 의의

송상용,김덕환,서연림,고영혜,김대식,남석진,양정현 대한병리학회 1998 Journal of Pathology and Translational Medicine Vol.32 No.12

산문의 중첩과 불전의 분화 과정을 중심으로 본 사찰 배치 변천 연구

양상현 순천향대학교 부설 산업기술연구소 2001 순천향 산업기술연구소논문집 Vol.7 No.1

Entering the times of Chosun dynasty, the regulated layout of temples shifts from that in the age of the three empires to the era of unified Shilla, which was centered on stupa and the main pavilion. The new compositional method concerned the system of superimposed gates and the division on pavilions.

성인 막성신병증의 임상적 고찰

양종오,이상주,박기현,장윤경,이강욱,서광선,신영태 충남대학교 의학연구소 2001 충남의대잡지 Vol.28 No.2

Membranous nephropathy (MN) is a glomerular disease characterized by diffuse thickening of the glomerular basement membrane without significant mesangial proliferative change and is usually manifested by the nephrotic syndrome. To evaluate the clinical and pathologic characteristics of this disease in adults, we analyzed 65 patients with primary membranous nephropathy who were diagnosed at Department of Internal Medicine, Chungnam National University Hospital from February 1986 to February 2001. The results are as follows: 1) Of total 96 patients with membranous nephropathy, 67.7% was primary MN. Hepatitis B-associated MN and lupus MN were 22.9%, and 9.4%, respectively. Median duration of follow-up was 35.1 months(0.3∼177) in primary MN, 49.6 months(2.5∼103) in lupus MN, and 35.6 months(0.5∼108) in hepatitis B-associated MN. 2) Mean age of the patients with primary MN at the time of diagnosis(43.3 years) was significantly higher than that of lupus MN(30.4 years) and HBV-associated MN(36.2 years). Male to female ratio of primary MN was 1.03:l. 3) At the time of diagnosis, 89.2% of primary MN was presented with nephrotic syndrome. Twenty seven percent of patients showed hypertension. Hematuria was found in 58.5% of primary MN patients. Azotemia was noted in 3.1 %. 4) Global sclerosis, tubular atrophy and interstitial fibrosis were noted in 39.8, 16.1 and 11.3% of primaty MN, respectively. IgG and C3 were deposited on the glomerular capillary loop in 92.7% and 29% of primary MN patients. There was no significant correlation between the electron microscopic pathologic stage and clinical findings. 5) Of 56 patients with primary MN followed more than 6 months, 50(90.9%) patients were treated with prednisolone, cyclophosphamide or cyclosporin. Complete remission was obtained in 29 patients(51.8%), partial remission in 6 patients(10.7%), and no response in 18 patients(32.1%). Of 6 patients who were not treated with immunosuppressive drugs, 3 patients showed spontaneous complete or partial remission. Three patients who did not show clinical improvement progressed to end-stage renal failure. There were no significant clinical difference including renal pathology at the time of diagnosis between the patients who showed complete or partial remission and patients who did not. In conclusion, it was difficult to predict the long-term prognosis of primary MN at the time of diagnosis, clinically. The response to therapeutic modality would be the most important to predict long-term prognosis of primary MN.