선박용 유배출 감시 장치(ODME)를 위한 유분 농도계 설계

손교훈,이승희,김재형 國立 昌原大學校 産業技術硏究所 1998 産技硏論文集 Vol.12 No.-

본 논문에서는 태형 탱커선의 의무 장비인 유배출 감시 장비 (Oil Discharge Monitoring Equipment)를 위한 유분 농도계의 설계에 대하여 연구하였다. ODME는 국제해사기구(IMO)에서 규정된 ton 이상의 대형 선박에 의무적으로 설치하도록 규정하고 있으며 이는 날로 심각해지는 해양 오염을 방지하는데 목적이 있다. ODME의 구성요소 중 가장 중요한 것은 유분 농도계이며 이는 선박에서 배출되는 물에 포함된 유 성분을 ppm 단위로 계측하는 것이다. 본 연구에서는 선박에서 사용이 용이한 산란방식의 유분 농도계의 설게에 대한 농도 계산 알고리즘에 대하여 고찰하였으며 0~100ppm 범위에서 ±5%의 오차 이내로 측정이 가능함을 보였다. 이는 IMO의 규격에 만족하는 수치이다.

유화확산법을 위한 유화제로서의 수용성 mPEG-PLGA 공중합체의 사용

한승훈,손서연,김중현 한국공업화학회 2004 응용화학 Vol.8 No.1

Drug carrier formed by a poly(ethylene glycole) (PEG) corona, sterically protects the carrier, avoids their interaction with plasma proteins and phagocytic cells, and thus significantly increase the circulatory blood half-lives of these carrier. Poly(D,L-lactide-co-glycolide) (PLGA) is biodegradable and biocompatible. Non-biodegradable surfactant, such as poly(vinyl alcohol) (PVA), remains in the final composition of the particles. Residual PVA amounts as high as 52%. BiodegradableSurfactant would replace the commonly non-bidoegradable surfactant. In this study, PEG-PLGA di/block copolymer with different HLB was synthesized by ring-opening polymerization. CMC was determined by surface0tension meter. Drug loaded nanoparticles were prepared by emulsification0diffusion method. The size and zeta potentialof the nanoparticles were determined using photo correlation spectroscopy (PCS) and microelectrophoresis.

한국어판 정신분열병 삶의 질 척도의 개발과 PANSS와의 관련성

김진훈,임선진,민성길,김승업,손소정,Diane J Wild,박성혁,이황빈 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.5

Objectives : The present study was performed to verify the validity and value of 4th revision of Schizophrenia Quality of Life Scale (SQLS-R4) as an assessment tool in a Korean-language version (SQLS-R4K). Methods : The subjects for present study were 174 patients with a diagnosis of schizophrenia as defined by DSM-IV. The SQLS-R4K was administered together with self-report Korean version of World Health Organization Quality of Life-Brief Scale(WHOQOL-BREF) to assess validity. A subset of respondents also completed the SQLS-R4K for a second time to assess test-retest reliability. To evaluate the relationship SQLS-R4K and clinical characteristics, psychotic symptoms and general functioning were evaluated using the Positive and Negative Syndrome Scale (PANSS) and the Global Assessment of Functioning Scale (GAF) score respectively. Results : All the scales of SQLS-R4K showed good internal consistency reliability. The correlations of items with their scale total revealed that all items were significantly correlated with their own scale score. In test-retest reliability, paired t-tests indicated that responses did not alter significantly between the two assessment. There was moderate correlation between WHOQOL-BREF sub-scores and SQLS-R4K score total. Also relevant correlations between PANSS, current GAF and SQLS-R4K were proved. Conclusion : From the results of the testing the reliability and validity of the SQLS-R4K, it is concluded that the SQLS-R4K is a simple and reliable scale for measuring quality of life in schizophrenic patients.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

Influence of tree thinning on the abundance of mammals in a Japanese larch Larix kaempferi plantation

Son, Seung-Hun,Hwang, Hyun-Su,Lee, Jae-Kang,Eom, Tae-Kyung,Park, Chan-Ryul,Lee, Eun-Jae,Kang, Jung-Hoon,Rhim, Shin-Jae Taylor Francis 2017 Animal cells and systems Vol.21 No.1

A Pilot Study on Single-dose Toxicity Testing of Scolopendrid Pharmacopuncture in Sprague-Dawley Rats

Son, Ilhong,Lee, Sangmi,Kim, Doho,Jeong, Hohyung,Cho, Seung-Hun,Lee, Eun-Yong,Lee, Seung-Deok,Ahn, Seong-Hun,Kim, Sungchul KOREAN PHARMACOPUNCTURE INSTITUTE 2014 Journal of pharmacopuncture Vol.17 No.2

Objectives: This study was performed to analyze single dose toxicity and the lethal dose of Scolopendrid Pharmacopuncture in rats. Methods: All experiments were conducted at the Korea Testing & Research Institute (KTR), an institution authorized to perform non-clinical studies, under the regulations of Good Laboratory Practice (GLP). Sprague-Dawley rats were chosen for the pilot study. Doses of Scolopendrid pharmacopuncture, 0.1, 0.5, and 1.0 mL, were administered to the experimental group, and 1.0 mL doses of normal saline solution were administered to the control group. This study was conducted under the approval of the Institutional Animal Ethic Committee. Results: No deaths or abnormalities occurred in any of the groups. No significant changes in the weight, hematological parameters or clinical chemistry were noted between the control group and the experimental group. To check for abnormalities in organs and tissues, we used microscopy to examine representative histological sections of each specified organ; the results showed no significant differences in any of the organs or tissues. Conclusion: The above findings suggest Scolopendrid Pharmacopuncture is a relatively safe to use for treatment. Further studies on the subject should be conducted to yield more concrete evidence.

Influences of Temperature and Humidity on Breeding Ecology of Tits Parus spp. used Artificial Nest Boxes in a Coniferous Forest

Seung-Hun Son(손승훈),Kyu-Jung Kim(김규중),Hyun-Su Hwang(황현수),Shin-Jae Rhim(임신재) 한국조류학회II 2012 한국조류학회지 Vol.19 No.1

This study was conducted to clarify the influences of temperature and humidity on breeding ecology of tits Parus spp. used artificial nest boxes in a coniferous forest from March through July, 2009 and 2010. There were differences in the mean temperatures in March, April, and July between 2009 and 2010. Temperature of early breeding season was higher in 2009 than in 2010. Relative humidity was not significantly different between 2009 and 2010. In our study, varied tit Parus varius, marsh tit P. palustris, coal tit P. ater, and great tit P. major bred in the artificial nest boxes at the study area. The number of used artificial nest boxes, rate of used artificial nest boxes, number of total bred pairs, and rate of breeding success of Parus spp. were higher in 2009 than in 2010. The incubation period and fledging period of P. palustris and P. ater were longer in 2010 than in 2009. The increase of chicks' body weight and tarsus were different between 2009 and 2010. Our results suggest that change in temperature can disrupt breeding phenology of P. palustris and P. ater. Long-term studies provide a unique opportunity to observe how changes of the physical environment (including climate change) affect the biology and ecology of birds at both individual and population levels on long-time scales. 본 연구는 침엽수림에 설치한 인공새집에서 번식을 실시한 박새류의 번식에 기온과 습도가 미치는 영향을 파악하기 위해 2009년과 2010년의 3월부터 7월까지의 기간 동안 실시되었다. 번식기 동안 매달 평균기온은 2009년이 2010년에 비해서 높은 것으로 나타났으며, 습도는 차이가 없었다. 설치한 인공새집에서는 곤줄박이, 쇠박새, 진박새, 박새가 번식을 하였으며, 2009년의 이용된 인공 새집의 수, 인공새집 이용률, 번식쌍수, 번식성공률이 2010년에 비해서 높은 것으로 나타났다. 쇠박새와 진박새의 경우, 포란 기간과 육추 기간이 2009년에 비해 2010년이 길었으며, 새끼와 부척의 성장 역시 다른 것으로 나타났다. 이러한 결과로 보아 번식기 동안의 기온이 박새류의 번식에 영향을 주는 것으로 판단되며, 기후변화를 포함해 환경의 변화가 조류의 번식에 미치는 영향에 대한 장기적인 생태 연구가 수행되어야 할 것이다.

Current status of alert alien species management for the establishment of proactive management systems in Korea

Son, Seung Hun,Jo, A-Ram,Kim, Dong Eon The Ecological Society of Korea 2021 Journal of Ecology and Environment Vol.45 No.1

Background: Some of the introduced alien species introduced settle, multiply, and spread to become invasive alien species (IAS) that threaten biodiversity. To prevent this, Korea and other countries legally designate and manage alien species that pose a risk to the environment. Moreover, 2160 alien species have been introduced in South Korea, of which 1826 animals and 334 plants are designated. The inflow of IAS can have negative effects such as ecosystem disturbance, habitat destruction, economic damage, and health damage to humans. To prevent damage caused by the inflow of IAS in advance, species that could potentially pose a risk to the environment if introduced in South Korea were designated as alert alien species (AAS). Results: The designation criteria were in accordance with the "Act on the Conservation and Use of Biological Diversity" and the "Regulations on the Ecological Risk Assessment of AAS and IAS" by the National Institute of Ecology. The analysis result of risk and damage cases indicated that mammals affect predation, competition, human economic activity, virus infection, and parasite infection. Birds have been demonstrated to affect predation, competition, human economic activity, and health. It was indicated that plants intrude on the ecosystem by competing with native species with their high-population density and capacity to multiply and cause allergic inducement. Interestingly, 300 species, including 25 mammals, 7 birds, 84 fishes, 28 amphibians, 22 reptiles, 1 insect, 32 spiders, 1 mollusk, 1 arthropod, and 99 plants, are included in the list of AAS. Conclusions: AAS designation plays a role in preventing the reduction of biodiversity by IAS in South Korea and preserving native species. Moreover, it is determined to provide considerable economic benefits by preventing socio-economic losses and ecological damage.

조직동일시가 지식공유행동에 미치는 영향 -직업적 자기효능감의 매개효과를 중심으로-

장승훈 ( Seung Hun Jang ),노명화 ( Myung Hwa Roh ),안상철 ( Ang Chul An ),손승연 ( Seung Yeon Son ) 한국인적자원관리학회 2014 인적자원관리연구 Vol.21 No.3

The purpose of this study is to examine influences of organizational identification on employees’ knowledge sharing behavior which is composed of written contribution, organizational communications and personal interactions. And also this study has verified the mediating effect of occupational self-efficacy between organizational identification and knowledge sharing behavior. The samples are obtained from pilots who are serving in ROK Air Force fighter squadrons and analyzed by using AMOS and SPSS program. The results of this study are as follows. First, organizational identification has a positive effect on organizational communications and personal interactions. However, organizational identification does not impact on written contribution. Second, occupational self-efficacy acts as a complete mediator between organizational identification and organizational communications and as a partial mediator between organizational identification and personal interactions. The last part of this study summarizes all the results and provides the contribution and implications of this study. And directions for future studies are discussed.