Intestinal Behçet’s Disease: A True Inflammatory Bowel Disease or Merely an Intestinal Complication of Systemic Vasculitis?

김덕환,천재희 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.1

Behçet’s disease (BD) is a multi-systemic inflammatory disorder of an unknown etiology and shows a chronic recurrent clinicalcourse. When the disease involves the alimentary tract, it is called intestinal BD because of its clinical importance. Intestinal BD ismore frequently reported in East Asian countries than in Western or Middle Eastern countries. While any part of the gastrointestinaltract can be involved, the most common location of intestinal BD is the ileocecal area. A few, large, deep ulcerations with discreteborder are characteristic endoscopic findings of intestinal BD. Currently, there is no single gold standard test or pathognomonicfinding of intestinal BD. However, recently developed novel diagnostic criteria and a disease activity index have helped inassessing intestinal BD. As intestinal BD shares a lot of characteristics with inflammatory bowel disease, including genetic background,clinical manifestations, and therapeutic strategies, distinguishing between the two diseases in clinical practice is quitedifficult. However, biologic agents such as anti-tumor necrosis factor α antibody shows a considerable efficacy similar to inflammatorybowel disease cases. It is important to distinguish and treat those two disease entities separately from the standpoint ofprecise medicine. Clinicians should require comprehensive knowledge regarding the similarities and differences between intestinalBD and inflammatory bowel disease for making an accurate clinical decision.

Pathogenesis of Inflammatory Bowel Disease and Recent Advances in Biologic Therapies

김덕환,천재희 대한면역학회 2017 Immune Network Vol.17 No.1

Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disorder with an unknown etiology. IBD is composed of two different disease entities: Crohn’s disease (CD) and ulcerative colitis (UC). IBD has been thought to be idiopathic but has two main attributable causes that include genetic and environmental factors. The gastrointestinal tract in which this disease occurs is central to the immune system, and the innate and the adaptive immune systems are balanced in complex interactions with intestinal microbes under homeostatic conditions. However, in IBD, this homeostasis is disrupted and uncontrolled intestinal inflammation is perpetuated. Recently, the pathogenesis of IBD has become better understood owing to advances in genetic and immunologic technology. Moreover, new therapeutic strategies are now being implemented that accurately target the pathogenesis of IBD. Beyond conventional immunesuppressive therapy, the development of biological agents that target specific disease mechanisms has resulted in more frequent and deeper remission in IBD patients, with mucosal healing as a treatment goal of therapy. Future novel biologics should overcome the limitations of current therapies and ensure that individual patients can be treated with optimal drugs that are safe and precisely target IBD.

한 줌의 재로 사라져 버린 로또의 꿈

김덕환 한국화재조사학회 2018 한국화재조사학회 학술대회 Vol.2018 No.11

Real-Time Locomotion Mode Recognition Employing Correlation Feature Analysis Using EMG Pattern

김덕환,조치영,류재환 한국전자통신연구원 2014 ETRI Journal Vol.36 No.1

This paper presents a new locomotion mode recognitionmethod based on a transformed correlation featureanalysis using an electromyography (EMG) pattern. Eachmovement is recognized using six weighted subcorrelationfilters, which are applied to the correlation feature analysisthrough the use of six time-domain features. The proposedmethod has a high recognition rate because it reflects theimportance of the different features according to themovements and thereby enables one to recognize real-timeEMG patterns, owing to the rapid execution of thecorrelation feature analysis. The experiment results showthat the discriminating power of the proposed method is85.89% ( ± 2.5) when walking on a level surface, 96.47%( ± 0.9) when going up stairs, and 96.37% ( ± 1.3) whengoing down stairs for given normal movement data. Thismakes its accuracy and stability better than that found forthe principal component analysis and linear discriminantanalysis methods

천궁밭 발생잡초 및 군락특성

김덕환,박재만,강상모,이석민,서창우,이인용,이인중 한국잔디학회 2015 Weed & Turfgrass Science Vol.4 No.4

The present research was carried out in order to investigate the occurrence of problematic weed species in Cnidium officinale Makino. Field in South Korea. Total 53 sites of the 3 different regions in S. Korea were investigated from May to October, 2014. In Cnidium officinale fields, the identified weeds were distributed in 35 families and 99 species. Total 5 communities that consist of Commelina communis, Eleocharis kuroguwai, Persicaria vulgaris, Chenopodium album-Acalypha australis, and Galinsoga ciliata dominated the appearance. The weeds occurred in Cnidium officinale fields were divided into three groups in principal component plot analysis (PCA). It was observed that in control weeds plots; 20 plants of Cnidium officinale fresh weight is 739.9 g while the uncontrolled plots have no Cnidium officinale plants. The current investigation could be useful for estimation of future weeds occurrence, weed flora dynamics and establishment of weed control methods in Cnidium officinale fields in Korea. 천궁밭에 발생하는 잡초와 군락의 유형을 분석하여 천궁밭 잡초방제을 위한 기초자료로 활용하기 위하여 2014년 5 월부터 10월까지 총 6회에 걸쳐 잡초조사를 실시하였다. 천궁밭에는 총 35과 99종이 출현하였고, 일년생잡초는 55종, 다년생잡초는 44종으로 분류되었다. 식물사회학적 군락분석에 의한 결과, 닭의장풀, 털별꽃아재비, 봄여뀌, 올방개, 명아주-깨풀이 우점하여 군락의 형태를 보였다. 또한 PCA plot 분석결과 식물사회학적 군락분석과 유사하게 올방개, 명아주-깨풀, 봄여뀌, 닭의장풀, 털별꽃아재비가 군락으로유형화되었으며, 잡초무방제구의 천궁 생산이 전혀 없을정도로 잡초에 대한 천궁의 피해가 심각하였다. 천궁은 8 월 이전 지상부 생육이 왕성해지기 전까지 집중적인 잡초관리가 이루어져야 하며, 흑색멀칭을 하지 않는 헛골에 발생되는 잡초에 대한 초기방제 체계를 마련해야 할 것으로판단된다.

연구품질 향상을 위한 연구기록물 관리 및 효과성 분석 사례

김덕환 한국경영과학회 2016 한국경영과학회 학술대회논문집 Vol.2016 No.4

B.7.5 : 연구개발 품질보증을 위한 핵심연구품질요소 도출

김덕환,지두환,최상진 한국품질경영학회 2013 한국품질경영학회 학술대회 Vol.2013 No.2

Nutritional issues in patients with cancer

김덕환 대한장연구학회 2019 Intestinal Research Vol.17 No.4

Cancer is a catabolic inflammatory disease that causes patients to often experience weight loss, or even cachexia in severe cases. Undernourishment in patients with cancer impairs the quality of life and therapeutic response, further leading to poor prognosis. Active and frequent nutritional screening and assessment using valid tools are important for fast and appropriate nutritional intervention. Additionally, a suitable individualized nutritional intervention strategy should be established based on the nutritional assessment result. In general, nutritional intervention begins with nutritional counseling of patients diagnosed with cancer, and a well­planned nutritional counseling improves the treatment adherence and nutritional status. When planning nutritional supplementation for cancer patients, specific nutrients, including amino acids and fatty acids, should be considered. However, there has been no consistent result showing that any particular nutrient significantly improves the prognosis of cancer patients. Hence, continuous attention from clinical physicians is needed to plan nutritional improvement in patients with cancer.

Support Vector Machine Learning for Region-Based Image Retrieval with Relevance Feedback

김덕환,Jae-Won Song,Ju-Hong Lee,Bum-Ghi Choi 한국전자통신연구원 2007 ETRI Journal Vol.29 No.5

We present a relevance feedback approach based on multi-class support vector machine (SVM) learning and cluster-merging which can significantly improve the retrieval performance in region-based image retrieval. Semantically relevant images may exhibit various visual characteristics and may be scattered in several classes in the feature space due to the semantic gap between low-level features and high-level semantics in the user's mind. To find the semantic classes through relevance feedback, the proposed method reduces the burden of completely re-clustering the classes at iterations and classifies multiple classes. Experimental results show that the proposed method is more effective and efficient than the two-class SVM and multi-class relevance feedback methods.

Prediction and Prevention of Postpolypectomy Bleeding: Necessity of a Different Approach for Patients Using Antithrombotic Agents

김덕환 대한소화기내시경학회 2017 Clinical Endoscopy Vol.50 No.3

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