胃의 癌 및 良性 疾患에 있어서 胃粘膜의 細胞學的 診斷

姜大榮 충남대학교 대학원 1976 論文集 Vol.6 No.-

In order to evaluate cytologic diagnosis in benign and malignant lesions in the stomach 91 unfixed gastrectomized specimen were studied, which were submitted to department of pathology, Chungnam National University School of Medicine from January 1975 to September 1975 The cytologic smears were taken from central portions and margins of the ulcer of the lesions, and compared with that of histologic pattern with clinical considerations The results obtained were as follows 1) 91 cases were consisted of 40 carcinomas (44.0%), 39 benign peptic ulcers(42.9%) and 12 gastritis wth other diseases (13.%) 2) Among gastric carcinomas there were noted 4 early gastric cancers originated from primary chronic peptic ulcers, which were not detected clinically 3) Sec distr bution of stomach cancr was 20 malse (65%), and 14 females (35%) having 1 9 ratio Age distribution of stomach cancer was showing the highest in 6th decade, 23 cases (57.5%), 5th decade, 10 cases (25.0%) and more than 80% were noted from 40 year to 60 year-old age groups 4) Sex distribution of chronic peptic ulcer was consisted mainly of male cases showing 37 cases of a total 39 patients (94.9%) Age distribution was the highest in both 4th decade 12 cases (30.8%) and 12 cases(30.8%) in 5th decade 5) The average diameter of malignant ulcers was 3.0-3.9 ㎝ in 14 cases (35.0%), and 6 cases were mort than 5.0㎝ in diameter In benign peptic ulcer mose frequent average size was 1.0-1.9 ㎝ in 16 cases (41.0%)and there was no case meauring over 5.0 ㎝ in diameter 6) The most malignant ulcers were located along the lesser curvature of the antrum in 33 cases (82.5%), and 5 cases (12.5%) were along the greater curvature of the stomach The peptc ulcers also, were located most frequently along the lesser curvature of the antrum in 32 cases (82.1%). 7) Cytologic diagnosis smeared from center and margins of the malignant ulcers was positive in 85%, but that smeared from peripheral portions of the lesion was positive only in 27.5% of cases. 8) The positive diagnosis in well differentiated and moderately differentiated type of the stomach cancer was 100%, and showed one case of pseudonegative in 18 cases of poorly differentiated type 9) The doutful cytological diagnosis in chronic peptic ulcers was 16 cases (41.0%), and those were associated with chronic gastritis or with marked inestinal metaplasia with atypical glandular hyperplasia.

Butylated Hydroxytoluene 투여가 3´-Methyl-4-Dimethylaminoazobenzene으로 유발된 백서 간암 발생과정에 미치는 영향에 대한 연구 (I)

강대영,최정목 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2

A morphologic study on the effect of butylated hydroxytoluene(BHT) on experimental hepatocarcinogenesis induced by 3'-methyl-4-dimethylaminoazobenzene(3'-MeDAB) was investigated. A total of 184 Sprague-Dawley male rats weighing about 200g each were used in the experiment, and divided into 4 groups: the 3'-MeDAB treated group, the 3'-MeDAB+BHT treated group, the BHT treated group, and the contol group. The first and second groups received continuous pelletized feeding containing 0.09% 3'-MeDAB with and without 0.5% BHT, respectively. The third and fourth groups received feeding with and without 0.5% BHT, respectively. Four to eight rats in each group were sacrified on the 4th, 8th, 14th and 16th experimental week. The liver was examined with histochemical and immunohistochemical staining, and by light microscopy. The results were as follows; The following histopathological changes were noted in the 3'-MeDAB administered group: oval cell proliferation, bile ductular proliferation, nodular lesions(vacuolated, eosinophilic, basophilic and mixed), cholangiofibrosis and carcinoma. However, compared with the 3'-MeDAB treated group, the 3'-MeDAB+BHT treated group showed decreased presence of oval cells, bile ductular proliferation, cholangiofibrosis and carcinoma. The histopathologic changes in the BHT treated group were similar to those of the control group. Masson trichrome staining intensity increased over time from the 4th to the 16th week. Strong staining was especially detected at the portal areas and periphery of the proliferated bile ductules in portal areas of the 3'-MeDAB and the 3'-MeDAB+BHT treated groups. The staining intensity of the 3 MeDAB+BHT treated group decreased compared with that of 3'-MeDAB treated group. The expression of GST-P was examined with immunohistochemical staining. In the 3'MeDAB treated group, GST-P positive area was present in the cytoplasm and nuclei of the hepatocytes of the preneoplastic or neoplastic lesions and proliferated bile ductules. Staining intensity increased over time from the 4th to 16th week, Whereas negative staining was seen in the control and BHT groups. But the staining intensity of the 3'-MeDAB+BHT group decreased compared with that of the 3'-MeDAB group. These results suggest that dietary butylated hydroxytoluene has a protective/inhibitive effect on hepatocarcinogensis induced by 3'-methyl-4-dimethylamino-azobenzene.

胃에 發生한 巨大한 平滑筋腫의 1例

姜大榮,金在權,朴成均 충남대학교 의과대학 지역사회의학연구소 1977 충남의대잡지 Vol.4 No.2

Benign tumor of stomach is relatively rare, and leiomyoma is about 26% in all benign tumors of stomach. It's true etiology is unknown, and it is more prevalent in male. Abdominal pain, gastrointestinal bleeding and a palpable mass were the main symptoms and signs. Although incorrect still, radiologic finding was a clue of diagnosis. Recently we have experienced a case of very large smooth muscle tumor. A brief review of literatures and a discussion concerning leiomyoma of stomach are presented in this paper.

睾丸에 原發한 橫紋筋肉腫의 1例

姜大榮,金在權,李泰淑 충남대학교 의과대학 지역사회의학연구소 1977 충남의대잡지 Vol.4 No.2

Rhabdomyosarcoma of testis is a very rare and highly malignant tumor. We have experienced a case of rhabdomy osarcoma originating from the testis of a fifteen year old Korean boy, with the chief complaint of a swollen mass in the scrotum. So we present this case report with the article review.

胃의 癌 및 良性 疾患에 있어서 胃粘膜의 細胞學的 診斷

姜大榮,李泰淑 충남대학교 의과대학 지역사회의학연구소 1976 충남의대잡지 Vol.3 No.1

In order to evaluate cytologic diagnosis in benign and malignant lesions in the stomach, 91 unfixed gastrectomized specimen were studied, which were submitted to department of pathology, Chungnam National University School of Medicine from January 1975 to September 1975. The cytologic smears were taken from central portions and margins of the ulcer of the lesions, and compared with that of histologic pattern, with clinical considerations. The results obtained were as follows: 1) 91 cases were consisted of 40 carcinomas (44.0%), 39 benign peptic ulcers(42.9%) and 12 gastritis with other diseases(13.1%). 2) Among gastric carcinomas there were noted 4 early gastric cancers originated from primary chronic peptic ulcers, which were not detected clinically. 3) Sex distribution of stomach cancer was 20 males(65%), and 14 females (35%) having 1.9:1 ratio. Age distribution of stomach cancer was showing the highest in 6th decade, 23 cases(57.5%), 5th decade, 10 cases (25.0%) and more than 80% were noted from 40 year to 60 year-old age groups. 4) Sex distribution of chronic peptic ulcer was consisted mainly of male cases showing 37 cases of a total 39 patients (94.9%). Age distribution was the highest in both 4th decade 12 cases (30.8%), and 12 cases (30.8%) in 5th decade. 5) The average diameter of malignant ulcers was 3.0∼3.9cm in 14 cases (35.0%), and 6 cases were more than 5.0cm in diameter. In benign peptic ulcer, most frequent average size was 1.0∼1.9cm in 16 cases (41.0%) and there was no case measuring over 5.0cm in diameter. 6) The most malignant ulcers were located along the lesser curvature of the antrum in 33 cases (82.5%), and 5 cases (12.5%) were along the grater curvature of the stomach. The peptic ulcers, also, were located most frequently along the lesser curvature of the antrum in 32 cases (82.1%). 7) Cytologic diagnosis smeared from center and margins of the malignant ulcers was positive in 85%, but that smeared from peripheral portions of the lesion was positive only in 25.5% of cases. 8) The positive diagnosis in well differentiated and moderately differentiated type of the stomach cancer was 100%, and showed one case of pseudonegative in 18 cases of poorly differentiated type. 9) The doutful cytological diagnosis in chronic peptic ulcers was 16 cases (41.0%), and those were associated with chronic gastritis or with marked inestinal metaplasia with atypical glandular hyperlasial.

Dimethylhydrazine의 중독에 의한 만성 간 병변에 대한 연구

강대영 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

In an attempt to elucidate the chronic hepatic lesions induced by 1, 2-dimethylhydrazine (DMH), the present study in male Sprague-Dawley rats was undertaken to evaluate the death rate, the number of dyslastic cells, the average cell and nuclear size, hyperplastic lesion and bile duct changes. Hepatic lesions were induced in male Sprague-Dawley rats with 24 doses DMH 20mg/kg or 40mg/kg administered subcutaneously at the weekly intervals. All animals were sacrified at the 28th week. All organs were examined macroscopically and fixed in 10% buffered formalin. The results were as follows: 1. Dysplastic cells were only present in the DMH treated groups. The number of liver dysplastic cells of the DMH 40mg treated group was 4-7(average 5.2)/HPF, while that of the DMH 20mg treated group was 3-6 (average 4.3)/HPF. 2. The average cell size of the control group was 9.57±1.37mm, while those of the DMH 20mg, 40mg treated groups were 13.45±2.88mm and 17.10±3.18mm, respectively (P<0.001). 3. The average nuclear size of the control group was 4.50±0.52mm, while those of the DMH 20mg, 40mg treated groups were 7.30±0.92mm and 9.31±1.30mm respectively (P<0.001). 4. Bile duct proliferation with cystic dilatation in the DMH 40mg treated group was severe, but that of the DMH 20mg treated group was very mild. 5. Of the DMH induced bowel neoplasms, all (100%) developed colonic tumors. In summary, the result obtained by the present study indicates 1, 2-dimethylhydrazine induces liver cell dysplasia and bile duct proliferation accompanied by intestinal tumorigenesis.

卵巢 畸形腫의 病理組織學的 硏究

姜大榮,姜俊求 충남대학교 의과대학 지역사회의학연구소 1984 충남의대잡지 Vol.11 No.2

For study on cystic teratoma of ovary, the operation specimens were collected at the depatment of pathology, Chungnam National University College of Medicine from July 1975 to June 1984 and analyzed its histopathologic characteristics and clinical features. The results were as follows; 1. The total number of cystic teratorna were 220 cases, which were 105 cases (47. 7%) in the right ovary, 93 cases (42.3%) in the left ovary, and 22 cases (10%) in both ovaries. They occurred almost equally on either side. 2. The age distribution was highest in the third decade, 91 cases (41%). Ninety percent occurred during the reproductive years. 3. The average diameter was 8.7cm. 4. Microscopically ectodermal derivatives were most frequently present, followed by mesodermal structures and endodermal derivatives. 5. Most common complaint was palpable mass (37%), followed by pain. Most frequent complication was torsion, in which 23 cases (10%) were included. Malignant transformation was found in 2 cases (about 1%).

蒸熱, 乾燥에 의한 毛織物의 치수變化에 관한 硏究

姜大榮 단국대학교 대학원 1988 學術論叢 Vol.12 No.-

By steaming and drying the woven wool fabrics of Tropical, Milled geogette, and Gabadine, etc. by means of A.D.C, tester, The relations of time, regain, dimensional change, and steam press were compared and examined. After this experiment, I have come to the conclusion as follows. 1. The change of regain according to that of time ascends rapidly up to five minutes and after the length of time reaches the hear equilibrium condition. 2. Dimensional change according to regain reaches the top and later descends as regain goes by yond 20%. 3. The relation between steam press and temperature regain is not influenced by the amount of steam press. 4. Each time steaming-drying is practised in the given temperature, regain comes to be stable.

식도의 전암성 병변과 암종에서 p53단백 발현에 관한 면역조직화학적 연구

강대영,최정목 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

The immunohistochemical expression of p53 protein was evaluated in formalin fixed, paraffin embedded surgical specimens from 27 patients with esophageal carcinoma. We tested p53 expression in 17 samples of low grade and 24 samples of high grade esophageal dysplasia(ED) coexisting with esophageal cancer(ESC) in 27 patients who underwent partial or total esophagectomy. In the normal mucosa, a positive immunoreaction was detected in 8 of 27 cases, always restricted to the lower half of the esophageal mucosa thickness. We detected p53 positive nuclei in 10 of 17, 17 of 24, and 21 of 27 samples of low grade ED, high-grade ED, and ESC, respectively. Cases exhibiting positive nuclear staining in dysplastic samples also demonstrated positive immunoreaction in the carcinomatous tissue. Immunoreactivity in cancer cells was never found in the absence of positive dysplastic nuclei. A significantly higher score of p53 positive nuclei was detected in high grade dysplasia versus low grade dysplasia, and in low grade dysplastic lesions compared with normal mucosa. These results sugggest that p53 mutation may represent an early event in eso phageal oncogenesis.

乳房 疾患의 病理組織學的 硏究

姜大榮,宋圭祥 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.2

A histopathologic study was made on 844 cases of the breast lesions of female, which were collected, from Jan. 1980 to July 1985, at the Department of Pathology, School of Medicine, Chungnam National University. The results were as follows 1. Among 844 cases of the breast lesions of female the age distribution shows the highest frequency in the third decade(317 cases, 37.6%), followed by the 4th decade(260 cases, 30.8%), the 5th decade(147 cases, 17.4%), the 6th decade(53 cases, 6.3%), and the second decade(42 cases, 5.0%) in decreasing order of frequency. 2. The most: frequent breast lesion was the nonneoplastic lesion(345 cases, 40.9%), followed by benign tumor(326 cases, (38.6%), malignant tumor(130 cases, 15.4%), and inflammatory disease(43 cases, 5.1%). 3. Among inflammatory disease, acute mastitis and abscess was 21 cases and chronic mastitis and plasma cell mastitis was 20 cases. Seventeen cases of inflammatory disease were present in the third decade. 4. The most prevalent nonneoplastic lesion was fibrocystic disease(297 cases, 86.1%), which reveals the highest frequency in the fourth decade(129 cases), followed by third decade(93 cases) and the fifth decade(54 cases). The mean age of fibrocystic disease was 32.9 years. 5. Among benign tumor fibroadenoma was 269 cases (82.5%), intraductal papilloma and lactating adenoma, 17 cases, respectively, lipoma 7 cases, and tubular adenoma, cystosarcoma phyllodes, fibroma, 4 cases, each. The most prevalent age of fibroadenoma was the third decade(the mean age; 27.7 years). 6. Among 130 cases of malignant tumor infiltrating duct carcinoma shows the highe incidence(112 cases, 86.1%), followed by noninfiltrating duct carcinoma 10 cases, lobula carcinoma 4 cases, and sarcoma 3 cases, in decreasing order of frequency. The most frequen subtype of infiltrating duct carcinoma was simple type, followed by scirrhous, medullary, papillary, colloid, and infiltrating comedocarcinoma. The malignant tumor shows highest incidence in the fifth decade and the mean age was 47.6 years.