한의학(韓醫學)의 좌우리론(左右理論)에 관(關)한 고찰(考察)

박승미 ( Seung Mi Park ),박히준 ( Hi Joon Park ),이향숙 ( Hyang Sook Lee ),손양선 ( Yang Sun Son ),임사비나 ( Sabina Lim ),이혜정 ( Hye Jung Lee ) 대한경락경혈학회 2001 Korean Journal of Acupuncture Vol.18 No.1

We could summerize the concept of the right and left mentioned in Nai-Gyung and some literature of oriental medicine as follow At first the right and left is a directional right and left which implys left-liver-right-lung(左肝右肺), left-yang-right-eum(左陽右陰), secondly it is also the road of eumyang which implys man-left-woman-right (男左女右), left-blood-right-ki(左血右氣), left-sinsu-right-myungmon(左腎水右命門), and left-right of pulse. left-liver-right-lung(左肝右肺), left-yang-right-eum(左陽右陰) and man-left-woman-right(男左女右) are expressions of the movement of yang which is a core of chang, at the same time, left-blood-right-ki(左血右氣), left-sinsu-right-myungmon(左腎水右命門), and left-right of pulse are expressions of the eum in response to the movement of yang. (go up and down of water and fire) Finally, both a directional right and left and a road of eumyang mean a road of going up and down of eumyang so, this is very important index in circulation and keeping ballance of eumyang (ki-Hyul: 氣血) in the human body therefore, we can treat a disease with acupuncture in the use of this charater, for example when a disease occurs in the left side, we can treat it with acupuncture in the right side, the same applys to right.

한의학(韓醫學)의 좌우이론(左右理論)에 관(關)한 고찰(考察)

박승미,박히준,이향숙,손양선,임사비나,이혜정,Park Seung-Mi,Park Hi-Joon,Lee Hyang-Sook,Son Yang-Sun,Lim Sa-Bi-Na,Lee Hye-Jung 경락경혈학회 2001 Korean Journal of Acupuncture Vol.18 No.1

We could summerize the concept of the right and left mentioned in Nai-Gyung and some literature of oriental medicine as follow At first the right and left is a directional right and left which implys left-liver-right-lung(左肝右肺), left-yang-right-eum(左陽右陰), secondly it is also the road of eumyang which implys man-left-woman-right(男左女右), left-blood-right-ki(左血右氣), left-sinsu-right-myungmon(左腎水右命門), and left-right of pulse. left-liver-right-lung(左肝右肺), left-yang-right-eum(左陽右陰) and man-left-woman-right(男左女右) are expressions of the movement of yang which is a core of chang, at the same time, left-blood-right-ki(左血右氣), left-sinsu-right-myungmon(左腎水右命門), and left-right of pulse are expressions of the eum in response to the movement of yang. (go up and down of water and fire) Finally, both a directional right and left and a road of eumyang mean a road of going up and down of eumyang so, this is very important index in circulation and keeping ballance of eumyang (ki-Hyul:氣血) in the human body therefore, we can treat a disease with acupuncture in the use of this charater, for example when a disease occurs in the left side, we can treat it with acupuncture in the right side, the same applys to right.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

공동주택수요 예측인자 영향도 분석에 의한 상관인자선정

양승원,박근준 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1

This research describes a interactive process of analysing the demand factors for apartment on Cheonan area. Using subjective statistical data for demand factor the process are categorized into main factors explained for the sensitiveness of correlation coefficient. Consequently, this paper provides useful information about correlationship, but has limit of regional boundary for effectiveness.

천안시 아파트 수요추정 모형구축에 관한 연구

양승원,한용대,박근준 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

This study attempted to address certain elements that are measurable in order forecast the growth demand for apartments in Cheon-An area. A good forecasting method needs to include both regional condition and historical trend-based data. Accordingly, this study was conducted to analyze elements of demands for apartments and develop the model of forecasting demands for apartments by using them. The main conclusions drawn from the analysis of elements related with demands for apartment in Cheon-An area are that the expectation of apartment supplies can be estimated from the model forecasting demands of apartments.

Sol-gel法에 의한 超微細 Co_(0.9)Zn_(0.1)Fe₂O₄粉末의 合成과 磁氣的 特性에 關한 硏究

李承和,梁桂儁,金賢哲 충주대 산업과학기술연구소 2001 産業科學論文集 Vol.9 No.-

Ultrafine Co0.9Zn0.1Fe2O4 particles are fabricated by a sol-gel method. The magnetic and structural properties of powders were investigated by x-ray diffraction, vibrating sample magnetometery and Mo¨ssbauer spectroscopy. Co-Zn ferrite powders that were annealed at and above 673 K have only a single phase spinel structure and behave ferrimagnetically. Powders annealed at 523 K and 573 K have a typical spinel structure and are simultaneously paramagnetic and ferrimagnetic in nature. The magnetic behavior of Co-Zn ferrite powders annealed at and above 573 K shows that an increase of the annealing temperature yields a decrease of the coercivity and an increase of the saturation magnetization. The maximum of the coercivity and the saturation magnetization of Co-Zn ferrite powders are 1328 Oe and 81.1 emu/g, respectively. Mo¨ssbauer spectra of Co-Zn ferrite have been obtained at various temperatures from 20 to 800 K. The isomer shifts indicate that the iron ions were ferric at the tetrahedral [A] and the otahdral [B]. The Ne´el temperature was determined to be TN=790 K. It is found that Debye temperature for A and B sites of the sample annealed at 1,123 K is found to be ΘA=756± 5K and ΘB=199±5K.

Rat의 복강에 삽입한 Fluorouracil-Polyglycolic acid 제형의 Fluorouracil 용출에 관한 연구

노승무,정경수,오정연,김진향,양준묵,강대영,송규상,최정목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

A common form of relapse in adenocarcinoma of the stomach is intraperitoneal dissemination, in fact, among gastric adenocarcinoma patients who have undergone surgery intended to cure, approximately 50% of the patients develope initial recurrence in the peritoneal cavity regardless of the anatomic site of the primary tumor within the stomach. The efficacy of systemic postoperative chemotherapy to prevent peritoneal recurrence of gastrric adcnocarcinoma is not satisfactory. There is still a great need for improved therapeutic strategies on the disseminated microscopic disease and small miliary nodules remaining on the peritoneal surface or lymphatics after operation. The authers have made fluorouracil-polyglycolic acid composite disks(Fu-PGA disks) with fluorouracil and biodegradable polymer: polyglycolic acid for more effective intraperitoneal chemotherapy. We inserted the Fu-PGA disk(s) in the peritoneal cavity of rat and pharmacokinetic study was performed to measure fluorouracil concentration in the peritoneal fluid, plasma, liver, kidney and heart tissue at 24 hour, 72 hour and 168 hour after insertion of Fu-PGA disk(s). Myelosuppressive action of this composite also was determined following its administration. The data of this study suggested that Fu-PGA composite will be a new device releasing drugs in a controlled manner and having targetability to peritoneum, and this device will be improving the efficacy of intraperitoneal chemotherapy for gastric adenocarcinoma.

위선암에서 p53과 P-glycoprotein의 분포에 관한 연구

김대중,김의한,강상균,양승하,민병철 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.1

Gastric adenocarcinoma express many oncogenes, such as p53, c-erbB, k-sam, etc. The p53 especially acts as tumor suppressor in normal tissue and various mutational changes. of p53 are known as doing important role in carcinogenesis of gastric adenocarcinoma. P-glycoprotein, as a pleotrophic membrane transport protein, shows specific distribution in many normal tissues and malignant tumors. This protein, produced by MDR gene, shows multidrug resistance to anticancer drug by pumping out intracellular drug. resulting in resistance to chemotherapeutics. The expression of p53 and P-glycoprotein according to clincopathologic findings in gastric adenocarcinoma has been studied, even though their results are controversial. To observe the relationship between both antigens and clinicopathologic findings of gastric adenocarcinoma. we were analysesed 40 cases gastric adenocarcinoma then processed for immunohistochemical stain by SLAB method using p53 and JSB-1 monoclonal antibodies. The results were as followings: 1) The p53 and P-glycoprotein showed positive in 20 cases(50%) and 21 cases(52.5%) of 40 cases respectively, and 10 cases(25%) showed positive reaction to both antigens. 2) p53 revealed higher positive rate in intestinal type(54.6%), differentiated form(57.1%), advanced form(58.1%) compared to diffuse type(28.6%), poorly differentiated form(42.1%), early cancer(22.2%), but no difference according to age, sex, lymphatic metastasis and signet ring cell within tumor. 3) P-glycoprotein revealed higher positive rate in interstinal type(54.6%), differentiated form(61.9%), advanced form(58.1%), absence of signet ring cell (63.3%) compared to diffuse type (28.6%), poorly differentiated form (36.8%), early cancer(33.3%), presence of signet ring cell(20.0%), but no difference according to sex, age, lymphatic metastasis. 4) Positive rate in intestinal type, differentiated form, advanced form, and presence of signet ring cells in gastric adenocarcinoma showing both positive reaction of p53 and P-glycoprotein, are higher, but no difference according to age, sex, lymphatic metastasis. 5) In noneoplastic mucosa adjacent to cancer, p53 revealed negative reaction in all cases. P-glycoprotein showed positive reaction in all metaplastic glands 33 cases and parietal cells 17 cases, and in 16 cases(40%) of 40 cases of luminal surface and gastric glandular epthelium, and showed negative reaction in all 12 cases of chief cell. Above results revealed that positive rates of p53 and P-glycoprotein in gastric adenocarcinoma are almost same and there is no relationships between both antigens. Both antigens showed simillar high positive rate in intestinal type, differentiated form and advanced form, indicating association with these clinicopathologic findings.

인체에서 방사되는 생물광자(生物光子)에 대한 소고

이승호,김진수,박하준,양준모,소광섭,임사비나 경희대학교 동서의학연구소 2006 東西醫學硏究所 論文集 Vol.2006 No.-

Objectives : The purpose of this study is to review research papers published by Korean research groups on biophoton of human beings based on experiment subject and methodology. Methods : In order to review human biophoton research executed in Korea, all the papers published in Korean and international journals by Korean research groups were selected. Several key foreign papers were also reviewed for clarification of this study. Based on experiment subjects, experiment methodology, and interpretation of experiment results were analyzed. On each experiment, its original interpretation was directly quoted. Issues on the experiment methodology and interpretation were expressed at the end of each subject. Results and Conclusions : We found that experiments on human biophoton were compelling. However it seemed that mom experiments, especially on their sample sizes, ate needed to demonstrate its clinical application. Interpretations based on Korean traditional medicine also need to be elaborated more. In order to do accomplish clinical application of biophoton, interdisciplinary works are required. Some suggestions on biophoton experiments were made.

백서에서 N-dimethylnitrosamine에 의한 간독성 작용에 L-ascorbic Acid가 미치는 영향에 관한 연구

송준민,양승하,변광의,강상균 순천향대학교 1994 논문집 Vol.17 No.2

Toxic effect of NDMA on liver is variable due to dose and duration of administration. Experimental studies showed hemorrhagic necrosis, liver cirrhosis and hepatoma development with NDMA administration. To observe the protective action of L-ascorbic acid on NDMA toxicity of the liver, experimental studies were carried out. Rats were divided into two groups' acute and chronic intoxication. Acute group was divided into three subgroups regarding to dose and duration of NDMA administration, AGI-1(NDMA 40㎎/㎏) and AGI-2(NDMA with L-ascorbic acid 720㎎/㎏), AGII-1(NDMA 20㎎/㎏ for 2 days) and AGII-2(same with AGII-1 with AGII-1 with L-ascorbic acid 360㎎/㎏ for first day, and 10㎎/㎏, 180㎎/㎏ for 2nd and third day). Serological study of liver function and histologic study were carried out 48 hours after NDMA administration. Animal were sacrified on 9th week, then serological and histological studies were carried out. Also ultrastructural observation were performed for the liver tissue. The results were following as : 1. Acute NDMA intoxication group reveals low level of serum protein and albumin while elevation of total bilirubin, alkaline phosphatase and marked elevation of SGOT and SGPT. Histologically, marked hemorrhagic necrosis was noted in the central zone of hepatic lobules. 2. In chronic NDMA intoxication, serological studies showed slight elevation of SGOT and SGPT, and normal levels of total protein, total bilirubin, and ALP. Histologically, swelling of hepatocyte, necrosis of individual cells, enlargement of nucleus with prominent nucleoli were evident. 3. Chronic intoxication of NDMA groups does not showed special difference between NDMA alone and combined L-ascorbic acid administration. 4. Both acute and chronic NDMA intoxication groups showed ultrastructural changes, such as nuclear irregularity, dilatation of cisternae of RER, partially obscured cisternae with increased density of mitochondira, and focal lipid droplet accumulation in the cytoplasm. The above results show that L-ascorbic acid may play a protective role in toxicity of NDMA.